Read the full article by Dr Benjamin Elias & Dr Anabell Decottignies here
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio
Royal Society of Chemistry
Dr Jin Zhang received her PhD in Chemistry from University of Chicago in 2000. After completing her postdoctoral work in the laboratory of Roger Tsien at UC San Diego, she joined the faculty of Johns Hopkins University School of Medicine in 2003. She was promoted to Professor of Pharmacology, Neuroscience and Chemical and Biomolecular Engineering in 2013. In 2015 she moved back to UC San Diego and is currently Professor and vice Chair in Department of Pharmacology. She is also a member of the Moores Cancer Centre and an Affiliate Professor in Departments of Bioengineering and Chemistry & Biochemistry at UC San Diego. She co-directs the Centre for Cell Signaling San Diego with Dr Alexandra Newton. Research in her lab focuses on developing enabling technologies to probe the active molecules in their native environment and characterizing how these active molecules change in diseases including cancer. Dr Zhang is a recipient of Biophysical Society Margaret Oakley Dayhoff Award (2009), NIH Director’s Pioneer Award (2009), John J. Abel Award in Pharmacology (2012), Pfizer Award in Enzyme Chemistry (2012), NCI Outstanding Investigator Award (2015 and 2022), Novartis Global Scholar Award (2021), Robert R. Ruffolo Career Achievement Award in Pharmacology (2022) and the Protein Society Christian B. Anfinsen Award (2022). She was elected as a Fellow of the American Association for the Advancement of Science (AAAS) in 2014, a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) in 2019 and a Fellow of American Society for Pharmacology and Experimental Therapeutics in 2021 (FASPET). Dr Zhang also received UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2019 and Outstanding Graduate Student Mentoring Award in UC San Diego Jacobs School of Engineering in 2022. Dr Zhang will be receiving the Carolyn Cohen Innovation Award from the Biophysical Society in 2023.
About RSC Chemical Biology
Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.
As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio
Royal Society of Chemistry
RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Medicinal Chemistry Small Molecule Probes’, guest edited by John Spencer (University of Sussex, UK), Gemma Nixon (University of Liverpool, UK), and Miraz Rahman (King’s College London, UK).
Contributions are welcome which investigate general medicinal chemistry, chemical probes for imaging, proteomics, protacs, fragment-based drug discovery, covalent binders, chemical tools for protein profiling and activity modulation, and natural product inspired medicinal chemistry and chemical biology.
The deadline for submissions is 1 June 2023. Submit your work to the collection now!
Promotion of the collection is scheduled for late 2023, with articles published online as soon as they’re accepted.
Authors are welcome to submit original research in the form of a Communication or Full Paper. Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.
Explore all open calls for papers from RSC journals!
About RSC Chemical Biology:
Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.
As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.
We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.
Guest-edited by Chengqi Yi (Peking University, China) and Yan Zhang (Nanjing University, China), this collection highlights work on bio-orthogonal chemistry, reactions and probes in labeling, manipulating, imaging and sequencing of protein, DNA, RNA and bioactive metabolites.
The article line-up is provided below. All articles in RSC Chemical Biology are open access and free to read.
Introduction to ‘Development of bio-orthogonal tools’
Yan Zhang and Chengqi Yi
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90045A
Labeling and sequencing nucleic acid modifications using bio-orthogonal tools
Hui Liu, Yafen Wang and Xiang Zhou
RSC. Chem. Biol., 2022, 3, 994–1007, DOI: 10.1039/D2CB00087C
Imitate to illuminate: labeling of bacterial peptidoglycan with fluorescent and bio-orthogonal stem peptide-mimicking probes
Huibin Lin, Chaoyong Yang and Wei Wang
RSC. Chem. Biol., 2022, 3, 1198–1208, DOI: 10.1039/D2CB00086E
A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications
Benton Swanson, Margaret Durdan, Miranda Eberle, Seth Woodbury, Ava Mauser, Jason Gregory, Boya Zhang, David Niemann, Jacob Herremans, Peter X. Ma, Joerg Lahann, Megan Weivoda, Yuji Mishina and Colin F. Greineder
RSC. Chem. Biol., 2022, 3, 748–764, DOI: 10.1039/D2CB00030J
Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ
Diana Torres-García, Merel A. T. van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G. J. Groenewold, Alexi J. C. Sarris, Luuk Klein, Herman S. Overkleeft and Sander I. van Kasteren
RSC. Chem. Biol., 2022, 3, 1325–1330, DOI: 10.1039/D2CB00120A
We hope you enjoy this new themed collection from RSC Chemical Biology.
RSC Chemical Biology and RSC Medicinal Chemistry are delighted to welcome papers for an online themed collection on ‘Molecular and nanotheranostics’, guest edited by Prof. Thimmaiah Govindaraju (Jawaharlal Nehru Centre for Advanced Scientific Research, India).
Over a decade of intense research has positioned theranostics as a promising and integrated approach to advance biomedical research and medicine. The term theranostics essentially conveys the idea of combining therapeutic and diagnostic modalities to provide a holistic solution for disease management. Theranostics is also referred to as diagnostic therapy, wherein molecular and/or material tools for non-invasive treatment and diagnostic imaging are strategically embedded into a single system. For instance, multifunctional diagnostic platforms carrying therapeutic and target tracking agents offer remedial effects and imaging of markers in tissue or organs, which is used to assess disease staging, treatment planning and therapeutic efficacy.
Theranostics has the potential to revolutionize the practice and adaptation of personalized medicine to tackle chronic disease conditions like cancer and neuronal disorders. Generally, radiopharmaceutical, nano and macromolecular systems armed with tools to detect, treat, track, and image biomolecular targets in real-time have been employed as theranostics to effectively manage disease progression and cure.
In recent years, the field has witnessed the emergence of small molecules or small molecular conjugates as theranostic tools. This special collection in RSC Chemical Biology and RSC Medicinal Chemistry intends to cover and highlight advancements in molecular theranostics with particular emphasis on chemical biology of molecular design of theranostic tools and their selective interaction with the biomolecular targets to image and ameliorate the pathological conditions. This themed collection is anticipated to catalyze the development of precision theranostics as advanced and personalizable tools in chemical biology and modern medicine.
The deadline for submissions has been extended to 30 June 2023.
Articles can be submitted via the appropriate journal’s website, where you can find details on their scopes and focus. RSC Chemical Biology accepts exceptionally significant and breakthrough findings of interest to the chemical biology community, while RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science.
RSC Chemical Biology: rsc.li/rsc-chembio
RSC Medicinal Chemistry: rsc.li/rsc-medchem
Authors are welcome to submit original research in the form of a Communication or Full Paper. Note that RSC Chemical Biology is a gold open access, journal, however submissions for this collection will have their article processing charges (APCs) waived.
When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed. Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.
RSC Chemical Biology is highlighting some upcoming conferences in January 2023 that we think would be of interest to our broad chemical biology readership. We’re sponsoring these conferences and attending one too! Please consider registering!
12-13th Jan 2023
Paris, France
Registration deadline: 31st Oct 2022
Poster abstract deadline: 30th Nov 2022
RSC Chemical Biology will be attending this conference!
13th Jan 2023
Belfast, United Kingdom
Oral/poster abstract deadline: 11th Nov 2022
Registration deadline: 25th Nov 2022
24-25 Jan 2023
Frankfurt, Germany
Poster abstract submission deadline: 31st Oct 2022
Last minute poster deadline: 6th Jan 2022
We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.
Guest-edited by Dennis Bong (Ohio State University), Philipp Holliger (MRC Laboratory of Molecular Biology), and Chaoyong Yang (Xiamen University), this themed collection covers all aspects of modified nucleic acids in chemical and synthetic biology including both in vitro as well as in vivo applications, and new chemistries. Taken together, the papers collected in this themed collection represent the state of the art on XNAs and highlights work at the interface of chemistry and biology.
A selection of the articles has been provided below. All articles in RSC Chemical Biology are open access and free to read.
Introduction to the themed collection on XNA xenonucleic acids
Dennis Bong, Philipp Holliger and Chaoyong Yang
RSC. Chem. Biol., 2022, 3, DOI: 10.1039/D2CB90036J
From polymerase engineering to semi-synthetic life: artificial expansion of the central dogma
Leping Sun, Xingyun Ma, Binliang Zhang, Yanjia Qin, Jiezhao Ma, Yuhui Du and Tingjian Chen
RSC Chem. Biol., 2022, 3, 1173-1197, DOI: 10.1039/D2CB00116K
Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
Chaturong Suparpprom and Tirayut Vilaivan
RSC Chem. Biol., 2022, 3, 648-697, DOI: 10.1039/D2CB00017B
Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues
John R. D. Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger and Alexander I. Taylor
RSC Chem. Biol., 2022, 3, 1209-1215, DOI: 10.1039/D2CB00035K
Dependence of click-SELEX performance on the nature and average number of modified nucleotides
Julia Siegl, Olga Plückthun and Günter Mayer
RSC Chem. Biol., 2022, 3, 288-294, DOI: 10.1039/D2CB00012A
Synthesis and structure–activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown
Enrico Cadoni, Francesca Pennati, Penthip Muangkaew, Joke Elskens, Annemieke Madder and Alex Manicardi
RSC Chem. Biol., 2022, 3, 1129-1143, DOI: 10.1039/D2CB00095D
Stimuli-responsive assembly of bilingual peptide nucleic acids
Hector S. Argueta-Gonzalez, Colin S. Swenson, George Song and Jennifer M. Heemstra
RSC Chem. Biol., 2022, 3, 1035-1043, DOI: 10.1039/D2CB00020B
Mutant polymerases capable of 2′ fluoro-modified nucleic acid synthesis and amplification with improved accuracy
Trevor A. Christensen, Kristi Y. Lee, Simone Z. P. Gottlieb, Mikayla B. Carrier and Aaron M. Leconte
RSC Chem. Biol., 2022, 3, 1044-1051, DOI: 10.1039/D2CB00064D
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Anna Dysko, Ysobel R. Baker, Graham McClorey, Matthew J. A. Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer and Tom Brown
RSC Chem. Biol., 2022, 3, 765-772, DOI: 10.1039/D2CB00100D
Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
Ryosuke Kita, Takashi Osawa and Satoshi Obika
RSC Chem. Biol., 2022, 3, 728-738, DOI: 10.1039/D1CB00240F
A ruthenium–oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser and Marcel Hollenstein
RSC Chem. Biol., 2022, 3, 85-95, DOI: 10.1039/D1CB00146A
Targeting a conserved structural element from the SARS-CoV-2 genome using L-DNA aptamers
Jing Li and Jonathan T. Sczepanski
RSC Chem. Biol., 2022, 3, 79-84, DOI: 10.1039/D1CB00172H
We hope you enjoy this new themed collection from RSC Chemical Biology.
We are delighted to introduce the latest series of Desktop Seminars on the Interface of Chemistry & Biology.
This exciting Series will feature talks from authors and Board Members from across the RSC’s publishing portfolio, including RSC Chemical Biology, RSC Advances, ChemComm, Chemical Science, and Molecular Omics.
Each session will include two talks from a range of international speakers highlighting their research in relation to the interface of chemistry and biology.
RSC Desktop Seminar with ChemComm – Register Here
Join us on Wednesday 26th October 2022, at 15:00 GMT / 10:00 EST
Featuring Prof. Mingxu You, University of Massachusetts Amherst, USA, and Prof. Amanda Hargrove, Duke University, USA
RSC Desktop Seminar with RSC Chemical Biology – Register Here
Join us on Friday 11th November 2022, at 14:00 GMT / 15:00 CET
Featuring Prof. Jennifer Andexer, University of Freiburg, Germany, and Prof. Roderich Suessmuth, TU Berlin, Germany
RSC Desktop Seminar with Chemical Science – Register Here
Join us on Thursday 17th November 2022, at 15:00 GMT / 10:00 EST
Featuring Prof. Gonçalo Bernardes, University of Cambridge, UK, and Prof. Dorothea Fiedler, Research Institute for Molecular Pharmacology (FMP) and Humboldt University of Berlin, Germany
RSC Desktop Seminar with RSC Advances – Register Here
Join us on Thursday 24th November 2022, at 11:00 GMT / 16:30 IST
Featuring Prof. Surajit Ghosh, Indian Institute of Technology Jodhpur, India, and Dr. Christine Beemelmanns, Hans-Knoll Institute, Germany
RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Chemical Biology of Metals’, guest edited by Christopher J. Chang (University of California, Berkeley, USA); Angela Casini (Technical University of Munich, Germany); Hongzhe Sun (University of Hong Kong, China); and Hui Chao (Sun Yat-Sen University, China).
Contributions are welcome which investigate the fundamental inorganic chemistry of life and/or use inorganic chemistry for medicine. New chemical methods for sensing and imaging, metalloproteomics, metal-based therapeutics and diagnostics, as well as structural and functional consequences of novel protein and nucleic acid metallobiochemistry in vitro and in living systems, are welcome for this themed collection on emerging topics in chemical biology of metals research.
The deadline for submissions is 6 March 2023. Submit your work to the collection now!
Promotion of the collection is scheduled for mid-2023, with articles published online as soon as they’re accepted.
Authors are welcome to submit original research in the form of a Communication or Full Paper. Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.
Explore all open calls for papers from RSC journals!
About RSC Chemical Biology:
Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.
As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.
We’re pleased to announce that our first guest-edited themed collection, on the Synthesis and Chemical Biology of Macrocycles, has now been published online! We thank the Guest Editors, Gong Chen (Nankai University), Monika Raj (Emory University), and Andrei Yudin (University of Toronto) for their work editing this collection.
Macrocycles are an important class of compounds with a long-recognised, significant role in chemical biology and drug discovery. This themed collection offers a collection of articles that showcase the ongoing interest in the chemical biology of macrocycles. Recent years have witnessed the development of new synthetic and biological strategies to construct large rings composed of amino acid residues. In addition, significant progress has been made in efforts to understand and predict the properties of macrocycles. We have collected contributions that are representative of the tremendous promise and pace of growth in this area.
The work in this collection covers all areas of the synthesis and chemical biology of macrocycles, including new synthetic and biosynthetic pathways for synthesis of diverse range of macrocycles; peptide and peptidomimetics macrocycles; design and synthesis of macrocycles for biological and medicinal applications; cell permeable macrocycles for targeting intracellular proteins; structural studies of macrocycles to expand the conformational drug space, and much more. Taken together, the papers collected in this themed collection represent the state of the art in macrocycles and highlight work at the interface of chemistry and biology.
Introduction to ‘Synthesis and chemical biology of macrocycles’
RSC Chem. Biol., 2022, 3, 993-993. DOI: 10.1039/D2CB90018A
Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang and Weiping Gao
RSC Chem. Biol., 2022, 3, 815-829. DOI: 10.1039/D1CB00246E
Cyclic peptide drugs approved in the last two decades (2001–2021)
Huiya Zhanga and Shiyu Chen
RSC Chem. Biol., 2022, 3, 18-31. DOI: 10.1039/D1CB00154J
Targeted disruption of PKC from AKAP signaling complexes
Ameya J. Limaye, George N. Bendzunasa and Eileen J. Kennedy
RSC Chem. Biol., 2021, 2, 1227-1231. DOI: 10.1039/D1CB00106J
Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
Aline D. de Araujo, Junxian Lim, Kai-Chen Wu, Huy N. Hoang, Huy T. Nguyen and David P. Fairlie
RSC Chem. Biol., 2022, 3, 895-904. DOI: 10.1039/D1CB00231G
Navigating complex peptide structures using macrocycle conformational maps
Timothy J. McTiernan, Diego B. Diaz, George J. Saunders, Fiona Spranga and Andrei K. Yudin
RSC Chem. Biol., 2022, 3, 739-747. DOI: 10.1039/D2CB00016D
Structural impact of thioamide incorporation into a β-hairpin
Kristen E. Fiore, Martijn J. Patist, Sam Giannakoulias, Cheng-Hsin Huang, Hitesh Verma, Bhavesh Khatri, Richard P. Cheng, Jayanta Chatterjee and E. James Petersson
RSC Chem. Biol., 2022, 3, 582-591. DOI: 10.1039/D1CB00229E
Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions
Kleopas Y. Palate, Zhongzhen Yang, Adrian C. Whitwood and William P. Unsworth
RSC Chem. Biol., 2022, 3, 334-340. DOI: 10.1039/D1CB00245G
Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue
Masanobu Nagano, Satoshi Ishida and Hiroaki Suga
RSC Chem. Biol., 2022, 3, 295-300. DOI: 10.1039/D1CB00225B
Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Anselm F. L. Schneider, Joerg Kallen, Johannes Ottl, Patrick C. Reid, Sebastien Ripoche, Stephan Ruetz, Therese-Marie Stachyra, Samuel Hintermann, Christoph E. Dumelin, Christian P. R. Hackenberger and Andreas L. Marzinzik
RSC Chem. Biol., 2021, 2, 1661-1668. DOI: 10.1039/D1CB00056J
Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain
Ilona Christy Unarta, Jianchao Xu, Yuan Shang, Carina Hey Pui Cheung, Ruichi Zhu, Xudong Chen, Siqin Cao, Peter Pak-Hang Cheung, Donald Bierer, Mingjie Zhang, Xuhui Huang and Xuechen Li
RSC Chem. Biol., 2021, 2, 1274-1284. DOI: 10.1039/D1CB00087J
