Archive for the ‘News’ Category

RSC Chemical Biology Advisory Board

New additions to the RSC Chemical Biology Advisory Board!

We are delighted to welcome Professors Lei Liu & Guifang Jia, and Dr Chudi Ndubaku to the RSC Chemical Biology Advisory Board!  They join 19 other prominent researchers in the chemical biology field.

Explore the current Advisory Board line-up below.  For more information on the Editorial Board, visit rsc.li/rsc-chembio.

Dr Chudi Ndubaku, ORIC Pharmaceuticals, USA

Dr Ndubaku is the Vice President for Drug Discovery at ORIC Pharmaceuticals.

Professor Guifang Jia, Peking University, China

Professor Jia’s research focuses on the functions of RNA modifications in regulation of human diseases and plant development.

Professor Lei Liu, Tsinghua University, China

Research in the Lei group focuses on chemical protein synthesis and its applications to biomedical studies.

Professor Paul Dyson, EPFL, Switzerland

The research in Professor Dyson’s lab centres on organometallic chemistry at the interface with medicine, catalysis and material science.

Professor Luc Brunsveld, TU Eindhoven, Netherlands

Professor Brunsveld’s research interests are focused on chemical biology approaches studying protein-protein interactions, particularly drug discovery and supramolecular signalling systems.

Professor Peng Chen, Peking University, China

Professor Chen’s research focus is to develop novel technologies for protein manipulation in living cells, including protein-based bioorthoganol chemistry and precise protein engineering.

Professor Donald Hilvert, ETH Zurich, Switzerland

The group of Professor Hilvert are using chemical biology tools to understand and engineer proteins for various applications.

Professor May Khanna, University of Arizona, USA

The work of Professor Khanna’s lab looks to combine biochemical and biophysical techniques to target key protein-protein and protein-RNA interactions in neurodegenerative disease.

Professor Hermen Overkleeft, Leiden University, Netherlands

The research of the Overkleeft lab is characterized by the design, synthesis and application of chemical probes in glycobiology and immunology.

Professor Giulio Superti-Furga, CeMM, Austria

The Superti-Furga laboratory addresses the mechanisms by which cells respond to challenges that perturb homeostasis, and how homeostasis can subsequently be restored.

Professor Xiu-Jie Wang, Chinese Academy of Sciences, China

Professor Wang’s research interests include developing computational methods to analyze biological data, identifying new non-coding regulatory RNA genes and studying the functions of non-coding RNAs.

Professor Christopher Chang, University of California Berkeley, USA

Professor Chang’s research interests include transition metal signaling, activity-based sensing and artificial photosynthesis.

Professor Russell Cox, Leibniz University Hannover, Germany

The Cox group is interested in understanding and engineering the biosynthesis of natural products by fungi.

Professor Dorothea Fiedler, FMP Berlin, Germany

The goal of the Fiedler lab is to develop new chemical and biochemical tools that will provide a mechanistic picture of inositol phosphate signaling.

Professor Christian Hackenberger, FMP Berlin, Germany

The research projects of Professor Hackenberger’s group focus on understanding how nature generates specific biological function in complex cellular environments.

Professor Maja Köhn, University of Freiburg, Germany

Professor Köhn’s group explores integrative signaling research on phosphatase chemistry and biology.

Professor Yamuna Krishnan, University of Chicago, USA

Work in Professor Krishnan’s lab aims to build quantitative chemical maps of organelle lumens using the tools of bionanotechnology.

Professor Elizabeth Nolan, Massachusetts Institute of Technology, USA

Professor Nolan and her team investigate the chemistry and biology of small molecules, peptides, and proteins that participate in the human innate immune response and host/pathogen interaction.

Professor Jennifer Prescher, University of California Irvine, USA

The research in Professor Prescher’s lab has the aim of crafting novel chemical probes and noninvasive imaging technologies to interrogate cells in their native habitats.

Professor Christopher Schofield, University of Oxford, UK

Professor Schofield aims to define functions for all human ‘2OG oxygenases’ at biochemical, cellular, and physiological level.

Professor Pamela Silver, Harvard Medical School, USA

Professor Silver’s research interests include cell programming, therapeutic design, and environment & pathogen sensing.

Professor Kira Weissman, University of Lorraine, France

Professor Weissman is expert in multiple aspects of the biosynthesis of polyketides and related secondary metabolites.

1 year of RSC Chemical Biology – the covers

This month we are celebrating our fantastic first year of RSC Chemical Biology!  We have seen six issues, containing 56 high quality articles, and two editorials.

We have chosen some of our favourite covers from all the wonderful artwork that has featured on the journal so far.  Thank you to all the authors who have provided these amazing artworks!

We invite you to join us on Twitter to vote for your favourite cover of the year from the shortlist below.

Click on each of the images for a close-up look of each cover.

 

Join us on Twitter to vote for your favourite

A

Vol. 1, Issue 1

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis
Joshua C. Corpuz, Larissa M. Podust, Tony D. Davis, Matt J. Jaremko and Michael D. Burkart
RSC Chem. Biol., 2020,1, 8-12; DOI: 10.1039/C9CB00015A

B

Vol. 1, Issue 3 Inside cover

Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry
Dorothée Ganz, Dennis Harijan and Hans-Achim Wagenknecht
RSC Chem. Biol., 2020,1, 86-97; DOI: 10.1039/D0CB00047G

C

Vol. 1, Issue 5

Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance
M. Rhia L. Stone, Urszula Łapińska, Stefano Pagliara, Muriel Masi, Joanne T. Blanchfield, Matthew A. Cooper and Mark A. T. Blaskovich
RSC Chem. Biol., 2020,1, 395-404; DOI: 10.1039/D0CB00118J

D

Vol. 2, Issue 2

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery
Marta Pazo, Giulia Salluce, Irene Lostalé-Seijo, Marisa Juanes, Francisco Gonzalez, Rebeca Garcia-Fandiño and Javier Montenegro
RSC Chem. Biol., 2021,2, 503-512; DOI: 10.1039/D0CB00103A

The RSC Chemical Biology “Editor’s choice” article collection

The RSC Chemical Biology “Editor’s choice” article collection

The Editor’s choice collection for RSC Chemical Biology celebrates the very best work published in the journal to date, including regularly added articles personally chosen by our world-renowned Editorial Board, as well as those highlighted as “HOT” during the peer review process.

 


July

This month, Editorial Board Member Ali Tavassoli has selected two fantastic articles to highlight.

Professor Tavassoli’s choice are detailed below. Access the full collection for free.

Review

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation
Michael J. Bond and Craig M. Crews
RSC Chem. Biol., 2021, 2, 725-742
DOI: 10.1039/ D1CB00011J

Professor Tavassoli, “PROTACs are an exciting new drug modality that hold much promise as potential therapeutics. This timely review provides an excellent summary of this important field and is a great starting point for those interested in learning more about PROTACs.”

 

Paper

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
Roman O. Fedoryshchak, Cory A. Ocasio, Benjamin Strutton, Jo Mattocks, Andrew J. Corran and Edward W. Tate
RSC Chem. Biol., 2020, 1, 68-78
DOI: 10.1039/ D0CB00020E

Professor Tavassoli, “This paper is an excellent example of the power and utility of chemical biology and chemical proteomics. The authors identify inhibitors of Z. tritici N-myristoyltransferase, and use these compounds in a chemical proteomics approach to profile the myristolated proteome in Z. tritici. These studies lead to the identification of an unusual mechanism by which the fungus defends itself from NMT inhibitors.”

 


June

In June, three exciting articles were chosen by Editorial Board Member Jen Heemstra.

Professor Heemstra’s choices are detailed below.  Access the full collection for free

Review

Interfacing non-enzymatic catalysis with living microorganisms
Joanna C. Sadler, Jonathan A. Dennis, Nick W. Johnson and Stephen Wallace
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/ D1CB00072A

Professor Heemstra, “Chemical catalysis and biocatalysis each have unique advantages and limitations toward the synthesis of high-value compounds. This review highlights recent progress in biocompatible chemistry, which empowers chemists to interface biotic and abiotic catalysts to develop improved synthetic routes.”

 

Communication

An activity-based fluorescent sensor for the detection of the phenol sulfotransferase SULT1A1 in living cells
Regina A. Baglia, Kira R. Mills, Koushambi Mitra, Jasmine N. Tutol, Darby Ball, Kierstin M. Page, Jyothi Kallu, Sriharika Gottipolu, Sheena D’Arcy, Steven O. Nielsen and Sheel C. Dodani
RSC Chem. Biol., 2021, 2, 830-834
DOI: 10.1039/ D0CB00231C

Professor Heemstra, “SULT1 enzymes play important roles in biology and this paper reports the first activity-based probe for an enzyme in this class. The naphthol-based sensor functions in vitro and in live cells, providing a useful tool for drug screening and the study of cellular functions of SULT1A1.”

 

Paper

Synthesis and application of a 19F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs
Wen Ann Wee, Ji Hye Yum, Shingo Hirashima, Hiroshi Sugiyama and Soyoung Park
RSC Chem. Biol., 2021, 2, 876-882
DOI: 10.1039/ D1CB00020A

Professor Heemstra, “Non-canonical DNA structures such as cytosine-rich i-motifs likely have biological importance yet are elusive to study. The authors report a new cytidine analogue that shows increased fluorescence enhancement upon folding and is also compatible with 19F NMR.”

 


April

In April Associate Editor Roderich Süssmuth selected two high quality articles to add to the collection.

Below are his choices.  Access the full collection for free.

Review

Biosynthesis of alkyne-containing natural products
Xinyang Li, Jian-Ming Lv, Dan Hu and Ikuro Abe
RSC Chem. Biol., 2021, 2, 166-180
DOI: 10.1039/D0CB00190B

Professor Süssmuth, “A review article was long time due, since the alkyne group is of eminent importance in biological chemistry, particularly as a handle for the click reaction. It is interesting to see, that nature also synthesizes this functionality, which is present in various natural products.”

 

Paper

Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases
Florian Mayerthaler, Anna-Lena Feldberg, Jonas Alfermann, Xun Sun, Wieland Steinchen, Haw Yang and Henning D. Mootz
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/D0CB00220H

Professor Süssmuth, “The work addresses dynamics of non-ribosomal peptide synthetases. The understanding of the gross architecture of the NRPSs from x-ray structures is now followed in this study to understand the dynamics, an aspect of increasing importance.”

 


March

In March it was the turn of Associate Editor Cai-Guang Yang to highlight three of his favourite articles to date.

Below are his choices.  Access the full collection for free.

Review

Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry
Dorothée Ganz, Dennis Harijan and Hans-Achim Wagenknecht
RSC Chem. Biol., 2020, 1, 86-97
DOI: 10.1039/D0CB00047G

Professor Yang, “This review summarizes DNA and RNA labelling by means of bioorthogonal cycloaddition chemistry in the cellular environment. It also describes current status of orthogonal dual and triple labelling of DNA and RNA in vitro to demonstrate the potential in vivo applications for future.”

 

Papers

Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi and Hiroaki Suga
RSC Chem. Biol., 2020, 1, 26-34
DOI: 10.1039/D0CB00016G

Professor Yang, “By applying a unique RaPID display screening technique, this work reports the first instance of de novo macrocyclic peptides acting as direct binders of a highly hydrophobic and not commonly targeted Wnt protein or similar unstable proteins.”

 

A live-cell assay for the detection of pre-microRNA–protein interactions
Sydney L. Rosenblum, Daniel A. Lorenz and Amanda L. Garner
RSC Chem. Biol., 2021, 2, 241-247
DOI: 10.1039/D0CB00055H

Professor Yang, “This work reports the efforts in the development of a new approach for detection of RNA–protein interactions (RPIs), RNA interaction with Protein- mediated Complementation Assay (RiPCA). RiPCA could serve as a useful tool for detecting RPIs in live cells.”

 


February

February saw Associate Editor Seung-Bum Park has added his choice to the collection.

Below is Professor Park’s choice.  Access the full collection for free.

Communication

In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
Sophie V. Morse, Tamara Boltersdorf, Tiffany G. Chan, Felicity N. E. Gavins, James J. Choi and Nicholas J. Long
RSC Chem. Biol., 2020, 1, 385-389
DOI: 10.1039/D0CB00140F

 


January

In January we launched the collection with 3 papers chosen by our Editorial Chair, Professor Hiroaki Suga, alongside some of our hottest papers published in 2020.

Below are Professor Suga’s choices. Access the full collection for free.

Review

The chemical biology of coronavirus host–cell interactions
Suprama Datta, Erik C. Hett, Kalpit A. Vora, Daria J. Hazuda, Rob C. Oslund, Olugbeminiyi O. Fadeyi and Andrew Emili
RSC Chem. Biol., 2021, 2, 30-46
DOI: 10.1039/D0CB00197J

Professor Suga, “This review timely and comprehensively summarizes the biological events linked to the coronavirus outbreak.”

 

Papers

A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
Taylor A. Lundy, Shogo Mori and Sylvie Garneau-Tsodikova
RSC Chem. Biol., 2020, 1, 233-250
DOI: 10.1039/D0CB00092B

Professor Suga, “The families of interrupted A domains and types of M domains in nonribosomal peptide class of natural products have been categorized. It has illuminated patterns and insights on how to harness them for engineering studies in the future.”

 

Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
Kuan Hu, Lin Xie, Masayuki Hanyu, Yiding Zhang, Lingyun Li, Xiaohui Ma, Kotaro Nagatsu, Hisashi Suzuki, Weizhi Wang and Ming-Rong Zhang
RSC Chem. Biol., 2020, 1, 214-224
DOI: 10.1039/D0CB00070A

Professor Suga, “Authors of this paper have developed an impressive PET imaging tool for the most famous immune check point mediated by the PD-1 and PD-L1 interaction, demonstrating not only cell culture and ex vivo detection but also in vivo detection in mice.”

 


We hope you enjoy reading these articles!

 

DECHEMA Advances in Chemical Biology Conference

DECHEMA Advances in Chemical Biology conference: Online, 26-28 January 2021

 

This upcoming conference boasts an innovative and interactive programme of events: RSC Chemical Biology welcomes you to join.

 

From expert talks and a virtual exhibition, to lectures by young researchers and ePoster presentations, this promises to be a diverse and inspiring conference. Hot topics will include nucleic acids and proteins, peptides and carbohydrates, targeted synthesis concepts and phenotypic screening. For more information, please visit the conference site.

 

RSC Chemical Biology is delighted to be sponsoring this event as a media partner and invites you to register here now, and check out our virtual booth and join our Meet the Editor Event. 

 

Looking forward to seeing you there,

RSC Chemical Biology Team

 

RSC Desktop Seminar – 28 August 2020: featuring RSC Chemical Biology Editors Seung Bum Park, Anna Rulka and Hiroaki Suga

RSC Desktop Seminars are a new initiative from the Royal Society of Chemistry to bring cutting-edge research directly to you.

Now, more than ever, there is a crucial need for sharing research, and Executive Editor Anna Rulka of new journal RSC Chemical Biology is delighted to present Hiroaki Suga, Chair of the Editorial Board, and Seung Bum Park, Associate Editor to share their research with you.

RSC Desktop Seminar, hosted by RSC Chemical Biology: Register now

28 August 2020 16:00-17:30, JST, KST (UTC+09:00), 08:00-09:30, BST (UTC+01:00)

  • Opening remarks
  • Professor Seung Bum Park: ​“FITGE (Fluorescence difference In Two-dimensional Gel Electrophoresis) – based Target Identification: New Tools in Chemical Biology & Drug Discovery” – with Q&A
  • Dr Anna Rulka: RSC Chemical Biology: an innovative home for breakthrough discoveries”
  • Professor Hiroaki Suga: “The next generation of RaPID (Random nonstandard Peptide Integrated Discovery) display” – with Q&A
  • Open discussion and Q&A for any of the talks
  • Closing remarks

Featuring:

Seung Bum Park
Seoul National University, South Korea
Associate Editor, RSC Chemical Biology

Seung Bum Park is Professor of the Chemistry Department and Director of the CRI Center for Chemical Proteomics at Seoul National University. He is an alumnus of Yonsei, Texas A&M and Harvard universities, and founded the bio-venture SPARK Biopharma, Inc in 2016. His research interests include molecular diversity, fluorescent bioprobes, phenotypic screening, and target identification for drug discovery targeting protein-protein interaction.

Scientific talk: FITGE (Fluorescence difference In Two-dimensional Gel Electrophoresis) – based Target Identification: New Tools in Chemical Biology & Drug Discovery

 

Hiroaki Suga
University of Tokyo, Japan
Editorial Board Chair, RSC Chemical Biology
 
Hiroaki Suga is Professor of the Department of Chemistry, Graduate School of Science in the University of Tokyo and a founder of PeptiDream Inc. Tokyo. He is an alumnus of Okayama University and MIT, and his research interests are in the field of bioorganic chemistry, chemical biology and biotechnology related to RNA, translation, and peptides. He has received many awards, most recently a Humboldt Research Award in 2020.
 
Scientific talk: The next generation of RaPID (Random nonstandard Peptide Integrated Discovery) display

We hope that you can join us for this exciting event.

 

Congratulations to Hiroaki Suga, awarded the Humboldt Research Award

Congratulations to Professor Hiroaki Suga, RSC Chemical Biology Editorial Board Chair, who has been elected the recipient of a Humboldt Research Award.

“The award is granted in recognition of a researcher’s entire achievements to date to academics whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future.”

Award recipients are nominated by established German academics, and Prof. Suga was nominated by Professor Roderich Sußmuth.

RSC Chemical Biology hosts new RSC Desktop Seminar Series

COVID-19 has rendered in-person events to be suspended or cancelled disrupting connections around the globe. The impact of these cancellations on the sharing of information and ideas, especially in the research landscape, has been dramatic.

In an effort to help researchers to stay connected to advances in chemical research and share support, RSC Chemical Biology is proud to announce the launch of the RSC’s first online-only seminar series.

Introducing RSC Desktop Seminars!

The RSC Desktop Seminar Series is an effort to not only replace in-person research seminars during the current pandemic situation but to also expand access for researchers around the world looking to connect to some of the leading minds in the chemical sciences.

Each seminar is 1 hour and 15 minutes long, and will feature two Small Group Informal Sessions, which will offer researchers in attendance a direct line to the speaker to ask questions and build a network with other like-minded individuals.

While these initial RSC Desktop Seminars are taking place in the Eastern US time zone working hours, we encourage any and all interested to register and attend!

 

Next RSC Desktop Seminars in this Series:

11 June 2020 12:00 EST / 17:00 BST

Our next Desktop Seminar event will take place at 12:00 EST (17:00 BST) on 11 June 2020, and will feature Prof. Dr. Christian Hackenberger – Humboldt-Universität zu Berlin, Leibniz-Institut für Molekulare Pharmakologie; Associate Editor, Organic & Biomolecular Chemistry; Advisory Board member, RSC Chemical Biology

Professor Hackenberger will deliver a talk on “The power of chemoselectivity: Functional protein-conjugates for extra- and intracellular targeting”

Register here now

Previous RSC Desktop Seminars in this Series:

4 June 2020 12:00 PM EST / 17:00 BST
“Understanding and Re-engineering the Programming of Iterative Highly Reducing Polyketide Synthases”
Prof. Dr. Russell Cox
 – Leibniz Universität Hannover; Editor in Chief, RSC Advances; Advisory Board member, RSC Chemical Biology

28 May 2020 12:00 PM EST / 17:00 BST
“Platforms for the generation and high-throughput screening of cyclic peptide libraries”
Dr. Ali Tavassoli
– Professor of Chemical Biology, University of Southampton, Editorial Board member, RSC Chemical Biology

 

21 May 2020 12:00 PM EST / 17:00 BST
“Interrogating Enzymatic Reactions using Nucleic Acid Molecular Recognition and Assembly”
Dr. Jennifer Heemstra – Professor of Chemistry, Emory University, Editorial Board member, RSC Chemical Biology

This inaugural seminar of the series took place on 21 May 2020 12:00 PM EST / 17:00 BST, and was attended by over 150 participants from 20 countries around the world.