Read the full article by Phillip Holliger & Alexander Taylor here
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio
Royal Society of Chemistry
Read the full article by Dr Benjamin Elias & Dr Anabell Decottignies here
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio
Royal Society of Chemistry
RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Medicinal Chemistry Small Molecule Probes’, guest edited by John Spencer (University of Sussex, UK), Gemma Nixon (University of Liverpool, UK), and Miraz Rahman (King’s College London, UK).
Contributions are welcome which investigate general medicinal chemistry, chemical probes for imaging, proteomics, protacs, fragment-based drug discovery, covalent binders, chemical tools for protein profiling and activity modulation, and natural product inspired medicinal chemistry and chemical biology.
The deadline for submissions is 1 June 2023. Submit your work to the collection now!
Promotion of the collection is scheduled for late 2023, with articles published online as soon as they’re accepted.
Authors are welcome to submit original research in the form of a Communication or Full Paper. Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.
Explore all open calls for papers from RSC journals!
About RSC Chemical Biology:
Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.
As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.
We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.
Guest-edited by Chengqi Yi (Peking University, China) and Yan Zhang (Nanjing University, China), this collection highlights work on bio-orthogonal chemistry, reactions and probes in labeling, manipulating, imaging and sequencing of protein, DNA, RNA and bioactive metabolites.
The article line-up is provided below. All articles in RSC Chemical Biology are open access and free to read.
Introduction to ‘Development of bio-orthogonal tools’
Yan Zhang and Chengqi Yi
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90045A
Labeling and sequencing nucleic acid modifications using bio-orthogonal tools
Hui Liu, Yafen Wang and Xiang Zhou
RSC. Chem. Biol., 2022, 3, 994–1007, DOI: 10.1039/D2CB00087C
Imitate to illuminate: labeling of bacterial peptidoglycan with fluorescent and bio-orthogonal stem peptide-mimicking probes
Huibin Lin, Chaoyong Yang and Wei Wang
RSC. Chem. Biol., 2022, 3, 1198–1208, DOI: 10.1039/D2CB00086E
A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications
Benton Swanson, Margaret Durdan, Miranda Eberle, Seth Woodbury, Ava Mauser, Jason Gregory, Boya Zhang, David Niemann, Jacob Herremans, Peter X. Ma, Joerg Lahann, Megan Weivoda, Yuji Mishina and Colin F. Greineder
RSC. Chem. Biol., 2022, 3, 748–764, DOI: 10.1039/D2CB00030J
Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ
Diana Torres-García, Merel A. T. van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G. J. Groenewold, Alexi J. C. Sarris, Luuk Klein, Herman S. Overkleeft and Sander I. van Kasteren
RSC. Chem. Biol., 2022, 3, 1325–1330, DOI: 10.1039/D2CB00120A
We hope you enjoy this new themed collection from RSC Chemical Biology.
RSC Chemical Biology and RSC Medicinal Chemistry are delighted to welcome papers for an online themed collection on ‘Molecular and nanotheranostics’, guest edited by Prof. Thimmaiah Govindaraju (Jawaharlal Nehru Centre for Advanced Scientific Research, India).
Over a decade of intense research has positioned theranostics as a promising and integrated approach to advance biomedical research and medicine. The term theranostics essentially conveys the idea of combining therapeutic and diagnostic modalities to provide a holistic solution for disease management. Theranostics is also referred to as diagnostic therapy, wherein molecular and/or material tools for non-invasive treatment and diagnostic imaging are strategically embedded into a single system. For instance, multifunctional diagnostic platforms carrying therapeutic and target tracking agents offer remedial effects and imaging of markers in tissue or organs, which is used to assess disease staging, treatment planning and therapeutic efficacy.
Theranostics has the potential to revolutionize the practice and adaptation of personalized medicine to tackle chronic disease conditions like cancer and neuronal disorders. Generally, radiopharmaceutical, nano and macromolecular systems armed with tools to detect, treat, track, and image biomolecular targets in real-time have been employed as theranostics to effectively manage disease progression and cure.
In recent years, the field has witnessed the emergence of small molecules or small molecular conjugates as theranostic tools. This special collection in RSC Chemical Biology and RSC Medicinal Chemistry intends to cover and highlight advancements in molecular theranostics with particular emphasis on chemical biology of molecular design of theranostic tools and their selective interaction with the biomolecular targets to image and ameliorate the pathological conditions. This themed collection is anticipated to catalyze the development of precision theranostics as advanced and personalizable tools in chemical biology and modern medicine.
The deadline for submissions has been extended to 30 June 2023.
Articles can be submitted via the appropriate journal’s website, where you can find details on their scopes and focus. RSC Chemical Biology accepts exceptionally significant and breakthrough findings of interest to the chemical biology community, while RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science.
RSC Chemical Biology: rsc.li/rsc-chembio
RSC Medicinal Chemistry: rsc.li/rsc-medchem
Authors are welcome to submit original research in the form of a Communication or Full Paper. Note that RSC Chemical Biology is a gold open access, journal, however submissions for this collection will have their article processing charges (APCs) waived.
When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed. Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.
We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.
Guest-edited by Dennis Bong (Ohio State University), Philipp Holliger (MRC Laboratory of Molecular Biology), and Chaoyong Yang (Xiamen University), this themed collection covers all aspects of modified nucleic acids in chemical and synthetic biology including both in vitro as well as in vivo applications, and new chemistries. Taken together, the papers collected in this themed collection represent the state of the art on XNAs and highlights work at the interface of chemistry and biology.
A selection of the articles has been provided below. All articles in RSC Chemical Biology are open access and free to read.
Introduction to the themed collection on XNA xenonucleic acids
Dennis Bong, Philipp Holliger and Chaoyong Yang
RSC. Chem. Biol., 2022, 3, DOI: 10.1039/D2CB90036J
From polymerase engineering to semi-synthetic life: artificial expansion of the central dogma
Leping Sun, Xingyun Ma, Binliang Zhang, Yanjia Qin, Jiezhao Ma, Yuhui Du and Tingjian Chen
RSC Chem. Biol., 2022, 3, 1173-1197, DOI: 10.1039/D2CB00116K
Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
Chaturong Suparpprom and Tirayut Vilaivan
RSC Chem. Biol., 2022, 3, 648-697, DOI: 10.1039/D2CB00017B
Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues
John R. D. Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger and Alexander I. Taylor
RSC Chem. Biol., 2022, 3, 1209-1215, DOI: 10.1039/D2CB00035K
Dependence of click-SELEX performance on the nature and average number of modified nucleotides
Julia Siegl, Olga Plückthun and Günter Mayer
RSC Chem. Biol., 2022, 3, 288-294, DOI: 10.1039/D2CB00012A
Synthesis and structure–activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown
Enrico Cadoni, Francesca Pennati, Penthip Muangkaew, Joke Elskens, Annemieke Madder and Alex Manicardi
RSC Chem. Biol., 2022, 3, 1129-1143, DOI: 10.1039/D2CB00095D
Stimuli-responsive assembly of bilingual peptide nucleic acids
Hector S. Argueta-Gonzalez, Colin S. Swenson, George Song and Jennifer M. Heemstra
RSC Chem. Biol., 2022, 3, 1035-1043, DOI: 10.1039/D2CB00020B
Mutant polymerases capable of 2′ fluoro-modified nucleic acid synthesis and amplification with improved accuracy
Trevor A. Christensen, Kristi Y. Lee, Simone Z. P. Gottlieb, Mikayla B. Carrier and Aaron M. Leconte
RSC Chem. Biol., 2022, 3, 1044-1051, DOI: 10.1039/D2CB00064D
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Anna Dysko, Ysobel R. Baker, Graham McClorey, Matthew J. A. Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer and Tom Brown
RSC Chem. Biol., 2022, 3, 765-772, DOI: 10.1039/D2CB00100D
Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
Ryosuke Kita, Takashi Osawa and Satoshi Obika
RSC Chem. Biol., 2022, 3, 728-738, DOI: 10.1039/D1CB00240F
A ruthenium–oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser and Marcel Hollenstein
RSC Chem. Biol., 2022, 3, 85-95, DOI: 10.1039/D1CB00146A
Targeting a conserved structural element from the SARS-CoV-2 genome using L-DNA aptamers
Jing Li and Jonathan T. Sczepanski
RSC Chem. Biol., 2022, 3, 79-84, DOI: 10.1039/D1CB00172H
We hope you enjoy this new themed collection from RSC Chemical Biology.
We’re pleased to announce that our first Emerging Investigators collection has now been published online!
RSC Chemical Biology is committed to supporting and recognizing the excellent work of early career researchers. We are thus proud to present our first annual Emerging Investigators collection. The collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stage of their independent careers who are making outstanding contributions to their respective fields. Each contributor was recommended by an expert in their field for carrying out work with the potential to influence future directions. The collection encompasses the entire scope of the journal.
Looking forward, we will soon be inviting for an Emerging Investigators Collection that will be published in 2023, and you are encouraged to recommend a colleague at the beginning of their career by contacting the Editorial Office. To be considered, a scientist must be a research group leader with less than 10 years of independent research (although the timescale is flexible in cases of career breaks and personal circumstances).
Congratulations to all the featured researchers on their work. Join us in celebrating their contributions!
RSC Chemical Biology Emerging Investigators Collection and Outstanding Paper Award
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90027K
Contributors to the RSC Chemical Biology Emerging Investigators Collection 2022
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90028A
The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas
RSC. Chem. Biol., 2022, 3, 426–430, DOI: 10.1039/D1CB00252J
A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules
Feifei Wang, Hao Kong, Xiangfeng Meng, Xiao Tian, Changjiang Wang, Lei Xu, Xiang Zhang, Lei Wang and Ran Xie
RSC. Chem. Biol., 2022, 3, 539–545, DOI: 10.1039/D2CB00072E
A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy
Zhaoxuan Yang, Jiaqi Huang, Yaying Lin, Xiangjie Luo, Haojin Lin, Hongyu Lin and Jinhao Gao
RSC. Chem. Biol., 2022, 3, 853–858, DOI: 10.1039/D1CB00257K
Fluorescent metabolic labeling-based quick antibiotic susceptibility test for anaerobic bacteria
Juan Gao, Juanxiu Qin, Chenling Ding, Yuan Gao, Junnan Guo, Min Li, Chaoyong Yang and Wei Wang
RSC Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00163B
Proteomic characterization of phagocytic primary human monocyte-derived macrophages
Regan F. Volk, José L. Montaño, Sara E. Warrington, Katherine L. Hofmann and Balyn W. Zaro
RSC. Chem. Biol., 2022, 3, 783–793, DOI: 10.1039/D2CB00076H
Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing
Xinlu Zhao, Shiming Sun, Wenhao Yu, Wenqi Zhu, Zihan Zhao, Yiqi Zhou, Xiuheng Ding, Nan Fang, Rong Yang and Jie P. Li
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00046F
Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
Samantha M. Horwitz, Tamra C. Blue, Joseph A. Ambarian, Shotaro Hoshino, Mohammad R. Seyedsayamdost and Katherine M. Davis
RSC. Chem. Biol., 2022, 3, 420–425, DOI: 10.1039/D1CB00255D
One-step asparaginyl endopeptidase (OaAEP1)-based protein immobilization for single-molecule force spectroscopy
Xuan Ding, Ziyi Wang, Bin Zheng, Shengchao Shi, Yibing Deng, Hanyang Yu and Peng Zheng
RSC Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00135G
Scope
Contributions are welcome which investigate structural and functional consequences of native RNA modifications in vitro and in living systems. New chemical and chemoenzymatic methods for detection, validation, and characterization of epitranscriptomic modifications and their functions are welcome for this themed collection on emerging topics in epitranscriptomic research.
Promotion of the collection is scheduled for spring 2023, with articles published online as soon as they’re accepted.
Authors are welcome to submit original research in the form of a Communication or Full Paper. Articles can be submitted via our website: rsc.li/rsc-chembio. We would be grateful if upon submission you would be able to mention that your manuscript is intended for this themed collection in the “notes to the editor” box.
If you have any questions about the journal or the collection, I would be happy to answer them in reply to this email.
With kind regards,
| Ralph Kleiner
Princeton, USA |
Claudia Höbartner
University of Würzburg, Germany |
Guifang Jia
Peking University, China |
About RSC Chemical Biology
Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.
As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.
RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio
Royal Society of Chemistry
We’re excited to share with you our new cross-journal themed collection on “Multimolecular Crowding in Biosystems” for RSC Chemical Biology and ChemComm.
Living cells comprise a variety of molecules from small cations/anions, metabolites, lipids, peptides, to biopolymers such as peptides/proteins, polysaccharides, and nucleic acids. These biomolecules are highly condensed inside the live cells and their distribution and concentration are heterogeneously varied (in a controlled manner). Such multimolecular crowding conditions are sharply distinct from those of conventional biochemical study, should be crucial for elucidating structures and functions of biomolecules in live cells, as well as for developing functional artificial molecules useful in chemical biology study, drug discovery, and medical diagnosis.
In this cross-journal themed issue, explore research papers, reviews, and communications in ChemComm and RSC Chemical Biology concerning chemical, physical, theoretical, or biological characterization of various biomolecules under the multimolecular crowding conditions. Also discover the development of chemical tools and devices enabling the detection and imaging of key biomolecules and the relevant events in live cells, methods for the structural modification and functional switching/control of biomolecules, and analytical or physical chemistry approaches applicable to study of multimolecular crowding biosystems.
Explore some of the papers in the collection below, and see the full collection here: Cross-journal themed collection on ‘Multimolecular Crowding in Biosystems’
Highlight
Fluorescent probes for targeting endoplasmic reticulum: design strategies and their applications
Deepmala Singh, Deeksha Rajput and Sriram Kanvah
Chem. Commun., 2022, 58, 2413-2429
DOI: 10.1039/D1CC06944F
Feature Article
Cancer diagnosis and analysis devices based on multimolecular crowding
Daisuke Onoshima and Yoshinobu Baba
Chem. Commun., 2021, 57, 13655-13661
DOI: 10.1039/D1CC05556A
Review
Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches
Yuta Miura, Akinobu Senoo, Tomohiro Doura and Shigeki Kiyonaka
RSC Chem. Biol., 2022, 3, 269-287
DOI: 10.1039/D1CB00195G
Paper
Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling
Marcus E. Graziotto, Liam D. Adair, Amandeep Kaur, Pauline Vérité, Sarah R. Ball, Margaret Sunde, Denis Jacquemin and Elizabeth J. New
RSC Chem. Biol., 2021, 2, 1491-1498
DOI: 10.1039/D1CB00128K
We hope you enjoy reading these articles!
Contact us: chembio-rsc@rsc.org
Visit our website – rsc.li/rsc-chembio
RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.
Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.
We’re excited to share with you our new topical collection on “Exploring proteins and their interactions” for RSC Chemical Biology, highlighting the excellent work published so far in the journal in this exciting area of research.
The study of proteins, their structure and function, interactions and roles in disease is a vast topic encompassing a range of different approaches, techniques and tools. Work in this collection reflects the variety and scope of this area of chemical biology research, including studies on the mechanisms of aromatases, coronavirus host-cell interactions, the mapping of epitopes, and much more.
Explore some of the papers in the collection below, and see the full collection here:
Review
Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins
Dominik P. Vogl, Anne C. Conibear and Christian F. W. Becker
RSC Chem. Biol., 2021, 2, 1441-1461
DOI: 10.1039/D1CB00045D
Communication
Protein–protein interaction based substrate control in the E. coli octanoic acid transferase, LipB
Thomas G. Bartholow, Terra Sztain, Megan A. Young, Tony D. Davis, Ruben Abagyan and Michael D. Burkart
RSC Chem. Biol., 2021, 2, 1466-1473
DOI: 10.1039/D1CB00125F
Paper
The identification and characterization of an oxalyl-CoA synthetase from grass pea (Lathyrus sativus L.)
Moshe Goldsmith, Shiri Barad, Yoav Peleg, Shira Albeck, Orly Dym, Alexander Brandis, Tevie Mehlman and Ziv Reich
RSC Chem. Biol., 2022, 3, 320-333
DOI: 10.1039/D1CB00202C
We hope you enjoy reading these articles!
RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.
Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.
Contact us: chembio-rsc@rsc.org
Visit our website – rsc.li/rsc-chembio
