Archive for the ‘Collections’ Category

‘Small molecules for Chemical Biology’ topical collection

We’re excited to share with you our new topical collection on “Small molecules for chemical biology” for RSC Chemical Biology, highlighting the excellent work published so far in the journal in this exciting area of research.

The use of small molecules in chemical biology encompasses a wide range of multidisciplinary research, including the use of chemical tools as probes for imaging and targetidentification, small molecule inhibitors of protein-protein interactions, signal inhibition and the assessment of ligand engagement among others.

Explore some of the papers in the collection below, and see the full collection here:  RSC Chemical Biology – Small molecules for chemical biology collection

  

Review

Targeting the RNA demethylase FTO for cancer therapy
Lin-Lin Zhou, Hongjiao Xu, Yue Huang and Cai-Guang Yang
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/D1CB00075F

 

Communication

A two-step resin based approach to reveal survivin-selective fluorescent probes
Andrew J. Ambrose, Nhan T. Pham, Jared Sivinski, Larissa Guimarães, Niloufar Mollasalehi, Paula Jimenez, Maria A. Abad, A. Arockia Jeyaprakash, Steven Shave, Letícia V. Costa-Lotufo, James J. La Clair, Manfred Auer and Eli Chapman
RSC Chem. Biol., 2021, 2, 181-186
DOI: 10.1039/D0CB00122H

 

Paper

Phosphinate esters as novel warheads for activity-based probes targeting serine proteases
Jan Pascal Kahler and Steven H. L. Verhelst
RSC Chem. Biol., 2021, 2, 1285-1290
DOI: 10.1039/D1CB00117E

 

We hope you enjoy reading these articles!

 


 

RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

Contact us:  chembio-rsc@rsc.org

Visit our website – rsc.li/rsc-chembio

‘The Chemical Biology of Peptides’ topical collection

 

We’re excited to share with you our new topical collection on “The Chemical Biology of Peptides” for RSC Chemical Biology, highlighting the excellent work published so far in the journal in this exciting area of research.

This collection features work where peptides are used to image immune checkpoints, where they are harnessed to develop novel GPCR ligands, and where they are used to inhibit protein-protein interactions, along with many more fascinating applications and studies.

Explore some of the papers in the collection below, and see the full collection here:  RSC Chemical Biology – The Chemical Biology of Peptides collection

  

Review

Matters of class: coming of age of class III and IV lanthipeptides
Julian D. Hegemann and Roderich D. Süssmuth
RSC Chem. Biol., 2020, 1, 110-127
DOI: 10.1039/D0CB00073F

 

Communication

Targeted disruption of PKC from AKAP signaling complexes
Ameya J. Limaye, George N. Bendzunas and Eileen J. Kennedy
RSC Chem. Biol., 2021, 2, 1227-1231
DOI: 10.1039/D1CB00106J

 

Paper

A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions
Han Yao, Chushu Li, Fang He, Teng Song, Jean-Philippe Brosseau, Huanbin Wang, Haojie Lu, Caiyun Fang, Hubing Shi, Jiang Lan, Jing-Yuan Fang and Jie Xu
RSC Chem. Biol., 2021, 2, 192-205
DOI: 10.1039/D0CB00157K

 

We hope you enjoy reading these articles!

 


 

 

RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

 

Call for papers: The Development of Bio-orthogonal tools

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on the ‘Development of bio-orthogonal tools’, guest edited by Professor Chengqi Yi (Peking University, China) and Professor Yan Zhang (Nanjing University, China).

 

Scope

We would welcome submissions on bio-orthorgonal chemistry, reactions and probes in labeling, manipulating, imaging and sequencing of protein, DNA, RNA and bioactive metabolites.

The deadline for submissions is 31 March 2022.

Promotion of the collection is scheduled for summer 2022, articles will be published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper.  Articles can be submitted via our website: rsc.li/rsc-chembio. We would be grateful if upon submission you would be able to mention that your manuscript is intended for this themed collection in the “notes to the editor” box.

Please note that before a final decision is made, all submissions are subject to an initial assessment to confirm the manuscript’s suitability for full peer review.

 If you have any questions about the journal or the collection, please contact the editorial office via chembio-rsc@rsc.org.

With kind regards,

Professor Chengqi Yi

Peking University, China

Professor Yan Zhang

Nanjing University, China

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

 

The RSC Chemical Biology “Editor’s choice” article collection

The RSC Chemical Biology “Editor’s choice” article collection

The Editor’s choice collection for RSC Chemical Biology celebrates the very best work published in the journal to date, including regularly added articles personally chosen by our world-renowned Editorial Board, as well as those highlighted as “HOT” during the peer review process.

 


October

After a summer break we are back this month, with Associate Editor Andrea Rentmeister selecting two fantastic articles to highlight.

Professor Rentmeister’s choices are detailed below. Access the full collection for free.

Review

Cell-free riboswitches
Takeshi Tabuchi and Yohei Yokobayashi
RSC Chem. Biol., 2021, 2, 1430-1440
DOI: 10.1039/D1CB00138H

Professor Rentmeister, “Cell-free systems with the ability to carry out complex functions are an important aspect of synthetic biology. This review focuses on cell-free riboswitches, an overview that has been missing so far. It introduces various prokaryotic and eukaryotic systems and highlights their applications.”

 

Paper

Click-based amplification: designed to facilitate various target labelling modes with ultralow background amplification
Jinyi Bai, Fusheng Guo, Mengyao Li, Yulong Li and Xiaoguang Lei
RSC Chem. Biol., 2021, 2, 906-916
DOI: 10.1039/D1CB00002K

Professor Rentmeister, “Bai et al present a versatile strategy to the problem of low signal that is often encountered when biological samples are labeled. In their “click-based amplification” a first azide is clicked to a biotin. Instead of using a regular streptavidin (SA), a modified SA with multiple azido-groups then serves as amplifier, allowing to click multiple biotins and to bind multiple reporter SAs. The authors achieved remarkable fluorescence enhancement in cultured cells and tissue.”

 


July

In July, Editorial Board Member Ali Tavassoli selected two of his favourite articles to highlight.

Professor Tavassoli’s choices are detailed below. Access the full collection for free.

Review

Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation
Michael J. Bond and Craig M. Crews
RSC Chem. Biol., 2021, 2, 725-742
DOI: 10.1039/ D1CB00011J

Professor Tavassoli, “PROTACs are an exciting new drug modality that hold much promise as potential therapeutics. This timely review provides an excellent summary of this important field and is a great starting point for those interested in learning more about PROTACs.”

 

Paper

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism
Roman O. Fedoryshchak, Cory A. Ocasio, Benjamin Strutton, Jo Mattocks, Andrew J. Corran and Edward W. Tate
RSC Chem. Biol., 2020, 1, 68-78
DOI: 10.1039/ D0CB00020E

Professor Tavassoli, “This paper is an excellent example of the power and utility of chemical biology and chemical proteomics. The authors identify inhibitors of Z. tritici N-myristoyltransferase, and use these compounds in a chemical proteomics approach to profile the myristolated proteome in Z. tritici. These studies lead to the identification of an unusual mechanism by which the fungus defends itself from NMT inhibitors.”

 


June

In June, three exciting articles were chosen by Editorial Board Member Jen Heemstra.

Professor Heemstra’s choices are detailed below.  Access the full collection for free

Review

Interfacing non-enzymatic catalysis with living microorganisms
Joanna C. Sadler, Jonathan A. Dennis, Nick W. Johnson and Stephen Wallace
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/ D1CB00072A

Professor Heemstra, “Chemical catalysis and biocatalysis each have unique advantages and limitations toward the synthesis of high-value compounds. This review highlights recent progress in biocompatible chemistry, which empowers chemists to interface biotic and abiotic catalysts to develop improved synthetic routes.”

 

Communication

An activity-based fluorescent sensor for the detection of the phenol sulfotransferase SULT1A1 in living cells
Regina A. Baglia, Kira R. Mills, Koushambi Mitra, Jasmine N. Tutol, Darby Ball, Kierstin M. Page, Jyothi Kallu, Sriharika Gottipolu, Sheena D’Arcy, Steven O. Nielsen and Sheel C. Dodani
RSC Chem. Biol., 2021, 2, 830-834
DOI: 10.1039/ D0CB00231C

Professor Heemstra, “SULT1 enzymes play important roles in biology and this paper reports the first activity-based probe for an enzyme in this class. The naphthol-based sensor functions in vitro and in live cells, providing a useful tool for drug screening and the study of cellular functions of SULT1A1.”

 

Paper

Synthesis and application of a 19F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs
Wen Ann Wee, Ji Hye Yum, Shingo Hirashima, Hiroshi Sugiyama and Soyoung Park
RSC Chem. Biol., 2021, 2, 876-882
DOI: 10.1039/ D1CB00020A

Professor Heemstra, “Non-canonical DNA structures such as cytosine-rich i-motifs likely have biological importance yet are elusive to study. The authors report a new cytidine analogue that shows increased fluorescence enhancement upon folding and is also compatible with 19F NMR.”

 


April

In April Associate Editor Roderich Süssmuth selected two high quality articles to add to the collection.

Below are his choices.  Access the full collection for free.

Review

Biosynthesis of alkyne-containing natural products
Xinyang Li, Jian-Ming Lv, Dan Hu and Ikuro Abe
RSC Chem. Biol., 2021, 2, 166-180
DOI: 10.1039/D0CB00190B

Professor Süssmuth, “A review article was long time due, since the alkyne group is of eminent importance in biological chemistry, particularly as a handle for the click reaction. It is interesting to see, that nature also synthesizes this functionality, which is present in various natural products.”

 

Paper

Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases
Florian Mayerthaler, Anna-Lena Feldberg, Jonas Alfermann, Xun Sun, Wieland Steinchen, Haw Yang and Henning D. Mootz
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/D0CB00220H

Professor Süssmuth, “The work addresses dynamics of non-ribosomal peptide synthetases. The understanding of the gross architecture of the NRPSs from x-ray structures is now followed in this study to understand the dynamics, an aspect of increasing importance.”

 


March

In March it was the turn of Associate Editor Cai-Guang Yang to highlight three of his favourite articles to date.

Below are his choices.  Access the full collection for free.

Review

Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry
Dorothée Ganz, Dennis Harijan and Hans-Achim Wagenknecht
RSC Chem. Biol., 2020, 1, 86-97
DOI: 10.1039/D0CB00047G

Professor Yang, “This review summarizes DNA and RNA labelling by means of bioorthogonal cycloaddition chemistry in the cellular environment. It also describes current status of orthogonal dual and triple labelling of DNA and RNA in vitro to demonstrate the potential in vivo applications for future.”

 

Papers

Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi and Hiroaki Suga
RSC Chem. Biol., 2020, 1, 26-34
DOI: 10.1039/D0CB00016G

Professor Yang, “By applying a unique RaPID display screening technique, this work reports the first instance of de novo macrocyclic peptides acting as direct binders of a highly hydrophobic and not commonly targeted Wnt protein or similar unstable proteins.”

 

A live-cell assay for the detection of pre-microRNA–protein interactions
Sydney L. Rosenblum, Daniel A. Lorenz and Amanda L. Garner
RSC Chem. Biol., 2021, 2, 241-247
DOI: 10.1039/D0CB00055H

Professor Yang, “This work reports the efforts in the development of a new approach for detection of RNA–protein interactions (RPIs), RNA interaction with Protein- mediated Complementation Assay (RiPCA). RiPCA could serve as a useful tool for detecting RPIs in live cells.”

 


February

February saw Associate Editor Seung-Bum Park has added his choice to the collection.

Below is Professor Park’s choice.  Access the full collection for free.

Communication

In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
Sophie V. Morse, Tamara Boltersdorf, Tiffany G. Chan, Felicity N. E. Gavins, James J. Choi and Nicholas J. Long
RSC Chem. Biol., 2020, 1, 385-389
DOI: 10.1039/D0CB00140F

 


January

In January we launched the collection with 3 papers chosen by our Editorial Chair, Professor Hiroaki Suga, alongside some of our hottest papers published in 2020.

Below are Professor Suga’s choices. Access the full collection for free.

Review

The chemical biology of coronavirus host–cell interactions
Suprama Datta, Erik C. Hett, Kalpit A. Vora, Daria J. Hazuda, Rob C. Oslund, Olugbeminiyi O. Fadeyi and Andrew Emili
RSC Chem. Biol., 2021, 2, 30-46
DOI: 10.1039/D0CB00197J

Professor Suga, “This review timely and comprehensively summarizes the biological events linked to the coronavirus outbreak.”

 

Papers

A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
Taylor A. Lundy, Shogo Mori and Sylvie Garneau-Tsodikova
RSC Chem. Biol., 2020, 1, 233-250
DOI: 10.1039/D0CB00092B

Professor Suga, “The families of interrupted A domains and types of M domains in nonribosomal peptide class of natural products have been categorized. It has illuminated patterns and insights on how to harness them for engineering studies in the future.”

 

Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
Kuan Hu, Lin Xie, Masayuki Hanyu, Yiding Zhang, Lingyun Li, Xiaohui Ma, Kotaro Nagatsu, Hisashi Suzuki, Weizhi Wang and Ming-Rong Zhang
RSC Chem. Biol., 2020, 1, 214-224
DOI: 10.1039/D0CB00070A

Professor Suga, “Authors of this paper have developed an impressive PET imaging tool for the most famous immune check point mediated by the PD-1 and PD-L1 interaction, demonstrating not only cell culture and ex vivo detection but also in vivo detection in mice.”

 


We hope you enjoy reading these articles!