Author Archive

Upcoming conferences highlighted for RSC Chemical Biology readers! January 2023

RSC Chemical Biology is highlighting some upcoming conferences in January 2023 that we think would be of interest to our broad chemical biology readership. We’re sponsoring these conferences and attending one too! Please consider registering!

3rd PSL Chemical Biology Symposium

12-13th Jan 2023
Paris, France
Registration deadline: 31st Oct 2022
Poster abstract deadline: 30th Nov 2022
RSC Chemical Biology will be attending this conference!

RSC Chemical Biology and Bio-organic Group Forum 2023

13th Jan 2023
Belfast, United Kingdom
Oral/poster abstract deadline: 11th Nov 2022
Registration deadline: 25th Nov 2022

Advances in Chemical Biology – DECHEMA

24-25 Jan 2023
Frankfurt, Germany
Poster abstract submission deadline: 31st Oct 2022
Last minute poster deadline: 6th Jan 2022

New themed collection on Xenonucleic acids (XNA)

We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.

Read the Collection

Guest-edited by Dennis Bong (Ohio State University), Philipp Holliger (MRC Laboratory of Molecular Biology), and Chaoyong Yang (Xiamen University), this themed collection covers all aspects of modified nucleic acids in chemical and synthetic biology including both in vitro as well as in vivo applications, and new chemistries. Taken together, the papers collected in this themed collection represent the state of the art on XNAs and highlights work at the interface of chemistry and biology.

A selection of the articles has been provided below. All articles in RSC Chemical Biology are open access and free to read.


Introduction to the themed collection on XNA xenonucleic acids
Dennis Bong, Philipp Holliger and Chaoyong Yang
RSC. Chem. Biol., 2022, 3, DOI: 10.1039/D2CB90036J


From polymerase engineering to semi-synthetic life: artificial expansion of the central dogma
Leping Sun, Xingyun Ma, Binliang Zhang, Yanjia Qin, Jiezhao Ma, Yuhui Du and Tingjian Chen
RSC Chem. Biol., 2022, 3, 1173-1197, DOI: 10.1039/D2CB00116K

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
Chaturong Suparpprom and Tirayut Vilaivan
RSC Chem. Biol., 2022, 3, 648-697, DOI: 10.1039/D2CB00017B


Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues
John R. D. Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger and Alexander I. Taylor
RSC Chem. Biol., 2022, 3, 1209-1215, DOI: 10.1039/D2CB00035K

Dependence of click-SELEX performance on the nature and average number of modified nucleotides
Julia Siegl, Olga Plückthun and Günter Mayer
RSC Chem. Biol., 2022, 3, 288-294, DOI: 10.1039/D2CB00012A


Synthesis and structure–activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown
Enrico Cadoni, Francesca Pennati, Penthip Muangkaew, Joke Elskens, Annemieke Madder and Alex Manicardi
RSC Chem. Biol., 2022, 3, 1129-1143, DOI: 10.1039/D2CB00095D

Stimuli-responsive assembly of bilingual peptide nucleic acids
Hector S. Argueta-Gonzalez, Colin S. Swenson, George Song and Jennifer M. Heemstra
RSC Chem. Biol., 2022, 3, 1035-1043, DOI: 10.1039/D2CB00020B

Mutant polymerases capable of 2′ fluoro-modified nucleic acid synthesis and amplification with improved accuracy
Trevor A. Christensen, Kristi Y. Lee, Simone Z. P. Gottlieb, Mikayla B. Carrier and Aaron M. Leconte
RSC Chem. Biol., 2022, 3, 1044-1051, DOI: 10.1039/D2CB00064D

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Anna Dysko, Ysobel R. Baker, Graham McClorey, Matthew J. A. Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer and Tom Brown
RSC Chem. Biol., 2022, 3, 765-772, DOI: 10.1039/D2CB00100D

Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
Ryosuke Kita, Takashi Osawa and Satoshi Obika
RSC Chem. Biol., 2022, 3, 728-738, DOI: 10.1039/D1CB00240F

A ruthenium–oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser and Marcel Hollenstein
RSC Chem. Biol., 2022, 3, 85-95, DOI: 10.1039/D1CB00146A

Targeting a conserved structural element from the SARS-CoV-2 genome using L-DNA aptamers
Jing Li and Jonathan T. Sczepanski
RSC Chem. Biol., 2022, 3, 79-84, DOI: 10.1039/D1CB00172H


We hope you enjoy this new themed collection from RSC Chemical Biology.

Themed collection on “Synthesis and chemical biology of macrocycles”

We’re pleased to announce that our first guest-edited themed collection, on the Synthesis and Chemical Biology of Macrocycles, has now been published online! We thank the Guest Editors, Gong Chen (Nankai University), Monika Raj (Emory University), and Andrei Yudin (University of Toronto) for their work editing this collection.

Read the collection

Macrocycles are an important class of compounds with a long-recognised, significant role in chemical biology and drug discovery. This themed collection offers a collection of articles that showcase the ongoing interest in the chemical biology of macrocycles. Recent years have witnessed the development of new synthetic and biological strategies to construct large rings composed of amino acid residues. In addition, significant progress has been made in efforts to understand and predict the properties of macrocycles. We have collected contributions that are representative of the tremendous promise and pace of growth in this area.

The work in this collection covers all areas of the synthesis and chemical biology of macrocycles, including new synthetic and biosynthetic pathways for synthesis of diverse range of macrocycles; peptide and peptidomimetics macrocycles; design and synthesis of macrocycles for biological and medicinal applications; cell permeable macrocycles for targeting intracellular proteins; structural studies of macrocycles to expand the conformational drug space, and much more. Taken together, the papers collected in this themed collection represent the state of the art in macrocycles and highlight work at the interface of chemistry and biology.


Introduction to ‘Synthesis and chemical biology of macrocycles’
RSC Chem. Biol., 2022, 3, 993-993. DOI: 10.1039/D2CB90018A


Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang and Weiping Gao
RSC Chem. Biol., 2022, 3, 815-829. DOI: 10.1039/D1CB00246E

Cyclic peptide drugs approved in the last two decades (2001–2021)
Huiya Zhanga and Shiyu Chen
RSC Chem. Biol., 2022, 3, 18-31. DOI: 10.1039/D1CB00154J


Targeted disruption of PKC from AKAP signaling complexes
Ameya J. Limaye, George N. Bendzunasa and Eileen J. Kennedy
RSC Chem. Biol., 2021, 2, 1227-1231. DOI: 10.1039/D1CB00106J


Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
Aline D. de Araujo, Junxian Lim, Kai-Chen Wu, Huy N. Hoang, Huy T. Nguyen and David P. Fairlie
RSC Chem. Biol., 2022, 3, 895-904. DOI: 10.1039/D1CB00231G

Navigating complex peptide structures using macrocycle conformational maps
Timothy J. McTiernan, Diego B. Diaz, George J. Saunders, Fiona Spranga and Andrei K. Yudin
RSC Chem. Biol., 2022, 3, 739-747. DOI: 10.1039/D2CB00016D

Structural impact of thioamide incorporation into a β-hairpin
Kristen E. Fiore, Martijn J. Patist, Sam Giannakoulias, Cheng-Hsin Huang, Hitesh Verma, Bhavesh Khatri, Richard P. Cheng, Jayanta Chatterjee and E. James Petersson
RSC Chem. Biol., 2022, 3, 582-591. DOI: 10.1039/D1CB00229E

Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions
Kleopas Y. Palate, Zhongzhen Yang, Adrian C. Whitwood and William P. Unsworth
RSC Chem. Biol., 2022, 3, 334-340. DOI: 10.1039/D1CB00245G

Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue
Masanobu Nagano, Satoshi Ishida and Hiroaki Suga
RSC Chem. Biol., 2022, 3, 295-300. DOI: 10.1039/D1CB00225B

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Anselm F. L. Schneider, Joerg Kallen, Johannes Ottl, Patrick C. Reid, Sebastien Ripoche, Stephan Ruetz, Therese-Marie Stachyra, Samuel Hintermann, Christoph E. Dumelin, Christian P. R. Hackenberger and Andreas L. Marzinzik
RSC Chem. Biol., 2021, 2, 1661-1668. DOI: 10.1039/D1CB00056J

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain
Ilona Christy Unarta, Jianchao Xu, Yuan Shang, Carina Hey Pui Cheung, Ruichi Zhu, Xudong Chen, Siqin Cao, Peter Pak-Hang Cheung, Donald Bierer, Mingjie Zhang, Xuhui Huang and Xuechen Li
RSC Chem. Biol., 2021, 2, 1274-1284. DOI: 10.1039/D1CB00087J