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The RSC Chemical Biology “Editor’s choice” article collection

The RSC Chemical Biology “Editor’s choice” article collection

The new Editor’s choice collection for RSC Chemical Biology celebrates the very best work published in the journal to date, including regularly added articles personally chosen by our world-renowned Editorial Board, as well as those highlighted as “HOT” during the peer review process.



This month, Associate Editor Cai-Guang Yang has highlighted three of his favourite articles to date.

Below are his choices.  Access the full collection for free.


Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry
Dorothée Ganz, Dennis Harijan and Hans-Achim Wagenknecht
RSC Chem. Biol., 2020, 1, 86-97
DOI: 10.1039/D0CB00047G

Professor Yang, “This review summarizes DNA and RNA labelling by means of bioorthogonal cycloaddition chemistry in the cellular environment. It also describes current status of orthogonal dual and triple labelling of DNA and RNA in vitro to demonstrate the potential in vivo applications for future.”



Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi and Hiroaki Suga
RSC Chem. Biol., 2020, 1, 26-34
DOI: 10.1039/D0CB00016G

Professor Yang, “By applying a unique RaPID display screening technique, this work reports the first instance of de novo macrocyclic peptides acting as direct binders of a highly hydrophobic and not commonly targeted Wnt protein or similar unstable proteins.”


A live-cell assay for the detection of pre-microRNA–protein interactions
Sydney L. Rosenblum, Daniel A. Lorenz and Amanda L. Garner
RSC Chem. Biol., 2021, 2, 241-247
DOI: 10.1039/D0CB00055H

Professor Yang, “This work reports the efforts in the development of a new approach for detection of RNA–protein interactions (RPIs), RNA interaction with Protein- mediated Complementation Assay (RiPCA). RiPCA could serve as a useful tool for detecting RPIs in live cells.”



February saw Associate Editor Seung-Bum Park has added his choice to the collection.

Below is Professor Park’s choice.  Access the full collection for free.


In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
Sophie V. Morse, Tamara Boltersdorf, Tiffany G. Chan, Felicity N. E. Gavins, James J. Choi and Nicholas J. Long
RSC Chem. Biol., 2020, 1, 385-389
DOI: 10.1039/D0CB00140F



In January we launched the collection with 3 papers chosen by our Editorial Chair, Professor Hiroaki Suga, alongside some of our hottest papers published in 2020.

Below are Professor Suga’s choices. Access the full collection for free.


The chemical biology of coronavirus host–cell interactions
Suprama Datta, Erik C. Hett, Kalpit A. Vora, Daria J. Hazuda, Rob C. Oslund, Olugbeminiyi O. Fadeyi and Andrew Emili
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/D0CB00197J

Professor Suga, “This review timely and complehensively summarizes the biological events linked to the coronavirus outbreak.”



A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
Taylor A. Lundy, Shogo Mori and Sylvie Garneau-Tsodikova
RSC Chem. Biol., 2020, 1, 233-250
DOI: 10.1039/D0CB00092B

Professor Suga, “The families of interrupted A domains and types of M domains in nonribosomal peptide class of natural products have been categorized. It has illuminated patterns and insights on how to harness them for engineering studies in the future.”


Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
Kuan Hu, Lin Xie, Masayuki Hanyu, Yiding Zhang, Lingyun Li, Xiaohui Ma, Kotaro Nagatsu, Hisashi Suzuki, Weizhi Wang and Ming-Rong Zhang
RSC Chem. Biol., 2020, 1, 214-224
DOI: 10.1039/D0CB00070A

Professor Suga, “Authors of this paper have developed an impressive PET imaging tool for the most famous immune check point mediated by the PD-1 and PD-L1 interaction, demonstrating not only cell culture and ex vivo detection but also in vivo detection in mice.”


We hope you enjoy reading these articles!


RSC Chemical Biology Desktop Seminar featuring Roderich Süssmuth and Maja Köhn

RSC Desktop Seminars are an ongoing initiative from the Royal Society of Chemistry to bring cutting-edge research directly to you. More than ever, there is a crucial need for sharing research, and connecting our community. This desktop seminar continues the RSC Chemical Biology series, presented by RSC Chemical Biology and featuring presentations from our world-renowned researcher board members.

This webinar will allow researchers of all professional levels to connect and share ideas and ask questions.

RSC Chemical Biology desktop seminar: Register now!

4 February 2021 15:00 – 16:30 GMT / 16:00 – 17:30 CET

  • Opening remarks
  • Ribosomal and non-ribosomal peptides from bacteria and fungi as sources for new antibiotics, Roderich Süssmuth, RSC Chemical Biology Associate Editor
  • RSC Chemical Biology: an innovative home for breakthrough discoveries, Anna RulkaRSC Chemical Biology Executive Editor
  • Peptide-based protein-protein-interaction inhibitors for protein phosphatase-1, Maja Köhn, RSC Chemical Biology Advisory Board member, and Chemcial Science Associate Editor
  • Open discussion/Q&A
  • Closing remarks


Professor Roderich Süssmuth
Roderich Süssmuth is Professor of the Department of Chemistry at the Technical University of Berlin. He received his Diploma in Chemistry (1995) and his PhD in Chemistry (1998) from the Eberhard Karls University of Tübingen. This was followed by a post-doctoral stay at The Scripps Research Institute, La Jolla (2000-2001) and an Assistant Professor position with an Emmy-Noether Fellowship at the University of Tübingen (2002-2004). Roderich was appointed to the position of Associate Professor at TU Berlin in 2004, and Full Professor in 2009. Roderich’s research interests are in the fields of peptide chemistry, peptide drugs, medicinal chemistry and the biosynthesis and mode of action of natural products. Roderich serves on various grant committees and has received various awards and recognitions.

Scientific talk: “Ribosomal and non-ribosomal peptides from bacteria and fungi as sources for new antibiotics”


Professor Maja Köhn
Maja Köhn is a Professor for Integrative Signaling Research at the Faculty of Biology, University of Freiburg, Germany. She studied chemistry at the University of Kiel and moved afterwards to the Max-Planck-Institute and the University in Dortmund, where she obtained her PhD under the direction of H. Waldmann in 2005. After Maja’s postdoctoral work with G. L. Verdine at Harvard University, she started her independent career in 2007 as a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany. In 2016 Maja moved to Freiburg for her current position. Research in her group focuses on the development and application of tools using synthetic chemistry and molecular cell biology to study and target phosphatases in health and disease.

Scientific talk: “Peptide-based protein-protein-interaction inhibitors for protein phosphatase-1”


We hope that you can join us for this exciting event.

Congratulations to Hiroaki Suga, awarded the Humboldt Research Award

Congratulations to Professor Hiroaki Suga, RSC Chemical Biology Editorial Board Chair, who has been elected the recipient of a Humboldt Research Award.

“The award is granted in recognition of a researcher’s entire achievements to date to academics whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future.”

Award recipients are nominated by established German academics, and Prof. Suga was nominated by Professor Roderich Sußmuth.

RSC Chemical Biology: first issue out now

Issue 1 is online and ready to read

We’re pleased to be able to share with you the first full issue of RSC Chemical Biology, our new, gold open access journal showcasing agenda-setting research of interest to the broad chemical biology community. Read issue 1 now

It includes:

Introduction to RSC Chemical Biology
Hiroaki Suga, Kathryn L. Gempf and Anna Rulka
RSC Chem. Biol., 2020, 1, 6-7. DOI: 10.1039/D0CB90001J

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis
Joshua C. Corpuz, Larissa M. Podust, Tony D. Davis, Matt J. Jaremko and Michael D. Burkart
RSC Chem. Biol., 2020, 1, 8-12. DOI: 10.1039/C9CB00015A

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor
Olawale G. Raimi, Ramon Hurtado-Guerrero, Vladimir Borodkin, Andrew Ferenbach, Michael D. Urbaniak, Michael A. J. Ferguson and Daan M. F. van Aalten
RSC Chem. Biol., 2020, 1, 13-25. DOI: 10.1039/C9CB00017H

Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi and Hiroaki Suga
RSC Chem. Biol., 2020, 1, 26-34. DOI: 10.1039/D0CB00016G


RSC Chemical Biology offers authors a trusted, reliable option for publishing their work open access.

As the first Royal Society of Chemistry journal to offer transparent peer review, authors also have the option to publish reviewers’ comments, the editor’s decision letter, and authors’ response alongside the article. It’s part of our commitment to make research and decision-making more open, robust and accessible.


Supporting an open future for vital research

All papers published in the journal will always be free to access. We are waiving article processing charges for the first two years, so until mid-2022 the journal will be completely free to publish in for authors, as well as free to read.


We hope you enjoy reading the exciting research in our first issue!
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