1 year of RSC Chemical Biology – the covers

This month we are celebrating our fantastic first year of RSC Chemical Biology!  We have seen six issues, containing 56 high quality articles, and two editorials.

We have chosen some of our favourite covers from all the wonderful artwork that has featured on the journal so far.  Thank you to all the authors who have provided these amazing artworks!

We invite you to join us on Twitter to vote for your favourite cover of the year from the shortlist below.

Click on each of the images for a close-up look of each cover.

 

Join us on Twitter to vote for your favourite

A

Vol. 1, Issue 1

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis
Joshua C. Corpuz, Larissa M. Podust, Tony D. Davis, Matt J. Jaremko and Michael D. Burkart
RSC Chem. Biol., 2020,1, 8-12; DOI: 10.1039/C9CB00015A

B

Vol. 1, Issue 3 Inside cover

Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry
Dorothée Ganz, Dennis Harijan and Hans-Achim Wagenknecht
RSC Chem. Biol., 2020,1, 86-97; DOI: 10.1039/D0CB00047G

C

Vol. 1, Issue 5

Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance
M. Rhia L. Stone, Urszula Łapińska, Stefano Pagliara, Muriel Masi, Joanne T. Blanchfield, Matthew A. Cooper and Mark A. T. Blaskovich
RSC Chem. Biol., 2020,1, 395-404; DOI: 10.1039/D0CB00118J

D

Vol. 2, Issue 2

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery
Marta Pazo, Giulia Salluce, Irene Lostalé-Seijo, Marisa Juanes, Francisco Gonzalez, Rebeca Garcia-Fandiño and Javier Montenegro
RSC Chem. Biol., 2021,2, 503-512; DOI: 10.1039/D0CB00103A

The RSC Chemical Biology “Editor’s choice” article collection

The RSC Chemical Biology “Editor’s choice” article collection

The new Editor’s choice collection for RSC Chemical Biology celebrates the very best work published in the journal to date, including regularly added articles personally chosen by our world-renowned Editorial Board, as well as those highlighted as “HOT” during the peer review process.

 


April

This month sees Associate Editor Roderich Süssmuth selecting two high quality articles to add to the collection.

Below are his choices.  Access the full collection for free.

Review

Biosynthesis of alkyne-containing natural products
Xinyang Li, Jian-Ming Lv, Dan Hu and Ikuro Abe
RSC Chem. Biol., 2021, 2, 166-180
DOI: 10.1039/D0CB00190B

Professor Süssmuth, “A review article was long time due, since the alkyne group is of eminent importance in biological chemistry, particularly as a handle for the click reaction. It is interesting to see, that nature also synthesizes this functionality, which is present in various natural products.”

 

Paper

Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases
Florian Mayerthaler, Anna-Lena Feldberg, Jonas Alfermann, Xun Sun, Wieland Steinchen, Haw Yang and Henning D. Mootz
RSC Chem. Biol., 2021, Advance Article
DOI: 10.1039/D0CB00220H

Professor Süssmuth, “The work addresses dynamics of non-ribosomal peptide synthetases. The understanding of the gross architecture of the NRPSs from x-ray structures is now followed in this study to understand the dynamics, an aspect of increasing importance.”

 


March

This month, Associate Editor Cai-Guang Yang has highlighted three of his favourite articles to date.

Below are his choices.  Access the full collection for free.

Review

Labelling of DNA and RNA in the cellular environment by means of bioorthogonal cycloaddition chemistry
Dorothée Ganz, Dennis Harijan and Hans-Achim Wagenknecht
RSC Chem. Biol., 2020, 1, 86-97
DOI: 10.1039/D0CB00047G

Professor Yang, “This review summarizes DNA and RNA labelling by means of bioorthogonal cycloaddition chemistry in the cellular environment. It also describes current status of orthogonal dual and triple labelling of DNA and RNA in vitro to demonstrate the potential in vivo applications for future.”

 

Papers

Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi and Hiroaki Suga
RSC Chem. Biol., 2020, 1, 26-34
DOI: 10.1039/D0CB00016G

Professor Yang, “By applying a unique RaPID display screening technique, this work reports the first instance of de novo macrocyclic peptides acting as direct binders of a highly hydrophobic and not commonly targeted Wnt protein or similar unstable proteins.”

 

A live-cell assay for the detection of pre-microRNA–protein interactions
Sydney L. Rosenblum, Daniel A. Lorenz and Amanda L. Garner
RSC Chem. Biol., 2021, 2, 241-247
DOI: 10.1039/D0CB00055H

Professor Yang, “This work reports the efforts in the development of a new approach for detection of RNA–protein interactions (RPIs), RNA interaction with Protein- mediated Complementation Assay (RiPCA). RiPCA could serve as a useful tool for detecting RPIs in live cells.”

 


February

February saw Associate Editor Seung-Bum Park has added his choice to the collection.

Below is Professor Park’s choice.  Access the full collection for free.

Communication

In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
Sophie V. Morse, Tamara Boltersdorf, Tiffany G. Chan, Felicity N. E. Gavins, James J. Choi and Nicholas J. Long
RSC Chem. Biol., 2020, 1, 385-389
DOI: 10.1039/D0CB00140F

 


January

In January we launched the collection with 3 papers chosen by our Editorial Chair, Professor Hiroaki Suga, alongside some of our hottest papers published in 2020.

Below are Professor Suga’s choices. Access the full collection for free.

Review

The chemical biology of coronavirus host–cell interactions
Suprama Datta, Erik C. Hett, Kalpit A. Vora, Daria J. Hazuda, Rob C. Oslund, Olugbeminiyi O. Fadeyi and Andrew Emili
RSC Chem. Biol., 2021, 2, 30-46
DOI: 10.1039/D0CB00197J

Professor Suga, “This review timely and comprehensively summarizes the biological events linked to the coronavirus outbreak.”

 

Papers

A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
Taylor A. Lundy, Shogo Mori and Sylvie Garneau-Tsodikova
RSC Chem. Biol., 2020, 1, 233-250
DOI: 10.1039/D0CB00092B

Professor Suga, “The families of interrupted A domains and types of M domains in nonribosomal peptide class of natural products have been categorized. It has illuminated patterns and insights on how to harness them for engineering studies in the future.”

 

Harnessing the PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
Kuan Hu, Lin Xie, Masayuki Hanyu, Yiding Zhang, Lingyun Li, Xiaohui Ma, Kotaro Nagatsu, Hisashi Suzuki, Weizhi Wang and Ming-Rong Zhang
RSC Chem. Biol., 2020, 1, 214-224
DOI: 10.1039/D0CB00070A

Professor Suga, “Authors of this paper have developed an impressive PET imaging tool for the most famous immune check point mediated by the PD-1 and PD-L1 interaction, demonstrating not only cell culture and ex vivo detection but also in vivo detection in mice.”

 


We hope you enjoy reading these articles!

 

RSC Chemical Biology Desktop Seminar featuring Roderich Süssmuth and Maja Köhn

RSC Desktop Seminars are an ongoing initiative from the Royal Society of Chemistry to bring cutting-edge research directly to you. More than ever, there is a crucial need for sharing research, and connecting our community. This desktop seminar continues the RSC Chemical Biology series, presented by RSC Chemical Biology and featuring presentations from our world-renowned researcher board members.

This webinar will allow researchers of all professional levels to connect and share ideas and ask questions.

RSC Chemical Biology desktop seminar: Register now!

4 February 2021 15:00 – 16:30 GMT / 16:00 – 17:30 CET

  • Opening remarks
  • Ribosomal and non-ribosomal peptides from bacteria and fungi as sources for new antibiotics, Roderich Süssmuth, RSC Chemical Biology Associate Editor
  • RSC Chemical Biology: an innovative home for breakthrough discoveries, Anna RulkaRSC Chemical Biology Executive Editor
  • Peptide-based protein-protein-interaction inhibitors for protein phosphatase-1, Maja Köhn, RSC Chemical Biology Advisory Board member, and Chemcial Science Associate Editor
  • Open discussion/Q&A
  • Closing remarks

Featuring:

Professor Roderich Süssmuth
Roderich Süssmuth is Professor of the Department of Chemistry at the Technical University of Berlin. He received his Diploma in Chemistry (1995) and his PhD in Chemistry (1998) from the Eberhard Karls University of Tübingen. This was followed by a post-doctoral stay at The Scripps Research Institute, La Jolla (2000-2001) and an Assistant Professor position with an Emmy-Noether Fellowship at the University of Tübingen (2002-2004). Roderich was appointed to the position of Associate Professor at TU Berlin in 2004, and Full Professor in 2009. Roderich’s research interests are in the fields of peptide chemistry, peptide drugs, medicinal chemistry and the biosynthesis and mode of action of natural products. Roderich serves on various grant committees and has received various awards and recognitions.

Scientific talk: “Ribosomal and non-ribosomal peptides from bacteria and fungi as sources for new antibiotics”

 

Professor Maja Köhn
Maja Köhn is a Professor for Integrative Signaling Research at the Faculty of Biology, University of Freiburg, Germany. She studied chemistry at the University of Kiel and moved afterwards to the Max-Planck-Institute and the University in Dortmund, where she obtained her PhD under the direction of H. Waldmann in 2005. After Maja’s postdoctoral work with G. L. Verdine at Harvard University, she started her independent career in 2007 as a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany. In 2016 Maja moved to Freiburg for her current position. Research in her group focuses on the development and application of tools using synthetic chemistry and molecular cell biology to study and target phosphatases in health and disease.

Scientific talk: “Peptide-based protein-protein-interaction inhibitors for protein phosphatase-1”

 

We hope that you can join us for this exciting event.

DECHEMA Advances in Chemical Biology Conference

DECHEMA Advances in Chemical Biology conference: Online, 26-28 January 2021

 

This upcoming conference boasts an innovative and interactive programme of events: RSC Chemical Biology welcomes you to join.

 

From expert talks and a virtual exhibition, to lectures by young researchers and ePoster presentations, this promises to be a diverse and inspiring conference. Hot topics will include nucleic acids and proteins, peptides and carbohydrates, targeted synthesis concepts and phenotypic screening. For more information, please visit the conference site.

 

RSC Chemical Biology is delighted to be sponsoring this event as a media partner and invites you to register here now, and check out our virtual booth and join our Meet the Editor Event. 

 

Looking forward to seeing you there,

RSC Chemical Biology Team

 

Tri-Institutional Chemical Biology Symposium

RSC Chemical Biology is proud to be sponsoring the 16th Annual Tri-Institutional Chemical Biology Symposium, which will take place virtually on the 1st of September, 2020, 09:00-18:30 EDT.

This event showcases research at the forefront of chemical biology, and is sponsored and organized by the Tri-Institutional PhD Program in Chemical Biology (TPCB), a joint graduate program of Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine in New York City.

Register for this free event here by the 28th of August 2020

Undergraduate students interested in chemical biology are especially encouraged to attend.

Poster submissions are welcomed from all attendees, including early college high school students, undergraduates, postbaccalaureate students, research assistants and technicians, graduate students, postdoctoral fellows, research staff, and faculty. Posters will be presented live by video in parallel meeting rooms, and judged by TPCB faculty members and keynote speakers for a selection of poster awards sponsored by TPCB and their promotional partners, including RSC Chemical Biology, Chemical Science and Organic & Biomolecular Chemistry.

For more information, please visit the Tri-Institutional Chemical Biology Symposium event page.

TPCB has been strongly committed to diversity and inclusion since its inception. It welcomes scientists from underrepresented minority groups and disadvantaged backgrounds, and those with disabilities.  It does not tolerate racism, discrimination, or harassment of any kind. All attendees are expected to maintain the highest standards of professional conduct throughout the symposium.

 

RSC Desktop Seminar – 28 August 2020: featuring RSC Chemical Biology Editors Seung Bum Park, Anna Rulka and Hiroaki Suga

Join us to hear cutting-edge chemical biology researchers: 28 August 2020 16:00-17:30, JST, KST (UTC+09:00)

RSC Desktop Seminars are a new initiative from the Royal Society of Chemistry to bring cutting-edge research directly to you.

Now, more than ever, there is a crucial need for sharing research, and Executive Editor Anna Rulka of new journal RSC Chemical Biology is delighted to present Hiroaki Suga, Chair of the Editorial Board, and Seung Bum Park, Associate Editor to share their research with you.

RSC Desktop Seminar, hosted by RSC Chemical Biology: Register now

28 August 2020 16:00-17:30, JST, KST (UTC+09:00), 08:00-09:30, BST (UTC+01:00)

  • Opening remarks
  • Professor Seung Bum Park: ​“FITGE (Fluorescence difference In Two-dimensional Gel Electrophoresis) – based Target Identification: New Tools in Chemical Biology & Drug Discovery” – with Q&A
  • Dr Anna Rulka: RSC Chemical Biology: an innovative home for breakthrough discoveries”
  • Professor Hiroaki Suga: “The next generation of RaPID (Random nonstandard Peptide Integrated Discovery) display” – with Q&A
  • Open discussion and Q&A for any of the talks
  • Closing remarks

Featuring:

Seung Bum Park
Seoul National University, South Korea
Associate Editor, RSC Chemical Biology

Seung Bum Park is Professor of the Chemistry Department and Director of the CRI Center for Chemical Proteomics at Seoul National University. He is an alumnus of Yonsei, Texas A&M and Harvard universities, and founded the bio-venture SPARK Biopharma, Inc in 2016. His research interests include molecular diversity, fluorescent bioprobes, phenotypic screening, and target identification for drug discovery targeting protein-protein interaction.

Scientific talk: FITGE (Fluorescence difference In Two-dimensional Gel Electrophoresis) – based Target Identification: New Tools in Chemical Biology & Drug Discovery

 

Hiroaki Suga
University of Tokyo, Japan
Editorial Board Chair, RSC Chemical Biology
 
Hiroaki Suga is Professor of the Department of Chemistry, Graduate School of Science in the University of Tokyo and a founder of PeptiDream Inc. Tokyo. He is an alumnus of Okayama University and MIT, and his research interests are in the field of bioorganic chemistry, chemical biology and biotechnology related to RNA, translation, and peptides. He has received many awards, most recently a Humboldt Research Award in 2020.
 
Scientific talk: The next generation of RaPID (Random nonstandard Peptide Integrated Discovery) display

We hope that you can join us for this exciting event.

 

Congratulations to Hiroaki Suga, awarded the Humboldt Research Award

Congratulations to Professor Hiroaki Suga, RSC Chemical Biology Editorial Board Chair, who has been elected the recipient of a Humboldt Research Award.

“The award is granted in recognition of a researcher’s entire achievements to date to academics whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future.”

Award recipients are nominated by established German academics, and Prof. Suga was nominated by Professor Roderich Sußmuth.

RSC Chemical Biology hosts new RSC Desktop Seminar Series

COVID-19 has rendered in-person events to be suspended or cancelled disrupting connections around the globe. The impact of these cancellations on the sharing of information and ideas, especially in the research landscape, has been dramatic.

In an effort to help researchers to stay connected to advances in chemical research and share support, RSC Chemical Biology is proud to announce the launch of the RSC’s first online-only seminar series.

Introducing RSC Desktop Seminars!

The RSC Desktop Seminar Series is an effort to not only replace in-person research seminars during the current pandemic situation but to also expand access for researchers around the world looking to connect to some of the leading minds in the chemical sciences.

Each seminar is 1 hour and 15 minutes long, and will feature two Small Group Informal Sessions, which will offer researchers in attendance a direct line to the speaker to ask questions and build a network with other like-minded individuals.

While these initial RSC Desktop Seminars are taking place in the Eastern US time zone working hours, we encourage any and all interested to register and attend!

 

Next RSC Desktop Seminars in this Series:

11 June 2020 12:00 EST / 17:00 BST

Our next Desktop Seminar event will take place at 12:00 EST (17:00 BST) on 11 June 2020, and will feature Prof. Dr. Christian Hackenberger – Humboldt-Universität zu Berlin, Leibniz-Institut für Molekulare Pharmakologie; Associate Editor, Organic & Biomolecular Chemistry; Advisory Board member, RSC Chemical Biology

Professor Hackenberger will deliver a talk on “The power of chemoselectivity: Functional protein-conjugates for extra- and intracellular targeting”

Register here now

Previous RSC Desktop Seminars in this Series:

4 June 2020 12:00 PM EST / 17:00 BST
“Understanding and Re-engineering the Programming of Iterative Highly Reducing Polyketide Synthases”
Prof. Dr. Russell Cox
 – Leibniz Universität Hannover; Editor in Chief, RSC Advances; Advisory Board member, RSC Chemical Biology

28 May 2020 12:00 PM EST / 17:00 BST
“Platforms for the generation and high-throughput screening of cyclic peptide libraries”
Dr. Ali Tavassoli
– Professor of Chemical Biology, University of Southampton, Editorial Board member, RSC Chemical Biology

 

21 May 2020 12:00 PM EST / 17:00 BST
“Interrogating Enzymatic Reactions using Nucleic Acid Molecular Recognition and Assembly”
Dr. Jennifer Heemstra – Professor of Chemistry, Emory University, Editorial Board member, RSC Chemical Biology

This inaugural seminar of the series took place on 21 May 2020 12:00 PM EST / 17:00 BST, and was attended by over 150 participants from 20 countries around the world.

 

RSC Chemical Biology: first issue out now

Issue 1 is online and ready to read

We’re pleased to be able to share with you the first full issue of RSC Chemical Biology, our new, gold open access journal showcasing agenda-setting research of interest to the broad chemical biology community. Read issue 1 now

It includes:

Editorial
Introduction to RSC Chemical Biology
Hiroaki Suga, Kathryn L. Gempf and Anna Rulka
RSC Chem. Biol., 2020, 1, 6-7. DOI: 10.1039/D0CB90001J

Communication
Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis
Joshua C. Corpuz, Larissa M. Podust, Tony D. Davis, Matt J. Jaremko and Michael D. Burkart
RSC Chem. Biol., 2020, 1, 8-12. DOI: 10.1039/C9CB00015A

Paper
A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor
Olawale G. Raimi, Ramon Hurtado-Guerrero, Vladimir Borodkin, Andrew Ferenbach, Michael D. Urbaniak, Michael A. J. Ferguson and Daan M. F. van Aalten
RSC Chem. Biol., 2020, 1, 13-25. DOI: 10.1039/C9CB00017H

Paper
Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi and Hiroaki Suga
RSC Chem. Biol., 2020, 1, 26-34. DOI: 10.1039/D0CB00016G

 

RSC Chemical Biology offers authors a trusted, reliable option for publishing their work open access.

As the first Royal Society of Chemistry journal to offer transparent peer review, authors also have the option to publish reviewers’ comments, the editor’s decision letter, and authors’ response alongside the article. It’s part of our commitment to make research and decision-making more open, robust and accessible.

 

Supporting an open future for vital research

All papers published in the journal will always be free to access. We are waiving article processing charges for the first two years, so until mid-2022 the journal will be completely free to publish in for authors, as well as free to read.

 

We hope you enjoy reading the exciting research in our first issue!
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