Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold

About this article

Explore the world of secondary messengers in cell signaling with our latest research on Diacylglycerol (DAG) lipids and their role in cellular communication. DAG kinases (DGK) control cellular DAG levels through phosphorylation, making them crucial in understanding cell signaling pathways. While small molecule inhibitors targeting DGK proteins are valuable tools for investigating DAG signaling, their development has been challenging due to limited information on binding pockets within cells.

Our ground-breaking approach combines chemical proteomics and AlphaFold technology to predict previously undiscovered binding regions for the development of covalent inhibitors.


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Royal Society of Chemistry