Now Published in the RSC Drug Discovery Series
Pharmaceutical Salts and Co-crystals
Edited by Johan Wouters and Luc Quere
Multi-component crystalline materials have received renewed interest in recent years mainly due to their importance in the pharmaceutical industry. Indeed these multi-component crystalline forms influence relevant physico-chemical parameters such as solubility, dissolution rate, chemical and physical stability, melting point and hygroscopicity, which can result in solids with properties superior to those of the free drug.
Combining both reports of the latest academic research and a comprehensive overview of basic principles with applied contributions from selected experts in industry this book will be essential reading for pharmaceutical development scientists, researchers in crystal engineering and equally useful to the more seasoned expert and graduate student.
Key topics covered include: fundamental aspects of salts and co-crystals; the role of fluorine in weak interactions in co-crystals; polymorph prediction of small organic molecules, co-crystals and salts; shape and polarity in co-crystal formation; the role of co-crystals in pharmaceutical development; solid forms and pharmacokinetics; the application of mechanochemistry in the synthesis and discovery of new pharmaceutical forms; co-crystallization in solution and scale-up issues; analytical techniques and strategies for salt/co-crystal characterisation; co-crystal solubility and thermodynamic stability; phase diagrams in co-crystal search and preparation and commercial opportunities and patent considerations.