Now Published in the RSC Drug Discovery Series
Kinase Drug Discovery
Edited by Richard A. Ward and Frederick W. Goldberg
Kinase drug discovery remains an area of significant interest across the pharmaceutical industry and academia. There are currently 13-FDA approved small molecule drugs and over 500 small molecules in active development targeting kinases. These agents have delivered significant benefits to patients that can be measured in life extension or improvement in the quality of life in diseases such as cancer and inflammation.
This exemplary new book will cover a broad range of themes on current ‘hot topics’ in kinase drug discovery. There will be discussion on how medicinal chemistry has been able to exploit this unique new target class, as well as reflections on the varied mechanisms of kinase inhibitors. Also addressed is resistance to kinase inhibition caused by amino acid mutations, non-protein kinases and applications beyond the human kinome into parasitic diseases. Modern approaches to finding kinase leads and reflections on how the field might progress over the coming years is also discussed.
The book will be essential reading for pharmaceutical scientists, biologists and medicinal chemists working in drug discovery and drug development.
http://www.rsc.org/shop/books/2011/9781849731744.asp
