Now Published in the RSC Drug Discovery Series
Proteinases as Drug Targets
Edited by Ben M. Dunn
This exemplary new book collects chapters from leading international scientists who are continuing the effort to identify new proteolytic enzymes that may serve as targets for drug discovery. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition the latest structural studies that are described in the book will permit rapid advances in drug design. Topics covered include selective studies of the enzymes known as dipeptidyl peptidases, the role of the cysteine proteinase B in Alzheimer’s disease, kallakreins, key representatives of the metallo-peptidase family such as meprins and glutamate carboxypeptidases and aspects of the proteins known as inactive serine proteases especially those from a significant human parasite.
The book will be essential reading for medicinal chemists, structural and chemical biologists, biological chemists and pharmaceutical scientists.
http://www.rsc.org/shop/books/2011/9781849730495.asp
