Now Published in the RSC Drug Discovery Series
Polyamine Drug Discovery
Edited by Patrick M. Woster and Robert A. Casero Jr.
Polyamines are ubiquitous molecules that are involved in a number of important cellular processes and aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infections.
This comprehensive new volume covers all aspects of the design and development of potential therapeutics targeting polyamine biosynthesis, metabolism and function. The book details research progress from 1975 to the present date, followed by discussions of the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in cancer chemotherapy and as treatments for parasitic infections including trypanosomiasis and malaria. Finally the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery and the design of polyamine-based epigenetic modulators are also discussed.
Written by a team of medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function, the book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in this field.
http://www.rsc.org/shop/books/2011/9781849731904.asp
