Now Published in the RSC Drug Discovery Series
Neurodegeneration: Metallostasis and Proteostasis
Edited by Danilo Milardi and Enrico Rizzarelli
Substantial evidence has accumulated indicating that diverse neurological disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. The latest advances suggest that deficiencies in protein homeostasis may lead to cell dysfunction and disease and small molecules with the potential to control metal homeostasis are expected to provide the framework for the design of novel proteostasis regulators.
This exemplary new book provides an up-to-date perspective on the latest developments in this fast moving field. Traditional views are compared with new emerging ideas in the neuroscience of metal ions. The book will be essential reading for neuroscientists and medicinal chemists working in both industry and academia.
http://www.rsc.org/shop/books/2011/9781849730501.asp
