Analyst Blog

Analyst Issue 23 now online

30 Oct 2012

Outside front cover, Analyst, 2012, Issue 23

Zenhausern et al., Analyst, 2012, 137, 5510

We enter the world of forensics for the outside front cover for this most recent issue of Analyst. Frederic Zenhausern and colleagues from the University of Arizona, USA, report on a prototype of a PCR on a plastic mircofluidic device.

Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis
Matthew D. Estes, Jianing Yang, Brett Duane, Stan Smith, Carla Brooks, Alan Nordquist and Frederic Zenhausern
Analyst, 2012, 137, 5510-5519
DOI: 10.1039/C2AN35768B

Inside front cover, Analyst, 2012, Issue 23

Ghafari & Hanley, Analyst, 2012, 137, 5520

From Homanaz Ghafari and Quentin S. Hanley at Nottingham Trent University, UK, comes our inside front cover. This paper reports on optically sectioned planar format assays detected using quantum dot (QD) reporters arrayed along the optical z-axis on mica or glass substrates to form volume encoded arrays.

Analysis of layered assays and volume microarrays in stratified media
Homanaz Ghafari and Quentin S. Hanley
Analyst, 2012, 137, 5520-5526
DOI: 10.1039/C2AN35767D

These papers will be free to read for 6 weeks.

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Reminder: SPEC 2012 – Optical Diagnosis themed issue

30 Oct 2012

By Rebecca Brodie, Deputy Editor.

SPEC 2012-Shedding New Light on Disease, Thailand, November 11-16 2012.

The SPEC 2012 conference will be held later this year in Chiang Mai, Thailand, November 11-16. This year entitled “Shedding New Light on Disease” it is being chaired by Bayden Wood and Don McNaughton from Monash University, Australia.

As with previous SPEC conferences, Analyst is publishing a themed issue on Optical Diagnosis to feature papers from the conference and to highlight the latest advances in diagnosis and novel biomedical applications of infrared and Raman spectroscopy. You can read the editorial from the last themed issue on Optical Diagnosis here, and read the issue here.

This themed issue is scheduled to be published in the middle of 2013. The deadline for submission is 1 February 2013.

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7th International Symposium on Enabling Technologies (ETP 2013)

30 Oct 2012

By Aliya Anwar.

7th International Symposium on Enabling Technologies (ETP 2013)

April 30 – May 1, 2013
Metro Toronto Convention Centre
255 Front Street
Toronto, Ontario, Canada

ETP 2013 provides an open, interdisciplinary forum for scientists, engineers and technologists to discuss research and development of innovative tools that extend the bioanalytical capabilities of researchers. Features include a world-class program of invited speakers from industry and academia, oral and poster presentations from submitted abstracts and exhibitor showcases.

ABSTRACT SUBMISSION – opens December 1, 2012

REGISTRATION – opens December 1, 2012
Fees include Breaks and Networking Reception

List of Speakers:

Dr. Perdita Barran, The University of Edinburgh
Dr. Ronald Beavis, Beavis Informatics Ltd.
Dr. John D. Brennan, McMaster University
Dr. Donald Douglas, University of British Columbia
Dr. Norman Dovichi, University of Notre Dame
Dr. Daniele Fabris, University at Albany
Dr. John Klassen, University of Alberta
Dr. X. Chris Le, University of Alberta
Dr. Richard Oleschuk, Queen’s University
Dr. Anthony Pawson, Mount Sinai Hospital
Dr. Pierre Thibault, Université de Montréal
Dr. Dietrich Volmer, Saarland University
Dr. John Wilkins, University of Manitoba

Symposium Chair: Dr. Daniel Figeys, University of Ottawa

We’ve collected together below some papers from these invited speakers, which will be free to access until 16 November – do use the opportunity to take a look.

How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas phase
Ewa Jurneczko and Perdita E. Barran
Analyst, 2011, 136, 20-28
DOI: 10.1039/C0AN00373E

Bioactive paper dipstick sensors for acetylcholinesterase inhibitors based on sol–gel/enzyme/gold nanoparticle composites
Roger E. Luckham and John D. Brennan
Analyst, 2010, 135, 2028-2035
DOI: 10.1039/C0AN00283F

Simplified sheath flow cuvette design for ultrasensitive laser induced fluorescence detection in capillary electrophoresis
Oluwatosin O. Dada, Bonnie J. Huge and Norman J. Dovichi
Analyst, 2012, 137, 3099-3101
DOI: 10.1039/C2AN35321K

Characterization of microstructured fibre emitters: in pursuit of improved nano electrospray ionization performance
Xinyun Wu, Richard D. Oleschuk and Natalie M. Cann
Analyst, 2012, 137, 4150-4161
DOI: 10.1039/C2AN35249D

Micro- and nanostructures and their application in gas chromatography
M. Mittermüller and D. A. Volmer
Analyst, 2012, 137, 3195-3201
DOI: 10.1039/C2AN35184F

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Determining sex from a fingerprint

30 Oct 2012

By Aliya Anwar.

UK scientists have used mass spectroscopy to determine the sex of a perpetrator from the peptides in fingerprints left at a crime scene.

Peptides naturally present in sweat and their relative abundance are distinctive for one sex or the other. © Shutterstock

Simona Francese from Sheffield Hallam University explains that peptides naturally present in sweat and their relative abundance are distinctive for one sex or the other. Francese and her team used matrix assisted laser desorption ionisation mass spectrometry to detect the peptides and their relative abundance from fingerprint samples. ‘Results can be obtained in 10 minutes from sample preparation to data acquisition and analysis with 85% accuracy,’ says Francese.

To read the full article visit Chemistry World

Direct detection of peptides and small proteins in fingermarks and determination of sex by MALDI mass spectrometry profiling
Leesa Susanne Ferguson, Florian Wulfert, Rosalind Wolstenholme, Judith Marlou Fonville, Malcolm Ronald Clench, Vikki Amanda Carolan and Simona Francese
Analyst, 2012,137, 4686-4692
DOI: 10.1039/C2AN36074H

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Delving deeper in the Hall of the Kings

25 Oct 2012

By Aliya Anwar.

A portable and non-invasive technique to study and characterise pigments in ancient architecture has been developed by scientists in Spain.

The Palace of the Lions in the Alhambra, Spain, was built and decorated during the Nasrid period in the 13–15th centuries, the last of the Moorish dynasties in Spain. After being taken over and adapted during the first period of Christian domination in the 16th century, it was neglected for centuries before restoration began in the 19th century.

Vertical section of one vault in the Hall of the Kings and the microspectrometer set up in a vault

To read the full article please visit Chemistry World

In situ noninvasive Raman microspectroscopic investigation of polychrome plasterworks in the Alhambra
Ana Dominguez-Vidal, Maria Jose de la Torre-Lopez, Ramon Rubio-Domene and Maria Jose Ayora-Cañada
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36027F

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Two-in-One Electrochemical Sensor

23 Oct 2012

By Rebecca Brodie, Deputy Editor.

Structures of decamethylferrocene and bisferrocene

Compton et al., Analyst, 2012, 137, 4951

By Pui Sai Lau, Web Writer

Electrochemistry continues to provide solutions to biosensing dilemmas namely due to its high reproducibility and low cost. However, electrochemical measurements can be influenced by changes in the local environment such as temperature and humidity. Richard G. Compton and his colleagues from the UK have developed a voltammetric sensing method to simultaneously detect temperature and humidity. Find out more about their discovery by accessing the link below, the paper will be free to read until Nov 6th:

A simultaneous voltammetric temperature and humidity sensor
Linhongjia Xiong, Ai M. Fletcher, Stephen G. Davies, Sarah E. Norman, Christopher Hardacre and Richard G. Compton
Analyst, 2012, 137, 4951-4957
DOI: 10.1039/C2AN35939A

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Quick Testing for Lead Poisoning in Blood

22 Oct 2012

By Laura Ruvuna, Web Writer.

Peroxidase mimicking DNA–gold nanoparticles for fluorescence detection of the lead ions in blood

Chang et al., Analyst, 2012, 137, 5222

Lead has no biological function in the human body, and high concentrations can cause detrimental health effects, especially for children. The large instruments used for detecting lead mostly test contaminated water, and cannot be transported to remote areas or test blood samples. Huan-Tsung Chang and researchers at National Taiwan University created a unique binding complex composed of gold nanoparticles, DNA, and Amplex UltraRed to combat this problem. In this system, lead ions form an alloy with the gold nanoparticles increasing catalytic activity, which results in oxidation of the DNA-conjugated Amplex UltraRed and production of a detectable fluorescent signal. This simple yet effective sensor detected lead concentrations down to 0.1 nM in blood samples.

This paper will be free to read until the end of the month.

Peroxidase mimicking DNA–gold nanoparticles for fluorescence detection of the lead ions in blood
Chi-Lin Li, Chih-Ching Huang, Wei-Hsi Chen, Cheng-Kang Chiang and Huan-Tsung Chang
Analyst, 2012, 137, 5222-5228
DOI: 10.1039/C2AN35599J

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Analyst Issue 22 HOT papers

18 Oct 2012

By Rebecca Brodie, Deputy Editor.

We have a bumper crop of nine HOT articles in this new issue 22 of Analyst!

Combining atomic force-fluorescence microscopy with a stretching device for analyzing mechanotransduction processes in living cells

Kranz et al., Analyst, 2012, 137, 5208

From the outside front cover we have Boris Mizaikoff, Christine Kranz and colleagues paper on a miniaturized cell stretching device for mechanically stimulating living cells at physiologically relevant levels applicable to a wide variety of adherent cell types.

Combining atomic force-fluorescence microscopy with a stretching device for analyzing mechanotransduction processes in living cells
E. Hecht, P. Knittel, E. Felder, P. Dietl, B. Mizaikoff and C. Kranz
Analyst, 2012, 137, 5208-5214
DOI: 10.1039/C2AN36001B

We also have a number of exciting papers on a range of topics including;

Selective fluorometric detection of pyrophosphate by 3-hydroxyflavone-diphenyltin(IV) complex in aqueous micellar medium
Raul Villamil-Ramos, Víctor Barba and Anatoly K. Yatsimirsky
Analyst, 2012, 137, 5229-5236
DOI: 10.1039/C2AN35999E

Layer-by-layer self-assembled graphene oxide/silica microsphere composites as stationary phase for high performance liquid chromatography
Xiaojing Liang, Shujuan Liu, Xinwang Song, Yangwen Zhu and Shengxiang Jiang
Analyst, 2012, 137, 5237-5244
DOI: 10.1039/C2AN36091H

One-step immobilization of Ru(bpy)₃²⁺ in a silica matrix for the construction of a solid-state electrochemiluminescent sensor with high performance
Jing Li, Fang-Nan Xiao and Xing-Hua Xia
Analyst, 2012, 137, 5245-5250
DOI: 10.1039/C2AN35980D

Rossi et al., Analyst, 2012, 137, 5251

Nanopatterned submicron pores as a shield for nonspecific binding in surface plasmon resonance-based sensing
Sabina Rebe Raz, Gerardo R. Marchesini, Maria G. E. G. Bremer, Pascal Colpo, Cesar Pascual Garcia, Guido Guidetti, Willem Norde and Francois Rossi
Analyst, 2012, 137, 5251-5259
DOI: 10.1039/C2AN35521C

Tactile multisensing on flexible aluminum nitride
Simona Petroni, Francesco Guido, Bruno Torre, Andrea Falqui, Maria Teresa Todaro, Roberto Cingolani and Massimo De Vittorio
Analyst, 2012, 137, 5260-5264
DOI: 10.1039/C2AN36015B

Protection and functionalisation of silver as an optical sensing platform for highly sensitive SPR based analysis
Gowri Manickam, Ram Gandhiraman, Rajani K. Vijayaraghavan, Laura Kerr, Colin Doyle, David E. Williams and Stephen Daniels
Analyst, 2012, 137, 5265-5271
DOI: 10.1039/C2AN35826C

Platinum nanoparticles intermediate layer in solid-state selective electrodes
Beata Paczosa-Bator, Leszek Cabaj, Robert Piech and Krzysztof Skupień
Analyst, 2012, 137, 5272-5277
DOI: 10.1039/C2AN35933B

These papers will be free to read until Oct 31st.

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HOT articles in Analyst

18 Oct 2012

By Aliya Anwar.

Cover 1 Take a look below at some wonderful HOT articles we’ve recently published this month in Analyst. There are papers covering a large variety of fields, including SPR-based analysis, platinum nanoparticles, and cancer cell research. These HOT papers will be free to read for two weeks.

Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells
Michael D. Scott , Rinku Dutta , Manas K. Haldar , Anil Wagh , Thomas R. Gustad , Benedict Law , Daniel L. Friesner and Sanku Mallik
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35877H

Aptamer carbon nanodot sandwich used for fluorescent detection of protein
Bailu Xu , Chuanqi Zhao , Weili Wei , Jinsong Ren , Daisuke Miyoshi , Naoki Sugimoto and Xiaogang Qu
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36174D

Microfluidic integration of Western blotting is enabled by electrotransfer-assisted sodium dodecyl sulfate dilution
Chenlu Hou and Amy E. Herr
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36033K

Affinity surface-assisted laser desorption/ionization mass spectrometry for peptide enrichment
Yannick Coffinier , Nhung Nguyen , Hervé Drobecq , Oleg Melnyk , Vincent Thomy and Rabah Boukherroub
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35803D

Protection and functionalisation of silver as an optical sensing platform for highly sensitive SPR based analysis
Gowri Manickam , Ram Gandhiraman , Rajani K. Vijayaraghavan , Laura Kerr , Colin Doyle , David E. Williams and Stephen Daniels
Analyst, 2012,137, 5265-5271
DOI: 10.1039/C2AN35826C

A terbium(III)-organic framework for highly selective sensing of cytidine triphosphate
Xi Juan Zhao , Rong Xing He and Yuan Fang Li
Analyst, 2012,137, 5190-5192
DOI: 10.1039/C2AN36188D

Platinum nanoparticles intermediate layer in solid-state selective electrodes
Beata Paczosa-Bator , Leszek Cabaj , Robert Piech and Krzysztof Skupień
Analyst, 2012,137, 5272-5277
DOI: 10.1039/C2AN35933B

Nanopatterned submicron pores as a shield for nonspecific binding in surface plasmon resonance-based sensing
Sabina Rebe Raz , Gerardo R. Marchesini , Maria G. E. G. Bremer , Pascal Colpo , Cesar Pascual Garcia , Guido Guidetti , Willem Norde and Francois Rossi
Analyst, 2012,137, 5251-5259
DOI: 10.1039/C2AN35521C

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Analyst Issue 23 now online

Reminder: SPEC 2012 – Optical Diagnosis themed issue

7th International Symposium on Enabling Technologies (ETP 2013)

Determining sex from a fingerprint

Top ten most accessed articles in September

Delving deeper in the Hall of the Kings

Two-in-One Electrochemical Sensor

Quick Testing for Lead Poisoning in Blood

Analyst Issue 22 HOT papers

HOT articles in Analyst

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