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Analyst issue 6 now online

23 Feb 2012

Analyst issue 6 is now published online with three exciting articles featured on the covers!

The front cover of this issue highlights work by Jin Cheng and colleagues from Tsinghua University and the National Engineering Research Centre for Beijing Biochip Technology, China. The group developed an electrical cell-substrate impedance sensing system for assessing in vitro cytotoxicity of anticancer drugs in a human kidney cell model. This system allowed for continuous and automatic measurements with a better resolution for drugs with different toxicity profiles.

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Analyst Issue 5 now online

07 Feb 2012

Front cover image, Analyst, Volume 137, Issue 5

Ellis et al., Analyst, 2012, 137, 1100-1110

Why not take a look at the latest issue of Analyst?

Featured on the front cover is a paper on the use of ambient ozone for the assignment of double bond position in unsaturated lipids. Stephen Blanksby and colleagues from the University of Wollongong, Australia, have made use of the fact that unsaturated lipids react with the low concentrations of ozone present in normal laboratory air.

Unsaturated lipids are deposited onto thin layer chromatography plactes and allowed to undergo ozonolysis. The products are then analysed by desorption electrospray ionization mass spectrometry (DESI-MS), providing unambiguous assignment of double bond positions without the need for instrument modifications.

Using ambient ozone for assignment of double bond position in unsaturated lipids
Shane R. Ellis, Jessica R. Hughes, Todd W. Mitchell, Marc in het Panhuis and Stephen J. Blanksby
Analyst, 2012, 137, 1100-1110
DOI: 10.1039/C1AN15864C

Back cover image, Analyst, Volume 137, Issue 5

Sun et al., Analyst, 2012, 137, 1125-1129

The back cover highlights research from Xiangying Sun and co-workers at Huaqiao University, Xiamen, China. They have developmed a novel dual-fluorescence quantum dot (QD) nanocomposite with tuning emission wavelength and fluorescence intensity which can selectively sense mercury ions (Hg²⁺) with a detection limit of 5.6 nM. They propose this can e used for the qualitative and semi-quantitative colorimetric analysis of Hg²⁺.

Dual-emission quantum dots nanocomposites bearing an internal standard and visual detection for Hg²⁺
Xiangying Sun, Bin Liu and Yibang Xu
Analyst, 2012, 137, 1125-1129
DOI: 10.1039/C2AN16026A

Both articles are free to access for 6 weeks.

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Analyst issue 4, 2012 – now online!

26 Jan 2012

The latest issue of Analyst is now available online!

In this issue, the front cover features work by Aaron Timperman and colleagues from West Virginia University, USA, who report the fabrication and performance of a microfluidic traveling-wave electrophoresis system, a promising new separation technique. It uses a locally defined traveling electric field wave within a microfluidic channel in order to achieve band transport and separation. The authors anticipate that this technique will open up many future lab-on-a-chip applications, processes and systems.

Fabrication and performance of a microfluidic traveling-wave electrophoresis system, Kyoo D. Jo, Jarrod E. Schiffbauer, Boyd E. Edwards, R. Lloyd Carroll and Aaron T. Timperman, Analyst, 2012, 137, 875-883

The inside front cover of this issue highlights work by Hui-Fen Wu and Kamlesh Shrivas from the National Sun Yat-Sen University, Taiwan, who report the rapid and sensitive protein extraction by cobalt oxide nanoparticle-based liquid-liquid microextraction coupled with MALDI-MS. The show for the first time that the metal oxide nanoparticles prepared in the organic phase can be successfully applied to the extraction and preconcentration of proteins, and their approach offers distinct advantages including high sensitivity for washing and separation-free MALDI-MS analysis of proteins.

Rapid and highly sensitive protein extraction viacobalt oxide nanoparticle-based liquid–liquid microextraction coupled with MALDI mass spectrometry, Kamlesh Shrivas and Hui-Fen Wu, Analyst, 2012, 137, 890-895

These articles have been made free to access until the 8th March 2012, so why not take a look…

See also the list of Hot articles appearing in this issue which will be free to access for 2 weeks!

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Analyst Issue 3, 2012: now online

11 Jan 2012

Analyst (2012), 137(3): 529-788

Take a look at the latest issue of Analyst, which features three excellent cover articles.

Featured on the front cover is work from Martin Pumera and colleagues of Nanyang Technological University, Singapore. They studied the performances of several chemically modified graphene nanomaterials as sensing platforms by using the electrochemical impedance spectroscopy technique for the detection and believe that their findings may present a foundation for further research and development in graphene-based impedimetric biosensing.

Detection of DNA hybridization on chemically modified graphene platforms
Marcella Giovanni, Alessandra Bonanni and Martin Pumera
Analyst, 2012, 137, 580-583
DOI: 10.1039/C1AN15910K

The inside front cover features a communication from Andreas Manz of KIST Europe, Germany and his collaborators. They present a label free quantitative detection method for DNA samples amplified by polymerase chain reaction (PCR) in aqueous medium using terahertz-time domain spectroscopy (THz-TDS)

Inside front cover

Communication: Terahertz-time domain spectroscopy for the detection of PCR amplified DNA in aqueous solution
Arun Arora, Trung Quan Luong, Matthias Krüger, Young Jun Kim, Chang-Hoon Nam, Andreas Manz and Martina Havenith
Analyst, 2012, 137, 575-579
DOI: 10.1039/C2AN15820E

Our back cover highlights research from Sangmin Jeon of Pohang University of Science and Technology (POSTECH), Korea, and his co-workers. They adopted a dynamic light scattering (DLS) method to measure the corrosion of iron nanoparticles. The nanoparticle corrosion rate determined by DLS was found to be almost identical to the value obtained by conventional immersion tests.

A rapid and facile method for measuring corrosion rates using dynamic light scattering
Jinmyoung Joo, Hyejung Seo, Changho Chun, Kunwoo Han, Hwangyo Jung, Sungjee Kim and Sangmin Jeon
Analyst, 2012, 137, 584-587
DOI: 10.1039/C2AN15975A

All these cover articles will be free to access for 6 weeks so let your colleagues know!

Back cover

This issue also features a number of HOT articles, which will be free for 2 weeks, and 5 papers from our continuing web theme on Future Electroanalytical Developments.

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Issue 2 now online

15 Dec 2011

The second issue of 2012 is now online.

Featured on the front cover are Optical Chemical Sensors (Optodes), which have proven to be a versatile and powerful analytical tool often comparable or even better than traditional electrochemical sensors. In this study Aron Hakonen from the University of Gothenburg and Niklas Strömberg of the SP Technical Research Institute of Sweden show that a nanoparticle enhanced ammonium fluorosensor is suitable for non-invasive high-quality ammonium imaging of complex samples.

The plasmon sensitized optical sensors were utilized as a bioanalytical tool for chemical imaging of natural degradation processes occurring in biological tissues. Analytical performance of the nanoparticle enhanced sensors confirmed superior sensitivity, reversibility, durability and overall image quality over non-doped sensing membranes.

In addition, a straightforward square root function was utilized to improve image quality and simplify the calibration process.

They say that the nanoparticle interaction/coextraction based sensing scheme utilized in this study is general and can be used for numerous ions, preferably combined with the diffusion consistent calibrations for superior analytical performance.

Diffusion consistent calibrations for improved chemical imaging using nanoparticle enhanced optical sensors
Aron Hakonen and Niklas Strömberg
Analyst, 2012, 137, 315-321
DOI: 10.1039/C1AN15528H

On the back cover is work from Hui-Fen Wua and colleagues at the National Sun Yat-Sen University, Kaohsiung, Taiwan on the detection of bacteria using physical preconcentration coupled ZnO NPs assisted MALDI-MS (PP-MALDI-MS). Ants and humans coexist closely and for the most part happily, but this work shows that perhaps these insects aren’t as harmless* as they seem. Their study is an attempt to highlight the ability of these seemingly harmless ants to collect bacteria from their surroundings and transport them, and they confirmed that ants are potent carriers of bacteria and are good indicators of the bacteria present in the specific environment.

Tracing the pathogen Staphylococcus aureus on laboratory ants using physical preconcentration coupled ZnO nanoparticle assisted MALDI-TOF MS
Judy Gopal, Hui-Fen Wu, Chia-Hsun Lee and Muthu Manikandan
Analyst, 2012, 137, 357-364
DOI: 10.1039/C1AN15625J

These articles will be free for 6 weeks so take a look and let your colleagues know.

(*as someone who has been bitten by a soldier ant in the jungle, I have to disagree with the assessment of these insects as harmless!)

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First issue of 2012 now online!

01 Dec 2011

Analyst, 2012, 137(1): 1-276

An early New Year present from Analyst: it’s Issue 1 of 2012, which has now been published online.

We start the year as we mean to go on, with some excellent cover articles with equally good cover images.

On the front cover is an article from Jason Greenwood and colleagues from Queen’s University, Belfast on mass spectra obtained from the interaction of intense, femtosecond laser pulses with 1,3-butadiene, 1-butene, and n-butane. They discuss potential mass spectrometry applications of the technique, such as the analysis of catalytic reaction products.

Communication: Femtosecond lasers for mass spectrometry: Proposed application to catalytic hydrogenation of butadiene
Orla Kelly, Martin J. Duffy, Raymond B. King, Louise Belshaw, Ian D. Williams, Jacinto Sá, Chris R. Calvert and Jason B. Greenwood
Analyst, 2012, 137, 64-69
DOI: 10.1039/C1AN15706J

Research from Analyst Editorial Board members features on the other covers of Issue 1. On the inside front cover, Justin Gooding and colleagues from the University of New South Wales describe a simple colorimetric method for the detection of copper ions in water. Nanoparticle cross-linking, evidenced as a colour change, is used for the detection of copper ions.

A novel route to copper(II) detection using ‘click’ chemistry-induced aggregation of gold nanoparticles
Carol Hua, William H. Zhang, Swahnnya R. M. De Almeida, Simone Ciampi, Danmar Gloria, Guozhen Liu, Jason B. Harper and J. Justin Gooding
Analyst, 2012, 137, 82-86
DOI: 10.1039/C1AN15693D

On the outside back cover, Steven Soper and co-workers report a simple and compact fluorescence single-molecule instrument that is straightforward to operate and consists of fiber optics directly coupled to a microfluidic device.

Design and development of a field-deployable single-molecule detector (SMD) for the analysis of molecular markers
Jason M. Emory, Zhiyong Peng, Brandon Young, Mateusz L. Hupert, Arnold Rousselet, Donald Patterson, Brad Ellison and Steven A. Soper
Analyst, 2012, 137, 87-97
DOI: 10.1039/C1AN15658F

Issue 1 of 2012 also contains information on all our Editorial Board members and an Editorial from Paul Bohn, Chair of the Board and May Copsey, Editor of Analyst.

Editorial: Analyst, unconfined by traditional discipline barriers
Analyst, 2012, 137, 17-20
DOI: 10.1039/C1AN90099D

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Issue 24 online

22 Nov 2011

Analyst, 2011, 136(24): 5093-5312

The final issue of Analyst for 2011 is now online.

On the front cover is a Minireview from Blake Plowman, Suresh Bhargava and Anthony O’Mullane of RMIT University, Melbourne, Australia. They highlight recent developments in the electrochemical fabrication of nanostructured materials on electrode surfaces that can be utilised for electroanalytical applications of environmental and biological importance.

Minireview: Electrochemical fabrication of metallic nanostructured electrodes for electroanalytical applications
Blake J. Plowman, Suresh K. Bhargava and Anthony P. O’Mullane
Analyst, 2011, 136, 5107-5119
DOI: 10.1039/C1AN15657H

The back cover shows work from Zhihui Dai and colleagues at Nanjing Normal University, Nanjing, China. They describe the use of water-soluble CdSe QDs as labels linked to anti-AFP, a sensitive and specific immunoassay method with sandwich assay approach for detecting α-fetoprotein (AFP) based on ECL.

CdSe quantum dots as labels for sensitive immunoassay of cancer biomarker proteins by electrogenerated chemiluminescence
Qian Liu, Min Han, Jianchun Bao, Xiaoqing Jiang and Zhihui Dai
Analyst, 2011, 136, 5197-5203
DOI: 10.1039/C1AN15581D

Thank you to all the authors who have provided us with excellent cover articles all through 2011. It’s been great to have twice as many opportunities to highlight work in this way now that we have 24 issues a year, and we look forward to more imaginative images in 2012!

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Issue 23 is now online

09 Nov 2011

The latest issue of Analyst is now available online.

Featured on the front cover is work from D. Marshall Porterfield and colleagues from Purdue University, USA, which illustrates single-walled carbon nanotubes modified with a single strand of DNA on Pt black. This nanocomposite showed enhanced biosensor performanace and could potentially be used for a variety of physiological sensing applications.

Microbiosensors based on DNA modified single-walled carbon nanotube and Pt black nanocomposites, Jin Shi, Tae-Gon Cha, Jonathan C. Claussen, Alfred R. Diggs, Jong Hyun Choi and D. Marshall Porterfield, Analyst, 2011, 136, 4916-4924.

The inside front cover of this issue features work from Detlef Günther of ETH Zurich and colleagues. They studied the addition of methane or methanol/water to an inductively coupled plasma (ICP) and found that it significantly improved the sensitivity of laser ablation-ICP-MS for some elements.

Sensitivity improvement in laser ablation inductively coupled plasma mass spectrometry achieved using a methane/argon and methanol/water/argon mixed gas plasma, Daniel Fliegel, Christian Frei, Gisela Fontaine, Zhaochu Hu, Shan Gao and Detlef Günther, Analyst, 2011, 136, 4925-4934.

On the back cover is research from Shuping Bi and colleagues from Nanjing University, who studied the effect of five different electrode pretreatments on the coverage of monolayers of dodecanethiol on gold.

Studies on the effect of electrode pretreatment on the coverage of self-assembled monolayers of dodecanethiol on gold by electrochemical reductive desorption determination, Guiying Feng, Tianxing Niu, Xueyan You, Zhongwei Wan, Qiuchen Kong and Shuping Bi, Analyst, 2011, 136, 5058-5063.

These articles are all free to access until the 18th December 2011!

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Analyst Issue 22: featuring Future Electroanalytical Developments

25 Oct 2011

Analyst, 2011, 136(22): 4605-4856

Analyst and Analytical Methods are combining forces to present some of the best work on Future Electroanalytical Developments. This web theme is ongoing for coming months and amongst the papers will be those invited from speakers at Eirelec ’11, which took place in Adare, Republic of Ireland in May.

Issue 22 features a number of papers from this web theme, including both cover articles.

On the front cover, Joe Wang and colleagues review electrochemically-propelled nanomotors, which offer numerous potential applications in biomedical diagnostics, environmental monitoring, and forensic analysis.

Minireview: Motion-driven sensing and biosensing using electrochemically propelled nanomotors
S. Campuzano, D. Kagan, J. Orozco and J. Wang
DOI: 10.1039/C1AN15599G

On the inside front cover, Mohtashim Hassan Shamsi and Heinz-Bernhard Kraatz use electrochemical impedance spectroscopy (EIS) and scanning electrochemical microscopy (SECM) to distinguish between bovine species based on mitochondrial DNA fragments.

Electrochemical identification of artificial oligonucleotides related to bovine species. Potential for identification of species based on mismatches in the mitochondrial cytochrome C₁ oxidase gene
Mohtashim Hassan Shamsi and Heinz-Bernhard Kraatz
DOI: 10.1039/C1AN15414A

Other papers from the web theme in Issue 22 are:

Minireview: Graphene and graphene-based nanomaterials: the promising materials for bright future of electroanalytical chemistry
Xiao-mei Chen, Geng-huang Wu, Ya-qi Jiang, Yi-ru Wang and Xi Chen
DOI: 10.1039/C1AN15661F

Electrochemical behaviour and voltammetric sensitivity at arrays of nanoscale interfaces between immiscible liquids
Mickaël Rimboud, Robert D. Hart, Thomas Becker and Damien W. M. Arrigan
DOI: 10.1039/C1AN15509A

Determination of morphine at gold nanoparticles/Nafion^® carbon paste modified sensor electrode
Nada F. Atta, Ahmed Galal and Shereen M. Azab
DOI: 10.1039/C1AN15423K

A disposable sensor for point of care wound pH monitoring
Jolene Phair, Laura Newton, Cliodhna McCormac, Marco F. Cardosi, Ray Leslie and James Davis
DOI: 10.1039/C1AN15675F

Electrochemical DNA sensor by the assembly of graphene and DNA-conjugated gold nanoparticles with silver enhancement strategy
Lei Lin, Yang Liu, Longhua Tang and Jinghong Li
DOI: 10.1039/C1AN15610A

Chemically-modified graphenes for oxidation of DNA bases: analytical parameters
Madeline Shuhua Goh, Alessandra Bonanni, Adriano Ambrosi, Zdeněk Sofer and Martin Pumera
DOI: 10.1039/C1AN15631D

Asymmetric logistic peak as a suitable function for the resolution of highly asymmetric voltammograms in non-bilinear systems
Mojtaba Kooshki, José Manuel Díaz-Cruz, Hamid Abdollahi, Cristina Ariño and Miquel Esteban
DOI: 10.1039/C1AN15396J

A microfluidic device based on a screen-printed carbon electrode with electrodeposited gold nanoparticles for the detection of IgG anti-Trypanosoma cruzi antibodies
Sirley V. Pereira, Franco A. Bertolino, Martín A. Fernández-Baldo, Germán A. Messina, Eloy Salinas, María I. Sanz and Julio Raba
DOI: 10.1039/C1AN15569E

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Issue 21 cover articles

12 Oct 2011

Analyst, 2011, 136(21): 4369-4604

Issue 21 is now available online, with the usual high-quality collection of reviews, communications and papers.

On the front cover:

In cytology, continuous, real time and non-invasive monitoring of cellular behaviour is important in advancing the understanding between cell-substrate interactions and its requisite behaviour. Results of this type of study are also important with respect to the design of cell-based biosensors.

In this paper from Michael Thompson and colleagues at the University of Toronto, the response of a TSM device to various neuronal changes of immortalized murine neurons are reported and analysed. In particular, the process of neuronal deposition, adhesion and proliferation are investigated.

Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation
Shilin Cheung, Laura J. Fick, Denise D. Belsham, David A. Lovejoy and Michael Thompson
Analyst, 2011, 136, 4412-4421
DOI: 10.1039/C1AN15534B

And on the back cover:

Protein glycosylation participates in many cellular events, such as cell adhesion, receptor activation, signal transduction, molecular trafficking and clearance, and endocytosis. Characterisation of protein glycosylation requires highly specific methods for the enrichment of glycopeptides because of their sub-stoichiometric glycosylation-site occupancy. Here, Xiuling Li of the Dalian Institute of Chemical Physics, and colleagues investigate the use of ZrO2/MPS microspheres to enrich glycopeptides in HILIC SPE microtips, compared with the glycopeptide binding selectivity and glycosylation heterogeneity coverage with sepharose-based enrichment.

Zirconia layer coated mesoporous silica microspheres as HILIC SPE materials for selective glycopeptide enrichment
Huihui Wan, Jingyu Yan, Long Yu, Qianying Sheng, Xiuli Zhang, Xingya Xue, Xiuling Li and Xinmiao Liang
Analyst, 2011, 136, 4422-4430
DOI: 10.1039/C1AN15554G

Both articles will be free for 6 weeks – take a look and let your colleagues know!

Also of interest:

Depolarization of surface-attached hypothalamic mouse neurons studied by acoustic wave (thickness shear mode) detector
Shilin Cheung, Laura J. Fick, Denise D. Belsham and Michael Thompson
Analyst, 2010, 135, 289-295
DOI: 10.1039/B919430B

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