Author Archive

ARF 2013 Poster Prizes

Helen Robinson, Deputy Editor Rebecca Brodie, and Arrandeep Basra at the Analytical Research Forum

At the Analytical Research Forum last month, held at GlaxoSmithKline and the University of Hertfordshire, UK, there were two poster prizes awarded by Analyst and Analytical Methods. We are pleased to announce that the winners were Helen Robinson, from the University of York, and Arrandeep Basra, from the University of Nottingham.

In Helen’s poster entitled “Capturing peptides on gold using self-assembled monolayers (SAMs) for MALDI-MS analysis“, she describes a developed technique to capture and label protein digests directly on a gold-coated MALDI chip, followed by direct analysis from the chip.

Arrandeep’s poster was entitled “Size-tunable biodegradable polymeric nanoparticles for controlled drug delivery“. In his poster he describes a study on the formation of nanoparticles and the results from adjusting the formulation parameters to get a range of different sizes and drug loading capabilities.

The winners were selected by a panel of judges and the prizes were awarded by Analyst and Analytical Methods Deputy Editor Rebecca Brodie. The prizes included a certificate, free electronic journal subscription, and a book from the RSC catalogue. Congratulations to Helen and Arrandeep!

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Analyst’s latest Impact Factor: 4.0

We are delighted to announce that our latest Impact Factor* is 4.0

Analyst remains the home of premier fundamental discoveries, inventions and applications in the analytical and bioanalytical sciences and is in the top 3 general analytical journals publishing primary research.

The Editorial Office thanks all of our Board members, authors and readers for their continued support.

We invite you to submit your latest piece of high impact work with us here.

*The Impact Factor provides an indication of the average number of citations per paper. Produced annually, Impact Factors are calculated by dividing the number of citations in a year by the number of citeable articles published in the preceding two years. Data based on 2012 Journal Citation Reports®, (Thomson Reuters, 2013).

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2013 Dreyfus Prize awarded to Graham Cooks

2013 Dreyfus Prize in the Chemical Sciences

The 2013 Dreyfus Prize in the Chemical Sciences has been awarded to Graham Cooks

The Camille and Henry Dreyfus Foundation has selected chemical instrumentation as the topic of the 2013 Dreyfus Prize in the Chemical Sciences. The Dreyfus Prize, awarded biennially, recognizes an individual for exceptional and original research in a selected area of chemistry that has advanced the field in a major way.

This year the Dreyfus Prize has been awarded to R. Graham Cooks, the Henry Bohn Hass Distinguished Professor of Chemistry at Purdue University, Advisory Board member of Analyst and Chemical Science. Graham Cooks is recognized internationally as an innovative giant in the field of mass spectrometry who has enriched analytical chemistry in unparalleled ways. Virtually every pharmaceutical and biotechnology company relies on mass spectrometry at a level that has become possible, in part, through Cooks’s innovations. Click to read more.

Take a look at a few of Graham’s recent papers in Analyst and Chemical Science below they will be free to read until the end of the month:

Rapid analysis of whole blood by paper spray mass spectrometry for point-of-care therapeutic drug monitoring
Ryan D. Espy, Nicholas E. Manicke, Zheng Ouyang and R. Graham Cooks
Analyst, 2012, 137, 2344-2349
DOI: 10.1039/C2AN35082C

Accelerated bimolecular reactions in microdroplets studied by desorption electrospray ionization mass spectrometry
Marion Girod, Encarnacion Moyano, Dahlia I. Campbell and R. Graham Cooks
Chem. Sci., 2011, 2, 501-510
DOI: 10.1039/C0SC00416B

Paper spray: a simple and efficient means of analysis of different contaminants in foodstuffs

Zhiping Zhang, R. Graham Cooks and Zheng Ouyang
Analyst, 2012, 137, 2556-2558
DOI: 10.1039/C2AN35196J

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The 36th Annual Meeting of the Brazilian Chemical Society – Aguas de Lindoia, Brazil 25-28 May 2013

The 36th Annual Meeting of the Brazilian Chemical Society is being held this month in Aguas de Lindoia, Brazil, 25th-28th May. Click here for more information.

Analyst and Analytical Methods are pleased to announce a cross journal web-themed issue on Analytical Sciences in Brazil. Interdisciplinary analytical science is particularly welcome. Guest Editor Ivo M. Raimundo Jr. will be in attendance at the Brazilian Chemical Society annual meeting.

Submission deadline: 31st Jan 2014
Articles published online in a web collection

Guest Editors: Boris Mizaikoff, University of Ulm
Ivo M. Raimundo Jr., UNICAMP

For more information please contact analyst-rsc@rsc.org

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Analyst paper highly commended in GSK 3Rs prize

The 3Rs prize has been running since 2004, sponsored by GSK it is the annual prize of the National Centre for the Replacement, Refinement and Reduction of Animals in Research. It aims to highlight the best original contribution to science that benefits the 3Rs globally (to replace, reduce and refine the use of animals in research).

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

The paper from Shuichi Takayama, University of Michigan, USA, has been highly commended by the judges in this years 3Rs prize:

In his paper he describes a 3D cell culture used to test anti-cancer drugs, which was shown to be more representative of clinical responses than standard 2D ‘flat’ cell cultures. This new testing method has the potential to replace and reduce the use of animals in pharmaceutical testing.

Click on the link below to read this highly commended paper. It will be free to read until March 15th.

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
Yi-Chung Tung, Amy Y. Hsiao, Steven G. Allen, Yu-suke Torisawa, Mitchell Ho and Shuichi Takayama
Analyst, 2011, 136, 473-478
DOI: 10.1039/C0AN00609B

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Rayleigh, Ramsay, Rutherford and Raman

In his recently published Editorial, Robin Clark talks about the key contributions of the four great Nobel Laureates – Lord Rayleigh, Sir William Ramsay, Lord Rutherford and Sir Chandrasekhara Raman – to the understanding of light scattering, to the identification and classification of the rare gases, and to the discovery of the Raman effect.

Rayleigh, Ramsay, Rutherford and Raman

Rayleigh, Ramsay, Rutherford and Raman – their connections with, and contributions to, the discovery of the Raman effect
Robin J. H. Clark
Analyst, 2013, 138, 729-734
DOI: 10.1039/C2AN90124B

To commemorate this wonderful editorial, we have gathered together a collection of papers from the last few year on Raman spectroscopy that have been published in Analyst. These papers will be free to read until March 22nd. Enjoy!

SERS-based sandwich immunoassay using antibody coated magnetic nanoparticles for Escherichia coli enumeration
Burcu Guven, Nese Basaran-Akgul, Erhan Temur, Ugur Tamer and İsmail Hakkı Boyacı
Analyst, 2011, 136, 740-748
DOI: 10.1039/C0AN00473A

Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains
Peter Hermann, Antje Hermelink, Veronika Lausch, Gudrun Holland, Lars Möller, Norbert Bannert and Dieter Naumann
Analyst, 2011, 136, 1148-1152
DOI: 10.1039/C0AN00531B

Surface enhanced optical spectroscopies for bioanalysis
Iain A. Larmour and Duncan Graham
Analyst, 2011, 136, 3831-3853
DOI: 10.1039/C1AN15452D

Recent advancements in optical DNA biosensors: Exploiting the plasmonic effects of metal nanoparticles
Hsin-I Peng and Benjamin L. Miller
Analyst, 2011, 136, 436-447
DOI: 10.1039/C0AN00636J

Non-invasive analysis of turbid samples using deep Raman spectroscopy
Kevin Buckley and Pavel Matousek
Analyst, 2011, 136, 3039-3050
DOI: 10.1039/C0AN00723D

Non-invasive analysis of turbid samples using deep Raman spectroscopy

Buckley & Matousek, Analyst, 2011, 136, 3039

Subcellular localization of early biochemical transformations in cancer-activated fibroblasts using infrared spectroscopic imaging
Sarah E. Holton, Michael J. Walsh and Rohit Bhargava
Analyst, 2011, 136, 2953-2958
DOI: 10.1039/C1AN15112F

Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries
Facundo M. Fernandez, Dana Hostetler, Kristen Powell, Harparkash Kaur, Michael D. Green, Dallas C. Mildenhall and Paul N. Newton
Analyst, 2011, 136, 3073-3082
DOI: 10.1039/C0AN00627K

Rapid, sensitive DNT vapor detection with UV-assisted photo-chemically synthesized gold nanoparticle SERS substrates
Maung Kyaw Khaing Oo, Chia-Fang Chang, Yuze Sun and Xudong Fan
Analyst, 2011, 136, 2811-2817
DOI: 10.1039/C1AN15110J

Surface enhanced Raman scattering for multiplexed detection
Jennifer A. Dougan and Karen Faulds
Analyst, 2012, 137, 545-554
DOI: 10.1039/C2AN15979A

Direct SERS detection of contaminants in a complex mixture: rapid, single step screening for melamine in liquid infant formula
Jordan F. Betz, Yi Cheng and Gary W. Rubloff
Analyst, 2012, 137, 826-828
DOI: 10.1039/C2AN15846A

A quantitative solid-state Raman spectroscopic method for control of fungicides
Bojidarka Ivanova and Michael Spiteller
Analyst, 2012, 137, 3355-3364
DOI: 10.1039/C2AN35174A

Extracting biological information with computational analysis of Fourier-transform infrared (FTIR) biospectroscopy datasets: current practices to future perspectives
Júlio Trevisan, Plamen P. Angelov, Paul L. Carmichael, Andrew D. Scott and Francis L. Martin
Analyst, 2012, 137, 3202-3215
DOI: 10.1039/C2AN16300D

Differentiating intrinsic SERS spectra from a mixture by sampling induced composition gradient and independent component analysis
Justin L. Abell, Joonsang Lee, Qun Zhao, Harold Szu and Yiping Zhao
Analyst, 2012, 137, 73-76
DOI: 10.1039/C1AN15623C

Surface enhanced Raman spectroscopy for microfluidic pillar arrayed separation chips
Lisa C. Taylor, Teresa B. Kirchner, Nickolay V. Lavrik and Michael J. Sepaniak
Analyst, 2012, 137, 1005-1012
DOI: 10.1039/C2AN16239C

Total internal reflection Raman spectroscopy
David A. Woods and Colin D. Bain
Analyst, 2012, 137, 35-48
DOI: 10.1039/C1AN15722A

Understanding the molecular information contained in principal component analysis of vibrational spectra of biological systems
F. Bonnier and H. J. Byrne
Analyst, 2012, 137, 322-332
DOI: 10.1039/C1AN15821J

2p or not 2p: tuppence-based SERS for the detection of illicit materials

Goodacre et al., Analyst, 2013, 138, 118

Streptococcus suis II immunoassay based on thorny gold nanoparticles and surface enhanced Raman scattering

Kun Chen, Heyou Han and Zhihui Luo
Analyst, 2012, 137, 1259-1264
DOI: 10.1039/C2AN15997J

2p or not 2p: tuppence-based SERS for the detection of illicit materials
Samuel Mabbott, Alex Eckmann, Cinzia Casiraghi and Royston Goodacre
Analyst, 2013, 138, 118-122
DOI: 10.1039/C2AN35974J

Toward development of a surface-enhanced Raman scattering (SERS)-based cancer diagnostic immunoassay panel
Jennifer H. Granger, Michael C. Granger, Matthew A. Firpo, Sean J. Mulvihill and Marc D. Porter
Analyst, 2013, 138, 410-416
DOI: 10.1039/C2AN36128K

3D confocal Raman imaging of endothelial cells and vascular wall: perspectives in analytical spectroscopy of biomedical research
Katarzyna Majzner, Agnieszka Kaczor, Neli Kachamakova-Trojanowska, Andrzej Fedorowicz, Stefan Chlopicki and Malgorzata Baranska
Analyst, 2013, 138, 603-610
DOI: 10.1039/C2AN36222H

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Showcase your own research at the Analytical Research Forum 2013 (ARF13)

Showcase your own research at the Analytical Research Forum 2013 (ARF13)

The deadline for submitting oral abstracts is fast approaching – 15 February 2013

This is the premier Analytical Science meeting of the RSC designed primarily for early-career analytical scientists (including PhD students and postdoctoral fellows) to present their latest results in the context of the wider analytical science community.

Analytical Research Forum 2013A major part of the programme will be oral and poster contributions from students and young researchers, medal winners and international leaders in the field – so make sure you don’t miss out! An added feature this year will be a tour of the GSK site in Stevenage, which is where the lectures and poster presentations will take place.

Make sure you don’t miss out – submit your abstract now!

Check out the event website to find out more – http://rsc.li/arf13

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2012 FACSS Innovation Award winner announced

FACCS logoThe Federation of Analytical Chemistry & Spectroscopy Societies (FACSS), of which the RSC is a member society, has announced the winner of the 2012 FACSS Innovation Award as Rohit Bhargava, from the University of Illinois, Beckman Institute for Advanced Science and Technology.

This is a juried prize awarded to the most innovative, creative, and outstanding work making its world debut at the FACSS-organized SciX conference. The winner is selected in a special oral session featuring five candidates selected from the many talks contributed to the program.

This year’s award was given for “Advancing Infrared Microscopy Instrumentation by Theory and Computation,” Rohit Bhargava, P. Scott Carney, Rohith Reddy, Kevin Yeh, Thomas van Dijk, Matthew Gelber, Matthew V. Schulmerich; University of Illinois, Beckman Institute for Advanced Science and Technology.

Dr Rohit Bhargava, recipient of the 2012 FACSS Innovation Award

Rohit Bhargava completed his PhD at Case Western Reserve University in 2000 after first completing his undergraduate degree at the Indian Institute of Technology. Since then he has worked at the UIUC Department of Bioengineering and is a full time faculty member with the Beckman Institute Bioimaging Science and Technology group. His research interests include infrared spectroscopy imaging, molecular imaging and cancer pathology research.

Take a look at a selection of papers published by Bhargava in Analyst. They will be free to read until December 24th.

Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data
Rohith K. Reddy and Rohit Bhargava
Analyst, 2010, 135, 2818-2825
DOI: 10.1039/C0AN00350F

Characterization of porcine skin as a model for human skin studies using infrared spectroscopic imaging
Rong Kong and Rohit Bhargava
Analyst, 2011, 136, 2359-2366
DOI: 10.1039/C1AN15111H

Subcellular localization of early biochemical transformations in cancer-activated fibroblasts using infrared spectroscopic imaging
Sarah E. Holton, Michael J. Walsh and Rohit Bhargava
Analyst, 2011, 136, 2953-2958
DOI: 10.1039/C1AN15112F

Characterization of tumor progression in engineered tissue using infrared spectroscopic imaging
Rong Kong, Rohith K. Reddy and Rohit Bhargava
Analyst, 2010, 135, 1569-1578
DOI: 10.1039/C0AN00112K

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Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model

Sulé-Suso et al., Analyst, 2013, Advance Article

By Jennifer A. Dougan, Imperial College London, Web Writer

Lung cancer has a poor survival rate worldwide and research to better diagnose and manage the disease is of paramount importance.  Recent work by Josep Sulé-Suso’s group from the Institute for Science and Technology in Medicine, based at Keele University attempts to improve our understanding of the behaviour of lung cancer.  The approach taken by the group and a collaborator from the J. Heyrovský Institute of Physical Chemistry in the Czech Republic, was to analyse the volatile components (VCs) excreted from lung cancer cells and compare those to healthy lung cells using Selected Ion Flow Tube Mass Spectrometry, SIFT-MS.  However, rather than analysing the headspace produced from a 2D growth of cells, the researchers aimed to mimic more closely the in vivo conditions by hosting the cells in a 3D hydrogel scaffold.  They found that moving from a 2D to 3D system did, indeed, have an effect on the levels of VCs for both cancerous and non-cancerous cells and that they were able to discriminate between the two cell types at some concentrations.  Although there is a way to go before SIFT-MS analysis reaches its ultimate aim; the analysis, diagnosis and management of lung cancer from patient exhalations, its ability to analyse multiple compounds simultaneously in humid air samples makes it an attractive technique for further studies.  To read more about this HOT new Analyst article click below, it will be free to read until Dec 6th.

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model
Abigail V. Rutter, Thomas W. E. Chippendale, Ying Yang, Patrik Španěl, David Smith and Josep Sulé-Suso
Analyst, 2013, Advance Article
DOI: 10.1039/C2AN36185J

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HOT papers in Analyst Issue 24

Analyst Issue 24, 2012As well as our two front covers, we have a number of additional HOT papers in this issue of Analyst. Take a look at some of the hot science that we have published in this latest issue.

These papers will be free to read until Nov 30th.

Highlighting a need to distinguish cell cycle signatures from cellular responses to chemotherapeutics in SR-FTIR spectroscopy
C. Hughes, M. D. Brown, F. J. Ball, G. Monjardez, N. W. Clarke, K. R. Flower and P. Gardner
Analyst, 2012, 137, 5736-5742
DOI: 10.1039/C2AN35633C

Analyst Issue 24, 2012A simplified electrospray ionization source based on electrostatic field induction for mass spectrometric analysis of droplet samples
Xiaohui Lu, Hong Chen, Xiang Li, Jianmin Chen and Xin Yang
Analyst
, 2012, 137, 5743-5748
DOI: 10.1039/C2AN35909J

A bacteriophage endolysin-based electrochemical impedance biosensor for the rapid detection of Listeria cells
Mona Tolba, Minhaz Uddin Ahmed, Chaker Tlili, Fritz Eichenseher, Martin J. Loessner and Mohammed Zourob
Analyst, 2012, 137, 5749-5756
DOI: 10.1039/C2AN35988J

In situ noninvasive Raman microspectroscopic investigation of polychrome plasterworks in the Alhambra
Ana Dominguez-Vidal, Maria Jose de la Torre-Lopez, Ramon Rubio-Domene and Maria Jose Ayora-Cañada
Analyst, 2012, 137, 5763-5769
DOI: 10.1039/C2AN36027F

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