Author Archive

Delving deeper in the Hall of the Kings

A portable and non-invasive technique to study and characterise pigments in ancient architecture has been developed by scientists in Spain.

The Palace of the Lions in the Alhambra, Spain, was built and decorated during the Nasrid period in the 13–15th centuries, the last of the Moorish dynasties in Spain. After being taken over and adapted during the first period of Christian domination in the 16th century, it was neglected for centuries before restoration began in the 19th century.

Vertical section of one vault in the Hall of the Kings and the microspectrometer set up in a vault

Vertical section of one vault in the Hall of the Kings and the microspectrometer set up in a vault

 To read the full article please visit Chemistry World

In situ noninvasive Raman microspectroscopic investigation of polychrome plasterworks in the Alhambra
Ana Dominguez-Vidal,  Maria Jose de la Torre-Lopez,  Ramon Rubio-Domene and Maria Jose Ayora-Cañada
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36027F

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HOT articles in Analyst

Cover 1Take a look below at some wonderful HOT articles we’ve recently published this month in Analyst. There are papers covering a large variety of fields, including SPR-based analysis, platinum nanoparticles, and cancer cell research. These HOT papers will be free to read for two weeks.

Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells
Michael D. Scott ,  Rinku Dutta ,  Manas K. Haldar ,  Anil Wagh ,  Thomas R. Gustad ,  Benedict Law ,  Daniel L. Friesner and Sanku Mallik
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35877H

Aptamer carbon nanodot sandwich used for fluorescent detection of protein
Bailu Xu ,  Chuanqi Zhao ,  Weili Wei ,  Jinsong Ren ,  Daisuke Miyoshi ,  Naoki Sugimoto and Xiaogang Qu
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36174D

Microfluidic integration of Western blotting is enabled by electrotransfer-assisted sodium dodecyl sulfate dilution
Chenlu Hou and Amy E. Herr
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36033K

Affinity surface-assisted laser desorption/ionization mass spectrometry for peptide enrichment
Yannick Coffinier ,  Nhung Nguyen ,  Hervé Drobecq ,  Oleg Melnyk ,  Vincent Thomy and Rabah Boukherroub
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35803D

Protection and functionalisation of silver as an optical sensing platform for highly sensitive SPR based analysis
Gowri Manickam ,  Ram Gandhiraman ,  Rajani K. Vijayaraghavan ,  Laura Kerr ,  Colin Doyle ,  David E. Williams and Stephen Daniels
Analyst, 2012,137, 5265-5271
DOI: 10.1039/C2AN35826C

A terbium(III)-organic framework for highly selective sensing of cytidine triphosphate
Xi Juan Zhao ,  Rong Xing He and Yuan Fang Li
Analyst, 2012,137, 5190-5192
DOI: 10.1039/C2AN36188D

Platinum nanoparticles intermediate layer in solid-state selective electrodes
Beata Paczosa-Bator ,  Leszek Cabaj ,  Robert Piech and Krzysztof Skupień
Analyst, 2012,137, 5272-5277
DOI: 10.1039/C2AN35933B

Nanopatterned submicron pores as a shield for nonspecific binding in surface plasmon resonance-based sensing
Sabina Rebe Raz ,  Gerardo R. Marchesini ,  Maria G. E. G. Bremer ,  Pascal Colpo ,  Cesar Pascual Garcia ,  Guido Guidetti ,  Willem Norde and Francois Rossi
Analyst, 2012,137, 5251-5259
DOI: 10.1039/C2AN35521C

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2p or not 2p: that is the title…

…of a recent paper from the RSC’s Analyst, followed by the tagline ‘tuppence-based SERS for the detection of illicit materials’.

In the paper, scientists from Manchester explain how they used a UK two pence piece (a.k.a. tuppence) to do some drug detection work!

Royston Goodacre and team from University of Manchester altered the surface of a copper two pence piece with silver to make it suitable for the vibrational spectroscopic technique surface-enhanced Raman scattering (SERS), which they then used to differentiate between the drugs: 4-methylmethcathinone (mephedrone), 5,6-methylenedioxy-2-aminoindane (MDAI) and 3,4-methylenedioxy-N-methylamphetamine (MDMA).

Photo

To read the full article please visit Chemistry World

2p or not 2p: Tuppence-based SERS for the detection of illicit materials
Samuel Mabbott, Axel Eckmann, Cinzia Casiraghi and Royston Goodacre
Analyst, 2012, Accepted Manuscript
DOI: 10.1039/C2AN35974J, Paper

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HOT articles in Analyst this September

An coverTake a look below at some wonderful HOT articles we’ve recently published this month in Analyst. There are papers covering a large variety of fields, including metabolomics, sample preparation, fluorimetry and electrochemiluminescent sensing. These HOT papers will be free to read for two weeks.

Selective fluorometric detection of pyrophosphate by 3-hydroxyflavone-diphenyltin(IV) complex in aqueous micellar medium
Raul Villamil-Ramos ,  Víctor Barba and Anatoly K. Yatsimirsky
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35999E

Morphological analysis of vibrational hyperspectral imaging data
Jacob Filik ,  Abigail V. Rutter ,  Josep Sulé-Suso and Gianfelice Cinque
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35914F

Layer-by-layer self-assembled graphene oxide/silica microsphere composites as stationary phase for high performance liquid chromatography
Xiaojing Liang ,  Shujuan Liu ,  Xinwang Song ,  Yangwen Zhu and Shengxiang Jiang
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36091H

Intramolecular vibrational coupling in water molecules revealed by compatible multiple nonlinear vibrational spectroscopic measurements
Shuji Ye ,  Sulan Ma ,  Feng Wei and Hongchun Li
Analyst, 2012,137, 4981-4987
DOI: 10.1039/C2AN35684H

Fenton’s reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device
Li-Pei Zhang ,  Xiao-Xing Zhang ,  Bo Hu ,  Li-Ming Shen ,  Xu-Wei Chen and Jian-Hua Wang
Analyst, 2012,137, 4974-4980
DOI: 10.1039/C2AN36049G

Sensitive spectrofluorometry of cellular prion protein based on the on–off interaction between fluorescent dye-labelled aptamers and multi-walled carbon nanotubes
Lei Zhan ,  Li Peng ,  Yan Yu ,  Shu Jun Zhen and Cheng Zhi Huang
Analyst, 2012,137, 4968-4973
DOI: 10.1039/C2AN35924C

One-step immobilization of Ru(bpy)32+ in a silica matrix for the construction of a solid-state electrochemiluminescent sensor with high performance
Jing Li ,  Fang-Nan Xiao and Xing-Hua Xia
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35980D

Implementation of a semi-automated strategy for the annotation of metabolomic fingerprints generated by liquid chromatography-high resolution mass spectrometry from biological samples
Frédérique Courant ,  Anne-Lise Royer ,  Sylvain Chéreau ,  Marie-Line Morvan ,  Fabrice Monteau ,  Jean-Philippe Antignac and Bruno Le Bizec
Analyst, 2012,137, 4958-4967
DOI: 10.1039/C2AN35865D

An cover 2

Applications of reversible covalent chemistry in analytical sample preparation
David Siegel
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35697J

Tactile multisensing on flexible aluminum nitride
Simona Petroni ,  Francesco Guido ,  Bruno Torre ,  Andrea Falqui ,  Maria Teresa Todaro ,  Roberto Cingolani and Massimo De Vittorio
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36015B

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Top ten most accessed articles in August

This month sees the following articles in Analyst that are in the top ten most accessed:-

Gold nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing 
Dongdong Zeng ,  Weijie Luo ,  Jiang Li ,  Huajie Liu ,  Hongwei Ma ,  Qing Huang and Chunhai Fan  
Analyst, 2012,137, 4435-4439 DOI: 10.1039/C2AN35900F  

A BODIPY derivative as a highly selective “Off–On” fluorescent chemosensor for hydrogen sulfate anion 
Qian Li ,  Yong Guo and Shijun Shao  
Analyst, 2012,137, 4497-4501 DOI: 10.1039/C2AN35904A  

A turn-on and reversible fluorescence sensor for zinc ion 
Hsiang-Yi Lin ,  Pi-Yun Cheng ,  Chin-Feng Wan and An-Tai Wu  
Analyst, 2012,137, 4415-4417 DOI: 10.1039/C2AN35752F  

Upconversion nanoparticles in biological labeling, imaging, and therapy 
Feng Wang ,  Debapriya Banerjee ,  Yongsheng Liu ,  Xueyuan Chen and Xiaogang Liu  
Analyst, 2010,135, 1839-1854 DOI: 10.1039/C0AN00144A  

Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change 
Rong Huang ,  Shengyong Yan ,  Xiaolong Zheng ,  Fengling Luo ,  Minggang Deng ,  Boshi Fu ,  Yijie Xiao ,  Xi Zhao and Xiang Zhou  
Analyst, 2012,137, 4418-4420 DOI: 10.1039/C2AN35671F  

A simple colorimetric device for rapid detection of Hg2+ in water 
Tingxiu Ye ,  Chunyan He ,  Yanqin Qu ,  Zhuo Deng ,  Yaqi Jiang ,  Meijin Li and Xi Chen  
Analyst, 2012,137, 4131-4134 DOI: 10.1039/C2AN35422E  

BSA-templated MnO2 nanoparticles as both peroxidase and oxidase mimics 
Xing Liu ,  Qi Wang ,  Huihui Zhao ,  Lichun Zhang ,  Yingying Su and Yi Lv  
Analyst, 2012,137, 4552-4558 DOI: 10.1039/C2AN35700C  

CTAB-capped Mn-doped ZnS quantum dots and label-free aptamer for room-temperature phosphorescence detection of mercury ions 
Wan Yi Xie ,  Wei Tao Huang ,  Hong Qun Luo and Nian Bing Li  
Analyst, 2012,137, 4651-4653 DOI: 10.1039/C2AN35777A  

Functionalized shell-isolated nanoparticle-enhanced Raman spectroscopy for selective detection of trinitrotoluene 
Kai Qian ,  Honglin Liu ,  Liangbao Yang and Jinhuai Liu  
Analyst, 2012,137, 4644-4646 DOI: 10.1039/C2AN35947B  

Electrochemical analysis based on nanoporous structures 
Sangyun Park ,  Hee Chan Kim and Taek Dong Chung  
Analyst, 2012,137, 3891-3903 DOI: 10.1039/C2AN35294J  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Analyst? Then why not submit to us today or alternatively email us  your suggestions.

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Biological fate of nanoparticles in the body

Metal oxide nanoparticles are currently used for a variety of applications including diagnostics and biomedicine. However, these nanoparticles are extremely difficult to detect and measure once they are distributed in a biological system. Now, Spanish scientists have developed a novel way for measuring their biodistribution.

Positron emission tomography image of the 18F-labelled metal oxide nanoparticles in vivo

Positron emission tomography image of the 18F-labelled metal oxide nanoparticles in vivo

Until now, labelling techniques have relied upon the functionalisation of the surface of the nanoparticle, which may alter the behaviour of the nanoparticle. Jordi Llop at the Centre for Cooperative Research in Biomaterials-CIC biomaGUNE, in San Sebastian, and co-workers, have developed a unique approach to avoid this by preparing metal oxides enriched with 18O. The 18O is incorporated to allow for more efficient cyclotron-mediated conversion to the radioactive 18F which can then be traced in vivo.

To read the full article please visit Chemistry World

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Carlos Pérez-Campaña ,  Vanessa Gómez-Vallejo ,  Abraham Martin ,  Eneko San Sebastián ,  Sergio E. Moya ,  Torsten Reese ,  Ronald F. Ziolo and Jordi Llop
Analyst, 2012,137, 4902-4906
DOI: 10.1039/C2AN35863H

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Seeing cells under stress

An analytical platform that imposes controlled mechanical strain onto live cells whilst monitoring changes in cell morphology and molecular signalling has been developed by scientists in Germany. Cellular processes induced by mechanical forces are crucial for bone healing and lung function. Understanding these processes could help to prevent and aid the development of therapies for mechanically induced lung and cardiovascular diseases and injuries.

Christine Kranz and colleagues from the University of Ulm combined fluorescence microscopy with atomic force microscopy to analyse the cells. They integrated a motorised cell stretching device into the system. ‘We combined the stretching device with biosensor technology, enabling localised measurements of adenosine triphosphate (ATP), for example, which is among the most important signalling molecule associated with mechanical stress,’ says Kranz. ‘Consequently, detecting ATP at the surface of mechanically stimulated cells facilitates investigation of the signalling cascades involved.’

The assembly includes a cell-stretching device, an atomic force microscopy head and an objective of the inverted microscope

The assembly includes a cell-stretching device, an atomic force microscopy head and an objective of the inverted microscope

To read the full article please visit Chemistry World.

Combining atomic force-fluorescence microscopy with a stretching device for analyzing mechanotransduction processes in living cells
E. Hecht ,  P. Knittel ,  E. Felder ,  P. Dietl ,  B. Mizaikoff and C. Kranz
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36001B

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Top ten most accessed articles in July

This month sees the following articles in Analyst that are in the top ten most accessed:-

Ni2+-modified gold nanoclusters for fluorescence turn-on detection of histidine in biological fluids 
Yu He ,  Xue Wang ,  Jingjing Zhu ,  Shuhua Zhong and Gongwu Song  
Analyst, 2012,137, 4005-4009 DOI: 10.1039/C2AN35712G  

A water soluble Al3+ selective colorimetric and fluorescent turn-on chemosensor and its application in living cell imaging 
Supriti Sen ,  Titas Mukherjee ,  Basab Chattopadhyay ,  Anuradha Moirangthem ,  Anupam Basu ,  Jaromir Marek and Pabitra Chattopadhyay  
Analyst, 2012,137, 3975-3981 DOI: 10.1039/C2AN35560D  

Nanoparticle-based substrates for surface-enhanced Raman scattering detection of bacterial spores 
Han-Wen Cheng ,  Shuang-Yan Huan and Ru-Qin Yu  
Analyst, 2012,137, 3601-3608 DOI: 10.1039/C2AN35448A  

BODIPY based colorimetric fluorescent probe for selective thiophenol detection: theoretical and experimental studies 
Dnyaneshwar Kand ,  Pratyush Kumar Mishra ,  Tanmoy Saha ,  Mayurika Lahiri and Pinaki Talukdar 
Analyst, 2012,137, 3921-3924 DOI: 10.1039/C2AN35524H  

Ultrasensitive aptamer biosensor for arsenic(iii) detection in aqueous solution based on surfactant-induced aggregation of gold nanoparticles 
Yuangen Wu ,  Le Liu ,  Shenshan Zhan ,  Faze Wang and Pei Zhou 
Analyst, 2012,137, 4171-4178 DOI: 10.1039/C2AN35711A  

A BODIPY-functionalized bimetallic probe for sensitive and selective color-fluorometric chemosensing of Hg2+ 
Hyunjong Son ,  Ji Ha Lee ,  Yang-Rae Kim ,  In Su Lee ,  Sanyang Han ,  Xiaogang Liu ,  Justyn Jaworski and Jong Hwa Jung  
Analyst, 2012,137, 3914-3916 DOI: 10.1039/C2AN35704F  

A Zn2+ specific triazole based calix[4]arene conjugate (L) as a fluorescence sensor for histidine and cysteine in HEPES buffer milieu 
Rakesh Kumar Pathak ,  Khatija Tabbasum ,  Ankit Rai ,  Dulal Panda and Chebrolu Pulla Rao  
Analyst, 2012,137, 4069-4075 DOI: 10.1039/C2AN35740B  

Protein-templated gold nanoclusters as fluorescence probes for the detection of methotrexate 
Zhanguang Chen ,  Sihua Qian ,  Xi Chen ,  Wenhua Gao and Yuejuan Lin  
Analyst, 2012,137, 4356-4361 DOI: 10.1039/C2AN35786K  

Ultrasensitive colorimetric detection of heparin based on self-assembly of gold nanoparticles on graphene oxide 
Xiuli Fu ,  Lingxin Chen and Jinhua Li  
Analyst, 2012,137, 3653-3658 DOI: 10.1039/C2AN35552C  

Upconversion nanoparticles in biological labeling, imaging, and therapy 
Feng Wang ,  Debapriya Banerjee ,  Yongsheng Liu ,  Xueyuan Chen and Xiaogang Liu 
Analyst, 2010,135, 1839-1854 DOI: 10.1039/C0AN00144A  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Analyst? Then why not submit to us today or alternatively email us your suggestions.

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Groundwater arsenic detector

Groundwater contaminated with arsenic has led to an epidemic of arsenic poisoning in parts of Bangladesh and India. Scientists in China have developed a sensor to detect arsenic quickly and accurately in water.

The sensor may help to produce clean drinking water as seen here © Paul Prescott/Shutterstock.com

The sensor may help to produce clean drinking water as seen here © Paul Prescott/Shutterstock.com

Pei Zhou at Shanghai Jiao Tong University and colleagues’ sensor detects arsenic using an arsenic-binding aptamer, gold nanoparticles and a cationic surfactant.

Read the full article at Chemistry World.

Ultrasensitive aptamer biosensor for arsenic(III) detection in aqueous solution based on surfactant-induced aggregation of gold nanoparticles
Yuangen Wu, Le Liu, Shenshan Zhan, Faze Wang and Pei Zhou
Analyst, 2012, 137, 4171-4178
DOI: 10.1039/C2AN35711A

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Top ten most accessed articles in June

This month sees the following articles in Analyst that are in the top ten most accessed:-

Easy Dual-Mode Ambient Mass Spectrometry with Venturi Self-Pumping, Canned Air, Disposable Parts and Voltage-Free Sonic-Spray Ionization
Nicolas V. Schwab ,  Andreia M. Porcari ,  Mirela B. Coelho ,  Eduardo M. Schmidt ,  Jose L. Jara ,  Jesui V. Visentainer and Marcos N. Eberlin
Analyst, 2012,137, 2537-2540 DOI: 10.1039/C2AN16312H  

   
A Ratiometric Fluorescent Chemosensor for Iron: Discrimination of Fe2+ and Fe3+ and Living Cell Application 
Supriti Sen ,  Sandipan Sarkar ,  Basab Chattopadhyay ,  Anuradha Moirangthem ,  Anupam Basu ,  Koushik Dhara and Pabitra Chattopadhyay 
Analyst, 2012,137, 3335-3342 DOI: 10.1039/C2AN35258C     

Ultrasensitive Colorimetric Detection of Heparin Based on Self-assembly of Gold Nanoparticles on Graphene Oxide 
Xiuli Fu ,  Lingxin Chen and Jinhua Li  
Analyst, 2012,137, 3653-3658 DOI: 10.1039/C2AN35552C     

A new fluorescent and colorimetric probe for Cu2+ in live cells 
Wei-Yong Liu ,  Hai-Ying Li ,  Bao-Xiang Zhao and Jun-Ying Miao  
Analyst, 2012,137, 3466-3469 DOI: 10.1039/C2AN35559K     

A colorimetric sensor based on catechol-terminated mixed self-assembled monolayers modified gold nanoparticles for ultrasensitive detections of copper ions 
Siqiu Ye ,  Xinhao Shi ,  Wei Gu ,  Yixuan Zhang and Yuezhong Xian 
Analyst, 2012,137, 3365-3371 DOI: 10.1039/C2AN35311C    

Upconversion Nanoparticles in Biological Labeling, Imaging, and Therapy 
Feng Wang ,  Debapriya Banerjee ,  Yongsheng Liu ,  Xueyuan Chen and Xiaogang Liu  
Analyst, 2010,135, 1839-1854 DOI: 10.1039/C0AN00144A     

Bacteriophage based probes for pathogen detection 
Amit Singh ,  Denis Arutyunov ,  Christine M. Szymanski and Stephane Evoy  
Analyst, 2012,137, 3405-3421 DOI: 10.1039/C2AN35371G     

A sensitive dual signal amplification method in western blotting based on antibody-functionalised graphene oxide and gold nanoparticles 
Hongjun Lin ,  Jingrui Huo ,  Aihong Zhang ,  Yingfu Liu ,  Qingming Wang ,  Yun Cai ,  Wantao Ying ,  Weijie Qin ,  Yangjun Zhang and Xiaohong Qian  
Analyst, 2012,137, 3620-3623 DOI: 10.1039/C2AN35242G    

Micro- and nanostructures and their application in gas chromatography 
M. Mittermüller and D. A. Volmer  
Analyst, 2012,137, 3195-3201 DOI: 10.1039/C2AN35184F     

A Fluorescent Probe Directly Detect Peroxynitrite Based on Boronate Oxidation and Its Applications for Fluorescence Imaging in Living Cells 
Fabiao Yu ,  Ping Song ,  Peng Li ,  Bingshuai Wang and Keli Han  
Analyst, 2012,137, 3740-3749 DOI: 10.1039/C2AN35246J     

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Analyst? Then why not submit to us today or alternatively email us  your suggestions.

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