Issue 21 cover articles

12 Oct 2011

Analyst, 2011, 136(21): 4369-4604

Issue 21 is now available online, with the usual high-quality collection of reviews, communications and papers.

On the front cover:

In cytology, continuous, real time and non-invasive monitoring of cellular behaviour is important in advancing the understanding between cell-substrate interactions and its requisite behaviour. Results of this type of study are also important with respect to the design of cell-based biosensors.

In this paper from Michael Thompson and colleagues at the University of Toronto, the response of a TSM device to various neuronal changes of immortalized murine neurons are reported and analysed. In particular, the process of neuronal deposition, adhesion and proliferation are investigated.

Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation
Shilin Cheung, Laura J. Fick, Denise D. Belsham, David A. Lovejoy and Michael Thompson
Analyst, 2011, 136, 4412-4421
DOI: 10.1039/C1AN15534B

And on the back cover:

Protein glycosylation participates in many cellular events, such as cell adhesion, receptor activation, signal transduction, molecular trafficking and clearance, and endocytosis. Characterisation of protein glycosylation requires highly specific methods for the enrichment of glycopeptides because of their sub-stoichiometric glycosylation-site occupancy. Here, Xiuling Li of the Dalian Institute of Chemical Physics, and colleagues investigate the use of ZrO2/MPS microspheres to enrich glycopeptides in HILIC SPE microtips, compared with the glycopeptide binding selectivity and glycosylation heterogeneity coverage with sepharose-based enrichment.

Zirconia layer coated mesoporous silica microspheres as HILIC SPE materials for selective glycopeptide enrichment
Huihui Wan, Jingyu Yan, Long Yu, Qianying Sheng, Xiuli Zhang, Xingya Xue, Xiuling Li and Xinmiao Liang
Analyst, 2011, 136, 4422-4430
DOI: 10.1039/C1AN15554G