British and French researchers have used modern computing power to enhance mass spectrometry and analyse an extremely complex collagen molecule in a short time scale.
Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry (2D FT-ICR MS), developed in the 1980s, links the mass-to-charge ratios of precursors and fragments in complex samples. Compared to tandem mass spectrometry, 2D FT-ICR MS does not require isolated precursors and shows better resolution. Its applications have been limited, however, due to a lack of sophisticated computers.
H. J. Simon, M. A. van Agthoven, P. Y. Lam, F. Floris, L. Chiron, M.-A. Delsuc, C. Rolando, M. P. Barrow and P. B. O’Connor
Analyst, 2016, Advance Article
DOI: 10.1039/C5AN01757B, Paper
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