A disease biomarker is a key indicator that when detected from the body can help determine whether an individual is at risk to develop a certain disease. Thus, the discovery of suitable biomarkers is very important to enable earlier diagnosis of disease, better treatment options, and lower overall healthcare costs. Over the years, substantial progress has been made in the field of proteomics to study proteins as disease biomarkers. However, while most effort has been made towards identifying new biomarkers, less focus has been made towards understanding and optimizing the methodologies, which is required in order to find effective biomarkers.
Nina Bergman and Jonas Bergquist from Uppsala University in Sweden have written a review article to outline the proteomic methods that are currently used for biomarker identification and analysis, assess some of the advantages and disadvantages of each method and provide insight into what the future may hold for biomarker discovery. Click on the link below to learn more (free access until September 6th):
Recent developments in proteomic methods and disease biomarkers
Nina Bergman and Jonas Bergquist
Analyst, 2014, Advance Article