August 2014 – Analyst Blog

Archive for August, 2014

Call for Applications: Visiting Researchers Programme to Visit China in 2015

28 Aug 2014

Image courtesy of © iStock

The State Administration for Foreign Experts Affairs (SAFEA) is a division of the Chinese Government with which RSC has a cooperation agreement. Under this agreement the RSC and SAFEA will jointly fund researchers from the UK to visit Chinese Universities. The purpose of the visits are to stimulate collaboration between UK and Chinese institutions. They will allow the visitor to contribute their experience towards the development of excellent emerging science and build links with the Chinese Chemistry community.

In addition, the visitor will advise Chinese research groups on all aspects of presenting their research to an international audience. The programme will strengthen links between the UK and Chinese Science and between the RSC and our partners in China.

We would be very grateful if you could please send us the following information as part of your application:

• Detailed CV containing your career progress

• A letter detailing your objectives and what you hope to achieve in China

• Current research interests, especially areas where you wish to collaborate

• List of current collaborators in China (If any)

• List of your current and past publications

• Preferred dates to travel to China

Applications are open until the 31^st October 2014 for RSC members based in the UK and Ireland. Visits usually last up to a week. The Royal Society of Chemistry covers up to £1500 for international flights, and visa and local costs are usually covered by the local Chinese host universities. Prior collaboration in China is not necessary because SAFEA and the RSC will work together to find appropriate Chinese University hosts.

Please email to register your interest in participating in the programme.

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Printed sensors kick up a stink

26 Aug 2014

Methyl mercaptan is easily detectable by the human nose © Shutterstock

Scientists in Canada have used an inkjet-printer to create sensors that give off a smell when a target biomolecule is present.

Visual outputs, such as fluorescence and colour changes, are what indicate a positive reading in most sensors. Carlos Filipe and his team at McMaster University, however, have come up with a sensor where the output comes in the form of a smell. ‘People use the sense of smell in their everyday-lives but this fact has been largely under-explored for analytical purposes. A very convenient aspect of using smell is that a person or user does not have to be constantly looking at a read-out or a display to get a signal, the signal will come to the user.’

Read the full article in Chemistry World»

Read the original journal article in Analyst – it’s free to access until 3rd October:

An inkjet-printed bioactive paper sensor that reports ATP through odour generation
Zhuyuan Zhang, Jingyun Wang, Robin Ng, Yingfu Li, Zaisheng Wu, Vincent Leung, Spencer Imbrogno, Robert Pelton, John D. Brennan and Carlos D. M. Filipe
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01113A, Communication

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HOT articles in Analyst!

13 Aug 2014

Take a look at our recent HOT Analyst articles, these are now free to access for the next few weeks!

A label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-triggered in situ catalysis of split DNAzyme
Hui Shi, Duo Li, Fengzhou Xu, Xiaoxiao He, Kemin Wang, Xiaosheng Ye, Jinlu Tang and Chunmei He
Analyst, 2014,139, 4181-4184
DOI: 10.1039/C4AN00561A, Communication

A three-dimensional interpenetrating electrode of reduced graphene oxide for selective detection of dopamine
Xiaowen Yu, Kaixuan Sheng and Gaoquan Shi
Analyst, 2014,139, 4525-4531
DOI: 10.1039/C4AN00604F, Paper

Fine structural features of nanoscale zero-valent iron characterized by spherical aberration corrected scanning transmission electron microscopy (Cs-STEM)
Airong Liu and Wei-xian Zhang
Analyst, 2014,139, 4512-4518
DOI: 10.1039/C4AN00679H, Paper

On-chip monitoring of skeletal myoblast transplantation for the treatment of hypoxia-induced myocardial injury
Juan He, Chao Ma, Wenming Liu and Jinyi Wang
Analyst, 2014,139, 4482-4490
DOI: 10.1039/C4AN00697F, Paper

Global in vivo terminal amino acid labeling for exploring differential expressed proteins induced by dialyzed serum cultivation
Li-Qi Xie, Ai-Ying Nie, Shu-Jun Yang, Chao Zhao, Lei Zhang, Peng-Yuan Yang and Hao-Jie Lu
Analyst, 2014,139, 4497-4504
DOI: 10.1039/C4AN00728J, Paper

A novel variable selection approach that iteratively optimizes variable space using weighted binary matrix sampling
Bai-chuan Deng, Yong-huan Yun, Yi-zeng Liang and Lun-zhao Yi
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00730A, Paper

Using electron paramagnetic resonance to map N@C60 during high throughput processing
Simon R. Plant and Kyriakos Porfyrakis
Analyst, 2014,139, 4519-4524
DOI: 10.1039/C4AN00734D, Paper

Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies
Michael W. Handlogten, Jared F. Stefanick, Peter E. Deak and Basar Bilgicer
Analyst, 2014,139, 4247-4255
DOI: 10.1039/C4AN00780H, Paper

Real-time detection of metal ions using conjugated polymer composite papers
Ji Eun Lee, Hyeon Woo Shim, Oh Seok Kwon, Yang-Il Huh and Hyeonseok Yoon
Analyst, 2014,139, 4466-4475
DOI: 10.1039/C4AN00804A, Paper

Identification and discrimination of binding sites of an organoruthenium anticancer complex to single-stranded oligonucleotides by mass spectrometry
Suyan Liu, Kui Wu, Wei Zheng, Yao Zhao, Qun Luo, Shaoxiang Xiong and Fuyi Wang
Analyst, 2014,139, 4491-4496
DOI: 10.1039/C4AN00807C, Paper

Simultaneous analysis of nanoparticles and small molecules by high-performance liquid chromatography using a silica monolithic column
Naoki Itoh, Akira Sano, Tomofumi Santa and Masaru Kato
Analyst, 2014,139, 4453-4457
DOI: 10.1039/C4AN00819G, Communication

Parameters affecting ion intensities in transmission-mode direct analysis in real-time mass spectrometry
Lindsay P. Harding, Gareth M. B. Parkes and James D. Townend
Analyst, 2014,139, 4176-4180
DOI: 10.1039/C4AN00859F, Communication

Simultaneous multiplexed quantification of nicotine and its metabolites using surface enhanced Raman scattering
Omar Alharbi, Yun Xu and Royston Goodacre
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00879K, Paper

A graphene oxide-based enzyme-free signal amplification platform for homogeneous DNA detection
Zhen Zhang, Yufei Liu, Xinghu Ji, Xia Xiang and Zhike He
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00933A, Paper

A spatiotemporally defined in vitro microenvironment for controllable signal delivery and drug screening
Ching-Te Kuo, Hao-Kai Liu, Guan-Syuan Huang, Chi-Hao Chang, Chen-Lin Chen, Ken-Chao Chen, Ruby Yun-Ju Huang, Ching-Hung Lin, Hsinyu Lee, Chiun-Sheng Huang and Andrew M. Wo
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00936C, Paper

Detection of strep throat causing bacterium directly from medical swabs by touch spray-mass spectrometry
Alan K. Jarmusch, Valentina Pirro, Kevin S. Kerian and R. Graham Cooks
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00959B, Communication

A rapid method to estimate the concentration of citrate capped silver nanoparticles from UV-visible light spectra
D. Paramelle, A. Sadovoy, S. Gorelik, P. Free, J. Hobley and D. G. Fernig
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00978A, Paper

Diagnosing malaria infected cells at the single cell level using focal plane array Fourier transform infrared imaging spectroscopy
Bayden R. Wood, Keith. R. Bambery, Matthew W. A. Dixon, Leann Tilley, Michael J. Nasse, Eric Mattson and Carol J. Hirschmugl
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00989D, Communication

A napthelene–pyrazol conjugate: Al(III) ion-selective blue shifting chemosensor applicable as biomarker in aqueous solution
Manjira Mukherjee, Siddhartha Pal, Somenath Lohar, Buddhadeb Sen, Supriti Sen, Samya Banerjee, Snehasis Banerjee and Pabitra Chattopadhyay
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01039F, Paper

Microfluidic device with tunable post arrays and integrated electrodes for studying cellular release
Asmira Selimovic, Jayda L. Erkal, Dana M. Spence and R. Scott Martin
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01062K, Paper

High efficiency tandem mass spectrometry analysis using dual linear ion traps
Linfan Li, Xiaoyu Zhou, James W. Hager and Zheng Ouyang
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01070A, Communication

Detection of counterfeit electronic components through ambient mass spectrometry and chemometrics
Kevin P. Pfeuffer, Jack Caldwell, Jake T. Shelley, Steven J. Ray and Gary M. Hieftje
Analyst, 2014,139, 4505-4511
DOI: 10.1039/C4AN01071J, Paper

Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors
Mohamed M. Salim, Eric A. Owens, Tielong Gao, Jeong Heon Lee, Hoon Hyun, Hak Soo Choi and Maged Henary
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01104J, Paper

An inkjet-printed bioactive paper sensor that reports ATP through odour generation
Zhuyuan Zhang, Jingyun Wang, Robin Ng, Yingfu Li, Zaisheng Wu, Vincent Leung, Spencer Imbrogno, Robert Pelton, John D. Brennan and Carlos D. M. Filipe
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01113A, Communication

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Call for papers: themed issue dedicated to sensing using biological and synthetic nanopores and nanopipettes.

07 Aug 2014

You are invited to contribute to the upcoming Analyst themed issue showcasing fundamental discoveries, progress and developments in sensing using biological and synthetic nanopores and nanopipettes.

For your article to be considered for the themed issue we must receive your manuscript by December 1st 2014.

Guest Edited by Dr Joshua Edel and Professor Sang-Hyun Oh, this upcoming themed issue will highlight the significant progress in developments related to single molecule biosensing using nanopores and nanopipettes. The issue will feature review articles, original research papers and communications across the breadth of the subject area.

If you would like to contribute a review article or original research paper to the biological and synthetic nanopores and nanopipettes themed issue, please contact us.

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Understanding the “How” of Disease Biomarker Discovery

07 Aug 2014

An Overview of Biomarker Discovery

A disease biomarker is a key indicator that when detected from the body can help determine whether an individual is at risk to develop a certain disease. Thus, the discovery of suitable biomarkers is very important to enable earlier diagnosis of disease, better treatment options, and lower overall healthcare costs. Over the years, substantial progress has been made in the field of proteomics to study proteins as disease biomarkers. However, while most effort has been made towards identifying new biomarkers, less focus has been made towards understanding and optimizing the methodologies, which is required in order to find effective biomarkers.

Nina Bergman and Jonas Bergquist from Uppsala University in Sweden have written a review article to outline the proteomic methods that are currently used for biomarker identification and analysis, assess some of the advantages and disadvantages of each method and provide insight into what the future may hold for biomarker discovery. Click on the link below to learn more (free access until September 6th):

Recent developments in proteomic methods and disease biomarkers
Nina Bergman and Jonas Bergquist
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00627E

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Strep throat spotted in seconds

01 Aug 2014

Scientists have developed a non-invasive mass spectrometry-based diagnostic technique that can diagnose strep throat in less than 10 seconds.

Almost all of us will experience a sore throat at some point in our lives, and a number of these sore throats (~30%) will be caused by infections with Streptococci bacteria. Streptococcal pharyngitis, which is usually caused by Streptococcus pyogenes, is commonly known as ‘strep throat’ and can be treated with antibiotics if successfully diagnosed. Although the vast majority of strep throat cases resolve themselves within a few days, Streptococcal infections can lead to serious complications, such an inflammatory disease called rheumatic fever that can result in heart failure and even death. Children and the elderly are particularly susceptible to complications, so for these individuals, the rapid diagnosis and treatment of strep throat can be life-saving.

Touch spray-mass spectrometry can detect strep throat causing bacterium directly from medical swabs

Read the full article in Chemistry World»

Read the original journal article in Analyst – it’s free to access until 12th September:
Detection of strep throat causing bacterium directly from medical swabs by touch spray – mass spectrometry
Alan K Jarmusch, Valentina Pirro, Kevin S Kerian and R. Graham Cooks
Analyst, 2014, Accepted Manuscript, DOI: 10.1039/C4AN00959B

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Analyst Blog

Archive for August, 2014

Call for Applications: Visiting Researchers Programme to Visit China in 2015

Printed sensors kick up a stink

HOT articles in Analyst!

Call for papers: themed issue dedicated to sensing using biological and synthetic nanopores and nanopipettes.

Understanding the “How” of Disease Biomarker Discovery

Strep throat spotted in seconds

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