July 2013 – Analyst Blog

Archive for July, 2013

CMOS Imaging as a Potential Solution for Diabetic Patients

31 Jul 2013

CMOS Image Sensor for Glucose Monitoring

Millions of people suffer from diabetes, and the disease is quickly becoming a global epidemic. To address patient need, many electrochemical- and biochemical-based technologies have been developed over the last decade.

While considerable progress has been made, many of these methods still do not possess the sensitivity, specificity, accuracy, and user friendliness required to meet patient demands.

Researchers from Gachon University in the Republic of Korea, have developed the latest glucose sensor based on complementary metal oxide semiconductor (CMOS) imaging that provides enhanced efficiency for glucose monitoring. The novel method measures the concentration of oxidized glucose in blood plasma by the intensity of color produced, which leads to variations in photon count detected by the CMOS sensor.

Assess the link below for more details. This paper will be free to read for the next three weeks:

CMOS image sensors as an efficient platform for glucose monitoring
Jasmine Pramila Devadhasan, Sanghyo Kim and Cheol Soo Choi
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00805C

What are your thoughts on this new discovery? Let us know by leaving a comment.

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The second reason to attend HPLC 2013 – Hobart

25 Jul 2013

Hear Prof. Justin Gooding present his plenary lecture on

“Designing and Characterising Bioaffinity Surfaces for Sensing”,

Then treat your own senses to the sights, sounds and aromas of Hobart’s historic Sullivans Cove and Salamanca Markets, location to some of Australia’s freshest and naturally delicious steak and seafood restaurants.

This is a unique opportunity for you to meet with scientists from throughout the world and to share your latest results!

Just over 1 week till the HPLC 2013 Hobart Abstract Deadline Closes!

Abstract Deadline – 31^st July 2013

Early bird Registration Deadline – 16^th August 2013

Don’t miss out and submit your abstract to be considered for the conference program
Click here to register and submit for the conference

http://www.hplc2013-hobart.org/

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HOT Articles in Analyst

25 Jul 2013

Take a look below at the new HOT Articles just published in Analyst. They will be free to read until August 16th. Enjoy!

Multiplexed DNA detection with a composite molecular beacon based on guanine-quenching
Dong-Shan Xiang, Kun Zhai and Lian-Zhi Wang
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN01060K

In vivo characterization of protein uptake by yeast cell envelope: single cell AFM imaging and μ-tip-enhanced Raman scattering study
Denys Naumenko, Valentinas Snitka, Elena Serviene, Ingrida Bruzait and Boris Snopok
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00362K

Luminol-labeled gold nanoparticles for ultrasensitive chemiluminescence-based chemical analyses
Lateef U. Syed, Luxi Zhang Swisher, Hannah Huff, Caitlin Rochford, Fengli Wang, Jianwei Liu, Judy Wu, Mark Richter, Sivasai Balivada, Deryl Troyer and Jun Li
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN01005H

Toward optimal spatial and spectral quality in widefield infrared spectromicroscopy of IR labelled single cells
Eric C. Mattson, Miriam Unger, Sylvain Clède, François Lambert, Clotilde Policar, Asher Imtiaz, Roshan D’Souza and Carol J. Hirschmugl
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00383C

Energy-selective neutron imaging for morphological and phase analysis of iron–nickel meteorites
S. Peetermans, F. Grazzi, F. Salvemini, E. H. Lehmann, S. Caporalid and G. Pratesie
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00985H

Metal–tag labeling coupled with multiple reaction monitoring-mass spectrometry for absolute quantitation of proteins
Xueying Wang, Xin Wang, Weijie Qin, Hongjun Lin, Jifeng Wang, Junying Wei, Yangjun Zhang and Xiaohong Qian
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00613A

A novel miniaturized radiofrequency potentiometer tag using ion-selective electrodes for wireless ion sensing
Marta Novell, Tomàs Guinovart, Ivana Murković Steinberg, Matthew Steinberg, F. Xavier Rius and Francisco J. Andrade
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00727H

3D pulsed laser-triggered high-speed microfluidic fluorescence-activated cell sorter
Yue Chen, Ting-Hsiang Wu, Yu-Chun Kung, Michael A. Teitell and Pei-Yu Chiou
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN01266B

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Forensic fingers

24 Jul 2013

A team in the US has developed a detection system that crime scene investigators can wear on their fingertips to rapidly identify suspected traces of explosives and gunshot residue.

With the increase in crimes related to explosives and firearms, fast and accurate detection of possible traces of explosives and gunshot residue is of considerable importance. Forensic analysis is typically carried out in a central laboratory, requiring time-consuming sampling, transportation and storage. Joseph Wang and colleagues at the University California, San Diego, have built on their expertise with wearable sensors to move forensic analysis away from the lab and to the crime scene.

Their new sensor is made up of two components: an electrode screen-printed onto a stretchable sheath worn on the index finger and a second sheath, worn on the thumb, coated with a solid-state ionogel electrolyte. ‘Initially we intended to use a hydrogel, but the lifetime of this media was finite due to evaporation of water,’ says Wang. The ionogel circumvents the need for carrying additional liquid reagents, making the device highly portable.

To read the full article please visit Chemistry World.

Solid-state Forensic Finger sensor for integrated sampling and detection of gunshot residue and explosives: towards ‘Lab-on-a-finger’
Amay J. Bandodkar, Aoife M. O’Mahony, Julian Ramírez, Izabela A. Samek, Sean M. Anderson, Joshua R. Windmiller and Joseph Wang Analyst, 2013, Advance Article
DOI: 10.1039/C3AN01179H

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Free to access Cancer Nanotechnology collection 2013

23 Jul 2013

We are pleased to present a new Web Collection of articles from publications across the RSC journal portfolio demonstrating the use of (nano)technology in the diagnosis, imaging and treatment of cancer.

This web collection will be free to access until July 28th, so register for an RSC Publishing personal account and read this cutting edge research for free this week!

Here are just a few of the cancer nanotechnology articles:

Quantification of ovarian cancer markers with integrated microfluidic concentration gradient and imaging nanohole surface plasmon resonance
Carlos Escobedo, Yu-Wei Chou, Mohammad Rahman, Xiaobo Duan, Reuven Gordon, David Sinton, Alexandre G. Brolo and Jacqueline Ferreira
Analyst, 2013,138, 1450-1458
DOI: 10.1039/C3AN36616B

Magnetic beads-based electrochemiluminescence immunosensor for determination of cancer markers using quantum dot functionalized PtRu alloys as labels
Yan Zhang, Shenguang Ge, Shaowei Wang, Mei Yan, Jinghua Yu, Xianrang Song and Weiyan Liu
Analyst, 2012,137, 2176-2182
DOI: 10.1039/C2AN16170B

Magnetic quantitative immunoanalysis of carcinoembryonic antigen by ICP-MS with mercury labels
Hanyong Peng, Beibei Chen, Man He, Yuan Zhang and Bin Hu
J. Anal. At. Spectrom., 2011,26, 1217-1223
DOI: 10.1039/C1JA00007A

A microfluidic system for introduction of nanolitre sample in inductively coupled plasma mass spectrometry using electrokinetic flow combined with hydrodynamic flow
Heyong Cheng, Zigang Xu, Jinhua Liu, Xiuzhong Wanga and Xuefeng Yin
J. Anal. At. Spectrom., 2012,27, 346-353
DOI: 10.1039/C1JA10273G

Visualising gold inside tumour cells following treatment with an antitumour gold(I) complex
Louise E. Wedlock, Matt R. Kilburn, John B. Cliff, Luis Filgueira, Martin Saunders and Susan J. Berners-Price
Metallomics, 2011,3, 917-925
DOI: 10.1039/C1MT00053E

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Protein analysis unlocks museum mysteries

23 Jul 2013

Animal soft tissues feature regularly in cultural artefacts but it can be difficult to pinpoint their origin. Visual identification of these tissues relies on the skill of the examiner and the condition of the material. Analytical techniques, like gas chromatography-mass spectrometry, can detect and broadly classify proteins but give no answers as to their source. Precise identification of the sinews used for stitching is often impossible. Now, researchers in the US and UK have shown that peptide mass fingerprinting can be used to determine the animal species of collagen-based materials in a diverse range of museum objects.

Peptide mass fingerprinting (PMF) uses enzymes to digest proteins to produce a mixture of peptides. The mass spectrum of this mixture will have characteristic marker ions – called a peptide mass fingerprint – which are compared to a database of species-specific markers to identify the proteins.

Peabody Museum of Archaeology and Ethnology, #69-30-10/1619 © President and Fellows of Harvard College, US

To read the full article please visit Chemistry World.

Identification of collagen-based materials in cultural heritage
Daniel P. Kirby, Michael Buckley, Ellen Promise, Sunia A. Traugerd and T. Rose Holdcraft
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00925D

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Spiers Memorial Award 2013 Winner: Joe Wang

12 Jul 2013

Joe Wang receiving the Spiers Memorial Award from Faraday Division President Graham Hutchings

Professor Joseph Wang is the 2013 winner of the Spiers Memorial Award announced at Faraday Discussion 164 last week in Durham, UK.

Faraday Discussions are unique international discussion meetings which focus on rapidly developing areas of physical chemistry and its interfaces with other scientific disciplines, with the aim to provide a forum with academic experts and users. A number of meetings are organised each year by the Faraday Division , the most recent in association with the Analytical Division of the RSC, with the meeting having an analytical chemistry component.

The meeting was held at Durham University and focused on Electroanalysis at the Nanoscale, a growing area of interest which finds applications in various disciplines including biology, fuel cells, material science and sensing. The Spiers Memorial Award was presented by Faraday Division President Graham Hutchings to to the introductory lecturer who provided a most stimulating and wide-ranging introduction to the discussion.

Joe Wang is a Distinguished Professor and Vice Chair of Nanoengineering at the University of California, San Diego (UCSD), USA, is an Honorary Professor from 6 different universities and recipient of two National American Society Awards for Electrochemistry and Instrumentation. Research in his laboratory is focused on nanobioelectronics, an emerging field aimed at integrating nano- and biomaterials with electronic transducers. His highly multidisciplinary research combines fundamental studies with forward-looking engineering efforts.

With his work, Professor Wang has provided great contributions to the areas of electroanalytical chemistry and nanobiotechnology and highlighted the most recent advances in the development of nanomotors, nanoactuators, electrochemical biosensors and wearable sensor systems.

Click here to read more.

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HOT Articles in Analyst

10 Jul 2013

Here are some new HOT papers for you to enjoy! Access to the full articles by clicking the links below. These papers will be free to read until August 3^rd.

Carbon dots and chitosan composite film based biosensor for the sensitive and selective determination of dopamine
Qitong Huang, Shirong Hu, Hanqiang Zhang, Jianhua Chen, Yasan He, Feiming Li, Wen Weng, Jiancong Ni, Xiuxiu Bao and Yi Lin
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00510K

Biomolecular dual-ion-trap mass analyzer
Yun-Fei Hsu, Jung-Lee Lin, Ming-Lee Chu and Chung-Hsuan Chen
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00653K

Protein-binding aptamer assisted signal amplification for the detection of influenza A (H1N1) DNA sequences based on quantum dot fluorescence polarization analysis
Juanni Zhang, Jianniao Tian, Yanlong He, Sheng Chen, Yixuan Jiang, Yanchun Zhao and Shulin Zhao
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00830D

Quantifying degradation of collagen in ancient manuscripts: the case of the Dead Sea Temple Scroll
R. Schütz, L. Bertinetti, I. Rabin, P. Fratzl and A. Masic
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00609C

pH-independent optical sensing of heparin based on ionic liquid-capped gold nanoparticles
Bahram Hemmateenejad, Samira Dorostkar, Fatemeh Shakerizadeh-Shirazi and Mojtaba Shamsipur
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN36895E

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An new aptasensing platform for detection of multiple analytes

10 Jul 2013

Detecting multiple target species simultaneously via a single detection mechanism remains an attractive goal for biologically relevant studies.

Ruo Yuan and Jingdong Peng from the College of Chemistry and Chemical Engineering, Southwest University, China, have successfully developed a multiplexed electrochemical sensor for two biological targets.

Multiplexed electrochemical sensor for two biological targets

In the study, gold nanoparticles were electrochemically deposted on a highly polished glass carbon electrode and functionalised by thrombin- and ochratoxin A-binding apatmers. In the presence of the targets, an exonuclease digestion occurred allowing the target molecules to be recycled. The single stranded product of the exonuclease digestions were then used as initiation sequences for concatamer reaction designed to introduce two distinct electrochemically active species in a sequence specific manner. Only by the initial presence of either target would the related concatamer and, by extention, the electroactive species be present.

By this elaborate system of aptamer binding, exonuclease digestion, concatamer reaction and electrochemical detection the researchers were able to simultaneously detect thrombin, a blood-clotting protein, over the range 0.1 pM – 40 nM and ochratoxin A, a nephrotic toxin, over the range 0.4 pM – 35 nM.

To read the full article, please click on the link below:

An aptasensing platform for simultaneous detection of multiple analytes based on the amplification of exonuclease-catalyzed target recycling and DNA concatemers
Liping Jiang, Jingdong Peng, Ruo Yuan, Yaqin Chai, Yali Yuan, Lijuan Bai and Yan Wang
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00757J

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Analyst Blog

Archive for July, 2013

CMOS Imaging as a Potential Solution for Diabetic Patients

The second reason to attend HPLC 2013 – Hobart

HOT Articles in Analyst

Forensic fingers

Free to access Cancer Nanotechnology collection 2013

Protein analysis unlocks museum mysteries

Top ten most accessed articles from April – June 2013

Spiers Memorial Award 2013 Winner: Joe Wang

HOT Articles in Analyst

An new aptasensing platform for detection of multiple analytes

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