FTIR spectral signature of anticancer drug effects on cancer cells: any influence of the cell cycle?

Jennifer A. Dougan is a guest web-writer for Analyst. She is currently a Post-Doctoral Research Associate at Imperial College London, UK.

Visible image, infrared image, propidium iodide fluorescence image of a cell smear

Erik Goormaghtigh and co-workers from the Centre for Structural Biology and Bioinformatics at the Unversité Libre de Bruxelles have investigated the use of Fourier transformfo infrared (FTIR) spectroscopy r studying the effect of an anti-cancer drug, paclitaxel, on a human prostate cancer cell line.

The researchers combined fluorescence spectroscopy with FTIR spectroscopy using a fluorescent DNA intercalator to identify cell cycle stage.  By doing so, they sought to understand the drug’s effect on cell cycle and/or metabolic perturbation. The authors discuss both the application and limitation of this approach to cell studies.

Read more about this study in this HOT Analyst paper, free for you until May 24th .

FTIR spectral signature of anticancer drug effects on PC-3 cancer cells: is there any influence of the cell cycle?
Allison Derenne, Alix Mignolet and   Erik Goormaghtigh  
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN00225J

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Leave a Reply

You must be logged in to post a comment.