Youn-Suk Choi and Soo Suk Lee from the Samsung Advanced Institute of Technology, Republic of Korea, have developed a point of care diagnostic test for cardiac troponin I (cTnI).
The researchers fabricated a bubble-free microfluidics device based on a gold-nanoparticle immunoassay and a surface acoustic wave immunosensor. The authors highlight a limit of detection of 6.7 pg mL-1 as a clinically relevant result and a first for centrifugally-based microfluidic devices. In this work, the researchers developed the device for the detection of cTnI, a biomarker for acute myocardial infarction for which rapid analysis would be beneficial for patient prognosis. The group is now extending studies to alternative systems.
To read more about the current results, access this Analyst HOT article clicking on the link below. This paper will be free to read for the next 10 days.
A centrifugally actuated point-of-care testing system for the surface acoustic wave immunosensing of cardiac troponin I
Woochang Lee , Jaeyeon Jung , Young Ki Hahn , Sang Kyu Kim , Yeolho Lee , Joonhyung Lee , Tae-Han Lee , Jin-Young Park , Hyejung Seo , Jung Nam Lee , Jin Ho Oh , Youn-Suk Choi and Soo Suk Lee
Analyst, 2013,138, 2558-2566