Take a look at Analyst Editorial Board member Duncan Graham’s contribution to our ongoing theme on Grand Challenges, which is included as part of Issue 19.
There remain several challenges to overcome in order to achieve widespread clinical use of surface enhanced techniques. In this review, Iain Larmour and Duncan Graham consider the substrates employed to achieve enhancement before reviewing each enhanced optical technique in detail; surface plasmon resonance, localised surface plasmon resonance, surface enhanced fluorescence, surface enhanced infrared absorption spectroscopy and surface enhanced (resonance) Raman spectroscopy.
Critical Review: Surface enhanced optical spectroscopies for bioanalysis
Iain A. Larmour and Duncan Graham
Analyst, 2011, 136, 3831-3853
DOI: 10.1039/C1AN15452D