In this HOT communication, Zongxiu Nie and his team from China and Taiwan report the development of a miniature cylindrical ion trap mass spectrometer (CIT-MS) equipped with laser-induced acoustic ionization and a charge detector. They describe its use in the measurement of the total dry mass of red blood cells after calibration with standard polystyrene beads.
The novel miniature CIT-MS has, compared with a previous lab scale quadrupole ion trap mass spectrometer (QIT-MS), smaller volume, simpler ion trap fabrication and overall instrument construction, requires a lower trapping voltage and has reduced weight, power and cost. The new miniaturized instrument has potential for applications in field-portable, biological and aerosol analysis.
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Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum
Zhiqiang Zhu, Caiqiao Xiong, Gaoping Xu, Hao Liu, Xiaoyu Zhou, Rui Chen, Wen-Ping Peng and Zongxiu Nie
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00911C
