‘Chemists’ historical exploration of chemical space has been highly uneven and unsystematic’ write Adam Nelson and coworkers. In this Perspective article they seek to pull together synthetic strategies that have been designed to allow a more systematic discovery of biologically active small molecules, with particular emphasis on combinatorial strategies.
- The “build–couple–pair” approach
- Ambiphile pairing reactions
- Folding and branching pathways
- Oligomer-based approaches to scaffold diversity
This hot article is free to access for the next four weeks – download today to read more on the ‘challenge for synthetic chemists in the twenty-first century’:
Towards the systematic exploration of chemical space
Mark Dow, Martin Fisher, Thomas James, Francesco Marchetti and Adam Nelson