HOT: Increased affinity of LewisX mimics for DC-SIGN

The binding of two α-fucosylamide-based mimics of LewisX to DC-SIGN ECD (Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin extracellular domain) using STD NMR and docking studies has been investigated by Pedro M. Nieto and coworkers.  The mimics are shown to bind in a similar way to LewisX, through the fructose moiety and in a multi-modal fashion, but with increased affinity due to the aromatic moiety.

Insights into molecular recognition of LewisX mimics by DC-SIGN using NMR and molecular modelling
Cinzia Guzzi, Jesús Angulo, Fabio Doro, José J. Reina, Michel Thépaut, Franck Fieschi, Anna Bernardi, Javier Rojo and Pedro M. Nieto
Org. Biomol. Chem., 2011, 9, 7705-7712
DOI: 10.1039/C1OB05938F

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