Carbohydrates are the most diverse and one of the most important classes of biomolecules in nature. However, it is still difficult to find carbohydrate-based drugs in the market nowadays. The high polarity of this kind of drugs represents an issue for the pharmacological properties. Therefore, understanding and being able to modify these properties would help with the development of more ‘drug-like’ carbohydrate-based drugs.
In this review, M Carmen Galan and co-workers at University of Bristol, give and up-date on the latest advancements in carbohydrate chemistry and the role thy play in drug discovery.
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Carbohydrate chemistry in drug discovery
M. Carmen Galan, David Benito-Alifonso and Gregory M. Watt
Org. Biomol. Chem., 2011, 9, 3598-3610
DOI: 10.1039/C0OB01017K
