Piet Herdewijn from the Catholic University of Leuven, Belgium, and colleagues have designed a series of leaving groups that are compatible with HIV-1 reverse transcriptase (an enzyme that synthesises DNA from RNA).
The manuscript has been highlighted in Highlights on Chemical Biology and it is also a OBC Hot article which will be free to access until the end of the year.
Tha referees said that it was a VIP paper that made a very important contribution to the field.
Read more here
3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase
Shiqiong Yang, Mathy Froeyen, Eveline Lescrinier, Philippe Marlière and Piet Herdewijn
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00554A , Paper
