Archive for March, 2012

There is still time to join ICPOC21!

Good news!

There’s still a chance to submit your oral abstract to ICPOC21: 21st IUPAC International Conference on Physical Organic Chemistry organised by the Organic Division of the RSC on behalf of IUPAC, to be held 9 – 13 September 2012 at Durham University.

The Scientific Committee is currently reviewing all submissions, and has agreed to accept contributions up to Friday 13 April to allow for the Easter holiday break.

Why join ICPOC21?

 
Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award. and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

Make sure you are one of them! Don’t miss the oral abstract submission deadline – 13 April.

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Top ten most accessed articles in February

This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
Nat. Prod. Rep., 2012, 29, 144-222
DOI: 10.1039/C2NP00090C

Natural products as kinase inhibitors
Jing Liu, Yi Hu, David L. Waller, Junfeng Wang and Qingsong Liu
Nat. Prod. Rep., 2012, 29, 392-403
DOI: 10.1039/C2NP00097K

Electrophilic and nucleophilic enzymatic cascade reactions in biosynthesis
Barbara T. Ueberbacher, Mélanie Hall and Kurt Faber
Nat. Prod. Rep., 2012, 29, 337-350
DOI: 10.1039/C2NP00078D

Advances in Aspergillus secondary metabolite research in the post-genomic era
James F. Sanchez, Amber D. Somoza, Nancy P. Keller and Clay C. C. Wang
Nat. Prod. Rep., 2012, 29, 351-371
DOI: 10.1039/C2NP00084A

Hot off the press
Robert A. Hill and Andrew Sutherland
Nat. Prod. Rep., 2012, 29, 129-133
DOI: 10.1039/C1NP90052H

The chemical ecology of cyanobacteria
Pedro N. Leão, Niclas Engene, Agostinho Antunes, William H. Gerwick and Vitor Vasconcelos
Nat. Prod. Rep., 2012, 29, 372-391
DOI: 10.1039/C2NP00075J

Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R. Liedl and Judith M. Rollinger
Nat. Prod. Rep., 2012, 29, 11-36
DOI: 10.1039/C1NP00053E

Key achievements in the total synthesis of vibsane-type diterpenoids
Jeffrey Y. W. Mak and Craig M. Williams
Nat. Prod. Rep., 2012, 29, 440-448
DOI: 10.1039/C2NP00067A

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
Zhao-Li Zhou, Ya-Xi Yang, Jian Ding, Yuan-Chao Li and Ze-Hong Miao
Nat. Prod. Rep., 2012, 29, 457-475
DOI: 10.1039/C2NP00088A

The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus
Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo
Nat. Prod. Rep., 2012, Advance Article
DOI: 10.1039/C2NP00073C

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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Latest Natural Product Research in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles from OBC have been collated here:

  • Also of Interest:
    The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble
  • Want to see your natural products article featured on this blog? Submit online here
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Vibsane-type diterpenoids on the cover of NPR issue 4

Welcome to NPR issue 4, 2012!

This month’s cover features the work of Jeffrey Y. W. Mak and Craig M. Williams who highlight the key accomplishments in the total synthesis of visbanins, which are rare, structurally dense diterpenes occuring exclusively in the Viburnum species.

Key achievements in the total synthesis of vibsane-type diterpenoids
Jeffrey Y. W. Mak and Craig M. Williams
Nat. Prod. Rep., 2012, 29, 440-448
DOI: 10.1039/C2NP00067A

Also in the issue, read the latest Hot Of The Press article by Robert A. Hill and Andrew Sutherland,

A Highlight by Jiyong Hong and Hendrik Luesch  on Largazole,  a potent inhibitor of histone deacetylases (HDACs) which has attracted considerable interest from the scientific community. This Highlight summarizes recent advances to date in the characterization of this marine natural product: 

A review article by Yuan-Chao Li and Ze-Hong Miao et al. focusing on thunder god vine’s (Tripterygium wilfordii Hook F) principal bioactive ingredient triptolide:

Richard Robins and Guillaume Tcherkez et al. ‘s review discussing biochemical and physiological factors underlying the site-specific, non-random distribution of 13C/12C isotope ratios within plant metabolites, which can be determined by isotopic 13C NMR spectrometry:

R. Kiss and coworkers present both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds, covering the literature published since 2000:

View the issue

 

Also of Interest:
The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble

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Top ten most accessed articles in January

This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
Nat. Prod. Rep., 2012, 29, 144-222
DOI: 10.1039/C2NP00090C

Hot off the press
Robert A. Hill and Andrew Sutherland
Nat. Prod. Rep., 2012, 29, 129-133
DOI: 10.1039/C1NP90052H

Advances in Aspergillus secondary metabolite research in the post-genomic era
James F. Sanchez, Amber D. Somoza, Nancy P. Keller and Clay C. C. Wang
Nat. Prod. Rep., 2012, 29, 351-371
DOI: 10.1039/C2NP00084A

Natural products as kinase inhibitors
Jing Liu, Yi Hu, David L. Waller, Junfeng Wang and Qingsong Liu
Nat. Prod. Rep., 2012, 29, 392-403
DOI: 10.1039/C2NP00097K

The chemical ecology of cyanobacteria
Pedro N. Leão, Niclas Engene, Agostinho Antunes, William H. Gerwick and Vitor Vasconcelos
Nat. Prod. Rep., 2012, 29, 372-391
DOI: 10.1039/C2NP00075J

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis
Madan K. Kharel, Pallab Pahari, Micah D. Shepherd, Nidhi Tibrewal, S. Eric Nybo, Khaled A. Shaaban and Jürgen Rohr
Nat. Prod. Rep., 2012, 29, 264-365
DOI: 10.1039/C1NP00068C

Biosynthesis of 3,5-AHBA-derived natural products
Qianjin Kang, Yuemao Shen and Linquan Bai
Nat. Prod. Rep., 2012, 29, 243-263
DOI: 10.1039/C2NP00019A

The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus
Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo
Nat. Prod. Rep., 2012, Advance Article
DOI: 10.1039/C2NP00073C

Marine natural products
John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote and Michèle R. Prinsep
Nat. Prod. Rep., 2011, 28, 196-268
DOI: 10.1039/C005001F

Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R. Liedl and Judith M. Rollinger
Nat. Prod. Rep., 2012, 29, 11-36
DOI: 10.1039/C1NP00053E

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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Natural Products in OBC and MedChemComm

Organic & Biomolecular Chemistry and MedChemComm, our sister journals, publish many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s and MedChemComm‘s e-alerts (free service), and receive their tables of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

The microbial cell factory
Cormac D. Murphy
Org. Biomol. Chem., 2012, 10, 1949-1957
DOI: 10.1039/C2OB06903B, Perspective

Fungal biofilm inhibitors from a human oral microbiome-derived bacterium
Xiaoru Wang, Lin Du, Jianlan You, Jarrod B. King and Robert H. Cichewicz
Org. Biomol. Chem., 2012, 10, 2044-2050
DOI: 10.1039/C2OB06856G, Paper

Pyrazine alkaloids via dimerization of amino acid-derived α-amino aldehydes: biomimetic synthesis of 2,5-diisopropylpyrazine, 2,5-bis(3-indolylmethyl)pyrazine and actinopolymorphol C
Sandhya Badrinarayanan and Jonathan Sperry
Org. Biomol. Chem., 2012, 10, 2126-2132
DOI: 10.1039/C2OB06935K, Paper

Novel, unifying mechanism for amphotericin B and other polyene drugs: electron affinity, radicals, electron transfer, autoxidation, toxicity, and antifungal action
Peter Kovacic and Andrew Cooksy
Med. Chem. Commun., 2012, 3, 274-280
DOI: 10.1039/C2MD00267A, Review

Intramolecular proton transfer impact on antibacterial properties of ansamycin antibiotic rifampicin and its new amino analogues
Krystian Pyta, Piotr Przybylski, Barbara Wicher, Maria Gdaniec and Joanna Stefańska
Org. Biomol. Chem., 2012, 10, 2385-2388
DOI: 10.1039/C2OB00008C, Communication

Efficient syntheses of 2,3-disubstituted natural quinazolinones via iridium catalysis
Jie Fang and Jianguang Zhou
Org. Biomol. Chem., 2012, 10, 2389-2391
DOI: 10.1039/C2OB07178A, Communication

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