We’ve got more in the Top 10%

So. We take the articles that get the highest scores during peer review and we make them HOT. Then we send that shortlist to the Lab on a Chip Editor to choose the Top 10%. These papers demonstrate breakthroughs in device technology or methodology, or demonstrate important new results.

Today we add three more to the Top 10% collection!


Frontier Article

Elevating sampling, Joseph M. Labuz and Suichi Takayama, DOI: 10.1039/C4LC00125G

Does the effectiveness of sample preparation stand in the way of demonstrating new technology? This article highlights recent successes as well as assesses current challenges and opportunity in the area of sample collection and prep in micro- and nanofluidics.


Research Paper

Influenza A virus-specific aptamers screened by using an integrated microfluidic system, Hsien-Chih Lai, Chih-Hung Wang, Tong-Miin Liou and Gwo-Bin Lee, DOI: 10.1039/C4LC00187G

Early and rapid diagnosis of the influenza A virus is crucial in preventing and controlling outbreaks. In this paper, a microfluidic system was used to screen an aptamer for the influenza virus, in an automated and highly efficient manner.


Focus Article

Patent protection and licensing in microfluidics, Ali K. Yetisen and Lisa R. Volpatti, DOI: 10.1039/C4LC00399C

Is your microfluidic device ready for a patent? Authors aim to overview the terminology in patent law, describe the process of filing for a patent, discuss strategies for licencing a patent and explain tactics to defend an existing patent.




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Top ten most accessed LOC articles in Q1 2014

This month sees the following articles in Lab on a Chip that are in the top ten most accessed January – March:-

Continuous focusing of microparticles using inertial lift force and vorticity via multi-orifice microfluidic channels 
Jae-Sung Park, Suk-Heung Song and Hyo-Il Jung 
Lab Chip, 2009,9, 939-948 
DOI: 10.1039/B813952K  
  
Paper-based microfluidic point-of-care diagnostic devices 
Ali Kemal Yetisen, Muhammad Safwan Akram and Christopher R. Lowe    
Lab Chip, 2013,13, 2210-2251
DOI: 10.1039/C3LC50169H  
 
Rare cell isolation and analysis in microfluidics 
Yuchao Chen, Peng Li, Po-Hsun Huang, Yuliang Xie, John D. Mai, Lin Wang, Nam-Trung Nguyen and Tony Jun Huang    
Lab Chip, 2014,14, 626-645
DOI: 10.1039/C3LC90136J  
  
Droplet microfluidics 
Shia-Yen Teh, Robert Lin, Lung-Hsin Hung and Abraham P. Lee    
Lab Chip, 2008,8, 198-220
DOI: 10.1039/B715524G  
  
Lab-in-a-pen: a diagnostics format familiar to patients for low-resource settings 
Max M. Gong, Brendan D. MacDonald, Trung Vu Nguyen, Kinh Van Nguyen and David Sinton    
Lab Chip, 2014,14, 957-963
DOI: 10.1039/C3LC51185E  
 
Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry 
Lisen Wang, Lisa A. Flanagan, Noo Li Jeon, Edwin Monuki and Abraham P. Lee    
Lab Chip, 2007,7, 1114-1120
DOI: 10.1039/B705386J  
 
Particle separation using virtual deterministic lateral displacement (vDLD) 
David J. Collins, Tuncay Alan and Adrian Neild    
Lab Chip, 2014,14, 1595-1603
DOI: 10.1039/C3LC51367J  
 
Light-assisted direct-write of 3D functional biomaterials 
Kolin C. Hribar, Pranav Soman, John Warner, Peter Chung and Shaochen Chen    
Lab Chip, 2014,14, 268-275 
DOI: 10.1039/C3LC50634G 
 
Wettability patterning for high-rate, pumpless fluid transport on open, non-planar microfluidic platforms 
Aritra Ghosh, Ranjan Ganguly, Thomas M. Schutzius and Constantine M. Megaridis    
Lab Chip, 2014,14, 1538-1550
DOI: 10.1039/C3LC51406D 
 
Automated analysis of dynamic behavior of single cells in picoliter droplets 
Mohammad Ali Khorshidi, Prem Kumar Periyannan Rajeswari, Carolina Wählby, Haakan N. Joensson and Helene Andersson Svahn    
Lab Chip, 2014,14, 931-937
DOI: 10.1039/C3LC51136G  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions

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New UTube videos

Imaging adherent cell in microfluidic channel hidden by flowing RBCs as occluding objects by holographic method 

 
 
  
Microdevice arrays of high aspect ratio Poly(DiMethylSiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties 

 
   
Event-Triggered Logical Flow Control for Comprehensive Process Integration of Multi-Step Assays on Centrifugal Microfluidic Platforms 

 
 
  
Phaseguide assisted liquid lamination for magnetic particle-based assays 

 
   
Preparation of Monodisperse Microbubbles using an Integrated Embedded Capillary T-Junction with Electrohydrodynamic Focusing 

 
 
  
Hydrogel Bioprinted Microchannel Networks for Vascularization of Tissue Engineering Constructs 

 
 
   
A high-efficiency microfluidic device for size-selective trapping and sorting 

 
 
  
In-fiber integrated optofluidic device based on optical fiber with an inner core 

 
 
  
Automated single cell microbioreactor for monitoring intracellular dynamics and cell growth in free solution 

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes
Gregory A. Cooksey and Javier Atencia  
Lab Chip, 2014,14, 1665-1668
DOI: 10.1039/C4LC00173G, Technical Innovation

Graphical abstract: Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes
Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication
Timothy Kwa, Qing Zhou, Yandong Gao, Ali Rahimian, Lydia Kwon, Ying Liu and Alexander Revzin  
Lab Chip, 2014,14, 1695-1704
DOI: 10.1039/C4LC00037D, Paper

Graphical abstract: Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication
Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics
David Erickson, Dakota O’Dell, Li Jiang, Vlad Oncescu, Abdurrahman Gumus, Seoho Lee, Matthew Mancuso and Saurabh Mehta  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00142G, Frontier

Graphical abstract: Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics
*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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New UTube videos

The Microfluidic Puzzle: Chip-oriented Rapid Prototyping 
 
  
 
Fluoropolymer surface coatings to control droplets in microfluidic devices 
 
 
  
Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles 
   

Caterpillar Locomotion–inspired Valveless Pneumatic Micropump using Single Teardrop-shaped Elastomeric Membrane 
 
   
  
In-fiber integrated optofluidic device based on optical fiber with an inner core 
 
 
  
Solvent Immersion Imprint Lithography 
 
 
    
Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations 
 
   
 
Shaken and Stirred: Oscillatory Segmented Flow for Controlled Size-Evolution of Colloidal Nanomaterials 
 
 
  
Particles Optical Trapping and Binding in Optofluidic Stable Fabry–Pérot Resonator with Single-Sided Injection 

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Another four articles make it into the Top 10%

By now you know the Top 10% story. But here’s a quick refresher:

The Top 10% represents our highest impact papers, which demonstrate a breakthrough in device technology or methodology, or demonstrate important new results. The papers included are chosen by our Editor from among the Lab on a Chip HOT articles, which score highly in peer review.

We’ve added four new papers to the Top 10%. Download your copies by clicking the links below…


Research Paper: Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing, L. I. Segerink et al.




Critical Review: Microfluidic spinning of micro- and nano-scale fibers for tissue engineering, S.-H. Lee et al.




Research Paper: Structural shimming for high-resolution nuclear magnetic resonance spectroscopy in lab-on-a-chip devices, M. Utz et al.




Research Paper: Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication, A. Revzin et al.


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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections
Liesbet Van Heirstraeten, Peter Spang, Carmen Schwind, Klaus S. Drese, Marion Ritzi-Lehnert, Benjamin Nieto, Marta Camps, Bryan Landgraf, Francesc Guasch, Antoni Homs Corbera, Josep Samitier, Herman Goossens, Surbhi Malhotra-Kumar and Tina Roeser  
Lab Chip, 2014,14, 1519-1526
DOI: 10.1039/C3LC51339D, Paper

Graphical abstract: Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections

Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing
J.-P. Frimat, M. Bronkhorst, B. de Wagenaar, J. G. Bomer, F. van der Heijden, A. van den Berg and L. I. Segerink  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00050A, Paper

Graphical abstract: Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing

Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips
Laura Restrepo-Pérez, Lluís Soler, Cynthia S. Martínez-Cisneros, Samuel Sánchez and Oliver G. Schmidt  
Lab Chip, 2014,14, 1515-1518
DOI: 10.1039/C3LC51419F, Communication

Graphical abstract: Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips

*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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DVD diagnostics

Chemistry World story written by Megan Tyler.

A pregnancy test based on standard DVD technology has the potential to be turned into a diagnostic platform that screens for abnormal pregnancies or even testicular cancer.

The DVD assay design and signal reading principle

We all hate waiting for tests results, especially when it comes to medical tests where the uncertainty of not knowing what’s wrong can be a real worry. As a result, the development of diagnostic tests that can be performed wherever the patient is, whether that is at home, in a doctor’s surgery or in a medical centre in the developing world, obtaining almost instantaneous results is a current hot topic. Over the past few years, a wide range of point-of-care diagnostic platforms have been developed and the field holds tremendous potential, perhaps one day eliminating the need for laboratory-based diagnostic tests altogether.

To read the full article please visit Chemistry World.

DVD technology-based molecular diagnosis platform: quantitative pregnancy test on a disc
Xiaochun Li, Samuel Weng, Bixia Ge, Zhihui Yao and Hua-Zhong Yu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51411K, Paper

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Pioneers of Miniaturisation Lecture 2014 – deadline 30th June!

Miniaturisation plays a significant role in our daily lives; devices are becoming smaller and smaller, and this trend is set to continue. Current micro and nanofluidic research encompasses many scientific developments and technologies that will increase our understanding of phenomena at the micro and nano scale and potentially have a huge positive impact on our lives in the future. The use of micro and nano fluidic technologies will impact on a diverse range of industries ranging from their use in motor cars, through health improvement applications and to their use in protecting national and environmental security needs.

At Lab on a Chip, we strongly believe in this technology and have been willing to show the necessary commitment and financial support to back the development of this research community. It is in this vein we present this award to honour and support the up and coming, next generation pioneers in this field of endeavour. So Lab on a Chip will again join forces with Corning Incorporated to award the ninth ‘Pioneers of Miniaturisation’ Lectureship at µTAS, including a certificate of recognition and a prize of $5000. The lectureship will be presented at the µTAS 2014 Conference in San Antonio, Texas.

Who should you nominate?

The award is for early to mid-career scientists (nominees must be no older than 45 by the closing date for nominations).

The award is for extraordinary or outstanding contributions to the understanding or development of miniaturised systems. This will be judged mainly through their top 1-3 papers and/or an invention documented by patents/or a commercial product. Awards and honorary memberships may also be considered. The awardee is required to give a short lecture at the µTAS Conference in the same year.

The 2013 Pioneers of Miniaturisation Lectureship was awarded to Shuichi Takayama, University of Michigan. 

See here for further information, including past winners.

Nominations to Lab on a Chip Executive Editor Harp Minhas by 30th June

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New YouTube Videos

A high-throughput device for size based separation of C. elegans developmental stages 


 
  
 Packaging Commercial CMOS Chips for Lab on a Chip Integration 


 
  
 
Microfluidic chip for plasma separation from undiluted human whole blood sample using low voltage contactless dielectrophoresis and capillary force 

 
   
 
Novel side electrode configuration integrated in fused silica microsystems for synchronous optical and electrical spectroscopy 

 
 
  
 Clog-free Cell Filtration Using Resettable Cell Traps 

 
 
  
 High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics 

 
   
 Acoustic Actuated Fluorescence Activated Sorting of Microparticles 

 
   
 
Photo-thermal Effect for Localized Desorption of Primary Lymphocytes Arrayed on an Antibody/DNA-based Biochip 

 
 
  
 A biocompatible open-surface droplet manipulation platform for detection of multi-nucleotide polymorphism 


 
 
 Wettability patterning for high-rate, pumpless fluid transport on open, non-planar, microfluidic platforms 

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