Archive for the ‘Themed Collections’ Category

200th Issue of Lab on a Chip

We are delighted to announce the publication of our 200th issue of Lab on a Chiphow we have grown!

Launched in 2001, publishing 2 issues with a total of 31 articles that year, LOC is now publishing 24 issues a year. Many of the young researchers that published in the first issue have now become Professors themselves, and many have gone on to become award winners. Read the full editorial by our Editor, Harp Minhas to find out more!

This picture shows how the image of LOC has developed from the original cover to the LOC we are familiar with today.

To celebrate this achievement, we have made all of the HOT articles in the 200th issue of LOC free* to access throughout August. Click on the links below to download.

Ana I. Barbosa, Ana P. Castanheira, Alexander D. Edwards and Nuno M. Reis
Lab Chip, 2014, 14, 2918-2928
DOI: 10.1039/C4LC00464G
Yu-Chih Chen, Yu-Heng Cheng, Hong Sun Kim, Patrick N. Ingram, Jacques E. Nor and Euisik Yoon
Lab Chip, 2014, 14, 2941-2947
DOI: 10.1039/C4LC00391H

Lab on a Chip itself has had an enormous influence on the development of the field, by setting very high scientific standards, by providing a common forum and vocabulary, by highlighting significant results, and by attracting some of the best scientists. The journal, and Harp Minhas as the spirit of the journal, have provided a coherence to Lab-on-a-chip science and technology that have had enormous influence in channeling the direction of the field”

Professor George Whitesides, Chair of Editorial Board, Lab on a Chip

*Access is free through a registered RSC account until 31st August 2014 – click here to register

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New challenges spawn new innovations

Emerging Investigators

Guest edited by Dino di Carlo, Helene Andersson-Svah and Yanyi Huang, this issue celebrates the best and brightest amongst early career miniaturisation scientists around the world. Their editorial reflects on the past before introducing the upcoming challenges that new generations of investigators are facing. These challenges are demonstrated in the range of topics covered in this issue.

Read the full Emerging Investigator themed collection now – we hope you enjoy the articles

This issue features three HOT articles, which received particularly high scores at peer review. They are free* to access for a limited time only so click on the links below to download the full articles

Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du
Lab Chip, 2014, 14, 2614-2625
DOI: 10.1039/C4LC00081A
Lab Chip, 2014, 14, 2626-2634
DOI: 10.1039/C4LC00039K
J.-P. Frimat, M. Bronkhorst, B. de Wagenaar, J. G. Bomer, F. van der Heijden, A. van den Berg and L. I. Segerink
Lab Chip, 2014, 14, 2635-2641
DOI: 10.1039/C4LC00050A

*Access is free through a registered RSC account untill 22nd September 2014 – click here to register

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Themed Issue dedicated to Kahp-Yang Suh

An extraordinarily insightful and productive scientist in the field of nanotechnology, material science and bio-inspired systems, Kahp-Yang Suh has published over 200 articles over his short academic life.

Guest edited by Pilnam Kim, Noo Li Jeon and Ali Khademhosseini, this issue includes seven research papers concerning various areas of lab-on-a-chip, written by friends and colleagues of Khap-Yang and includes contributions on a  range of topics related to Kahp-Yang’s work. These papers demonstrate the directions in which lab-on-a-chip and intelligent manufacturing of biomaterials could contribute to the development of the next generation of healthcare systems.

Click here to read the full collection, celebrating Kahp-Yang’s contribution to microfluidics research.

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LOC issue 4 – the Neuroengineering 2013 themed issue is online now!


Lab on a Chip’s 2013 Neuroengineering themed issue is introduced by guest editors David T. Eddington and Justin Williams, who also contributed the outside front cover design. This is followed by profiles of all of the contributors to the Neuroengineering themed issue.

David T. Eddington and Justin Williams
DOI: 10.1039/C3LC90003G


As well as plenty of cutting-edge primary research into lab on a chip technology for neuroengineering, Issue 4 includes two Critical Reviews.

A critical review of the development of engineered cell culture substrates and techniques for investigating axon development guidance by Santiago Costantino et al. at University of Montreal and McGill University, Canada, is highlighted on the inside front cover. They look at the opportunities that are now opening up due to these new technological developments, the biological insights that can now be gained and the breakthroughs waiting to happen in the near future.

Engineered cell culture substrates for axon guidance studies: moving beyond proof of concept
Joannie Roy, Timothy E. Kennedy and Santiago Costantino
DOI: 10.1039/C2LC41002H


The second critical review from Noo Li Jeon et al. at Seoul National University, Korea, and The Salk Institute, USA, summarises the most recent technological developments of BioMEMs devices and their application to neuroscience research. They look at platforms for disease culture, modelling disease in vitro, neuron electrophysiology and stem cell biology.

Advances in microfluidics-based experimental methods for neuroscience research
Jae Woo Park, Hyung Joon Kim, Myeong Woo Kang and Noo Li Jeon
DOI: 10.1039/C2LC41081H


The HOT articles in this issue include:

Integration of pre-aligned liquid metal electrodes for neural stimulation within a user-friendly microfluidic platform
Nicholas Hallfors, Asif Khan, Michael D. Dickey and Anne Marion Taylor
DOI: 10.1039/C2LC40954B

Inherent amplitude demodulation of an AC-EWOD (electrowetting on dielectric) droplet
Myung Gon Yoon, Sang Hyun Byun and Sung Kwon Cho
DOI: 10.1039/C2LC41043E

One-step polymer surface modification for minimizing drug, protein, and DNA adsorption in microanalytical systems
Esben Kjær Unmack Larsen and Niels B. Larsen
DOI: 10.1039/C2LC40750G


To learn all about the exciting advances happening in applying microtechnology to neuroengineering, read the full issue here

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Issue 22 – Focus on Scandinavia

Issue 22 of Lab on a Chip features work from Scandinavia – read the editorial from the Guest Editors Professors Thomas Laurell and Jörg Kutter here. The issue features 8 articles from Scandinavian authors, and profiles of the athours included can be found here.

The front cover features work from Jörg Kutter and co-workers at the Technical University of Denmark, reporting on the optical properties of gold nanoparticle probes, used as sensors for environmental contaminants.

Gold nanoparticle-based optical microfluidic sensors for analysis of environmental pollutants
Josiane P. Lafleur, Silja Senkbeil, Thomas G. Jensen and Jörg P. Kutter
DOI: 10.1039/C2LC40543A

Artwork linked to research from Vincent Aimez and colleagues from the Université de Sherbrooke can be seen on the inside front cover of the issue – they have developed a microfluidic device to monitor the radioactivity concentration in the blood of rats and mice in real time.

Blood compatible microfluidic system for pharmacokinetic studies in small animals
Laurence Convert, Frédérique Girard Baril, Vincent Boisselle, Jean-François Pratte, Réjean Fontaine, Roger Lecomte, Paul G. Charette and Vincent Aimez
DOI: 10.1039/C2LC40550D

The back cover of the issue features work from Samir Iqbal and co-workers at the University of Texas and Lehigh University. The team designed a Hele-Shaw device with aptamer functionalized glass beads to isolate cancer cells from a cellular mixture.

Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array
Yuan Wan, Yaling Liu, Peter B. Allen, Waseem Asghar, M. Arif Iftakher Mahmood, Jifu Tan, Holli Duhon, Young-tae Kim, Andrew D. Ellington and Samir M. Iqbal
DOI: 10.1039/C2LC21251J

Other HOT papers in the issue include:

Two-hundredfold volume concentration of dilute cell and particle suspensions using chip integrated multistage acoustophoresis
Maria Nordin and Thomas Laurell
DOI: 10.1039/C2LC40629B

Inertial microfluidics in parallel channels for high-throughput applications
Jonas Hansson, J. Mikael Karlsson, Tommy Haraldsson, Hjalmar Brismar, W. van der Wijngaart and Aman Russom
DOI: 10.1039/C2LC40241F

Low cost integration of 3D-electrode structures into microfluidic devices by replica molding
Benjamin Mustin and Boris Stoeber
DOI: 10.1039/C2LC40728K

A microfluidic device with removable packaging for the real time visualisation of intracellular effects of nanosecond electrical pulses on adherent cells
C. Dalmay, M. A. De Menorval, O. Français, L. M. Mir and B. Le Pioufle
DOI: 10.1039/C2LC40857K

Programmable microfluidic synthesis of spectrally encoded microspheres
R. E. Gerver, R. Gómez-Sjöberg, B. C. Baxter, K. S. Thorn, P. M. Fordyce, C. A. Diaz-Botia, B. A. Helms and J. L. DeRisi
DOI: 10.1039/C2LC40699C

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Hot articles from our Emerging Investigators

We’re delighted to announce the publication of our 2012 Emerging Investigators issue, which contains a massive 6 HOT articles!  Read the editorial from Amy Herr and Aaron Wheeler to find out why this group of researchers is affectionately known as control freaks..

Lab on a Chip Emerging Investigators

Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells
Ran Chen, Peng-Fei Dong, Jian-Hong Xu, Yun-Dong Wang and Guang-Sheng Luo
DOI: 10.1039/C2LC40387K

A rotary microsystem for simple, rapid and automatic RNA purification
Byung Hyun Park, Jae Hwan Jung, Hainan Zhang, Nae Yoon Lee and Tae Seok Seo
DOI: 10.1039/C2LC40487G

Cytotoxicity analysis of water disinfection byproducts with a micro-pillar microfluidic device
Austin Hsiao, Yukako Komaki, Syed M. Imaad, Benito J. Mariñas, Michael J. Plewa and G. Logan Liu
DOI: 10.1039/C2LC40374A

Lab on a Chip Emerging Invesitgators

Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level
Zhi Zhu, Wenhua Zhang, Xuefei Leng, Mingxia Zhang, Zhichao Guan, Jiangquan Lu and Chaoyong James Yang
DOI: 10.1039/C2LC40461C

Enantioselective analysis of melagatran via an LSPR biosensor integrated with a microfluidic chip
Longhua Guo, Yuechun Yin, Rong Huang, Bin Qiu, Zhenyu Lin, Huang-Hao Yang, Jianrong Li and Guonan Chen
DOI: 10.1039/C2LC40388A

Real-time full-spectral imaging and affinity measurements from 50 microfluidic channels using nanohole surface plasmon resonance
Si Hoon Lee, Nathan C. Lindquist, Nathan J. Wittenberg, Luke R. Jordan and Sang-Hyun Oh
DOI: 10.1039/C2LC40455A

These articles will be free to access for the next 4 weeks. (Free access to individuals is provided through an RSC Publishing personal account. Registration is quick, free and simple.)

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Hot articles in optofluidics

You might have already seen our themed issue on optofluidics but in case you haven’t, here are the HOT articles from this issue:

Yi-Chung Tung et al. review the recent advances in optofluidic technologies that will open up new possibilities for on-chip phenotyping

Optofluidic detection for cellular phenotyping
Yi-Chung Tung, Nien-Tsu Huang, Bo-Ram Oh, Bishnubrata Patra, Chi-Chun Pan, Teng Qiu, Paul K. Chu, Wenjun Zhang and Katsuo Kurabayashi
DOI: 10.1039/C2LC40509A

Optofluidic nose
Kevin Raymond et al. have developed an ‘optofluidic nose’ for sensing organic liquids based on wetting in photonic-crystal arrays.

Combinatorial wetting in colour: an optofluidic nose
Kevin P. Raymond, Ian B. Burgess, Mackenzie H. Kinney, Marko Lončar and Joanna Aizenberg
DOI: 10.1039/C2LC40489C

An electrokinetically tunable optofluidic bi-concave lens
Haiwang Li and colleagues demonstrate the design of a bi-concave lens to perform both light focusing and diverging in-plane.

An electrokinetically tunable optofluidic bi-concave lens
Haiwang Li, Chaolong Song, Trung Dung Luong, Nam-Trung Nguyen and Teck Neng Wong
DOI: 10.1039/C2LC40406K

Highly sensitive optofluidic chips for biochemical liquid assay
Yasutaka Hanada and coworkers show how to create a highly sensitive optofluidic chip for biochemical liquid assays by coating microfluidic channels with a low refractive index polymer and use of an optical waveguide.

Highly sensitive optofluidic chips for biochemical liquid assay fabricated by 3D femtosecond laser micromachining followed by polymer coating
Yasutaka Hanada, Koji Sugioka and Katsumi Midorikawa
DOI: 10.1039/C2LC40377C

Optical imaging techniques in microfluidics

Jigang Wu,  Guoan Zheng and Lap Man Lee focus on compact systems in their review of optical imaging techniques that can be integrated with microfluidics.

Optical imaging techniques in microfluidics and their applications
DOI: 10.1039/C2LC40517B

Optofluidics and synthetic biologyChao-Min Cheng and colleagues provide thoughtful insight into the application of optofluidics to synthetic biology in this forward-looking Frontier article.

Frontiers of optofluidics in synthetic biology
Cheemeng Tan, Shih-Jie Lo, Philip R. LeDuc and Chao-Min Cheng
DOI: 10.1039/C2LC40828G

Microplasma in dielectrophoresis-driven bubbles
Shih-Kang Fan’s team manipulate 200 nL bubbles with DEP and ignite microplasma within them, with potential for future applications in the biomedical field.

Atmospheric-pressure microplasma in dielectrophoresis-driven bubbles for optical emission spectroscopy
Shih-Kang Fan, Yan-Ting Shen, Ling-Pin Tsai, Cheng-Che Hsu, Fu-Hsiang Ko and Yu-Ting Cheng
DOI: 10.1039/C2LC40499K

Optofluidic hydrogel microrobotsWenqi Hu, Kelly S. Ishii, Qihui Fan and Aaron T. Ohta report a hydrogel microrobot which can be manipulated by laser-induced bubbles.  Single or pairs of robots are able to assemble polystyrene beads and yeast cells into patterns.

Hydrogel microrobots actuated by optically generated vapour bubbles

Wenqi Hu, Kelly S. Ishii, Qihui Fan and Aaron T. Ohta
DOI: 10.1039/C2LC40483D

Remember, all our cover articles are free to access for 6 weeks, and our HOT articles for 4 weeks.  All you need to access them is an RSC Publishing Personal Account – signing up is quick and easy.

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Themed issue on optofluidics out now

Lab on a Chip is delighted to publish what we believe is the first issue dedicated to research in the exciting new field of optofluidics, guest edited by Professors Ai-Qun Liu (Nanyang Technological University) and Changhuei Yang (Caltech).

Read their editorial introduction to the issue, where they discuss some of the most innovative new developments in this rapidly blossoming field.

We’ve got some great artwork on the covers of this issue, highlighting the range of articles in this issue:

Lab on a Chip Cover Optofluidics Lab on a Chip cover optofluidics Lab on a Chip cover optofluidics Lab on a Chip cover optofluidics

Katsuo Kurabayashi et al. have discussed the promise of optofluidic technologies to enable on-chip cellular phenotyping in their critical review which features on the outside front cover. On the inside front cover Joanna Aizenberg and colleagues have developed an ‘optofluidic nose’ – a litmus test which can differentiate organics liquids based on wetting, while on the back cover Teck Neng Wong et al. have created an optofluidic bi-concave lens to both focus and diverge a light source by applying an external electric field to a constant flow.  On the other back cover Katsumi Midorikawa and coworkers fabricated highly sensitive optofluidic chips for biochemical liquid assays.

Don’t forget – all articles on our covers are free to access for 6 weeks! You just need to sign in with your RSC Publishing Personal Account.

View the rest of the issue

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Our latest themed issue: Focus on USA

Lab on a Chip: Focus on the USAWe’ve just published another themed issue, this time looking at some of the exciting work from labs in the USA.  The issue was partly inspired by the Wyss Institute Symposium on “Microfluidics and Medicine: Accelerating the Flow from Lab to the Clinic“, which focused on work in the microfluidics field that promises to have a transformative impact on medicine and clinical care.

Guest Editors Don Ingber and George Whitesides introduce the issue and discuss the impact of microfluidics on biological advances in their Editorial.

View the issue for HOT papers on high throughput drug screening, isolating rare circulating tumour cells, a microfluidic device that can screen whole worms and lots of organs on chips articles: brain slice on a chip and gut on a chip.

Remember, these articles are free to access for 4 weeks with an RSC Publishing account.

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Themed issue on analytical miniaturization and nanotechnologies just published

Cover for Analytical miniaturization and nanotechnologiesLab on a Chip is delighted to announce the publication of a themed issue dedicated to Analytical miniaturization and nanotechnologies, published in collaboration with the III International Workshop on Analytical Miniaturization and NANOtechnologies to be held next month in Barcelona. The issue was guest edited by Arben Merkoçi and Jörg P. Kutter, who introduce the issue in an editorial on the use of nanotechnologies and nanomaterials for the design and applications of lab-on-a-chip and other miniaturized analytical systems

We hope you will enjoy reading this collection of articles.

Tutorial Review

Lab-in-a-tube: ultracompact components for on-chip capture and detection of individual micro-/nanoorganisms
Elliot J. Smith, Wang Xi, Denys Makarov, Ingolf Mönch, Stefan Harazim, Vladimir A. Bolaños Quiñones, Christine K. Schmidt, Yongfeng Mei, Samuel Sanchez and Oliver G. Schmidt
Lab Chip, 2012, 12, 1917-1931
DOI: 10.1039/C2LC21175K

Critical Reviews

Nanomaterials and lab-on-a-chip technologies
Mariana Medina-Sánchez, Sandrine Miserere and Arben Merkoçi
Lab Chip, 2012, 12, 1932-1943
DOI: 10.1039/C2LC40063D

Cargo-towing synthetic nanomachines: Towards active transport in microchip devices
Joseph Wang
Lab Chip, 2012, 12, 1944-1950
DOI: 10.1039/C2LC00003B

Carbon nanotube based stationary phases for microchip chromatography
Klaus B. Mogensen and Jörg P. Kutter
Lab Chip, 2012, 12, 1951-1958
DOI: 10.1039/C2LC40102A


Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations
Fernando Cruz Moraes, Renato Sousa Lima, Thiago Pinotti Segato, Ivana Cesarino, Jhanisus Leonel Melendez Cetino, Sergio Antonio Spinola Machado, Frank Gomez and Emanuel Carrilho
Lab Chip, 2012, 12, 1959-1962
DOI: 10.1039/C2LC40141J

Contactless conductivity biosensor in microchip containing folic acid as bioreceptor
Renato S. Lima, Maria H. O. Piazzetta, Angelo L. Gobbi, Ubirajara P. Rodrigues-Filho, Pedro A. P. Nascente, Wendell K. T. Coltro and Emanuel Carrilho
Lab Chip, 2012, 12, 1963-1966
DOI: 10.1039/C2LC40157F


Bipolar electrochemistry for cargo-lifting in fluid channels
Gabriel Loget and Alexander Kuhn
Lab Chip, 2012, 12, 1967-1971
DOI: 10.1039/C2LC21301J

Capillary soft valves for microfluidics
Martina Hitzbleck, Laetitia Avrain, Valerie Smekens, Robert D. Lovchik, Pascal Mertens and Emmanuel Delamarche
Lab Chip, 2012, 12, 1972-1978
DOI: 10.1039/C2LC00015F

Microreactor with integrated temperature control for the synthesis of CdSe nanocrystals
Sara Gómez-de Pedro, Cynthia S. Martínez-Cisneros, Mar Puyol and Julián Alonso-Chamarro
Lab Chip, 2012, 12, 1979-1986
DOI: 10.1039/C2LC00011C

Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers
Daphné Duval, Ana Belén González-Guerrero, Stefania Dante, Johann Osmond, Rosa Monge, Luis J. Fernández, Kirill E. Zinoviev, Carlos Domínguez and Laura M. Lechuga
Lab Chip, 2012, 12, 1987-1994
DOI: 10.1039/C2LC40054E

Printed two-dimensional photonic crystals for single-step label-free biosensing of insulin under wet conditions
Tatsuro Endo, Masaya Sato, Hiroshi Kajita, Norimichi Okuda, Satoru Tanaka and Hideaki Hisamoto
Lab Chip, 2012, 12, 1995-1999
DOI: 10.1039/C2LC40066A

On-chip electrochemical detection of CdS quantum dots using normal and multiple recycling flow through modes
Mariana Medina-Sánchez, Sandrine Miserere, Sergio Marín, Gemma Aragay and Arben Merkoçi
Lab Chip, 2012, 12, 2000-2005
DOI: 10.1039/C2LC00007E

High NIR-purity index single-walled carbon nanotubes for electrochemical sensing in microfluidic chips
Diana Vilela, Alejandro Ansón-Casaos, María Teresa Martínez, María Cristina González and Alberto Escarpa
Lab Chip, 2012, 12, 2006-2014
DOI: 0.1039/C2LC40099E

Do you work at forefront of nanotechnology for miniaturisation?

Submit your next piece of exciting research to Lab on a Chip.

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