Archive for the ‘Hot Articles’ Category

Life in the Fast Lane

Microscale Inertial Flow Regimes

The Reynolds number, ratio of inertial to viscous forces, is low for most microfluidic platforms and has been approximated to zero to model most microscale fluid flows as linear and time-reversible (Stoke’s flow). Yet Dino Di Carlo’s group at the University of California- Los Angeles, among others, have shown that microfluidic systems in which Reynolds’ number ranges from 1 to 100 exhibit non-negligible inertial effects. These forces lead to separation and ordering of particles within channels by stream line crossing due to effects from the channel geometries (lift forces from the channel wall and velocity profile shear gradient). Inertial lift forces are regulated by the channel dimensions and geometry, particle diameter, and flow rate.[1]

Experimentally-derived intuitions have guided researchers to use the effects of inertial lift forces to produce high throughput flow cytometers to isolate bacteria from diluted blood samples,[2] systems capable of probing the deformability of cells to evaluate metastatic potential[3, 4] and platforms combined with Dean flow in curved channels to increase mixing of fluids or spirals to improve separation of particles.[5] Yet the physical underpinnings guiding these channel designs have been limited.

In this review, Amini and colleagues tackle many of the relationships which are important to create new devices by taking advantage of the unique contribution of inertial forces at the microscale. The behavior of non-Newtonian fluids (i.e., whole blood), the role of particle shape on focusing, particle-particle interactions, and the effect of protrusions along the channel length on flow (pillars, herringbone structures) are also discussed and can open exciting new applications in medical diagnostics, chemical synthesis, manufacturing of materials, and beyond. Inertial microfluidics platforms are en route to commercialization by Johnson & Johnson to sort rare circulating tumor cells from whole blood at 10 million cells per second (CTC-iChip[6]).

Download the full review for free* for a limited time only!

Inertial microfluidic physics
Hamed Amini, Wonhee Lee and Dino Di Carlo. Lab on a Chip, 2014, 14, 2739-2761.
DOI: 10.1039/C4LC00128A

References:
[1] D. Di Carlo, Lab on a Chip, 2009, 9, 3038-3046.
[2] A. J. Mach and D. Di Carlo, Biotechnol. Bioeng., 2010, 107, 302-311.
[3] J. S. Dudani, et al, Lab on a Chip, 2013, 13, 3728-3734.
[4] S. C. Hur, et al, Lab on a Chip, 2011, 11, 912-920.
[5] J. M. Martel and M. Toner, Scientific Reports, 2013, 3.
[6] E. Ozkumur, et al, Sci. Transl. Med., 2013, 5, 179ra47.

*Access is free through a registered RSC account until 25th August 2014 – click here to register

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200th Issue of Lab on a Chip

We are delighted to announce the publication of our 200th issue of Lab on a Chip- how we have grown!

Launched in 2001, publishing 2 issues with a total of 31 articles that year, LOC is now publishing 24 issues a year. Many of the young researchers that published in the first issue have now become Professors themselves, and many have gone on to become award winners. Read the full editorial by our Editor, Harp Minhas to find out more!

This picture shows how the image of LOC has developed from the original cover to the LOC we are familiar with today.

To celebrate this achievement, we have made all of the HOT articles in the 200th issue of LOC free* to access throughout August. Click on the links below to download.

Ana I. Barbosa, Ana P. Castanheira, Alexander D. Edwards and Nuno M. Reis
Lab Chip, 2014, 14, 2918-2928
DOI: 10.1039/C4LC00464G
Yu-Chih Chen, Yu-Heng Cheng, Hong Sun Kim, Patrick N. Ingram, Jacques E. Nor and Euisik Yoon
Lab Chip, 2014, 14, 2941-2947
DOI: 10.1039/C4LC00391H

Lab on a Chip itself has had an enormous influence on the development of the field, by setting very high scientific standards, by providing a common forum and vocabulary, by highlighting significant results, and by attracting some of the best scientists. The journal, and Harp Minhas as the spirit of the journal, have provided a coherence to Lab-on-a-chip science and technology that have had enormous influence in channeling the direction of the field”

Professor George Whitesides, Chair of Editorial Board, Lab on a Chip

*Access is free through a registered RSC account until 31st August 2014 – click here to register

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New challenges spawn new innovations

Emerging Investigators

Guest edited by Dino di Carlo, Helene Andersson-Svah and Yanyi Huang, this issue celebrates the best and brightest amongst early career miniaturisation scientists around the world. Their editorial reflects on the past before introducing the upcoming challenges that new generations of investigators are facing. These challenges are demonstrated in the range of topics covered in this issue.

Read the full Emerging Investigator themed collection now – we hope you enjoy the articles

This issue features three HOT articles, which received particularly high scores at peer review. They are free* to access for a limited time only so click on the links below to download the full articles

Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du
Lab Chip, 2014, 14, 2614-2625
DOI: 10.1039/C4LC00081A
Lab Chip, 2014, 14, 2626-2634
DOI: 10.1039/C4LC00039K
J.-P. Frimat, M. Bronkhorst, B. de Wagenaar, J. G. Bomer, F. van der Heijden, A. van den Berg and L. I. Segerink
Lab Chip, 2014, 14, 2635-2641
DOI: 10.1039/C4LC00050A

*Access is free through a registered RSC account untill 22nd September 2014 – click here to register

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Hepatic organoids for microfluidic drug screening
Sam H. Au, M. Dean Chamberlain, Shruthi Mahesh, Michael V. Sefton and Aaron R. Wheeler  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00531G, Paper

Graphical abstract: Hepatic organoids for microfluidic drug screening
Delayed voltammetric with respect to amperometric electrochemical detection of concentration changes in microchannels
Raphaël Trouillon and Martin A. M. Gijs  
Lab Chip, 2014,14, 2929-2940
DOI: 10.1039/C4LC00493K, Paper

Graphical abstract: Delayed voltammetric with respect to amperometric electrochemical detection of concentration changes in microchannels
 
A droplet-based heterogeneous immunoassay for screening single cells secreting antigen-specific antibodies
Samin Akbari and Tohid Pirbodaghi  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00082J, Communication

Graphical abstract: A droplet-based heterogeneous immunoassay for screening single cells secreting antigen-specific antibodies
A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood
Ana I. Barbosa, Ana P. Castanheira, Alexander D. Edwards and Nuno M. Reis  
Lab Chip, 2014,14, 2918-2928
DOI: 10.1039/C4LC00464G, Paper
Graphical abstract: A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood

Induced charge electroosmosis micropumps using arrays of Janus micropillars
Joel S. Paustian, Andrew J. Pascall, Neil M. Wilson and Todd M. Squires  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00141A, Paper

Graphical abstract: Induced charge electroosmosis micropumps using arrays of Janus micropillars
Nanoshuttles propelled by motor proteins sequentially assemble molecular cargo in a microfluidic device
Dirk Steuerwald, Susanna M. Früh, Rudolf Griss, Robert D. Lovchik and Viola Vogel  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00385C, Paper

Graphical abstract: Nanoshuttles propelled by motor proteins sequentially assemble molecular cargo in a microfluidic device
Femtosecond laser 3D micromachining: a powerful tool for the fabrication of microfluidic, optofluidic, and electrofluidic devices based on glass
Koji Sugioka, Jian Xu, Dong Wu, Yasutaka Hanada, Zhongke Wang, Ya Cheng and Katsumi Midorikawa  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00548A, Critical Review

Graphical abstract: Femtosecond laser 3D micromachining: a powerful tool for the fabrication of microfluidic, optofluidic, and electrofluidic devices based on glass
Continuous microcarrier-based cell culture in a benchtop microfluidic bioreactor
F. Abeille, F. Mittler, P. Obeid, M. Huet, F. Kermarrec, M. E. Dolega, F. Navarro, P. Pouteau, B. Icard, X. Gidrol, V. Agache and N. Picollet-D’hahan  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00570H, Paper

Graphical abstract: Continuous microcarrier-based cell culture in a benchtop microfluidic bioreactor
Multiplexed immunoassay based on micromotors and microscale tags
D. Vilela, J. Orozco, G. Cheng, S. Sattayasamitsathit, M. Galarnyk, C. Kan, J. Wang and A. Escarpa  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00596A, Paper

Graphical abstract: Multiplexed immunoassay based on micromotors and microscale tags
Double emulsions from a capillary array injection microfluidic device
Luoran Shang, Yao Cheng, Jie Wang, Haibo Ding, Fei Rong, Yuanjin Zhao and Zhongze Gu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00698D, Communication

Graphical abstract: Double emulsions from a capillary array injection microfluidic device
SU-8 as a material for lab-on-a-chip-based mass spectrometry
Steve Arscott  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00617H, Tutorial Review

Graphical abstract: SU-8 as a material for lab-on-a-chip-based mass spectrometry
Sorting drops and cells with acoustics: acoustic microfluidic fluorescence-activated cell sorter
Lothar Schmid, David A. Weitz and Thomas Franke  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00588K, Paper

Graphical abstract: Sorting drops and cells with acoustics: acoustic microfluidic fluorescence-activated cell sorter
Physics and technological aspects of nanofluidics
Lyderic Bocquet and Patrick Tabeling  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00325J, Frontier

Graphical abstract: Physics and technological aspects of nanofluidics

 *Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Donut-shaped chambers for analysis of biochemical processes at the cellular and subcellular levels
N. Zurgil, O. Ravid-Hermesh, Y. Shafran, S. Howitz, E. Afrimzon, M. Sobolev, J. He, E. Shinar, R. Goldman-Levi and M. Deutsch  
Lab Chip, 2014,14, 2226-2239
DOI: 10.1039/C3LC51426A

Graphical abstract: Donut-shaped chambers for analysis of biochemical processes at the cellular and subcellular levels

Dual-pore glass chips for cell-attached single-channel recordings
Brandon R. Bruhn, Haiyan Liu, Stefan Schuhladen, Alan J. Hunt, Aghapi Mordovanakis and Michael Mayer  
Lab Chip, 2014,14, 2410-2417
DOI: 10.1039/C4LC00370E

Graphical abstract: Dual-pore glass chips for cell-attached single-channel recordings

In situ fabrication of a temperature- and ethanol-responsive smart membrane in a microchip
Yi-Meng Sun, Wei Wang, Yun-Yan Wei, Nan-Nan Deng, Zhuang Liu, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu  
Lab Chip, 2014,14, 2418-2427
DOI: 10.1039/C4LC00273C

Graphical abstract: In situ fabrication of a temperature- and ethanol-responsive smart membrane in a microchip

Multiphase optofluidics on an electro-microfluidic platform powered by electrowetting and dielectrophoresis
Shih-Kang Fan and Fu-Min Wang  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00317A

Graphical abstract: Multiphase optofluidics on an electro-microfluidic platform powered by electrowetting and dielectrophoresis

Deformability-based microfluidic cell pairing and fusion
Burak Dura, Yaoping Liu and Joel Voldman  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00303A

Graphical abstract: Deformability-based microfluidic cell pairing and fusion

Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal
Yu-Chih Chen, Yu-Heng Cheng, Hong Sun Kim, Patrick N. Ingram, Jacques E. Nor and Euisik Yoon  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00391H

Graphical abstract: Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal

Inertial microfluidic physics
Hamed Amini, Wonhee Lee and Dino Di Carlo  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00128A

Graphical abstract: Inertial microfluidic physics

Nanocrystal synthesis in microfluidic reactors: where next?
Thomas W. Phillips, Ioannis G. Lignos, Richard M. Maceiczyk, Andrew J. deMello and John C. deMello  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00429A

Graphical abstract: Nanocrystal synthesis in microfluidic reactors: where next?
Diffusion-based microfluidic PCR for “one-pot” analysis of cells
Sai Ma, Despina Nelie Loufakis, Zhenning Cao, Yiwen Chang, Luke E. K. Achenie and Chang Lu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00498A 

Graphical abstract: Diffusion-based microfluidic PCR for “one-pot” analysis of cells
 *Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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Microfluidic valves and pumps for all

Over the years, the materials used to make microfluidic devices have dictated the progress of the field. The development of early silicon and glass devices progressed very slowly because the fabrication methods required to make these devices were prohibitively expensive and inaccessible.1 Since the arrival of polydimethylsiloxane (PDMS)-based devices made by elastomeric micromolding or “soft lithography” in 1998,2 the pace of microfluidic technology development has increased dramatically. For example, between 1998 and 2010, the number of microfluidic-related publications increased from hundreds to thousands per year.3 These developments were fueled by the simplicity of PDMS-soft lithography, and more importantly, the ability of PDMS to form pneumatic valves and pumps.4

Although soft lithography has become one of the most popular methods for microfluidic fabrication, clean room processes are still needed to make a micromold, and PDMS is not compatible with existing high-throughput manufacturing methods.1 For these reasons and others, researchers are developing alternative methods for device fabrication. For example, Dr. Cooksey at the National Institute of Standards and Technology, Gaithersburg and Prof. Atencia at the University of Maryland developed techniques to create microfluidic devices from cut-off laminates and double-sided tapes.5 Their article, which featured as a cover in Lab on a Chip, showed how these film-based devices can be rapidly fabricated without a cleanroom using in-expensive materials and widely available equipment (e.g. razor cutter, laser cutter).

Like conventional PDMS-devices, these film-based devices can support pneumatic valves and pumps by sandwiching a thin layer of PDMS between two layers of film with cut-out channels. Accurate alignment between these layers is achieved using a self-alignment strategy, in which features of adjacent layers are mirrored across a folding line on a single piece of tape. To demonstrate valve functionality, Cooksey and Atencia created a device that uses 3 valves to control flow from 3 fluidic inputs, and one that uses 8 valves to control a 2-inlet rotary mixer.

One interesting feature of this technology is that very thin devices can be formed (less than 0.5 mm), which enables the fabrication of devices with many layers. For example, using the self-alignment strategy, the researchers fabricated a 6-layer device comprising a valve layer and five fluidic layers that form liquid chambers of varying heights.

Perhaps the most fascinating trait of this technology is the ability to fold devices into 3D structures with fully functioning valves. As shown in the figure below, the researchers assembled a 3D microfluidic cube that can deliver reagents to specific locations on the cube using the fluid channels routed through the walls. The researchers filled the cube with agar and used it to study the chemotaxis of C. elegans. Within two hours, the worms migrated from the center of the cube toward the face introduced with food, and promptly moved away when the food was switched to a repellent.

In summary, Dr. Cooksey and Prof. Atencia developed a rapid prototyping technique that can create film-based devices with the similar valve functionalities as conventional PDMS-based devices. But because these devices are very thin, more complicated and unique devices structures can be created. This technology has the potential uncover new applications for microfluidics, and make microfluidic technologies more accessible to non-engineers (e.g. biologists and clinicians).


1.            E. K. Sackmann, A. L. Fulton and D. J. Beebe, Nature, 2014, 507, 181-189.

2.            D. C. Duffy, J. C. McDonald, O. J. A. Schueller and G. M. Whitesides, Analytical Chemistry, 1998, 70, 4974-4984.

3.            E. Berthier, E. W. K. Young and D. Beebe, Lab on a Chip, 2012, 12, 1224-1237.

4.            M. A. Unger, H.-P. Chou, T. Thorsen, A. Scherer and S. R. Quake, Science, 2000, 288, 113-116.

5.            Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes, Gregory A. Cooksey and Javier Atencia, Lab on a Chip, 2-14, 14, 1665-1668

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Free access to HOT Articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Fluoropolymer surface coatings to control droplets in microfluidic devices
Carson T. Riche, Chuchu Zhang, Malancha Gupta and Noah Malmstadt  
Lab Chip, 2014,14, 1834-1841
DOI: 10.1039/C4LC00087K
Graphical abstract: Fluoropolymer surface coatings to control droplets in microfluidic devices
Microfluidic generation of chitosan/CpG oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties
Song Chen, Huijie Zhang, Xuetao Shi, Hongkai Wu and Nobutaka Hanagata  
Lab Chip, 2014,14, 1842-1849
DOI: 10.1039/C4LC00015C

Graphical abstract: Microfluidic generation of chitosan/CpG oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties
Magnetically controllable 3D microtissues based on magnetic microcryogels
Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00081A

Graphical abstract: Magnetically controllable 3D microtissues based on magnetic microcryogels

Straightforward 3D hydrodynamic focusing in femtosecond laser fabricated microfluidic channels
Petra Paiè, Francesca Bragheri, Rebeca Martinez Vazquez and Roberto Osellame  
Lab Chip, 2014,14, 1826-1833
DOI: 10.1039/C4LC00133H

Graphical abstract: Straightforward 3D hydrodynamic focusing in femtosecond laser fabricated microfluidic channels

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations
Meltem Elitas, Rodrigo Martinez-Duarte, Neeraj Dhar, John D. McKinney and Philippe Renaud  
Lab Chip, 2014,14, 1850-1857
DOI: 10.1039/C4LC00109E

Graphical abstract: Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Simple, low cost MHz-order acoustomicrofluidics using aluminium foil electrodes
Amgad R. Rezk, James R. Friend and Leslie Y. Yeo  
Lab Chip, 2014,14, 1802-1805
DOI: 10.1039/C4LC00182F

Graphical abstract: Simple, low cost MHz-order acoustomicrofluidics using aluminium foil electrodes

Elevating sampling Joseph M. Labuz and Shuichi Takayama  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00125G

Graphical abstract: Elevating sampling
 
Microfluidic investigation of the deposition of asphaltenes in porous media
Chuntian Hu, James E. Morris and Ryan L. Hartman  
Lab Chip, 2014,14, 2014-2022
DOI: 10.1039/C4LC00192C

Graphical abstract: Microfluidic investigation of the deposition of asphaltenes in porous media

Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles
D. J. Paterson, J. Reboud, R. Wilson, M. Tassieri and J. M. Cooper  
Lab Chip, 2014,14, 1806-1810
DOI: 10.1039/C4LC00199K

Graphical abstract: Integrating microfluidic generation, handling and analysis of biomimetic giant unilamellar vesicles
 Microfluidics for single-cell genetic analysis
A. M. Thompson, A. L. Paguirigan, J. E. Kreutz, J. P. Radich and D. T. Chiu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00175C

Graphical abstract: Microfluidics for single-cell genetic analysis

A simple strategy for in situ fabrication of a smart hydrogel microvalve within microchannels for thermostatic control
Shuo Lin, Wei Wang, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00039K

Graphical abstract: A simple strategy for in situ fabrication of a smart hydrogel microvalve within microchannels for thermostatic control

Caterpillar locomotion-inspired valveless pneumatic micropump using a single teardrop-shaped elastomeric membrane
Hongyun So, Albert P. Pisano and Young Ho Seo  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51298C

Graphical abstract: Caterpillar locomotion-inspired valveless pneumatic micropump using a single teardrop-shaped elastomeric membrane

Microfluidic chip for plasma separation from undiluted human whole blood samples using low voltage contactless dielectrophoresis and capillary force
Chia-Chern Chen, Po-Hsiu Lin and Chen-Kuei Chung  
Lab Chip, 2014,14, 1996-2001
DOI: 10.1039/C4LC00196F

Graphical abstract: Microfluidic chip for plasma separation from undiluted human whole blood samples using low voltage contactless dielectrophoresis and capillary force

Influenza A virus-specific aptamers screened by using an integrated microfluidic system
Hsien-Chih Lai, Chih-Hung Wang, Tong-Miin Liou and Gwo-Bin Lee  
Lab Chip, 2014,14, 2002-2013
DOI: 10.1039/C4LC00187G

Graphical abstract: Influenza A virus-specific aptamers screened by using an integrated microfluidic system

Energy: the microfluidic frontier
David Sinton  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00267A

Graphical abstract: Energy: the microfluidic frontier

Patent protection and licensing in microfluidics
Ali K. Yetisen and Lisa R. Volpatti  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00399C

Graphical abstract: Patent protection and licensing in microfluidics

*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes
Gregory A. Cooksey and Javier Atencia  
Lab Chip, 2014,14, 1665-1668
DOI: 10.1039/C4LC00173G, Technical Innovation

Graphical abstract: Pneumatic valves in folded 2D and 3D fluidic devices made from plastic films and tapes
Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication
Timothy Kwa, Qing Zhou, Yandong Gao, Ali Rahimian, Lydia Kwon, Ying Liu and Alexander Revzin  
Lab Chip, 2014,14, 1695-1704
DOI: 10.1039/C4LC00037D, Paper

Graphical abstract: Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication
Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics
David Erickson, Dakota O’Dell, Li Jiang, Vlad Oncescu, Abdurrahman Gumus, Seoho Lee, Matthew Mancuso and Saurabh Mehta  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00142G, Frontier

Graphical abstract: Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics
*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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Free access to HOT articles

These HOT articles were recommended by our referees and are free to access for 4 weeks*

Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections
Liesbet Van Heirstraeten, Peter Spang, Carmen Schwind, Klaus S. Drese, Marion Ritzi-Lehnert, Benjamin Nieto, Marta Camps, Bryan Landgraf, Francesc Guasch, Antoni Homs Corbera, Josep Samitier, Herman Goossens, Surbhi Malhotra-Kumar and Tina Roeser  
Lab Chip, 2014,14, 1519-1526
DOI: 10.1039/C3LC51339D, Paper

Graphical abstract: Integrated DNA and RNA extraction and purification on an automated microfluidic cassette from bacterial and viral pathogens causing community-acquired lower respiratory tract infections

Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing
J.-P. Frimat, M. Bronkhorst, B. de Wagenaar, J. G. Bomer, F. van der Heijden, A. van den Berg and L. I. Segerink  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00050A, Paper

Graphical abstract: Make it spin: individual trapping of sperm for analysis and recovery using micro-contact printing

Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips
Laura Restrepo-Pérez, Lluís Soler, Cynthia S. Martínez-Cisneros, Samuel Sánchez and Oliver G. Schmidt  
Lab Chip, 2014,14, 1515-1518
DOI: 10.1039/C3LC51419F, Communication

Graphical abstract: Trapping self-propelled micromotors with microfabricated chevron and heart-shaped chips

*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, easy and more importantly – free – to register!

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Four new articles join the LOC Top 10%

Lab on a Chip publishes novel and high impact research focusing on miniaturisation both on- and off-chip.

From amongst all of our papers, those that score particularly well during peer review are added to our HOT article list.

From amongst these HOT articles, our Editor chooses the Lab on a Chip Top 10%. These papers demonstrate a breakthrough in device technology or methodology, or demonstrate important new results for chemistry, physics, biology or bioengineering enabled by miniaturisation. These are the papers to keep an eye on – we’ve just added four more to the list…

Focus Article: The regulation of mobile medical applications, by A. K. Yetisen and collegues. DOI: 10.1039/C3LC51235E


Research Paper: Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices, by A. Folch and colleagues. DOI: 10.1039/C3LC51360B


Critical Review: Recent advancements in optofluidics-based single-cell analysis: optical o-chip cellular manipulation, treatment, and property detection, by K. Kurabayashi and colleagues. DOI: 10.1039/C3LC51211H


Technical Innovation: Micro-patterning of mammalian cells on suspended MEMS resonant sensors for long-term growth measurements, by R. Bashir and colleagues. DOI: 10.1039/C3LC51217G


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