Lab on a Chip Issue 5 is online! Towards point-of-care biosensors, an RNAi screening method and a review of microfluidics for liposome production

The front cover of Issue 5 illustrates work from Peter Ertl and colleagues at AIT, Austria, in which they combine organic photodiodes and electrode structures in a lab on a chip to develop the ability to quickly determine cell number to standardise microfluidic cell culture and simultaneously measure cell adhesion and interactions.

Standardization of microfluidic cell cultures using integrated organic photodiodes and electrode arrays
Verena Charwat, Michaela Purtscher, Sandro F. Tedde, Oliver Hayden and Peter Ertl
DOI: 10.1039/C2LC40965H

Research by scientists at the National Research Council and McGill University, Canada, features on the striking inside front cover. Teodor Veres and co-workers take a step towards the development of point-of-care nanoplasmonic biosensors with their all-polymeric transmission surface plasmon resonance sensor. It uses a simple and widely available technique and they demonstrate its application in sensing glycoprotein sCD44 at picomolar to nanomolar concentrations.

All-thermoplastic nanoplasmonic microfluidic device for transmission SPR biosensing
Lidija Malic, Keith Morton, Liviu Clime and Teodor Veres
DOI: 10.1039/C2LC41123G

The back cover advert highlights research from the groups of Anup Singh and Oscar Negrete at Sandia National Laboratories, USA, on their advantageous microfluidic RNA interference screening method, which they validate using vesicular stomatitis virus and Rift Valley fever virus.

Microfluidic platforms for RNA interference screening of virus–host interactions
Benjamin R. Schudel, Brooke Harmon, Vinay V. Abhyankar, Benjamin W. Pruitt, Oscar A. Negrete and Anup K. Singh
DOI: 10.1039/C2LC41165B

This issue also features Research highlights from Ali Khademhosseini on biomimetic honeycombs, microfluidic vessel chips and BioMEMS, and a critical review written by Andrew deMello and Dirk van Swaay at ETH Zurich on the microfluidic technologies available for producing liposomes:

Research highlights
Gulden Camci-Unal, Šeila Selimović, Mehmet R. Dokmeci and Ali Khademhosseini
DOI: 10.1039/C3LC90002A

Microfluidic methods for forming liposomes
Dirk van Swaay and Andrew deMello
DOI: 10.1039/C2LC41121K


Find the issue in full here

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