The latest issue of Food & Function is now available online.
The front cover of this issue features work by Tony McGhie and colleagues from The New Zealand Institute for Plant & Food Research, and Nutrigenomics, New Zealand. The authors report the combined use of analytical-scale HPLC with a high sensitivity time-resolved fluorescence coupled with fluorescence resonance energy transfer (TR-FRET) to detect the JAK2 inhibitory activity of Boysenberry drink. The authors found that of the 84 fractions obtained from the Boysenberry drink, ellagitannin and ellagic acid fractors inhibited JAK2 activity. Interestingly, whilst anthocyanins made up the majority of the phytochemical components of the drink and have previously been shown to have anti-inflammatory activity, they did not demonstrate any JAK2 activity.
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The combination of analytical-scale HPLC separation with a TR-FRET assay to investigate JAK2 inhibitory compounds in a Boysenberry drink, Tony K. McGhie, Harry Martin and Rona C. M. Lunken, Food Funct., 2012, 14, 1170-1175
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