HOT Article: Role of Zn and Mn in Parkinson’s Disease

Model of the YPK9 proteinIn this HOT article, Zoroddu and coworkers present NMR (mono- and bi-dimensional) and EPR analysis of Zn and Mn complexation to small fragments of the Park9 gene  (a member of the P5-type ATPase family) important in Parkinson’s disease (PD).   This type of study may provide an insight into the understanding of the connection between genetic and environmental PD causes.  The group are planning further investigations, involving the role of the entire protein.

Read more for FREE until 16th April 2012 at:

Mn(II) and Zn(II) interactions with peptide fragments from Parkinson’s disease genes
Serenella Medici,  Massimiliano Peana,  Lucia Gemma Delogu and Maria Antonietta Zoroddu
Dalton Trans., 2012, 41, 4378-4388
DOI: 10.1039/C2DT12168A

The following critical review may also be of interest:

The potential application of iron chelators for the treatment of neurodegenerative diseases
Robert C. Hider,  Sourav Roy,  Yong Min Ma,  Xiao Le Kong and Jane Preston
Metallomics, 2011, 3, 239-249
DOI: 10.1039/C0MT00087F

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