Hot Paper: Schiff base-cobalt(II) coordination polymer with anti-cancer activity

The ligand, 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone, is coordinated through the ONO donor atoms to one   Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center to form a 1D polymeric unit.

The ligand, 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone, is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center to form a 1D polymeric unit.

Karuppannan Natarajan and colleagues have synthesised and characterised the Co(II) complex, {[Co(H2L)(H2O)2](NO3)2·3H2O}n.  Human cancer cytotoxicity studies have shown the complex is very specific for cancer cells and less toxic in comparison to the well-know cancer drug, cisplatin.

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A novel water soluble ligand bridged cobalt(II) coordination polymer of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone: evaluation of the DNA binding, protein interaction, radical scavenging and anticancer activity
Duraisamy Senthil Raja,  Nattamai S. P. Bhuvanesh and Karuppannan Natarajan
Dalton Trans., 2012
DOI: 10.1039/C2DT12274J

Take a look at some of the other papers published recently in Dalton Transactions on Schiff base complexes of transition metal ions…

Structural and luminescence studies of nickel(II) and copper(II) complexes with (1R,2R)-cyclohexanediamine derived unsymmetric Schiff base
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Dalton Trans., 2011, 40, 11012-11022
DOI: 10.1039/C1DT10882D

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Dalton Trans., 2012, 41, 2515-2524
DOI: 10.1039/C1DT11566A

Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity
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Dalton Trans., 2012
DOI: 10.1039/C2DT12387H

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