Author Archive

A trio of HOT Articles from Analyst

Three HOT articles from Analyst covering sampling bias, copper sensing and PDMS functionalisation for a photnoic lab-on-a-chip device.  All articles are free to read until 8th April.

Michael H. Ramsey and co-workers from Sussex and London describe a new method for estimating the uncertainty of analytical measurements caused by bias in sampling.

Improved evaluation of measurement uncertainty from sampling by inclusion of between-sampler bias using sampling proficiency testing
Michael H. Ramsey, Bastiaan Geelhoed, Roger Wood and Andrew P. Damant
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00705F

Improved evaluation of measurement uncertainty from sampling by inclusion of between-sampler bias using sampling proficiency testing
Development of ultra-high sensitive and selective electrochemiluminescent sensor for copper(II) ions: a novel strategy for modification of gold electrode using click chemistry Based on the Cu(I)-catalyzed alkyne–azide cycloaddition reaction, a novel ultra-high sensitive and selective ECL sensor for Cu(II) was developed and is reported in this paper from Guonan Chen and co-workers from Fuzhou University in China.

Development of ultra-high sensitive and selective electrochemiluminescent sensor for copper(II) ions: a novel strategy for modification of gold electrode using click chemistry
Suyan Qiu, Sen Gao, Xi Zhu, Zhenyu Lin, Bin Qiu and Guonan Chen
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00846J

César Fernández-Sánchez and co-workers from Spain and Germany report on a comparative study of different approaches for the selective immobilisation of biomolecules on the surface of poly(dimethylsiloxane) (PDMS). The motivation of this work is to set a robust and reliable protocol for the easy implementation of a biosensor device in a PDMS-based photonic lab-on-a-chip (PhLoC).

Selective functionalisation of PDMS-based photonic lab on a chip for biosensing
Bergoi Ibarlucea, César Fernández-Sánchez, Stefanie Demming, Stephanus Büttgenbach and Andreu Llobera
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00941E

Selective functionalisation of PDMS-based photonic lab on a chip for biosensing
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Miniature and portable cylindrical ion trap mass spectrometer

In this HOT communication, Zongxiu Nie and his team from China and Taiwan report the development of a miniature cylindrical ion trap mass spectrometer (CIT-MS) equipped with laser-induced acoustic ionization and a charge detector.  They describe its use in the measurement of the total dry mass of red blood cells after calibration with standard polystyrene beads.

Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum

The novel miniature CIT-MS has, compared with a previous lab scale quadrupole ion trap mass spectrometer (QIT-MS), smaller volume, simpler ion trap fabrication and overall instrument construction, requires a lower trapping voltage and has reduced weight, power and cost. The new miniaturized instrument has potential for applications in field-portable, biological and aerosol analysis.

Interested in knowing more? Read for free until April 4th.

Characterization of bioparticles using a miniature cylindrical ion trap mass spectrometer operated at rough vacuum
Zhiqiang Zhu, Caiqiao Xiong, Gaoping Xu, Hao Liu, Xiaoyu Zhou, Rui Chen, Wen-Ping Peng and Zongxiu Nie
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00911C

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Pesticide detection using a combined colorimetric and fluorescent probe

Dual-signal fenamithion probe by combining fluorescence with colorimetry based on Rhodamine B modified silver nanoparticlesThis study describes the development of an effective detection probe for the visualisation of organophosphorous pesticides based on the rare combination of both colorimetric and fluorescent output.

Haibing Li and co-workers at the Central China Normal University developed a versatile yet simple strategy for the fabrication of a highly selective and sensitive fenamithion probe based on Rhodamine B modified silver nanoparticles. They propose and prove a novel amino-containing analyte-induced etching mechanism to explain their results. This system allows prompt on-site and real-time detection of the pesticide, fenamithion, in real vegetable and water samples, with high sensitivity and excellent anti-disturbance ability.

Interested in knowing more? Read the article for free until March 1st.

Dual-signal fenamithion probe by combining fluorescence with colorimetry based on Rhodamine B modified silver nanoparticles
Zhimin Cui, Cuiping Han and Haibing Li
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00617C

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2nd International Congress on Analytical Proteomics

The 2nd International Congress on Analytical Proteomics will take place in Ournse, Spain from the 18th -20th July 2011.  This is one of the major proteomics events of 2011 in Europe.

The aims of this congress are to join the proteomics and analytical communities into a common objective: to develop robust, reproducible and reliable sample treatments that can be used in all branches of the Proteomics area with the confidence given by the driven motors of proteomics; those who need the analytical-based proteomics tools and those who develop analytical tools.

The 1st International Congress on Analytical Proteomics, which was held in Portugal in 2009, had an excellent acceptance among the scientific community.

ICAP Congress 2011 FlyerConfirmed plenary speakers

Prof. Alfred L. Yergey (National Institutes of Health)
Approaches to Optimize Use of Mass Spectrometric Data for Proteomics

Prof. Concha Gil (Complutense University)
Candida Albicans-Host interaction: Insights From Proteomics

Prof. R. John Solaro (Univ Illinois at Chicago College of Medicine.)
Workflow and Significance of Understanding the Cardiac Sarcomere Sub-Proteome

Prof. Juan J. Calvete (Instituto de Biomedicina de Valencia)
Snake venom proteomics to help fighting a neglected pathology

Prof. Juan Pablo Albar (Spanish Institute for Proteomics)

Prof. Wei Ning Chen (Nanyang Technological University)
Cell-based proteomics platform for biomedical applications

Prof. Ola Söderberg (Uppsala University)
Proximity Ligation Assays-Seeing is believing

Registration, Dates and Further Information

Please see the conference website for further information and details of how to register.

Early bird registration deadline: March 1st 2011

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HOT Article: Investigating the chemiluminescence of ruthenium complexes

Simultaneous control of spectroscopic and electrochemical properties in functionalised electrochemiluminescent tris(2,2′-bipyridine)ruthenium(II) complexesChemiluminescence has been extensively used for analytical purposes but very limited research has been devoted to the theoretical basics of the technique. In this study by Paul S. Francis and co-workers in Australia, a combination of electrochemical, spectroscopic and computational techniques are used to explore the properties of ruthenium complexes designed for coupling with other molecules or surfaces for electrochemiluminescence applications. 

Interested in knowing more?  Read for free here until 21st March!

Simultaneous control of spectroscopic and electrochemical properties in functionalised electrochemiluminescent tris(2,2-bipyridine)ruthenium(II) complexes
Gregory J. Barbante, Conor F. Hogan, David J. D. Wilson, Naomi A. Lewcenko, Frederick M. Pfeffer, Neil W. Barnett and Paul S. Francis
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00952K

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HOT Article: Reduced sample requirement and sensitivity loss in FI-CE

A novel cross-H-channel interface for flow injection-capillary electrophoresis to reduce sample requirement and improve sensitivity

In this study, Xing-guo Chen and co-workers in Lanzhou, China, established a new flow injection–capillary electrophoresis (FI–CE) system in which a cross-H-channel interface was constructed for coupling FI with CE. Compared with typical FI–CE, the advantages of this new technique include lower sample solution requirement, shorter analysis time, and higher sensitivity.

Interested in knowing more?  Read the full text here; free until 18th March!

A novel cross-H-channel interface for flow injection-capillary electrophoresis to reduce sample requirement and improve sensitivity
Hua-dong Zhu, Wenjuan Lü, Hong-hong Li, Yan-hua Ma, Shao-qiang Hu, Hong-li Chen and Xing-guo Chen
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00592D

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HOT Article: Using FTIR to diagnose cervical cancer

Correlation of p16INK4A expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells In this HOT Article a team from Dublin present an impressive study that links imunohistochemistry and fluorescence with FTIR to demonstrate the effectiveness of spectroscopic techniques in the diagnosis of cervical cancer.

Fluorescence microscopy and flow cytometry are used to deomonstrate that expression levels of the biomarker protein p16INK4A in cervical cancer cell lines correlates with HPV invection levels.  This confirms p16INK4A as a potential diagnostic marker of cervical cancer. FTIR imaging is then used to identify the specific spectral features of nuclear and cytoplasmic regions of the cervical cancer cells.  By correlating all the findings it was possible to construct a model which can predict the p16INK4A expression level based on a spectral fingerprint of a cell line, demonstrating the diagnostic potential of spectroscopic techniques.

Interested in knowing more?  Read the article here, free until March 11th.

Correlation of p16INK4A expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells
Kamila M. Ostrowska, Amaya Garcia, Aidan D. Meade, Alison Malkin, Ifeoluwapo Okewumi, John J. O’Leary, Cara Martin, Hugh J. Byrne and Fiona M. Lyng
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00910E

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Workshop: Surface chemistry and the non-specific binding problem in biosensor technology

Surface chemistry and the non-specific binding problem in biosensor technology

A one day workshop sponsored by the Applied Materials Group of the Royal Society of Chemistry

May 9th, 2011 (9.00 AM – 5.30 PM)
Burlington House, Royal Society of Chemistry, London, UK

The purpose of this symposium is to discuss surface coatings that can be used to address the issue of non-specific binding in biosensors. The symposium will be of interest to both academics and industrialists. While a number of international conferences are dedicated to biosensors, non-specific binding is only dealt with in an ad hoc manner. Considering that this phenomenon will ultimately dictate whether a biosensor can be commercialized or not, it is clear that this symposium dedicated to the subject is both timely and warranted. The symposium will be of interest to any researcher working in the fields of drug discovery, clinical diagnostics and environmental analysis, including homeland security and defence sectors.

Scheduled speakers:
M. Thompson and Christophe Blaszykowski, University of Toronto
Lisa Hall, University of Cambridge
H. Schnerr, TTP LabTech Ltd, Melbourn
J-F. Masson, University of Montreal
S. Reddy, University of Surrey
S. Brewer, DSTL, Porton Down

Registration fee:
75 pounds for academic delegates
100 pounds for industry delegates
Fee includes a lunch and all proceedings
Please contact Ms Wendy King (DSTL, UK) for registration form and payment

Please refer to the RSC Events pages for details on how to register and contact the organisers.

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