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2018 Reaction Chemistry & Engineering Hot Articles

04 Dec 2019

This collection of articles highlights the hottest articles published in Reaction Chemistry & Engineering in 2018, as selected by the editors. Congratulations to all the authors whose outstanding articles are featured, and we hope you enjoy reading them.

Integrated plug flow synthesis and crystallisation of pyrazinamide
C. Daniel Scott, Ricardo Labes, Martin Depardieu, Claudio Battilocchio, Matthew G. Davidson, Steven V. Ley, Chick C. Wilson and Karen Robertson
React. Chem. Eng., 2018, 3, 631-634
DOI:10.1039/C8RE00087E

Batch–flow hybrid synthesis of the antipsychotic clozapine
N. C. Neyt and D. L. Riley
React. Chem. Eng., 2018, 3, 17-24
DOI:10.1039/C7RE00146K

A hierarchical approach to chemical reactor engineering: an application to micro packed bed reactors
Stefano Rebughini, Mauro Bracconi, Anthony G. Dixon and Matteo Maestri
React. Chem. Eng., 2018, 3, 25-33
DOI:10.1039/C7RE00195A

OpenFlowChem – a platform for quick, robust and flexible automation and self-optimisation of flow chemistry
Nikolay Cherkasov, Yang Bai, Antonio José Expósito and Evgeny V. Rebrov
React. Chem. Eng., 2018, 3, 769-780
DOI:10.1039/C8RE00046H

Metal-based heterogeneous electrocatalysts for reduction of carbon dioxide and nitrogen: mechanisms, recent advances and perspective
Jun-Hao Zhou and Ya-Wen Zhang
React. Chem. Eng., 2018, 3, 591-625
DOI:10.1039/C8RE00111A

Efficient kinetic experiments in continuous flow microreactors
Kosi C. Aroh and Klavs F. Jensen
React. Chem. Eng., 2018, 3, 94-101
DOI:10.1039/C7RE00163K

Laser irradiated vortex fluidic mediated synthesis of luminescent carbon nanodots under continuous flow
Xuan Luo, Ahmed Hussein Mohammed Al-Antaki, Kasturi Vimalanathan, Jillian Moffatt, Kun Zheng, Yichao Zou, Jin Zou, Xiaofei Duan, Robert N. Lamb, Shujun Wang, Qin Li, Wei Zhang and Colin L. Raston
React. Chem. Eng., 2018, 3, 164-170
DOI:10.1039/C7RE00197E

Optimum catalyst selection over continuous and discrete process variables with a single droplet microfluidic reaction platform
Lorenz M. Baumgartner, Connor W. Coley, Brandon J. Reizman, Kevin W. Gao and Klavs F. Jensen
React. Chem. Eng., 2018, 3, 301-311
DOI:10.1039/C8RE00032H

Optimization of the high-throughput synthesis of multiblock copolymer nanoparticles in aqueous media via polymerization-induced self-assembly
Amy A. Cockram, Robert D. Bradley, Sylvie A. Lynch, Patricia C. D. Fleming, Neal S. J. Williams, Martin W. Murray, Simon N. Emmett and Steven P. Armes
React. Chem. Eng., 2018, 3, 645-657
DOI:10.1039/C8RE00066B

Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides
J. Döbber, M. Pohl, S. V. Ley and B. Musio
React. Chem. Eng., 2018, 3, 8-12
DOI:10.1039/C7RE00173H

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‘Robo-chemist’ optimises reactions in one day

28 Oct 2016

Reaction Chemistry & Engineering Chair Klavs Jensen and colleague Steve Buchwald have developed an intelligent automated reactor that drastically cuts the time it takes to optimise cross-coupling reactions.

Their automated flow reactor that can respond to the results of experiments and determine the optimum conditions for catalytic reactions within a single day.

suzuki miyaura optimisation

RCE Advisory Board member Ryan Hartman highly praises the research as a ‘vital contribution that advances both synthetic chemistry and chemical engineering’ in Chemistry World.

Check out the full story by Jamie Durrani here.

This article is open access

B J Reizman et al, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00153J

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Batch and flow: united at last

17 Oct 2016

Batch and flow chemistry can finally be carried out together on the same system!

Reaction Chemistry & Engineering Editorial Board member Steve Ley and colleague Daniel Fitzpatrick at the University of Cambridge have developed an automated reactor that can carry out both batch and flow processes, allowing for greater automation of multi-step synthesis.

Read the full story in Chemistry World.

This article is free to access until 25 November 2016

D E Fitzpatrick and S V Ley, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00160B

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Flow chemistry for on-demand chlorine

25 Aug 2016

No one wants to stock cylinders of toxic and corrosive chlorine in the lab. Now, researchers working with the gas can generate small amounts when and where they need it.

Read the full story by Abigail Hallowes in Chemistry World.

This article is free to access until 05 October 2016

F J Strauss et al, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00135A

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A colour is worth a thousand spectra

08 Aug 2016

Scientists from Germany have developed a quick and low-cost screening method for photocatalytic reactions based on a simple change of colour.

In a recent study in Reaction Chemistry & Engineering, Burkhard König and a colleague from the University of Regensburg have developed a simple colorimetric method to analyse the outcome of photocatalytic reactions. An organic dye changes colour if a reaction works and can even indicate how much of the starting materials has been consumed.

Read the full story by Michaela Mühlberg in Chemistry World.

This article is free to access until 19 September 2016:

Michal Poznik and Burkhard Konig, React. Chem. Eng, 2016, DOI: 10.1039/C6RE00117C

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Top 10 most-downloaded articles: Q2 April–June 2016

06 Jul 2016

Take a look at the most-downloaded Reaction Chemistry & Engineering articles from the months of April, May and June 2016 and let us know what you think!

Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate
Polina Yaseneva, Paul Hodgson, Jacek Zakrzewski, Sebastian Falß, Rebecca E. Meadows and Alexei A. Lapkin
React. Chem. Eng., 2016,1, 229-238
DOI: 10.1039/C5RE00048C

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
Jian-Siang Poh, Duncan L. Browne and Steven V. Ley
React. Chem. Eng., 2016,1, 101-105
DOI: 10.1039/C5RE00082C

Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems
D. C. Fabry, E. Sugiono and M. Rueping
React. Chem. Eng., 2016,1, 129-133
DOI: 10.1039/C5RE00038F

Environmental and economic assessment of glycerol oxidation to dihydroxyacetone over technical iron zeolite catalysts
Giacomo M. Lari, Cecilia Mondelli, Stavros Papadokonstantakis, Merten Morales, Konrad Hungerbühler and Javier Pérez-Ramírez
React. Chem. Eng., 2016,1, 106-118
DOI: 10.1039/C5RE00090D

Low-cost instant CO generation at room temperature using formic acid, mesyl chloride and triethylamine
Cedrick Veryser, Seger Van Mileghem, Brecht Egle, Philippe Gilles and Wim M. De Borggraeve
React. Chem. Eng., 2016,1, 142-146
DOI: 10.1039/C6RE00006A

Kinetics of nanocrystal synthesis in a microfluidic reactor: theory and experiment
Richard M. Maceiczyk, Leonard Bezinge and Andrew J. deMello
React. Chem. Eng., 2016,1, 261-271
DOI: 10.1039/C6RE00073H

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
Nicholas Holmes, Geoffrey R. Akien, Robert J. D. Savage, Christian Stanetty, Ian R. Baxendale, A. John Blacker, Brian A. Taylor, Robert L. Woodward, Rebecca E. Meadows and Richard A. Bourne
React. Chem. Eng., 2016,1, 96-100
DOI: 10.1039/C5RE00083A

Progress in reactor engineering of controlled radical polymerization: a comprehensive review
Xiaohui Li, Erlita Mastan, Wen-Jun Wang, Bo-Geng Li and Shiping Zhu
React. Chem. Eng., 2016,1, 23-59
DOI: 10.1039/C5RE00044K

A convenient numbering-up strategy for the scale-up of gas–liquid photoredox catalysis in flow
Yuanhai Su, Koen Kuijpers, Volker Hessel and Timothy Noël
React. Chem. Eng., 2016,1, 73-81
DOI: 10.1039/C5RE00021A

Simple efficient one-pot synthesis of 5-hydroxymethylfurfural and 2,5-diformylfuran from carbohydrates
Quentin Girka, Boris Estrine, Norbert Hoffmann, Jean Le Bras, Siniša Marinković and Jacques Muzart
React. Chem. Eng., 2016,1, 176-182
DOI: 10.1039/C5RE00004A

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Kinetics of Nanocrystal Synthesis in a Microfluidic Reactor

19 May 2016

New insight into nanocrystal nucleation and growth has emerged from researchers in Switzerland, giving vital knowledge and tools for large-scale quantum dot production.

Andrew DeMello and his team at ETH Zurich used a two-stage microfluidic reactor to precisely control the nucleation and growth stages of nanocrystal synthesis by automated control of reagent amounts, residence times and temperatures. This tight control combined with measurement of online spectroscopic data gave the scientists the ability to validate kinetic models of the synthesis – essential tools for chemical engineers to design processes for high quality, high volume quantum dot production.

Read the full paper here.

If you are unable to view journal content through automatic institutional access, register to gain free access to the first two volumes.

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Carbon monoxide where you want it, when you want it

24 Mar 2016

Synthetic chemists have invented two new room temperature methods for generating carbon monoxide from cheap precursors and using it straight away, so that deadly amounts of the gas never build up.

Carbon monoxide is toxic, flammable and disperses fast in air. It also happens to be one of the most useful C₁ building blocks for organic synthesis. Important industrial processes use bulk quantities. But concerns over safety, especially in cylinder storage and transportation, are hampering research. Carbon monoxide surrogates do exist, but involve costly components, high temperatures or harsh conditions.

To generate carbon monoxide at the point of use, Wim De Borggraeve and coworkers at KU Leuven, Belgium, have devised a triple system of cheap and common mesyl chloride, triethylamine and formic acid. Alternatively, collaborative work between the groups of Steven Ley at the University of Cambridge, UK, and Trond Ulven at the University of Southern Denmark, brings together chemistry developed in Denmark with flow chemistry technology from Cambridge.

Read the full story in Chemistry World.

Both articles are free to access:

Low-cost instant CO generation at room temperature using formic acid, mesyl chloride and triethylamine, Cedrick Veryser, Seger Van Mileghem, Brecht Egle, Philippe Gilles and Wim M. De Borggraeve, React. Chem. Eng., 2016, DOI: 10.1039/c6re00006a

Controlled generation and use of CO in flow, Steffen V. F. Hansen, Zoe E. Wilson, Trond Ulven and Steven V. Ley, React. Chem. Eng., 2016, DOI: 10.1039/c6re00020g

If you are unable to read Reaction Chemistry & Engineering content through automatic free institutional access, you can fill in this form to gain free individual access to the first two volumes.

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Reaction Chemistry & Engineering Blog

Archive for the ‘Hot articles’ Category

2018 Reaction Chemistry & Engineering Hot Articles

‘Robo-chemist’ optimises reactions in one day

Batch and flow: united at last

Flow chemistry for on-demand chlorine

A colour is worth a thousand spectra

Top 10 most-downloaded articles: Q2 April–June 2016

Kinetics of Nanocrystal Synthesis in a Microfluidic Reactor

Carbon monoxide where you want it, when you want it

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