Archive for October, 2016

‘Robo-chemist’ optimises reactions in one day

Reaction Chemistry & Engineering Chair Klavs Jensen and colleague Steve Buchwald have developed an intelligent automated reactor that drastically cuts the time it takes to optimise cross-coupling reactions.

Their automated flow reactor that can respond to the results of experiments and determine the optimum conditions for catalytic reactions within a single day.

suzuki miyaura optimisation

RCE Advisory Board member Ryan Hartman highly praises the research as a ‘vital contribution that advances both synthetic chemistry and chemical engineering’ in Chemistry World.

Check out the full story by Jamie Durrani here.


This article is open access

B J Reizman et al, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00153J

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Batch and flow: united at last

Batch and flow chemistry can finally be carried out together on the same system!

Reaction Chemistry & Engineering Editorial Board member Steve Ley and colleague Daniel Fitzpatrick at the University of Cambridge have developed an automated reactor that can carry out both batch and flow processes, allowing for greater automation of multi-step synthesis.

Read the full story in Chemistry World.

This article is free to access until 25 November 2016

D E Fitzpatrick and S V Ley, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00160B

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2016 AIChE Annual Meeting

The AIChE Annual Meeting is the premier educational forum for chemical engineers interested in innovation and professional growth. Academic and industry experts will cover a wide range of topics relevant to cutting-edge research, new technologies, and emerging growth areas in chemical engineering.

With the meeting fast-approaching, we are delighted to announce that Reaction Chemistry & Engineering will be running two sessions on Tuesday, 15 November:

Session 375: Reaction Chemistry and Engineering I
Chair: Klavs F. Jensen, Chair of Reaction Chemistry & Engineering

Session 434: Reaction Chemistry and Engineering II
Chair: Saif A. Khan, Scientific Editor for Reaction Chemistry & Engineering

These sessions will focus on the following topics:

  • Reaction mechanism and kinetics
  • Reaction analysis and monitoring
  • Catalytic reactions
  • Multiphase and new reactor technology

Check out the full Technical Program for the meeting and we look forward to seeing you in San Francisco!

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Top 10 Most-accessed Reaction Chemistry & Engineering articles – Q3 2016

This month sees the following articles in Reaction Chemistry & Engineering that are in the top ten most accessed from July – September 2016:

Why not take a look at the articles today and blog your thoughts and comments below.

Towards scalable and controlled synthesis of metal–organic framework materials using continuous flow reactors
Peter W. Dunne, Edward Lester and Richard I. Walton
React. Chem. Eng., 2016,1, 352-360
DOI: 10.1039/C6RE00107F

Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor
Nicholas Holmes, Geoffrey R. Akien, A. John Blacker, Robert L. Woodward, Rebecca E. Meadows and Richard A. Bourne
React. Chem. Eng., 2016,1, 366-371
DOI: 10.1039/C6RE00059B

Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate
Polina Yaseneva, Paul Hodgson, Jacek Zakrzewski, Sebastian Falß, Rebecca E. Meadows and Alexei A. Lapkin
React. Chem. Eng., 2016,1, 229-238
DOI: 10.1039/C5RE00048C

Monolith-based 68Ga processing: a new strategy for purification to facilitate direct radiolabelling methods
Ping He, Benjamin P. Burke, Gonçalo S. Clemente, Nathan Brown, Nicole Pamme and Stephen J. Archibald
React. Chem. Eng., 2016,1, 361-365
DOI: 10.1039/C6RE00081A

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
Jian-Siang Poh, Duncan L. Browne and Steven V. Ley
React. Chem. Eng., 2016,1, 101-105
DOI: 10.1039/C5RE00082C

Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow
Jason S. Moore, Christopher D. Smith and Klavs F. Jensen
React. Chem. Eng., 2016,1, 272-279
DOI: 10.1039/C6RE00007J

Controlled generation and use of CO in flow
Steffen V. F. Hansen, Zoe E. Wilson, Trond Ulven and Steven V. Ley
React. Chem. Eng., 2016,1, 280-287
DOI: 10.1039/C6RE00020G

Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation
Davide Albani, Gianvito Vilé, Mario Alejandro Beltran Toro, Rolf Kaufmann, Sharon Mitchell and Javier Pérez-Ramírez
React. Chem. Eng., 2016,1, 454-462
DOI: 10.1039/C6RE00114A

Hydrogenation of 2-methyl-3-butyn-2-ol over a Pd/ZnO catalyst: kinetic model and selectivity study
S. Vernuccio, R. Goy, Ph. Rudolf von Rohr, J. Medlock and W. Bonrath
React. Chem. Eng., 2016,1, 445-453
DOI: 10.1039/C6RE00093B

Hydrogenation of the liquid organic hydrogen carrier compound dibenzyltoluene – reaction pathway determination by 1H NMR spectroscopy
G. Do, P. Preuster, R. Aslam, A. Bösmann, K. Müller, W. Arlt and P. Wasserscheid
React. Chem. Eng., 2016,1, 313-320
DOI: 10.1039/C5RE00080G

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