Reaction Chemistry & Engineering Blog

Learnings from Developing a Multistage Flow API Process, a Chemists Perspective

22^nd June 2020 3pm

Biography of the speaker

Mark Hughes obtained his degree and D.Phil on Natural Product Total Synthesis from Oxford University.  After a brief spell as a Medicinal Chemist at Wyeth pharmaceuticals he joined Smith Kline and French as a Synthetic Chemist.  Mergers and site moves took him into process chemistry and reaction modelling and eventually continuous processing.

Synopsis
Flow chemistry offers a number of potential advantages for pharmaceutical synthesis:
• Enabling chemistry that is difficult to scale in batch.
• Improved process control leading to better reproducibility.
• Increased process velocity.

The webinar will present the “obvious in hindsight” challenges encountered in developing multistage continuous processes from the perspective of an organic chemist, whilst highlighting some of the benefits and engineering solutions! No assumptions of prior experience of continuous reactors will be made! This webinar will not directly address regulatory implications.

Registration for the webinar
Guests can register for the free webinar using the following link: https://attendee.gotowebinar.com/register/7096888368596983823

The Flow Chemistry Society‘s 6th biennial conference on Frontiers in Organic Synthesis Technology will take place from 18-20 October in Budapest, Hungary. The conference aims to stimulate the development of flow chemistry and its integration into everyday practice throughout the world for the benefit and progress of the chemistry community, including pharmaceutical, agro, fine-chemical, petro-chemical, fragrance industries, as well as in green chemistry and novel catalysis research.

The conference will also provide the opportunity for a young scientist, whose results are innovative and take place in an interesting segment of the field, to be gifted with a Poster Prize award, which is supported by Reaction Chemistry & Engineering and will be presented by RCE editorial board member Professor Steven Ley.

Main topics to be covered include:

• Perspectives in flow chemistry
• Safe production of hazardous chemicals in flow
• Flow chemistry in pharma industry
• Instruments for flow chemistry: microreactors
• Flow chemistry for drug discovery

Confirmed keynote speakers:

• C. Oliver Kappe (University of Graz, Austria)
• Steven V. Ley (University of Cambridge, UK)
• Timothy Noël (Eindhoven University of Technology, The Netherlands)

Deadline for poster abstracts: 31 August, 2017

End of early bird registration: 1 September, 2017

Visit the FROST 6 website to view the full agenda and further information.

Whether you are a chemist, chemical engineer, QA or safety specialist, your aims when scaling up your process are often the same:

• Achieving greater process efficiency, yield and throughput.
• Eliminating unsafe and non-green processes and materials.
• Decreasing the costs and number of steps involved.

Since the first conference in 1994, The Scale-Up of Chemical Processes has become the major international forum for the discussion of all these aspects of scale-up and more in the pharmaceutical, fine chemical and allied fields.

Key speakers presenting case studies and examples of some of the pitfalls and problems they encountered and how they overcame them. With unparalleled networking opportunities, this broad-based conference is the best place to learn about and discuss the latest novel ideas and techniques with the key people in the industry.

This year, the conference takes place in Rochester, NY from 21-23 June and includes speakers such as:

• Jim Bruno, (Chemical & Pharmaceutical Solutions, USA)
• Wim Dermaut, (Agfa Materials, Belgium)
• Emma McInturff, (Pfizer, USA)
• Vincent Ferey, (Sanofi, France)
• John W. Harder, (Kodak, USA)
• Sebastian Härtner, (EMD Performance Materials, Germany)

View the full programme here and visit their website to find out more and register for the event.

The RSC Special Chemicals Sector, in association with The Knowledge Transfer Network, is pleased to announce the 2017 International Symposium on Continuous Flow Chemistry for Industrial Processes, which will be held in conjunction with Chemspec Europe 2017.

This international symposium, held over two days at the Munich Trade Fair Centre, will highlight recent developments focused on the growth of continuous processes in the fine chemicals and pharmaceutical industries. The programme includes internationally acclaimed speakers, mostly from industry, and from companies making pioneering advances in the technology.

Confirmed speakers:

• Charlotte Wiles, (Chemtrix, The Netherlands)
• Andrea Adamo, (Zaiput Flow Technologies, USA)
• Chris Price, (University of Strathclyde, UK)
• Dirk Kirschneck, (Microinnova Engineering, Austria)
• Eric Beausoleil, (SiliCycle Inc, France)
• André de Vries, (Innosyn, The Netherlands)
• Sarah Hunter, (GSK, UK)
• Karim Engelmark Cassimjee, (EnginZyme, Sweden)
• Christian Hornung, (CSIRO, Australia)
• Zoel Codolà, (Medichem, Spain)

This event is free to attend – if you are interested in attending, please contact Pat Keen and visit the RSC Special Chemicals Sector webpage for more details.

The upcoming Faraday Discussion meeting on Bio-Resources: Feeding a Sustainable Chemical Industry will be held in London, UK on 19–21 June 2017.

This Faraday Discussion aims to address some of the critical issues in bio-resources, with themes on bio-based materials, bio-based chemicals, conversion technologies and feedstocks and analysis, by bringing together experts in different but complementary areas in the chemical sciences.

Faraday Discussions have a special format where research papers written by the speakers are distributed to all participants before the meeting, and most of the meeting is devoted to discussing the papers. Everyone contributes to the discussion – including presenting their own slide if it aids discussion. The discussion is recorded and will be published alongside the research papers in the Faraday Discussion Volume. Find out more about Faraday Discussions on the FAQs page.

Confirmed speakers:

• Bruce Dale (Michigan State University, USA)
• Andrzej Stankiewicz (Delft University of Technology, Netherlands)
• George Huber (University of Wisconsin-Madison, USA)
• Mark Mascal (University of California, Davis, USA)
• Avtar Matharu (University of York, UK)
• Xindong Mu (QIBEBT, China)
• Gadi Rothenberg (University of Amsterdam, Netherlands)
• Keith Waldron (Institute of Food Research, UK)
• Vania Zuin (Federal University of Sao Carlos, Brazil)

Poster submission deadline is 10 April – find out more about how to submit and register for the event here.

We are pleased to announce the 4^th Implementation of Microreactor Technology in Biotechnology conference, which will take place in Bled, Slovenia, from 23-26 April 2017.

The IMTB conference, which is a collaborative series between research groups from the University of Ljubljana, Slovenia, and the University of Zagreb, Croatia, aims to provide a platform for people from industry and academia, working in the cross-section of microfluidics, life sciences, analytics and bioprocess engineering.

Invited prominent speakers from leading research institutions and industry, together with participants of various backgrounds including chemical, mechanical and electrical engineering, medicine, pharmacy, chemistry, biochemistry, microbiology and biotechnology, will present their recent achievements in the fields of enzymatic microreactors, cells within microdevices, analytical microdevices and bioprocess intensification and integration within microdevices. Abstract submission prizes, as well as oral and poster prizes supported by Reaction Chemistry & Engineering, will also be presented.

Confirmed speakers include:

• Takehiko Kitamori, (University of Tokyo, Japan)
• Marko Mihovilovic, (Technical University Wien, Austria)
• Florian Hollfelder, (University of Cambridge, UK)
• Michal Přibyl, (University of Chemistry and Technology, Czech Republic)
• Jennifer Littlechild, (University of Exeter, UK)
• Jochen Büchs, (RWTH Aachen University, Germany)
• Manabu Tokeshi, (Hokkaido University, Japan)
• Brian Paul, (Oregon State University and Microproducts Breakthrough Institute, USA)

Visit the IMTB website now for more information on how to register and the full programme.

We are pleased to announce the McMaster University Chemical Engineering Conference (MUCEC), occurring this year on Tuesday 11 April at the McMaster Innovation Park (MIP), Hamilton, ON. The event will provide an opportunity for the university’s graduate students to present their research progress to their colleagues and the department faculty, as well as to attend a keynote presentation given by a distinguished alumnus of the department.

Students will also have the chance to compete for the A.E. Hamielec Award, a prestigious award honouring Dr. Archie Hamielec that represents the department’s commitment to academic communication, as well as departmental awards for the Graduate Student Poster Competition, supported by Reaction Chemistry & Engineering and Molecular Systems Design & Engineering.

Keynote speaker: Dr Laura Wells, (Queen’s University, Canada)

This event is free to attend for all McMaster Chemical Engineering graduate students. To find out more, visit the website here.

Reaction Chemistry & Engineering is proud to sponsor the Flow Chemistry Europe 2017 meeting, to be held by the Flow Chemistry Society at Magdalene College, University of Cambridge, UK, on 7–8 February 2017. Submit your poster abstract before 17 January 2017 for a chance to win a prize, courtesy of Reaction Chemistry & Engineering!

Conference Chairs:

• Volker Hessel (Eindhoven University of Technology, Reaction Chemistry & Engineering Editorial Board)
• Mimi Hii (Imperial College London, Reaction Chemistry & Engineering Advisory Board),

This meeting is dedicated to the integration of flow chemistry into everyday processes. By attending this industry-leading conference, you will benefit from the expert knowledge of academic and industry leaders who are pushing the boundaries of this rapidly evolving field. Agenda topics include:

• Back to Einstein – Electrification of chemistry – making use of the smallest units, photons and electrons
• Back to Health – Medicinal flow chemistry in the era of the FDA’s door opening towards emerging technologies
• Back to Nature – End-to-end continuous-flow production

Keynote Speaker

• Timothy Noel (Eindhoven University of Technology), presenting “A Conceptually New Photomicroreactor Design for Energy-efficient Solar Photochemistry“

Confirmed speakers include:

• Andrea Adamo (Zaiput Flow Technologies)
• Claudio Battilocchio (University of Cambridge)
• Richard Bourne (University of Leeds, Reaction Chemistry & Engineering Advisory Board)
• Doris Dallinger (University of Graz)
• Stevan Djuric (AbbVie)
• Amanda Evans (California State University Fullerton)
• Alain Favre-Reguillon (University of Lyon)
• Daniel Fitzpatrick (University of Cambridge)
• Antimo Gioiello (University of Perugia)
• Robert Green (University of Southampton)
• Heidrun Gruber-Woelfler (Graz University of Technology)
• Thomas Junkers (Hasselt University)
• Anita Maguire (University College Cork)
• Kevin Milburn (University of Bristol)
• Polona Znidarsic Plazl (University of Ljubljana)
• Igor Plazl (University of Ljubljana)
• Dominique Roberge (Lonza Group)
• Floris Rutjes (Radboud University Nijmegen)
• Guy Samburski (TEVA)
• Siegfried Waldvogel (Johannes Gutenburg-University Mainz, Reaction Chemistry & Engineering Advisory Board)
• Thomas Wirth (Cardiff University)

Early bird discounts are available until 10 January 2017 and the deadline for poster submission is 17 January 2017.

We are pleased to announce Organic Process Research& Development – The 37th International Conference and Exhibition, to be held on 6–8 March 2017 at the Westin Pasadena, Pasadena, USA.

On the agenda are discussions of the latest issues relating to synthetic route design, development and optimisation in the parmaceutical, fine chemical and related fields.

Keynote Speaker: Professor Robert Grubbs (CalTech, USA)

Confirmed speakers include:

• Jean Guy Boiteau (Galderma R&D, France)
• Peter Hermsen (DSM Chemical Technology R&D, The Netherlands)
• Scott Hecker (Rempex Pharmaceuticals, USA)
• Clemens Steuckler (Patheon Austria GmbH & Co KG, Austria)
• Ben Littler (Vertex Pharmaceuticals, USA)
• Jade Osei-Tutu (Johnson Matthey Plc, UK)
• David Rozzell (Provivi, Inc., USA)
• Scott Savage (Genentech, Inc., USA)
• Chris Senanayake (Boehringer Ingelheim Pharmaceuticals, Inc., USA)
• John Studley (Vertex Pharmaceuticals (Europe) Ltd, UK)
• Rajappa Vaidyanathan (Bristol-Myers Squibb, India)
• Phillip Wheeler (Materia Inc., USA)

Early bird discount is available if you register before 31 December 2016.

We are delighted to announce that 25th International Symposium: Synthesis in Organic Chemistry will be held in Oxford on 17 – 20 July 2017 – be sure to secure your place today!

Plenary speakers:

• Michael Krishe, University of Texas at Austin, USA
• Varinder Agaarwal, University of Bristol, UK

For the full list and details of speakers and conference themes, please visit the event web page.