Welcome to Issue 7 of Organic Chemistry Frontiers in 2015

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The latest OrgChemFront issue is published online now.

The cover story, Cu-catalyzed aerobic oxidative amidation of aryl alkyl ketones with azoles to afford tertiary amides via selective C–C bond cleavage is contributed by Wen Ding and Qiuling Song.

The inside front cover this issue features an article on Catalysis by electrons and holes: formal potential scales and preparative organic electrochemistry by Oana R. Luca, Jeffrey L. Gustafson, Sean M. Maddox, Aidan Q. Fenwick and Daryl C. Smith.

Following review article is also included in the current issue:

Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis
Zhong-Yan Cao and Jian Zhou
Org. Chem. Front., 2015, 2, 849-858
DOI: 10.1039/C5QO00092K


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Recent Hot OrgChemFront Articles Part 1

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Take best advantage of the free access to Organic Chemistry Frontiers, and read rencent HOT articles!


Difluoromethyl 2-pyridyl sulfone: a versatile carbonyl gem-difluoroolefination reagent
Bing Gao, Yanchuan Zhao, Jingyu Hu and Jinbo Hu
Org. Chem. Front., 2015,2, 163-168
DOI: 10.1039/C4QO00291A, Tutorial Account

Cationic Pd(II)-catalyzed cyclization of N-tosyl-aniline tethered alkynyl ketones initiated by hydropalladation of alkynes: a facile way to 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives
Kun Shen, Xiuling Han, Guoqin Xia and Xiyan Lu
Org. Chem. Front., 2015,2, 145-149
DOI: 10.1039/C4QO00286E, Research Article

Simple, versatile, and chemoselective reduction of secondary amides and lactams to amines with the Tf2O–NaBH4 or Cp2ZrHCl–NaBH4 system
Pei-Qiang Huang and Hui Geng
Org. Chem. Front., 2015,2, 150-158
DOI: 10.1039/C4QO00317A, Research Article

Gold(I)-catalyzed asymmetric [3 + 2]-cycloadditions of γ-1-ethoxyethoxy-propiolates and aldehydes
Feng Liu, Yidong Wang, Weiming Ye and Junliang Zhang
Org. Chem. Front., 2015,2, 221-225
DOI: 10.1039/C4QO00261J, Research Article

Indolizine synthesis via Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with nucleophiles
Ren-Rong Liu, Zheng-Yi Cai, Chuan-Jun Lu, Shi-Chun Ye, Bin Xiang, Jianrong Gao and Yi-Xia Jia
Org. Chem. Front., 2015,2, 226-230
DOI: 10.1039/C4QO00336E, Research Article


Selective syntheses of leuconolam, leuconoxine, and mersicarpine alkaloids from a common intermediate through regiocontrolled cyclizations by Staudinger reactions
Zining Li, Qian Geng, Zhe Lv, Beau P. Pritchett, Katsuaki Baba, Yoshitaka Numajiri, Brian M. Stoltz and Guangxin Liang
Org. Chem. Front., 2015,2, 236-240
DOI: 10.1039/C4QO00312H, Research Article

N-heterocyclic carbene-based ruthenium-catalyzed direct amidation of aldehydes with amines
Cheng Chen, Min Ha Kim and Soon Hyeok Hong
Org. Chem. Front., 2015,2, 241-247
DOI: 10.1039/C4QO00319E, Research Article

Catalytic dehydrogenative aromatization: an alternative route to functionalized arenes
Simon A. Girard, Huawen Huang, Feng Zhou, Guo-Jun Deng and Chao-Jun Li
Org. Chem. Front., 2015,2, 279-287
DOI: 10.1039/C4QO00358F, Tutorial Account



*Submit your work to OrgChemFront and benefit from rapid publishing, free colour and free access till the end of 2015*

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Louis Fensterbank wins the 2014 Clavel-Lespieau Prize

Congratulations to Professor Louis Fensterbank from the Université Pierre & Marie Curie (UPMC), the winner of the Prix Clavel-Lespiau in 2014!

Presented by the French Académie des Sciences, the Prix Clavel-Lespiau recognizes excellence in research in organic chemistry by a scientist who is currently working in France.

Professor Louis Fensterbank

Louis Fensterbank was born in Poitiers in 1967 and raised in Tours. While graduating from the Ecole Superieure de Chimie Industrielle de Lyon (ESCIL) in 1990, he joined the team of Scott Sieburth at SUNY Stony Brook, worked on silicon-tethered reactions and obtained his Ph.D. in 1993. After a temporary lecturer position at UPMC in 1994, he was appointed by the CNRS in 1995 as a Chargé de Recherche in Max Malacria’s team. In 2004, he obtained a professorship position at UPMC and in 2008, he was nominated junior member of the Institut Universitaire de France. In 2009, he was a Visiting Scientist at the Australian National University, Canberra. He was awarded by the French Academy of Science in 2014 the Clavel-Lespiau Prize for his work his organic synthesis.

His research interests concern the discovery of new molecular transformations relying on radical or organometallic processes and their applications to the synthesis of substrates with relevant properties (natural products, probes, ligands…).  He has co-authored more than 170 publications.

Representative chemistry

Find out more about Professor Fensterbank’s research by reading his publication in OrgChemFront:

Visible-light photocatalytic oxidation of 1,3-dicarbonyl compounds and carbon–carbon bond formation

Marion Daniel, Louis Fensterbank, Jean-Philippe Goddard and Cyril Ollivier
DOI: 10.1039/C4QO00071D


From themed collection In Celebration of Max Malacria’s 65th Birthday



Organic Chemistry Frontiers Articles are FREE to access till the end of 2016.

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Michael A. Kerr to receive the 2015 Alfred Bader Award

Organic Chemistry Frontiers congratulates the Advisory Board member Michael A. Kerr, who is awarded the 2015 Alfred Bader Award by the Canadian Society of Chemistry.

Professor Michael A. Kerr

Michael Kerr received his BSc in 1985 from the University of Waterloo where he worked as a research assistant under the supervision of Victor Snieckus. He then moved to the laboratories of Marcus Tius at the University of Hawaii where he was awarded a PhD in 1991. This was followed by two years of post-doctoral study under the guidance of K.C. Nicolaou at the Scripps Research Institute. Kerr began his independent career in 1993 as an assistant professor at the primarily undergraduate Acadia University and was promoted to associate professor with tenure in 1998.  In 1999, he moved to the more research intensive environment at The University of Western Ontario where he is currently full professor of chemistry. Kerr`s research focuses on the development of new methods related to heterocyclic chemistry and the application of these methods to the total synthesis of complex targets.

Representative chemistry

For more information about Alfred Bader Award and the past winners, please visit http://www.cheminst.ca/awards/csc-awards/alfred-bader-award.


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A letter from Erik Sorensen

Organic Chemistry Frontiers is proud to share with you a nice letter from the Associate Editor, Professor Erik Sorensen from Princeton University. In this responding letter to a referee, Erik talked about his motivation in working with OCF as well as the expectations to this high quality emerging journal.

The referee: “What do you envision as the niche for Organic Chemistry Frontiers?

Erik Sorensen (Associate Editor, OCF): “First, Happy New Year to you! I apologize for the long delay.  I just returned from lecturing in Norway.  I was distracted by the interesting science at that symposium, the process of slide making, and assigning manuscripts for Org. Chem. Front.

So, here are some words to express my feelings about that relatively new journal:  I really like the people associated with it, this includes the editorial board and the staff at RSC.  The RSC staff is terrific; they push when they need to and are always inclined to help.

I actually said ‘no’ to the first invitation I received to be an Assoc. Editor for OCF because I tend to feel that we already have plenty of journals for publishing achievements in organic chemistry.  Nevertheless, as time passed, my feelings started to soften.  Rob Eagling and Editor, Shengming Ma, overwhelmed me with their enthusiasm for OCF.  I was susceptible to that, in part, because I felt like I should start doing things that would allow me to give back to our field.  I was also intrigued by the idea that OCF could emerge as an attractive venue (with high standards!) for the research advances by the large and growing population of chemists in China.  Given my status as guest Professor at Tianjin University (during the summer months when I don’t teach at Princeton), I travel to China relatively often.  During my visits to China, I am frequently very impressed by the enthusiasm that exists there for organic chemistry, as well as the spirit to ‘get better’.  In fact, the chemists I encounter over there are working really hard to be innovative.  I confess that their spirit has had a positive effect on my own level of motivation.

So, my wish to start giving back to our field and my expanding interactions with organic chemists from China are the biggest reasons for my decision to get involved with OCF.  I am in my 2nd year as an Assoc. Editor, and I have no regrets.  I am as eager as ever to see OCF compete with all of the other journals that strive to publish original ideas and results in organic chemistry, especially in the area of organic chemical synthesis.  Some time is needed before we will know if this journal will earn its title– Organic Chemistry Frontiers.

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Top 10 most-read Organic Chemistry Frontiers articles – Q1 2015

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This month sees the following articles in Organic Chemistry Frontiers that are in the top 10 most accessed from January to March:

Transition metal-catalyzed direct remote C–H functionalization of alkyl groups via C(sp3)–H bond activation
Guanyinsheng Qiu and Jie Wu
Org. Chem. Front., 2015,2, 169-178
DOI: 10.1039/c4qo00207e

Catalytic enantioselective organic transformations via visible light photocatalysis
Chengfeng Wang and Zhan Lu
Org. Chem. Front., 2015,2, 179-190
DOI: 10.1039/c4qo00306c

Recent advances in directed C–H functionalizations using monodentate nitrogen-based directing groups
Min Zhang, Yuanfei Zhang, Xiaoming Jie, Huaiqing Zhao, Gang Li and Weiping Su
Org. Chem. Front., 2014,1, 843-895
DOI: 10.1039/c4qo00068d

Copper(ii)-catalyzed methoxylation of unactivated (hetero)aryl C–H bonds using a removable bidentate auxiliary
Xue-Song Yin, Yi-Chen Li, Jun Yuan, Wen-Jia Gu and Bing-Feng Shi
Org. Chem. Front., 2015,2, 119-123
DOI: 10.1039/c4qo00276h

Iron-catalyzed/mediated oxidative transformation of C–H bonds
Fan Jia and Zhiping Li
Org. Chem. Front., 2014,1, 194-214
DOI: 10.1039/c3qo00087g

Synthesis and characterization of N-2-aryl-1,2,3-triazole based iridium complexes as photocatalysts with tunable photoredox potential
Rong Cai, Wuming Yan, Matthew G. Bologna, Kaushalya de Silva, Zhao Ma, Harry O. Finklea, Jeffrey L. Petersen, Minyong Li and Xiaodong Shi
Org. Chem. Front., 2015,2, 141-144
DOI: 10.1039/c4qo00281d

Difluoromethyl 2-pyridyl sulfone: a versatile carbonyl gem-difluoroolefination reagent
Bing Gao, Yanchuan Zhao, Jingyu Hu and Jinbo Hu
Org. Chem. Front., 2015,2, 163-168
DOI: 10.1039/c4qo00291a

Asymmetric synthesis of poly-substituted spirocyclohexane oxindole via a squaramide catalyzed cascade Michael–Michael–aldol sequence
Qiang-Sheng Sun, Xiao-Yang Chen, Hua Zhu, Hua Lin, Xing-Wen Sun and Guo-Qiang Lin
Org. Chem. Front., 2015,2, 110-113
DOI: 10.1039/c4qo00299g

Selective syntheses of leuconolam, leuconoxine, and mersicarpine alkaloids from a common intermediate through regiocontrolled cyclizations by Staudinger reactions
Zining Li, Qian Geng, Zhe Lv, Beau P. Pritchett, Katsuaki Baba, Yoshitaka Numajiri, Brian M. Stoltz and Guangxin Liang
Org. Chem. Front., 2015,2, 236-240
DOI: 10.1039/c4qo00312h

Catalytic dehydrogenative aromatization: an alternative route to functionalized arenes
Simon A. Girard, Huawen Huang, Feng Zhou, Guo-Jun Deng and Chao-Jun Li
Org. Chem. Front., 2015,2, 279-287
DOI: 10.1039/c4qo00358f


Publish with Organic Chemistry Frontiers, benefit from rapid publication, free journal cover and free access to 2014 & 2015 content!

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Welcome to Issue 6 of Organic Chemistry Frontiers in 2015

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The latest OrgChemFront issue is published online now.

The cover story, Boronic esters of corannulene: potential building blocks toward icosahedral supramolecules is contributed by Sara Da Ros, Anthony Linden, Kim K. Baldridge and Jay S. Siegel.

The inside front cover this issue features an article on Atroposelective synthesis of axially chiral P,S-ligands based on arynes by Anaïs Berthelot-Bréhier, Armen Panossian, Françoise Colobert and Frédéric R. Leroux.

Following review articles are also included in the current issue:

Silylative coupling of olefins with vinylsilanes in the synthesis of functionalized alkenes
Justyna Szudkowska-Frątczak, Grzegorz Hreczycho and Piotr Pawluć
Org. Chem. Front., 2015, 2, 730-738
DOI: 10.1039/C5QO00018A

The Mitsunobu reaction in the 21st century
S. Fletcher
Org. Chem. Front., 2015, 2, 739-752
DOI: 10.1039/C5QO00016E


Publish with Organic Chemistry Frontiers, benefit from rapid publication, free journal cover and free access to 2014 & 2015 content!

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Welcome to Issue 5 of Organic Chemistry Frontiers in 2015

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The latest OrgChemFront issue is published online now.

The cover story, Handling diazonium salts in flow for organic and material chemistry is contributed by Nicolas Oger, Erwan Le Grognec and François-Xavier Felpin.

The inside front cover this issue features an article on Synthesis of silafluorenes and silaindenes via silyl radicals from arylhydrosilanes: intramolecular cyclization and intermolecular annulation with alkynes


Publish with Organic Chemistry Frontiers, benefit from rapid publication, free journal cover and free access to 2014 & 2015 content!

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Great Success at the 2nd Organic Chemistry Frontiers International Symposium

The 2nd Organic Chemistry Frontiers International Symposium was successfully held in Zhejiang University on 21 April 2015. Symposium this year was attended by over 250 researchers and students from more than 20 universities and institutes of mainland China.

12 excellent scientific talks were featured at the symposium covering many popular and advancing researches in organic chemistry. Scientific talks and speakers are listed as follow:

Toward a nature-inspired, dual-catalytic method to dehydrogenate hydrocarbons

Erik Sorensen, Princeton University, USA

Selectivity in Metal-Catalyzed C–H Activation

Lutz Ackermann, Georg August-Universität Göttingen, Germany

Direct Transformation of Benzyl Alcohols and Their Ethers

Zhangjie Shi, Peking University

Opportunities with N-Heterocyclic Carbene Organocatalysis: New Basic Activation Modes

Yonggui Robin Chi, Singapore Nanyang Technological University, Singapore

Some New Stories about Gold(I) and Related Catalyses

Louis Fensterbank, UPMC, France

Radical Anion on Nitrogen Compounds

Zhan Lu, Zhejiang University, China

Cyclization Cascades via N-Amidyl Radicals: Novel Access to Complex Heterocycles

Cristina Nevado, University of Zurich, Switzerland

Kinetic Resolution of Racemic Amino Alcohols through Intermolecular Acetalization Catalyzed by Chiral Brønsted Acid

Masahiro Terada, Tohoku University, Japan

Traceless C–C Bond Formations Using Sulfones

Chulbom Lee, Seoul National University, South Korea

Total Synthesis of Indole Terpenoids

Ang Li, Shanghai Institute of Organic Chemistry, China

Synthesis and Molecular Recognition of Corona[n]arenes

Mei-Xiang Wang, Tsinghua University, China

Chemical probes for targeting and imaging hypoxia in tumours

Stuart Conway, University of Oxford, UK

We thank very much the speakers for their excellent presentations, as well as the host organization Zhejiang University for their tireless efforts and generous financial support to ensure the successful Symposium!

Delegates are communicating at the coffee break

The lecture room was filled with attendees

Speakers, organizing committees and RSC staffs (left to right) -- Row 1: Yan-Guang Wang, Chulbom Lee, Yonggui Robin Chi, Ying Liu, Erik Sorensen, Shengming Ma, Wenjun Liu, Stuart Conway, Masahiro Terada, Bingfeng Shi; Row 2: Daping Zhang, Louis Fensterbank, Mei-Xiang Wang, Cristina Nevado, Lutz Ackermann, Zhangjie Shi, Ang Li, Zhan Lu.

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Organic Chemistry Frontiers at the 7th Pacific Symposium on Radical Chemistry

Organic Chemistry Frontiers is glad to sponsor two poster prizes at the 7th Pacific Symposium on Radical Chemistry (PSRC-7) to be held in Nanyang Technological University (NTU), Singapore, from 15 – 18 July 2015. The PSRC takes place every two years, and is recognized as being one of the three major international meetings on radical chemistry (the other two being the International Symposium on Organic Free Radicals and the EUCHEM Conference on Free Radical Chemistry).  The PSRC-7 follows the successful series of PSRC symposiums held in Vancouver (2013), Shirahama (2011), Shanghai (2009), Heron Island (2007), Daejeon (2006), and Kanazawa (2003).

The symposium will cover all aspects of free radical chemistry and will bring together industrial and academic chemists from all over the world to discuss the latest advances in synthetic radical reactions, radical polymerizations, mechanistic insights into important radical reactions, new radical-based functional molecules and materials, and radicals in biology.

Take your opportunity to attend PSRC-7 by the registration deadline at 15 June 2015. More information is available at http://conference.ntu.edu.sg/psrc7/Pages/index.aspx.

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