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2025 Organic Chemistry Frontiers Most-Popular Articles

To celebrate the Year of the Horse, we are delighted to highlight some of the most popular articles published in Organic Chemistry Frontiers.

We hope you enjoy reading these articles and wish you a happy and prosperous year of the Horse.

 

Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles

Rubal Sharma, Mitsuhiro Arisawa, Shinobu Takizawa and Mohamed S. H. Salem

Org. Chem. Front., 2025,12, 1633-1670
https://doi.org/10.1039/D4QO02157F

Recent advances in the synthesis of nitrogen heterocycles via Rh(III)-catalyzed chelation-assisted C–H activation/annulation with diazo compounds

Jidan Liu, Ruilian Liang, Qinglian Yan, Liyao Zheng, Zhao-Qing Liu and Shouzhi Pu

Org. Chem. Front., 2025,12, 3065-3106
https://doi.org/10.1039/D5QO00111K

EDA complex photochemistry as a strategy for C–S bond formation

Helena F. Piedra, Illán Tagarro and Manuel Plaza

Org. Chem. Front., 2025,12, 3920-3941
https://doi.org/10.1039/D5QO00258C

Recent advances in organocatalytic asymmetric multicomponent reactions

Peng-Ying Jiang, San Wu, Jun (Joelle) Wang, Shao-Hua Xiang and Bin Tan

Org. Chem. Front., 2025,12, 4126-4150
https://doi.org/10.1039/D5QO00347D

AI molecular catalysis: where are we now?

Zhenzhi Tan, Qi Yang and Sanzhong Luo

Org. Chem. Front., 2025,12, 2759-2776
https://doi.org/10.1039/D4QO02363C

Photoinduced diversity-oriented synthesis of α-ketoester β-enamino esters, 3,3-difluoro-4-pyrrolin-2-ones, and 3-fluoro-3-pyrrolin-2-ones from bromodifluoroacetates and β-enamino esters

Dewei Feng, Renhua Zheng, Zhifang Li, Xiao Geng and Lei Wang

Org. Chem. Front., 2025,12, 4305-4310
https://doi.org/10.1039/D5QO00050E
HFIP-promoted formal [2π + 2σ] cycloaddition of para-quinone methides with bicyclo[1.1.0]butanes: an approach towards spiro-bicyclo[2.1.1]hexanes

Haijian Wu, Manman Sun, Jing Zhang, Zhiming Wang, Jianguo Yang and Gangguo Zhu

Org. Chem. Front., 2025,12, 1951-1957
https://doi.org/10.1039/D4QO02226B

Divergent synthesis of functionalized indazole N-oxides with anticancer activity via the cascade reaction of N-nitrosoanilines with diazo compounds and HFIP

Yuqian Sun, Shengnan Yan, Kelin Wang, Bin Li, Chunhua Ma, Xinying Zhang and Xuesen Fan

Org. Chem. Front., 2025,12, 2219-2224
https://doi.org/10.1039/D4QO02392G

Palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of indoles with α-oxocarboxylic acids via C–H activation

Liwei Zhou, Pengyang Jing, Wenbo Deng, Shuyi Guo, Yun Liang and Yuan Yang

Org. Chem. Front., 2025,12, 1122-1128
https://doi.org/10.1039/D4QO02024C

Mastering palladium-catalyzed cross-coupling reactions: the critical role of in situ pre-catalyst reduction design

Tommaso Fantoni, Chiara Palladino, Riccardo Grigolato, Beatrice Muzzi, Lucia Ferrazzano, Alessandra Tolomelli and Walter Cabri

Org. Chem. Front., 2025,12, 1982-1991
https://doi.org/10.1039/D4QO02335H

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