Organic Chemistry Frontiers Blog

Welcome to issue 6 of Organic Chemistry Frontiers for 2017 ! The latest OrgChemFront issue is published online now.

The  front cover story， Synthesis of fully-substituted 1,2,3-triazoles via copper(I)-catalyzed three-component coupling of sulfoximines, alkynes and azides  is contributed  by Jian Xu and Qiuling Song. The inside cover features a story on Thiolate–palladium(IV) or sulfonium–palladate(0)? A theoretical study on the mechanism of palladium-catalyzed C–S bond formation reactions by Ruopeng Bai and his co-authors.

Follow review article is also included in current issue:

Cyclopropenes: a new tool for the study of biological systems
João M. J. M. Ravasco, Carlos M. Monteiro and Alexandre F. Trindade  
Org. Chem. Front., 2017,4, 1167-1198
http://dx.doi.org/10.1039/C7QO00054E

In Issue 5, we are pleased to introduce you the articles published from themed collection “Novel π-Electron Molecular Scaffolds”, guest edited by the following scientists.

Articles featured in this issue are dedicated to the following topics of novel π-electron systems:

• design of exciting new structures
• development of unprecedented synthetic methods
• illustration of the structure-property relationships
• investigations into (anti-)aromaticity, optical or redox properties, or conformational features

Front cover image

The front cover story is contributed by Diamond and Marder, which provides a critical review on the methodlogy and applications of the hexadehydro-Diels–Alder (HDDA) reaction between alkyne and a 1,3-diyne.

Read more:
Methodology and applications of the hexadehydro-Diels–Alder (HDDA) reaction
Org. Chem. Front., 2017, 4, 891
DOI: 10.1039/C7QO00071E

Inside front cover image

The inside front cover is produced by Takai and Takeuchi et al., reflecting the chemistry of 9-9’-BF derivatives that bear twisted C=C double bonds and the exciting optoelectronic properties they exhibit.

Read more:
The effect of a highly twisted C C double bond on the electronic structures of 9,9′-bifluorenylidene derivatives in the ground and excited states
Org. Chem. Front., 2017, 4, 650
DOI: 10.1039/C7QO00125H

A couple of the other images were also suggested for the cover of “Novel π-Electron Molecular Scaffolds” themed issue.

Gan et al. reported the selective insertion of a CH₂ or NH group at the 5,6-junction on the C₅₉N skeleton which led to the formation of two azafullerene derivatives, as shown in figure 1. These two structures look similar but are different in the details. This is reminiscent to the images between an object and its reflection in the water.

Read more:
Synthesis of homoazafullerene [C₅₉N(CH₂)]R and azahomoazafullerene [C₅₉N(NH)]R
Org. Chem. Front., 2017, 4, 750-754
DOI: 10.1039/C7QO00098G

Figure 1

Kuck et al. carried out systematic studies on the role of substituents in the bay-bridging cycloheptatriene ring formation around the tribenzotriquinacene (TBTQ) core. In figure 2, the small propellers were highlighted at large ones: C3-symmetric tribenzotriquinacenes can be extended by bridging their bays with three further aromatic units to generate a warped, fully conjugated π-electron periphery. Where will the wind blow them to?

Read more:
Electronic and steric effects on the three-fold Scholl-type cycloheptatriene ring formation around a tribenzotriquinacene core
Org. Chem. Front., 2017, 4, 817-822
DOI: 10.1039/C7QO00132K

Figure 2

The final cover suggestion came from Scott et al., where the first azacorannulene with a nitrogen on the rim, has been synthesized in seven steps from 4-bromoisoquinoline.

Read more:
5-Azadibenzo[a,g]corannulene
Org. Chem. Front., 2017, 4, 688-698
DOI: 10.1039/C6QO00831C

Figure 3

Read the full collection of articles for FREE before 16 June 2017. 

Organic Chemistry Frontiers is dedicated to reporting leading edge research across the broad organic chemistry, including the synthesis and property studies of functional organic molecules.

Organic materials related submissions to the Journal will be handled by Associate Editor Frank Würthner via a fair and rigorous reviewing process. Submit your high quality work to Frank’s Editorial office today!

Welcome to issue 4 of Organic Chemistry Frontiers for 2017 ! The latest OrgChemFront issue is published online now.

The  front cover story,  De novo synthesis of alkyne substituted tryptophans as chemical probes for protein profiling studies is contributed by R. N. Nair, J. J. Rosnow, T. A. Murphree, M. E. Bowden, S. R. Lindemann and A. T. Wright. The inside cover features a story on Sequential In-catalyzed intramolecular hydroarylation and Pd-catalyzed cross-coupling reactions using bromopropargyl aryl ethers and amines by José Pérez Sestelo and his co-authors.

Welcome to issue 2 of Organic Chemistry Frontiers for 2017 ! The latest OrgChemFront issue is published online now.

The  front cover story,  Aerobic oxidative decyanation–amidation of arylacetonitriles with urea as a nitrogen source is contributed by Xuezhao Xu, Bingnan Li, Yingwei Zhao and Qiuling Song. The inside cover features a story on Substrate-driven selective mono- and bis-couplings of ortho-(OTf/I/Br) substituted gem-dibromovinylarenes by Maddali L. N. Rao, Priyabrata Dasgupta and Sk Shamim Islam.