Focus: Functional Materials for Phototherapy

Phototherapy has emerged as a powerful approach for the treatment of cancer, bacterial infections, and other diseases through light-mediated therapeutic processes. This collection highlights recent articles in functional materials for phototherapy published on Materials Chemistry Frontiers and Inorganic Chemistry Frontiers, including photosensitizers, photothermal agents, and multifunctional theranostic platforms. Hope you find them enjoyable to read. Word cloud is generated by Copilot

 


Review Articles

Room-temperature phosphorescence based on doping systems: material design, mechanisms, and applications
Zhang, Taiyi; Jing, Yingying; Wang, Zhao; Wu, Wenxiu; Pak, Yen Leng; Gao, Xing; Guo, Yurong; Song, Jibin

Dual-organelle-targeted organic small-molecule photosensitizers in photodynamic therapy
Lin, Zhenxin; Huang, Shumei; Jiang, Yin; Zhang, Huatang; Sun, Hongyan

Engineering hybrid microgels: from rational design to next-generation smart materials
Chang, Hao; Zheng, Yue; Zhu, Mo; Li, Lianwei; Guan, Xin

Diagnosis and therapeutic strategies of inorganic nanomaterials in lymphatic system diseases
Yang, Huaixi; Pu, Luya; Zhao, Yanfu; Zhao, Yi; Fei, Rui; Shao, Zhiyu; Du, Jianshi

Anticancer iridium(iii) cyclopentadienyl complexes
Starha, Pavel

Metal-coumarin derivatives as promising photosensitizers: unlocking their cancer phototherapy potential
Vigueras, Gloria; Izquierdo-Garcia, Eduardo; de la Torre-Rubio, Elena; Abad-Montero, Diego; Santana, Maria Dolores; Marchan, Vicente; Ruiz, Jose

Nanogenerators with l-arginine loading: new choices as cascade and synergistic nitric oxide/photodynamic antitumor agents
Huang, Yue; Wu, Ziwei; Wang, Hanyang; An, Hao; Zhang, Jiabao; Bao, Zhihong

Stimuli-responsive photodynamic platforms for the treatment of bacterial infections
Chang, Mengyuan; Cheng, Huijuan; Lv, Xinyi; Song, Yanni; Dai, Chunhui; Yang, Dongliang

Nanozyme-enhanced ferroptosis for cancer treatment
Ming, Yue; Huang, Mingshu; Huang, Yisheng; Liu, Danqing; Sun, Min; Jia, Bo; Du, Jianzhong

Self-assembled phthalocyanine-based nano-photosensitizers in photodynamic therapy for hypoxic tumors
He, Lin; Ma, Ding

 


Research Articles

One arrow two eagles: design and synthesis of “all-in-one” nanoscale Cu-IR825 nanoparticles for photothermally augmented chemodynamic therapy
Wang, Wei; Luo, Dan; Huang, Yuzi; Zhang, Yuting; Geng, Peng; Jin, Qiancheng; Huang, Wenquan; Xiao, Shuzhang

Photocatalytic arylterpyridine iridium(iii) complexes trigger oncosis in 2D and 3D cancer cell models via NADH oxidation
Romero-Castellon, Isabel; Markova, Lenka; Piernas-Munoz, Maria Jose; Kostrhunova, Hana; Kasparkova, Jana; Janiak, Christoph; Alberto, Marta E.; Frances-Monerris, Antonio; Ruiz, Jose; Brabec, Viktor

Iridium nanoparticles with anti-inflammatory activity for improved tumor photothermal therapy
Yang, Xianghua; Yi, Siwen; Liu, Meiling; Huo, Linlin; Tan, Mingya; Zhao, Jiayi; Chu, Taotao; Zhao, Zhenghuan

Bi/Bi₄O₅Br₂ Ohmic-like heterojunction drives enhanced photocatalytic antibacterial action via electron transfer and ROS
Liu, Yan; Liu, Xiaomeng; Yang, Ruixuan; Song, Zhiguo; Li, Yongjin; Li, Qiyan; Pan, Jie

Ni-doped carbon dots unlock dual NIR-II photothermal and photodynamic cancer therapy
Song, Jun; Kang, Minghao; Li, Yongping; Guo, Jiaqing; Wang, Huibo; Liu, Liwei; Qu, Junle; Ye, Shuai

Ligand engineering enables efficient intracellular chemiluminescence-driven activation of luminol-functionalised Ir(iii) complexes
Morales-Pioz, Eva; Redrado, Marta; Mesdom, Pierre; Pedron, Manuel; Salluce, Giulia; Gasser, Gilles; Fernandez-Moreira, Vanesa

Insight into light-regulated antibacterial properties of morphology-controlled copper-based nanomaterials
Jiang, Wen-Jie; Chen, Zihao; Zhao, Wen-Jun; Zhang, Chen-Hao; Zhang, Qichun; Zhao, Dan

A ligand dissociable copper complex activates non-ionophore cuproptosis by exposing Cu sites with photothermal synergistic cancer therapy
Huang, Yuan; Liu, Zheng; Wu, Pengyu; Fang, Xinyue; Tian, Ye; Cai, Zhijia; Xiong, Xilin; Ke, Qi; Yu, Mengju; Ye, Wenjing; Wang, Suxiao

A cell membrane-targeted AIEgen nanoparticle synergistically enhances cisplatin chemotherapy via localized photodynamic therapy
You, Jiawei; Zhu, Shang; Yuan, Sisi; Zhuang, Yu; Hou, Jianquan; Zhao, Engui

Microenvironment engineering in photosensitizer@MOF composites for enhanced singlet oxygen production
Tomilov, Aleksandr S.; Yazikova, Anastasiya A.; Klyamer, Darya D.; Basova, Tamara V.; Livanovich, Kanstantsin S.; Aidakova, Kristina A.; Poryvaev, Artem S.; Fedin, Matvey V.

Photothermal-responsive nanocomposite hydrogel for intelligent drug release and alveolar bone regeneration
Wang, Junjie; Chen, Haojie; Wang, Dai; Chen, Jianzhao; Lan, Liujia; Li, Wenqiang; Shen, Shan

Stimuli-responsive drug delivery, antioxidant and photothermal antibacterial hydrogel wound dressing for MRSA-infected pressure ulcer repair
Wu, Yuling; Dong, Ruonan; Fang, Qingqing; Chen, Zikun; Duan, Xianglong; Guo, Baolin; Liu, Liangle

Hypoxia active cyclometalated Ir(iii) Nile red triplet photosensitisers
Fodor, Judit; Mazuryk, Olga; Condon, Claire C.; Careta, Oriol; Al Riyami, Amani B.; Nogues, Carme; Colleran, John J.; Xiao, Xiao; Zhao, Jianzhang; Draper, Sylvia M.

Engineering a Mn₃O₄ shell on PdAu nanosheets for enhanced MRI diagnosis and efficient photothermal/chemodynamic therapy of tumors and pulmonary metastases
Zhu, Xianglong; Qin, Kuankuan; Ding, Qianlin; Li, Chao; Li, Gang; Zhang, Heng; Zhang, Wenlong; Shi, Saige; Jin, Zhen; Xiong, Hehe

New members of the lanthanide titanium cluster family: Janus nanoclusters and their applications in optical imaging and photodynamic therapy
Li, Ru-Yan; Qin, Wen-Wen; Yang, Fan; Wang, Hai-Ling; Tang, Meng-Juan; Zou, Hua-Hong; Liang, Fu-Pei; Chen, De-Xin; Zhu, Zhong-Hong

Breaking the excitation barrier: visible-light-harvesting Ir(III)-Eu(III) dyads for circularly polarized luminescence and theranostics
Wang, Zhiming; Dong, Shiwei; Yang, Chuanliang; Chen, Jinyi; Wang, Wentao; Li, Tao; Yang, Guoqiang; Han, Zhong

A light-triggered nitric oxide-photothermal nanoplatform for combating bacterial infections and promoting wound healing
Qing, Dan; Sun, Weihao; Wang, Hanyang; Zhang, Jiabao; An, Hao; Li, Xurui; Wei, Xiuyan; Bao, Zhihong

Covalent organic frameworks as nanocarriers of tailored BODIPY for phototheragnostic applications
Jimenez-Duro, Miguel; Soriano-Teruel, Paula M.; Martinez-Fernandez, Marcos; Avellanal-Zaballa, Edurne; Soler-Beatty, Jennifer; Martinez, Jose I.; Garcia-Fernandez, Alba; Ortiz, Maria J.; Duran-Sampedro, Gonzalo; Banuelos, Jorge; Martinez-Manez, Ramon; Segura, Jose L.

Universal upconversion amplification via 4d-4f hybridization in Ln³⁺/MoO₄²⁻ co-doped fluorapatite: mechanism and applications
Wang, Boyang; Ren, Yuankun; Wei, Xiaohan; Yang, Wei; Su, Haoming; Liu, Yu; Liang, Jiaqi; Li, Xiyu

Supramolecular assembly of an organoplatinum(ii) complex boosts intersystem crossing for potentiated photocatalytic therapy and disulfidptosis
Yuan, Guotao; Liang, Xiaoting; Liu, Zhaoyang; Ma, Hongbiao; Li, Dan; Lin, Xintong; Yu, Bole; Wang, Hanqiang; Zhang, Pingyu

Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)-COUPY conjugates
Ortega-Forte, Enrique; Rovira, Anna; Ashoo, Pezhman; Izquierdo-Garcia, Eduardo; Hally, Cormac; Abad-Montero, Diego; Jorda-Redondo, Mireia; Vigueras, Gloria; Deya, Alba; Hernandez, Jose Luis; Galino, Jorge; Bosch, Manel; Alberto, Marta E.; Frances-Monerris, Antonio; Nonell, Santi; Ruiz, Jose; Marchan, Vicente

Conjugation of a cyclometalated Ir(iii) complex to human serum albumin for oncosis-mediated photodynamic therapy
Linero-Artiaga, Antonio; Servos, Lisa-Marie; Papadopoulos, Zisis; Rodriguez, Venancio; Ruiz, Jose; Karges, Johannes

Organelle-targeting activity-based hemicyanine derivatives for enhanced and selective type-I photodynamic therapy under hypoxia conditions
Dirak, Musa; Saymaz, Ayca; Acari, Alperen; Akkoc, Yunus; Kocak, Haluk Samet; Yenici, Cansu M.; Gozuacik, Devrim; Gunduz, Hande; Kolemen, Safacan

Enhanced ROS generation in AIE-active iridium(iii) photosensitizers by cationization engineering for advanced photodynamic therapy
Huang, Shanshan; Li, Yuancheng; Xie, Xiaohan; Tong, Jialin; Shan, Guo-Gang; Qin, Chao; Xiao, Xiyan; Wang, Qianruo; Li, Yuanyuan; Wang, Hualei

Luminescent iridium(iii) 2-cyanobenzothiazole complexes as site-specific labels to afford peptide-based phosphorogenic probes and hydrogels for enzyme activity sensing, cancer imaging and photodynamic therapy
Xu, Jun-Wen; Lee, Lawrence Cho-Cheung; Yip, Alex Man-Hei; Xu, Guang-Xi; Leung, Peter Kam-Keung; Lo, Kenneth Kam-Wing

Bioorthogonal activation and mitochondrial targeting of a near-infrared-emitting iridium(iii) nitrone complex via cyclooctynylated phosphonium cations for enhanced cellular imaging and photodynamic therapy
Walter, Edward R. H.; Lee, Lawrence Cho-Cheung; Leung, Peter Kam-Keung; Lo, Kenneth Kam-Wing; Long, Nicholas J.

Enhancing photodynamic therapy for cancer: a two-photon excited approach with a novel mitochondrial-targeted photosensitizer
Du, Wenhao; Shang, Wenzhao; Wen, Wei; Deng, Xiepeng; Xie, Dalu; Zhang, Yuhao; Su, Huifang; Liu, Hongjian

Fluorescence lifetime imaging-guided photodynamic therapy over two-photon responsive metal-organic frameworks
Li, Bo; Lu, Xin; Sun, Xianshun; Zhou, Hongping; Tian, Yupeng; Hai, Zijuan; Li, Dandan

Enhanced therapeutic efficacy of folic acid-decorated Ti₃C₂ MXenes in targeted combination therapy for liver vancer
Lv, Haizhen; Bai, Zhiqiang; Li, Yanjun; Zhao, Lu; Bai, Yunfeng; Feng, Feng

Four-in-one multifunctional iron(iii) complex for cancer theranostics: unique integration of targeted delivery, photodynamic therapy, and dual imaging modalities
Sarkar, Tukki; Rizzuti, Serena; Chongtham, Isorchand; Kushwaha, Rajesh; Bhattacharyya, Arnab; Banerjee, Samya; Gianolio, Eliana; Hussain, Akhtar

Novel zinc(ii) phthalocyanine nanoparticles as a diagnosis-treatment nanoprobe for photoacoustic-imaging-guided synergistic photothermal/photodynamic-enhanced cancer therapy
He, Min; Bin, Yidong; Huang, Lixian; Li, Caiying; Ma, Yuzhen; Luo, Yanni; Zhao, Shulin; Liang, Jinzhe

Regioisomeric manipulation of AIE-active photosensitizers towards multidrug-resistant bacterial eradication
Zhi, Meiliang; Sun, Tun; Wang, Deliang; Zeng, Qiying; Li, Ying; Su, Xiang; Feng, Xing; Tang, Ben Zhong

Steering the luminescence of donor-acceptor materials by regioisomerism of triazole linkers
Holzhauer, Laura; Francener, Carolina; Elsing, David; Danos, Andrew; Fuhr, Olaf; Jung, Nicole; Wenzel, Wolfgang; Monkman, Andrew P.; Brase, Stefan; Kozlowska, Mariana; Puttock, Emma V.

New encapsulated bis-cyclometalated Ir(III) complexes with very potent anticancer PDT activity
Bermejo-Casadesus, Cristina; Gonzalo-Navarro, Carlos; Organero, Juan Angel; Maria Rodriguez, Ana; Santos, Lucia; Zafon, Elisenda; Lima, Joao Carlos; Moro, Artur J.; Iglesias, Monica; Tavares, Pedro; Martinez, Daniel; Manzano, Blanca R.; Massaguer, Anna; Dura, Gema

Molecular engineering-facilitated AIE-active type-I photosensitizers for photothermal imaging-guided photodynamic therapy
Li, Xiufeng; Zhang, Shasha; Gu, Pengli; Zhang, Xinyi; Mei, Ju

Multifunctional nanozyme for tumor-targeted photothermal/catalytic combination therapy
Xin, Zhihui; Zhao, Lu; Li, Jianfeng; Bai, Zhiqiang; Bai, Yunfeng; Feng, Feng

Guanidinium-appended γ-cyclodextrin: efficient fullerene solubiliser for enhanced photodynamic therapy
Man, Mervyn Ho Kong; Yau, Henry Chak Man; Okuro, Kou

Photostable rubyrins bearing pentafluorophenyl pendants for enhanced reactive oxygen species generation using an 808 nm laser
Edwin, Aathira; Sulfikarali, Thondikkal; Raj, Gowtham; Naniyil, Athira; Varghese, Reji; Gokulnath, Sabapathi

Lysosome-targeted Ru(ii) complexes as oncosis inducers for boosting photodynamic anticancer therapy
Chen, Yu; Tao, Siyi; Kou, Manchang; Xu, Kuang; Peng, Jie; Shen, Zhifa; Tang, Xiaoliang; Ru, Jiaxi

Exploring the photophysics and excited state reactivity of [Ru(4,4′-BTFMB)2 (L)]2+ complexes (L = bpy, phen, TAP) as photodynamic therapy agents: a theoretical investigation
Quintao, Sandy Verissimo Morais; Bozzi, Aline de Souza; Rocha, Willian Ricardo

Profiting from light-induced metal-to-metal intramolecular electron transfer: towards highly efficient heterodinuclear photosensitizers for photodynamic therapy
Sanz-Villafruela, Juan; Servos, Lisa-Marie; Montesdeoca, Nicolas; Cuevas-Vicario, Jose V.; Moro, Artur J.; Lima, Joao C.; Martinez-Alonso, Marta; Espino, Gustavo; Karges, Johannes

Hydroxyl-modified fullerene C₇₀(OH)₈ induces pyroptosis for cancer therapy
Zhang, Hang; Liu, Zhen; Zhu, Xiao-Fei; Zhang, Jun-Long; Gan, Liangbing

GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy
Li, Bole; Wu, Zhujun; Xu, Xiaotong; Lv, Yanfei; Guo, Yunfei; Liang, Siyu; Wang, Zhimin; He, Lei; Song, Yu-Fei

Chalcogen modification: one-step strategy for tuning the photophysical properties and NIR phototherapy of iodinated BODIPY
Liu, Hongyi; Li, Hui; Li, Wen; Zhang, Jinjin; Ye, Jingtao; Liao, Shenglong; Li, Yang; Yin, Shouchun

Metal-BODIPY complexes: versatile photosensitizers for oxidizing amyloid-β peptides and modulating their aggregation profiles
Kim, Mingeun; Gupta, Gajendra; Lee, Junseong; Na, Chanju; Kwak, Jimin; Lin, Yuxi; Lee, Young-Ho; Lim, Mi Hee; Lee, Chang Yeon

Carbon dot-modified controllable drug delivery system for sonodynamic/chemotherapy of tumors
Meng, Qingxuan; Wang, Qian; Zhang, Qing; Wang, Jia; Li, Yuhao; Zhu, Senqiang; Liu, Rui; Zhu, Hongjun

A narrowband ultraviolet-B-emitting LiCaPO4:Gd3+ phosphor with super-long persistent luminescence for over 100 h
Shan, Xihui; Lv, Xulong; Chen, Dongxun; Zhang, Yi; Ning, Lixin; Liang, Yanjie

Indocyanine green-loaded porphyrin covalent organic frameworks for photothermal cancer therapy
Tong, Simiao; Li, Cheng; Wang, Kai; Wu, Fengshou

A heterocyclic strategy for regulating the proportion of type I and type II photodynamic therapy
Tang, Hui; Ma, Ning; Liu, Xiaochun; Wu, Shiyu; Li, Hairong; Chen, Kangyao; Jiang, Yitong; Zhang, Yahui; Wang, Zhouyu; Yu, Xiaoqi

A self-enhanced chemiexcited PDT system for targeted and efficient treatment of deeply seated tumors
Da, Xuwen; Xu, Yunli; Wang, Lei; Liu, Xiulian; Peng, Yatong; Wu, Yao; Zhou, Wanpeng; Wang, Wentao; Wang, Xuesong; Zhou, Qianxiong

X-ray-activated ultra-long UVA persistent luminescence from a Bi-doped perovskite LaGaO₃ for photodynamic activation
Liu, Bo-Mei; Lin, Yue; Liu, Yingchun; Zhang, Shanqing; Wang, Jing; Zhang, Hui; Zhu, Jesse

Exploring multi-stimuli-responsive Pt(II) complexes: supramolecular self-assembly, lysosome-specific targeted photodynamic therapy and photodegradation of organic pollutants
Ding, Hui; Deng, Xiepeng; Liu, Xiang; Shang, Wenzhao; Du, Xianchao; Wang, Sufan; Liu, Xia; Chen, Xiangrong; Liu, Hongjian; Su, Huifang

A novel multi-carboxyl functionalized MOF platform for effective photodynamic therapy with hypoxia modulation based on prominent self-oxygen generation
Gao, Guorui; Wang, Yifan; Jiang, Yu; Luo, Shiping; Li, Mengnan; Cao, Yanyu; Ma, Yu; Tang, Bo

Synthetic ease and exceptional in vivo performance of pyrazole-based cyclometallated iridium complexes
Redrado, Marta; Romanos, Eduardo; Benedi, Andrea; Canudo-Barreras, Guillermo; Marzo, Isabel; Gimeno, M. Concepcion; Fernandez-Moreira, Vanesa

Unusual singlet oxygen-dependent hydroxyl radical production by a unique ruthenium-polypyridyl-hydroxamate complex under visible light irradiation
Tang, Tian-Shu; Mao, Li; Huang, Chun-Hua; Zhao, Chuan-Fang; Liu, Zhi-Sheng; Chen, Jing; Zhu, Ben-Zhan

Highly efficient NIR-II photothermal conversion from a 2,2′-biquinoline-4,4′-dicarboxylate-based photochromic complex
Zhang, Ning-Ning; Liu, Ya-Tong; Li, Li; Liu, Xiang-Tong; Xu, Ke; Li, Zhen-Yu; Yan, Yong

Synthesis of lanthanide-based scintillator@MOF nanocomposites for X-ray-induced photodynamic therapy
Zhang, Lantian; Gao, Fan; Liu, Shiqi; Ju, Mei; Sun, Chao; Sun, Gengzhi; Ju, Qiang; Yang, Kai; Fang, Zhenlan

Optimizing mitochondrial-targeting groups of positively-charged BODIPY nanoparticles for enhanced photodynamic therapy
Qi, Huixuan; Qu, Ruobing; Shen, Jiaping; Wen, Hui; Yuan, Chunyu; Lin, Wenhai; Sun, Tingting; Li, Min

Coordination catalysis of metals and polydopamine enables controlled release of CO from MnCO by enhancing oxidative stress and the thermal effect
Zhang, Wen-Xin; Li, Lin-Yu; Shu, Yang; Wang, Jian-Hua

Aptamer-functionalized hollow carbon nanospheres for the targeted chemo-photothermal therapy of breast tumor
Xin, Zhihui; Zhao, Lu; Bai, Zhiqiang; Wang, Chaoyu; Liu, Zhixiong; Qin, Jun; Liu, Lizhen; Zhang, Haifei; Bai, Yunfeng; Feng, Feng

An esterase-activated diketopyrrolopyrrole-based theranostic prodrug for precise pyroptosis and synergistic chemo-photodynamic therapy of pancreatic cancer
Gu, Xixin; Yang, Kaini; Li, Sifan; Mei, Ju; He, Xiao-Peng; Chen, Wei; Hua, Jianli

A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy
Wang, Chaoyu; Xin, Zhihui; Bai, Zhiqiang; Mao, Jiaxin; Li, Yaru; Jia, Zhifang; Wang, Kewei; Zhao, Lu; Bai, Yunfeng; Feng, Feng

A bis-aromatic MOF system constructed with a copper iodine cluster and porphyrinic ligand for enhancing near-infrared photothermal conversion
Cao, Man; Wang, Qian-You; Li, Run-Meng; Dai, Fangfang; Wang, Shan; Luo, Peng; Hu, Jia-Hua; Dong, Xi-Yan; Huang, Ren-Wu

Single laser activated photodynamic/photothermal cancer therapy using a single mitochondria-targeted phototherapeutic agent with aggregation-induced emission characteristics
Li, Yanbin; Li, Xiaoyu; Cao, Xiaohan; Xu, Jiashuai; Zhao, Xiaowei; Lu, Hongguang

Au-based conjugated microporous polymers for combined photodynamic and radiation therapy in cancer treatment
Pan, Xinni; Cui, Shengsheng; Fan, Shanshan; Cao, Cheng; Jiao, Yingao; Fu, Yanfei; Niu, Jiaqi; Lin, Shujin; Zhu, Yueqi; Liu, Yanlei

New heater@luminescent thermometer nano-objects: Prussian blue core@silica shell loaded with a β-diketonate Tb³⁺/Eu³⁺ complex
Larquey, Aurore; Bellahsene, Houda; Felix, Gautier; Beaudhuin, Mickael; Pelluau, Tristan; Bouvet, Basile; Guari, Yannick; Sene, Saad; Larionova, Joulia

(WO plus ICG)@PLGA@lipid/plasmid DNA nanocomplexes as core-shell vectors for synergistic genetic/photothermal therapy
Bai, Yang; Feng, Guoqing; Yang, Qingbin; Hua, Tingting; Li, Bowen; Guo, Hao-Lin; Liu, Yuan; Yuan, Qing; Qian, Niansong; Zheng, Bin

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