2012 ESP Photobiology School

The European Society for Photobiology is pleased to announce the 2012 ESP Photobiology School, taking place in Brixen/Bressanone in South Tyrol, Italy. The purpose of the school is to provide an introductory overview of all main aspects of photobiology, presented by experts in each area.  The intention of the school is to cover the basic principles of photobiology and photochemistry of biomolecules as well as applications of such knowledge in understanding effects of climatic changes, influence of light on biological systems, applications of light in medicine and for other purposes.

The school will include basic lectures in each field that should be attended by all participants as well as optional special lectures in the same fields. The students will have the opportunity to present their results at a poster session. The course may act as a fundament for further research in the photobiological sciences.

The attendants may be MSc- and PhD-students, as well as others who would be interested in an overview of the photobiological sciences. However, the course will be designed for PhD students. The course will end with a short final test and an attendance certificate will be provided.

2012 ESP Photobiology School
Dates:
18-23 June, 2012
Location: “Casa della Gioventù Universitaria” of the University of Padova Via Rio Bianco 12, I-39042 Brixen/Bressanone, Italy

For further information please visit the website: http://www.esp-photobiology.it/school.html

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Top ten most accessed articles in December

This month sees the following articles in PPS that are in the top ten most accessed:-

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
Tanya Stuchinskaya, Miguel Moreno, Michael J. Cook, Dylan R. Edwards and David A. Russell
Photochem. Photobiol. Sci., 2011, 10, 822-831, DOI: 10.1039/C1PP05014A

Targeted photodynamic therapy – a promising strategy of tumor treatment
Andrzej M. Bugaj
Photochem. Photobiol. Sci., 2011, 10, 1097-1109, DOI: 10.1039/C0PP00147C

Photo-oxidation of proteins
David I. Pattison, Aldwin Suryo Rahmanto and Michael J. Davies
Photochem. Photobiol. Sci., 2011, Advance Article, DOI: 10.1039/C1PP05164D

Engineered photoreceptors as novel optogenetic tools
Andreas Möglich and Keith Moffat
Photochem. Photobiol. Sci., 2010, 9, 1286-1300, DOI: 10.1039/C0PP00167H, Perspective

Exploring structural change of protein bovine serum albumin by external perturbation using extrinsic fluorescence probe: spectroscopic measurement, molecular docking and molecular dynamics simulation
Sankar Jana, Shalini Ghosh, Sasanka Dalapati and Nikhil Guchhait
Photochem. Photobiol. Sci., 2012, 11, 323-332, DOI: 10.1039/C1PP05180F

A review of UVA-mediated photosensitivity disorders

E. Smith, F. Kiss, R. M. Porter and A. V. Anstey
Photochem. Photobiol. Sci., 2012, 11, 199-206, DOI: 10.1039/C1PP05191A

The specificity of UVA-induced DNA damage in human melanocytes
Stéphane Mouret, Anne Forestier and Thierry Douki
Photochem. Photobiol. Sci., 2012, Advance Article, DOI: 10.1039/C1PP05185G

Environmental effects of ozone depletion and its interactions with climate change: progress report, 2011
United Nations Environment Programme, Environmental Effects Assessment Panel
Photochem. Photobiol. Sci., 2012, 11, 13-27, DOI: 10.1039/C1PP90033A

5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma
Isabelle Coupienne, Grégory Fettweis, Noemí Rubio, Patrizia Agostinis and Jacques Piette
Photochem. Photobiol. Sci., 2011, 10, 1868-1878, DOI: 10.1039/C1PP05213F

Nanoparticles: their potential use in antibacterial photodynamic therapy
Stefano Perni, P. Prokopovich, Jonathan Pratten, Ivan P. Parkin and Michael Wilson
Photochem. Photobiol. Sci., 2011, 10, 712-720, DOI: 10.1039/C0PP00360C

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to PPS? Then why not submit to us today or alternatively email us your suggestions.

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PPS Issue 2 now online

Photochemical and Photobiological Sciences Volume 11, Issue 2 is now online, read the full issue here.  You can keep up to date with the latest developments from PPS by signing up for free table of contents alerts.

The front cover of Issue 2 features work from Xiaojing Wang and co-workers from South China Normal University in Guangzhou.  Light and gibberellings are important regulators of plant organ growth, however little is known about their roles in petal size determination.  In this paper the team report that light improves the length and width of the ray floret petals in Gerbera hybrida but gibberellic acid only promotes the petal length. The control of the petal size by light and gibberellic acid depends on cell size modulation, which is governed by the behaviour of cortical microtubule.  Their front cover shows that light promotes the growth and opening of Gerbera hybrida inflorescence even in the absence of gibberellic acid (upper left), while those cultivated in darkness without gibberellic acid are unable to open and grow regularly (lower right).

Interested in knowing more? Read the article for free for the next 6 weeks!

Cell expansion and microtubule behavior in ray floret petals of Gerbera hybrida: Responses to light and gibberellic acid
Lili Zhang, Lingfei Li, Jie Wu, Jianzong Peng, Lingrui Zhang and Xiaojing Wang
Photochem. Photobiol. Sci., 2012, 11, 279-288 DOI: 10.1039/C1PP05218G

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Multi-domain GFP-related proteins reported with a structure never seen before in nature

The 2008 Nobel prize was awarded for the discovery and development of the green fluorescent protein (GFP).  Since these initial discoveries almost 200 GFP-like Fluorescent proteins (FPs) have been described.  FPs have become indispensable in biomedical and basic research as a genetically encoded fluorescent label due to the unique ability of the protein family to synthesize light-emitting chromophores autocatalytically from their own three amino acid residues situated near the center of the FP globule.

Graphical abstract: Multi-domain GFP-like proteins from two species of marine hydrozoansA team from Austin, Texas have reported two new proteins displaying primary structures never before encountered in natural FPs in a recently published PPS article.  The proteins consist of multiple GFP-like domains repeated within the same polypeptide chain.  A two-domain green FP (abeGFP) and a four-domain orange-fluorescent FP (Ember) were isolated from the siphonophore Abylopsis eschscholtzii and an unidentified juvenile jellyfish (order Anthoathecata), respectively. 

There has never been any wild-type GFP-related proteins found which contain multiple GFP-like domains within a single polypeptide chain.  This paper describes two such proteins and explores possible relationships between individual domains within the four-domain orange-red protein from the anthoathecate jellyfish. 

The results reveal a previously unrecognized direction in which natural FPs have diversified, suggesting new avenues to look for FPs with novel and potentially useful features.

Interested in knowing more?  Read the full article for free until 15th February

Multi-domain GFP-like proteins from two species of marine hydrozoans
Marguerite E. Hunt, Chintan K. Modi, Galina V. Aglyamova, D. V. S. Ravikant, Eli Meyer and Mikhail V. Matz
Photochem. Photobiol. Sci., 2012, DOI: 10.1039/C1PP05238A

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Top three most accessed articles of 2011

As 2012 begins we take a look back to 2011 at three of the most highly accessed PPS articles.  These highly downloaded articles from 2011 are free to access until March 1st 2012

Issue 5 coverThe number one spot goes to an article from issue 5, the themed issue on photodynamic therapy.  The paper, ‘Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates’, comes from a team including Dylan Edwards and David Russell at the University of East Anglia, UK.  Their paper describes the development of a 4-component antibody–phthalocyanine–polyethylene glycol–gold nanoparticle conjugate which was stable, efficiently produced cytotoxic singlet oxygen and selectively targeted and destroyed breast cancer cells overexpressing the HER2 epidermal growth factor cell surface receptor.  Read the full article here and the full issue here.

Issue 4 CoverSecond position goes to a paper from PPS issue 4 ‘Photoinduced formation of reversible dye radicals and their impact on super-resolution imaging’.  Markus Sauer and co-workers from Germany demonstrate in this paper that upon irradiation with light of appropriate wavelength, standard organic dyes can be switched reversibly between a fluorescent and very stable non-fluorescent radical ion state with a lifetime of up to several hours. The high reliability of the photoswitching process permits super-resolution imaging with two laser lines.  Read the full article here.

Issue 2 CoverThe Montreal Protocol on Substances that Deplete the Ozone Layer is an international agreement on the protection of the stratospheric ozone layer, now ratified by 196 countries. Three Assessment Panels have continuously contributed information for facilitating informed decisions.  PPS published, in February 2011, the full report from the Environmental Effects Assessment Panel (EEAP) which presents key findings on ‘environmental effects of ozone depletion and its interactions with climate change’ and is the first full Assessment since 2006.  The article which was the third most downloaded in 2011 comes from this issue.  This perspective article ‘Ozone depletion and climate change: impacts on UV radiation’ is an assessment of the effects of ozone depletion and climate change on past and future UV radiation received at Earth’s surface. It comes from a group of co-authors from New Zealand, South Africa, Greece, China, Sweden, Malaysia and the USA!  Read the full article here and the full report here.

To keep up to date with Photochemical and Photobiological Sciences sign up for e-alerts here.

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Top ten most accessed articles in November

This month sees the following articles in PPS that are in the top ten most accessed:-

Engineered photoreceptors as novel optogenetic tools
Andreas Möglich and Keith Moffat
Photochem. Photobiol. Sci., 2010, 9, 1286-1300, DOI: 10.1039/C0PP00167H, Perspective

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
Tanya Stuchinskaya, Miguel Moreno, Michael J. Cook, Dylan R. Edwards and David A. Russell
Photochem. Photobiol. Sci., 2011, 10, 822-831, DOI: 10.1039/C1PP05014A

Photoelectrochemical, photophysical and morphological studies of electrostatic layer-by-layer thin films based on poly(p-phenylenevinylene) and single-walled carbon nanotubes
L. C. P. Almeida, V. Zucolotto, R. A. Domingues, T. D. Z. Atvars and A. F. Nogueira
Photochem. Photobiol. Sci., 2011, 10, 1766-1772, DOI: 10.1039/C1PP05221G

Photo-oxidation of proteins
David I. Pattison, Aldwin Suryo Rahmanto and Michael J. Davies
Photochem. Photobiol. Sci., 2011, Advance Article, DOI: 10.1039/C1PP05164D

Targeted photodynamic therapy – a promising strategy of tumor treatment
Andrzej M. Bugaj
Photochem. Photobiol. Sci., 2011, 10, 1097-1109, DOI: 10.1039/C0PP00147C

5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma
Isabelle Coupienne, Grégory Fettweis, Noemí Rubio, Patrizia Agostinis and Jacques Piette
Photochem. Photobiol. Sci., 2011, 10, 1868-1878, DOI: 10.1039/C1PP05213F

Ozone depletion and climate change: impacts on UV radiation
R. L. McKenzie, P. J. Aucamp, A. F. Bais, L. O. Björn, M. Ilyas and S. Madronich
Photochem. Photobiol. Sci., 2011, 10, 182-198, DOI: 10.1039/C0PP90034F

The human health effects of ozone depletion and interactions with climate change
M. Norval, R. M. Lucas, A. P. Cullen, F. R. de Gruijl, J. Longstreth, Y. Takizawa and J. C. van der Leun
Photochem. Photobiol. Sci., 2011, 10, 199-225, DOI: 10.1039/C0PP90044C

The specificity of UVA-induced DNA damage in human melanocytes
Stéphane Mouret, Anne Forestier and Thierry Douki
Photochem. Photobiol. Sci., 2012, Advance Article, DOI: 10.1039/C1PP05185G

Photoinduced formation of reversible dye radicals and their impact on super-resolution imaging
Sebastian van de Linde, Ivan Krstić, Thomas Prisner, Sören Doose, Mike Heilemann and Markus Sauer
Photochem. Photobiol. Sci., 2011, 10, 499-506, DOI: 10.1039/C0PP00317D

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to PPS? Then why not submit to us today or alternatively email us your suggestions.

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2012 Issue 1 online now: themed issue on UVA and UNEP progress report

Graphical abstract: Front coverWelcome to the first issue of 2012 a themed issue on the biology of UVA! This issue dedicated to UVA contains several in-depth perspectives and original articles in the field highlighting key advances and provides an interesting and comprehensive journey through the UVA field, even those for whom this particular area is less familiar. You can read an introduction to this issue in Evelyn Sage and Rex Tyrrell’s editorial. 

Graphical abstract: Environmental effects of ozone depletion and its interactions with climate change: progress report, 2011This issue is not only a themed issue, it also contains the 2011 progress report (an update on the full quadrennial report published in 2011 issue 2) from the United Nations Environment Programme, Environmental Effects Assessment Panel on the environmental effects of ozone depletion and its interactions with climate change.

Read 2012 Issue 1 online here!

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Novel Hydrophilic Photolabile Protecting Groups for Hydroxyl Protection

Hydrophilic photolabile protecting groups (PPGs) for hydroxyl protection have been developed by Pengfei Wang and co-workers from the University of Alabama at Birmingham. 

PPGs are protecting groups that can be removed with photo irradiation, they very useful tools in a range of basic and applied research areas.  One of these applications is their use as ‘photocages’ where the photochemical removal of the photogages often takes place in aqueous environments meaning that solubility issues are central to the use of caged biomolecules.

hydrophilic PPGs

This team have previously developed a novel PPG for hydroxyl groups, 3-(dimethylamino)trityl (DMATr) but its hydrophobicity obstructs its wide applications in aqueous environments so in their recently published PPS article they report their efforts to improve its water solubility.  The new PPGs the team developed were derived from DMATr by replacing the two methyl groups with two hydrophilic butyryl groups. The new PPG reagents can be readily prepared and installed. They are stable in the dark but can be removed cleanly and efficiently in aqueous environments upon irradiation with a UV lamp or sunlight.

This paper is part of a themed issue on photoremovable protecting groups due to be published in 2012.

Interested in knowing more? Read the full article for free until 20th December 2011

Development of hydrophilic photolabile hydroxyl protecting groups
Haishen Yang, Lei Zhou and Pengfei Wang
Photochem. Photobiol. Sci.
, 2012, DOI: 10.1039/C1PP05281K

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Final issue of the year now online!

issue 12 ofcPPS issue 12 is now online. The last issue of 2011 features work on the front cover from Jacques Piette and co-workers from the University of Liège and the Catholic University of Leuven in Belgium.

Their article ‘5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma’ which was featured on the PPS blog earlier this month gives new insights in to the mechanism of action of 5-aminolevulinic acid (5-ALA) based photodynamic therapy (PDT) against glioblastoma revealing the involvement of receptor-interacting protein 3 (RIP3) in necrosis induction. Read more about it here, the full article is free to access until 6th January 2012!

Read PPS issue 12 online here.

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Top ten most accessed articles in October

This month sees the following articles in PPS that are in the top ten most accessed:-

The specificity of UVA-induced DNA damage in human melanocytes
Stéphane Mouret, Anne Forestier and Thierry Douki
Photochem. Photobiol. Sci., 2012, Advance Article, DOI: 10.1039/C1PP05185G

Ozone depletion and climate change: impacts on UV radiation
R. L. McKenzie, P. J. Aucamp, A. F. Bais, L. O. Björn, M. Ilyas and S. Madronich
Photochem. Photobiol. Sci., 2011, 10, 182-198, DOI: 10.1039/C0PP90034F

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
Tanya Stuchinskaya, Miguel Moreno, Michael J. Cook, Dylan R. Edwards and David A. Russell
Photochem. Photobiol. Sci., 2011, 10, 822-831, DOI: 10.1039/C1PP05014A

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Gerd P. Pfeifer and Ahmad Besaratinia
Photochem. Photobiol. Sci., 2011, Advance Article, DOI: 10.1039/C1PP05144J

The human health effects of ozone depletion and interactions with climate change
M. Norval, R. M. Lucas, A. P. Cullen, F. R. de Gruijl, J. Longstreth, Y. Takizawa and J. C. van der Leun
Photochem. Photobiol. Sci., 2011, 10, 199-225, DOI: 10.1039/C0PP90044C

CdS-sensitized TiO2 nanocorals: hydrothermal synthesis, characterization, application
S. S. Mali, S. K. Desai, D. S. Dalavi, C. A. Betty, P. N. Bhosale and P. S. Patil
Photochem. Photobiol. Sci., 2011, Advance Article, DOI: 10.1039/C1PP05084B

Engineered photoreceptors as novel optogenetic tools
Andreas Möglich and Keith Moffat
Photochem. Photobiol. Sci., 2010, 9, 1286-1300, DOI: 10.1039/C0PP00167H, Perspective

Photo-oxidation of proteins
David I. Pattison, Aldwin Suryo Rahmanto and Michael J. Davies
Photochem. Photobiol. Sci., 2011, Advance Article, DOI: 10.1039/C1PP05164

Unravelling UVA-induced mutagenesis
Evelyne Sage, Pierre-Marie Girard and Stefania Francesconi
Photochem. Photobiol. Sci., 2011, Advance Article, DOI: 10.1039/C1PP05219E

UVA, UVB and incidence of cutaneous malignant melanoma in Norway and Sweden
Johan Moan, Zivile Baturaite, Alina Carmen Porojnicu, Arne Dahlback and Asta Juzeniene
Photochem. Photobiol. Sci., 2012, Advance Article, DOI: 10.1039/C1PP05215B

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to PPS? Then why not submit to us today or alternatively email us your suggestions.

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