Author Archive

ICP Prize Winners

We were delighted to award two delegates at the 16th International Congress on Photobiology, Córdoba, Argentina with Royal Society of Chemistry Poster Prizes.

María Julia Lamberti from Universidad Nacional de Rio Cuarto, Argentina and Francisco Lobos from the Universidad de Concepción, Chile were each awarded a Photochemical & Photobiological Sciences certificate and an RSC book voucher.

Maria presented a poster entitled “Photodynamic therapy mediates the ROS-dependent activation of the tumor prosurvival hypoxia-inducible factor I” and Francisco a poster on “Sequence, structure and function of the gamma 33 subunit of R-phycoerythrin from Gracilaria chilensis”.

Many congratulations to all the winners!


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Ozone depletion and climate change

On behalf of Professor Rex M. Tyrrell, Editor-in-Chief

Under the terms of the Montreal Protocol on protection of the ozone layer, regular assessments of the state of knowledge in this area are required by the signatory parties. The paper “Ozone depletion and climate change: impacts on UV radiation” by McKenzie and co-workers is part of one such assessment which was provided to the United Nations Environmental Panel (UNEP) through their Environmental Effects Assessment Panel (EEAP).

UV index over time

Change in the annual mean of noon-time clear-sky erythemally-weighted UV, 1960-2100, relative to the level in 1980.

The EEAP reports on the Environmental Impacts of Ozone Depletion and, in their more recent assessment, have been asked to comment on any interactions between ozone depletion and the climate change. In an attempt to make these assessments more accessible to the wider scientific community, they are also published in the peer reviewed scientific literature. Both the last two major assessments (2006 and 2010) and several interim reports of the EEAP have been published in Photochemical & Photobiological Sciences.

The paper by McKenzie et al. is essentially the first chapter of the most recent full assessment in 2010. That chapter assesses our progress towards understanding atmospheric research relevant to the effects of ozone depletion and climate change on solar UV radiation. It provides a link between (a) the more detailed and technical WMO/UNEP report on the Science of Ozone Depletion, and (b) the subsequent chapters of the EEAP assessment that report on the environmental effects on human health, the terrestrial environment, the aquatic environment, biogeochemical cycles, air quality, and material damage.

EEAP Panel

L. O. Björn, S. Madronich, R. L. McKenzie, A. F. Bais, P. J. Aucamp (M. Ilyas was absent, shown right). The photo was taken at the UNEP meeting in Zhengzhou China in August 2014 while working on the 2014 Assessment for which A. Bais will be the lead author.

These latter chapters are also published in the same special issue of Photochemical and Photobiological Sciences. Although not designed as a review, the chapter nevertheless provides a digestible short summary of important research results on the subjects of ozone depletion, UV radiation, and interactions between these issues and climate change that have appeared in the literature in the four years since the previous assessment.

Therefore, in addition to the primary purpose of providing an assessment for policymakers, the article also provides a useful introduction to the subject, especially for researchers new to the field and to educators. The scope is unique, as it provides a one-stop update of these diverse, yet interrelated issues. It is written in a style that makes it accessible to the general public without detailed knowledge of the issues.

As the topic is of wide interest to the scientific community, this 2011 article published in Photochemical and Photobiological Sciences is one of the most highly cited in the journal from recent years. The 2014 assessment is currently under review, and will be published in a special issue of Photochemical and Photobiological Sciences in early 2015.

Read the full paper to find out more:

Ozone depletion and climate change: impacts on UV radiation
R. L. McKenzie, P. J. Aucamp, A. F. Bais, L. O. Björn, M. Ilyas and S. Madronich
Photochem. Photobiol. Sci., 2011, 10, 182-198.

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Unravelling UVA-induced mutagenesis

UVB is the portion of the solar spectrum that is absorbed by DNA. It is a major contributor to the biological effect of sunlight, a property that has been known since the early 19th century. The genotoxic effects of UVA have attracted comparatively little interest however research into this portion of the solar spectrum has been revisited in the last twenty years.

Authors

The Sage group. Back (L–R): Pierre-Marie Girard (CNRS researcher), Sylvain Martineau (engineer), Ludovic Tessier (technician) Front : Angela Bellini (PhD student) and Ev Sage

There has been an intense effort to understand how UVA radiation damages DNA, induces mutations and is involved in human skin carcinogenesis. A classic Photochemical & Photobiological Sciences Perspective by Sage and co-workers summarizes the main results of such investigations.

The article highlights unresolved issues in the field and discusses the more controversial data in the recent literature. In particular, the authors summarise the evidence that the formation of cyclobutane pyrimidine dimers, the major DNA damage induced by UVA in mammalian cells, is caused by direct DNA-absorption of UVA photons rather than photosensitized reactions. This research is of particularly great importance for considering approaches to photoprotection.

Mutagenesis

Although contradictory data on UVA mutagenesis has been reported in the literature, the authors offer a critical analysis of the key findings and conclude that the main mutations induced by UVA are C to T transitions at bipyrimidine sites – the same process as for UVB. The authors propose that such a mutational specificity is a general UV signature, regardless of whether the UV radiation in question is UVB or UVA. This raises the question of what are the causative wavelengths when such mutations are observed in skin tumours.

The review also presents new insights on the genotoxic effects of UVA and provides a better understanding of the relative contribution of UVA to skin carcinogenesis, a crucial issue considering exposure of the human population to UVA radiation is unavoidable. The review presents mechanistic arguments that complement epidemiological studies on the risk of melanoma associated with the use of tanning beds, which emit over 99% UVA, and provides a platform for raising new questions on the potential effects of UVA radiation.

Since its publication in 2012, the Perspective has attracted considerable attention from researchers in the field, as evidenced by a growing number of citations.

To find out more, read the full article, which is free to access for 4 weeks:

Unravelling UVA-induced mutagenesis
Evelyne Sage, Pierre-Marie Girard and Stefania Francesconi
Photochem. Photobiol. Sci.,2012, 11, 74-80

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16th International Congress on Photobiology: Abstract submission deadline extended until 4th April

Deadline extended: Submit your abstracts by Friday 4th April 2014

Registration is still open for the 16th International Congress on Photobiology, to be held in Cordoba, Argentina, 7-12 September 2014.

The meeting starts with two talks and a reception on the evening of Sunday 7th and ends on the afternoon of Friday 12th. There are optional excursions on Wednesday afternoon and a special Darwin-steps trip is being organized to take place immediately after the Congress.

For further information and to submit your abstracts, visit: 

www.photobiology2014.com.ar  

16th ICP

 

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