Archive for the ‘News’ Category

Improving Cancer Detection with Multimodal Nanoparticles

New Nanoscale Communication

An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease

Xiaohu Xia, Miaoxin Yang, L. Kyle Oetjen, Yu Zhang, Qingge Li, Jingyi Chen and Younan Xia

Nanoscale, 2011, DOI: 10.1039/C0NR00874E

A particularly exciting aspect of research into new nanotechnology is the design and synthesis of multimodal nanomaterials. These are generally nanostructures which incorporate several different functional materials, such as magnetic and fluorescent substances, into a single structure which can then perform several tasks in parallel. It is anticipated that this sort of approach will improve the performance and efficiency of diagnostic and therapeutic nanomaterials in biomedical applications.

In this communication, Xia et al. describe their development of a new imaging probe constructed from gold nanocages functionalised with fluorescent dyes. Gold nanocages are already considered to be good candidates as contrast agents for optical imaging due to their tunable localized surface plasmon resonance features in the near-infrared region, and their compact sizes (<50 nm). They are of particular use in photoacoustic imaging due to their strong light absorption in the near-infrared, which can drastically improve contrast.

The team behind this work has extended the functionality of these gold nanocages by attaching dye molecules which will only fluoresce in the presence of protease (specifically, matrix metalloproteases, MMPs), a common indicator for cancer cell metastasis. In practice, this means that the distribution of the gold nanocages in targeted lesions can be mapped by photoacoustic imaging, while protease activity can be simultaneously mapped using fluorescence spectroscopy or microscopy.

Read this exciting work here.

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Top Ten most-read Nanoscale articles in November

The latest top ten most accessed Nanoscale articles

See the most-read papers of November 2010 here:

Wolfgang Schärtl, Nanoscale, 2010, 2, 829-843
DOI: 10.1039/C0NR00028K
 
Yen Hsun Su, Sheng-Lung Tu, Shih-Wen Tseng, Yun-Chorng Chang, Shih-Hui Chang and Wei-Min Zhang, Nanoscale, 2010, 2, 2639-2646
DOI: 10.1039/C0NR00330A
 
Wey Yang Teoh, Rose Amal and Lutz Mädler, Nanoscale, 2010, 2, 1324-1347
DOI: 10.1039/C0NR00017E
 
Idalia Bilecka and Markus Niederberger, Nanoscale, 2010, 2, 1358-1374
DOI: 10.1039/B9NR00377K
 
Wufeng Chen and Lifeng Yan, Nanoscale, 2010, 2, 559-563
DOI: 10.1039/B9NR00191C
 
Hualan Wang, Qingli Hao, Xujie Yang, Lude Lu and Xin Wang, Nanoscale, 2010, Advance Article
DOI: 10.1039/C0NR00224K
 
Frederik C. Krebs, Thomas Tromholt and Mikkel Jørgensen, Nanoscale, 2010, 2, 873-886
DOI: 10.1039/B9NR00430K
 
Yen Hsun Su, Sheng-Lung Tu, Shih-Wen Tseng, Yun-Chorng Chang, Shih-Hui Chang and Wei-Min Zhang, Nanoscale, 2010, 2, 2639-2646
DOI: 10.1039/C0NR00330A
 
Jiaguo Yu, Jiajie Fan and Kangle Lv, Nanoscale, 2010, 2, 2144-2149
DOI: 10.1039/C0NR00427H
 
Chae-kyu Kim, Partha Ghosh and Vincent M. Rotello, Nanoscale, 2009, 1, 61-67
DOI: 10.1039/B9NR00112C

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Merry Christmas from Nanoscale!

From the Nanoscale team, we would like to thank all our authors, Board members, readers and referees for your support. Nanoscale has quickly established itself as a platform for high-quality nanoscience and nanotechnology research, and that is all thanks to you!

For a ‘sneak peek’ of what’s happening for Nanoscale in 2011 (our 3rd Volume of publication!), take a look at our New Year Editorial.

You can be a part of our future success, submit your best research to Nanoscale!

Wishing you a Merry Christmas and all the best for the New Year!

The Nanoscale team

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Nanoscale article: Cutting edge chemistry in 2010

Cutting edge chemistry in 2010

Nanoparticles make leaves glow. Can street lights be replaced by trees?

Yen Hsun Su’s Nanoscale article about the use of gold nanoparticles to induce luminescence in leaves makes it to ChemistryWorld’s list Cutting edge chemistry in 2010.

The scientists from Taiwan created bio-LEDS by difussing into plant leaves gold nanoparticles shaped like sea urchins.

Read the paper today:

Influence of surface plasmon resonance on the emission intermittency of photoluminescence from gold nano-sea-urchins

Y. H. Su, S.-L. Tu, S.-W. Tseng, Y.-C. Chang, S.-H. Chang and W.-M. Zhang, Nanoscale, 2010, 2, 2639-2646

Check the discoveries that caused the biggest buzz in chemistry labs around the world in 2010. With the help of an expert panel of journal editors, Chemistry World reviews the ground breaking research and important trends in the year’s chemical science papers. Take a look today

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Top Ten most-read Nanoscale articles in October

The latest top ten most accessed Nanoscale articles

See the most-read papers of October 2010 here:

Rubén Mas-Ballesté, Cristina Gómez-Navarro, Julio Gómez-Herrero and Félix Zamora, Nanoscale, 2011, Advance Article
DOI: 10.1039/C0NR00323A
 
Benjamin Weintraub, Zhengzhi Zhou, Yinhua Li and Yulin Deng, Nanoscale, 2010, 2, 1573-1587
DOI: 10.1039/C0NR00047G
 
M. B. Avinash, K. S. Subrahmanyam, Y. Sundarayya and T. Govindaraju, Nanoscale, 2010, 2, 1762-1766
DOI: 10.1039/C0NR00024H
 
Wolfgang Schärtl, Nanoscale, 2010, 2, 829-843
DOI: 10.1039/C0NR00028K
 
Wufeng Chen and Lifeng Yan, Nanoscale, 2010, 2, 559-563
DOI: 10.1039/B9NR00191C
 
Poulomi Roy, Doohun Kim, Kiyoung Lee, Erdmann Spiecker and Patrik Schmuki, Nanoscale, 2010, 2, 45-59
DOI: 10.1039/B9NR00131J
 
Yugang Sun, Nanoscale, 2010, 2, 1626-1642
DOI: 10.1039/C0NR00258E
 
Idalia Bilecka and Markus Niederberger, Nanoscale, 2010, 2, 1358-1374
DOI: 10.1039/B9NR00377K
 
Hualan Wang, Qingli Hao, Xujie Yang, Lude Lu and Xin Wang, Nanoscale, 2010, Advance Article
DOI: 10.1039/C0NR00224K
 
Yinxi Huang, Xiaochen Dong, Yumeng Shi, Chang Ming Li, Lain-Jong Li and Peng Chen, Nanoscale, 2010, 2, 1485-1488
DOI: 10.1039/C0NR00142B
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Biomineralisation: Crystalline Calcium Carbonate

Tooth and claw

Biological structures such as teeth and bone are produced by a process called biomineralisation. The shape and structure of biominerals are controlled in an extremely precise way, from the nanoscale right up to the macroscopic level. The spontaneous formation of a tooth, claw, spine or shell is a truly amazing piece of chemistry, and unlocking the secrets of this could prove vital for materials scientists in their quest to engineer ever more complex nanostructures.

Biomineralisation of calcium carbonate

In  Nanoscale, we have recently published some papers on the formation of crystalline calcium carbonate (calcite) by biomineralisation. Yang et al., in their paper entitled ‘Biomineral nanoparticles are space filling’, present a study of biomineralisation in sea urchins, which contain spicules, spines and teeth (pictured left) all composed of calcium carbonate. They discuss the formation of crystalline biominerals through amorphous precursors, where one can imagine hydrated amorphous calcium carbonate nanoparticulate building blocks being able to flow and morph into the intricate shape of the final biomineral, followed by a period of dehydration and crystallization which forms the solid product. This process of dehydration and crystallization is discussed further by Rodriguez-Blanco et al., who used time-resolved X-ray diffraction in order to study the changes in crystal structure which occur when amorphous calcium carbonate crystallizes. They discovered that, under certain conditions, crystallization from the amorphous form to calcite occurs via another crystalline form, known as vaterite.

In November’s themed issue of Nanoscale, entitled Crystallization and Formation Mechanisms of Nanostructures, we published some other work on calcium biominarlisation, including studies of the formation and stability of amorphous calcium carbonate by Jiang et al. and Sommerdijk et al., and of calcium phosphate crystals by Mann et al., Taubert et al., Zhai et al., and Ibsen and Birkedal, which discussed the use of structure directing agents and organic additives to control crystal growth and morphology.

Papers like these are prime examples of how the study of natural processes can provide vital insight into the synthetic mechanisms which scientists are developing to produce new nanomaterials.

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Taking inspiration from the origin of life

On the origin of life

Professor Tony Ryan of the University of Sheffield visited the Royal Society of Chemistry in London to deliver a fascinating talk on Materials Chemistry and the Origin of Life. Professor Ryan described the origin of life in a ‘primordial soup’, fundamentally a mixture of organic building blocks such as sugars, fatty acids, amino acids and nucleotides, created by chemical reactions between methane, water, carbon dioxide and hydrogen cyanide (so the theory goes).

Watch the lecture now online: Materials Chemistry and the Origin of Life

Although it is not altogether clear how, from this soup sprung life, starting off as simple cells and eventually evolving into life as we know it today. Unimaginably complex molecules, structures, cells and organisms self-assemble from a simple list of ingredients, and give rise to the complex flora and fauna that is life on Earth. Professor Ryan went on to describe cell biology as ‘nanotechnology that works’, and indeed the internal workings of a cell are as a complex ‘nanosystem’ as we could ever hope to construct. He also discussed how, in his work, he has taken inspiration from the chemical basis of the ‘origin of life’, and used it directly in his materials chemistry research, a field which he refers to as ‘Soft Nanotechnology’.

From the bottom up

Current research in nanotechnology is striving towards heightened control and understanding of how to assemble complex and useful nanostructures. Just like the complex structures of living organisms self-assemble, we desire to be able to induce assembly of intricately designed and functional nanomaterials. In the decades since ‘bottom-up’ nanoparticle synthesis was pioneered, much attention has turned to the growth of anisotropic nanostructures. There has been a plethora of such structures reported in the literature, including tetrapods, wires, stars, nets and cages, amongst many others.

This month’s issue of Nanoscale, entitled ‘Crystallization and Formation Mechanisms of Nanostructures’, is a themed collection of papers which explore the various developments in solution-based crystal nucleation and growth mechanisms. In their editorial piece, Fiona Meldrum (University of Leeds, UK) and Helmut Cölfen (University of Konstanz, Germany) describe the synthesis of crystalline nanomaterials with well-defined sizes, morphologies and hierarchical structures as “one of the grand challenges of nanoscience and nanotechnology today”, but qualify this statement by explaining that “understanding of how these structures develop remains poor”. However, the works collected in this themed issue represent the state-of-the-art in our understanding of this field, and clearly illustrate that significant progress is being made in this fascinating, and fundamentally important, branch of science.

Meldrum and Cölfen go on to say that “it is also valuable to draw parallels between synthetic crystals, and their formation mechanisms, and crystals precipitated under biological control, namely biomaterials such as bones, teeth and seashells”. Again, inspiration can be taken from the complexity and beauty of these natural structures and used to shed further light on our studies in nanomaterial synthesis. The best efforts of synthetic chemists to control the growth, size and shape of nanomaterials pale in comparison with what occurs naturally in all living organisms. However, as we can presume we have only scratched the surface of possibilities here, one can anticipate that there remain many exciting discoveries and developments in this field of research.

Read the Nanoscale themed issue today for free: ‘Crystallization and Formation Mechanisms of Nanostructures

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Nanoparticles make leaves glow

glowing leavesCan street lights be replaced by trees? Taiwanese scientists believe that they can using gold nanoparticles to induce luminescence in leaves.

Yen Hsun Su and coworkers at Academia Sinica and the National Cheng Kung University in Taipei and Tainan have tackled this problem by synthesising gold nanoparticles shaped like sea urchins and diffusing them into plant leaves to create bio-LEDs.

Yuandi Li

Read this exciting Nanoscale paper today:
Influence of surface plasmon resonance on the emission intermittency of photoluminescence from gold nano-sea-urchins
Y. H. Su, S.-L. Tu, S.-W. Tseng, Y.-C. Chang, S.-H. Chang and W.-M. Zhang, Nanoscale, 2010
DOI: 10.1039/C0NR00330A

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New Advisory Board member for Nanoscale

We welcome our newest Advisory Board member, Professor Hong-Bo Sun from Jilin University.

Hong-Bo Sun obtained BS and PhD degrees in electronics from Jilin University. After spending some time in Japan, he returned to Jilin University to become a full professor in 2005.

His research in the passed 10 years has been focused on laser micro-nanofabrication, particularly in exploring novel laser technologies including direct writing and holographic lithography, as well as their applications on microoptics, micromachines, microfluids, and microsensors.

Become a fan of Nanoscale on Facebook or follow us on Twitter

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We welcome Wei Lu to our Editorial Board

Nanoscale is pleased to announce the appointment of a new co-Editor-in-Chief, Professor Wei Lu.

Wei Lu graduated in physics from Tsinghua University, Beijing, China, from where he moved to Houston, Texas to obtain a PhD from Rice University.

He is currently an Assistant Professor in Electrical Engineering and Computer Science, at the University of Michigan. His research interest lies in the application and fundamental understanding of nanostructures and nanodevices, including high-density memory and logic devices based on two-terminal resistive switches (memristors), and semiconductor nanowire based electronics.

Professor Lu will join Professors Bai, Niederberger, Stellacci and Wang in handling Nanoscale submissions. Welcome!



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