Archive for the ‘Nanoscale’ Category

New method to target malaria: Nanoscale article in Chemistry World

Malaria is a highly infectious and potentially fatal mosquito-borne disease. It affects millions of people each year; however, no effective vaccines exist. Now, scientists from Spain have discovered a new strategy to target the disease.

Plasmodium falciparum, the most deadly species of malaria parasite, infects red blood cells (RBCs) and changes their structure. The infected RBCs then bind to the walls of blood vessels in tissues, such as the brain and lungs, through a phenomenon known as sequestration. This allows the malaria parasites to replicate. Infected RBCs can also bind to non-infected RBCs, forming clumps known as rosettes, which narrows the blood vessels and can be fatal. The formation of rosettes is thought to be mediated by a protein called PfEMP1, which is expressed at the surface of infected RBCs. So, disrupting the activity of this protein could help prevent rosette formation and the onset of severe malaria.

Red blood cells infected with the malaria parasite can clump together and cause deadly blockages © Shutterstock

Interested to know more? Read the full article in Chemistry World here…

Read the article from Nanoscale:

Demonstration of specific binding of heparin to Plasmodium falciparum-infected vs. non-infected red blood cells by single-molecule force spectroscopy

Juan José Valle-Delgado ,  Patricia Urbán and Xavier Fernàndez-Busquets
Nanoscale, 2013, Advance Article
DOI: 10.1039/C2NR32821F

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Magnetic nanoparticles show potential use as gene delivery vehicles

Researchers from the Chinese Academy of Sciences have developed a potential magnetic resonance imaging (MRI) gene delivery vehicle by functionalising superparamagnetic iron oxide (SPIO) nanoparticles with an amphiphilic stearic acid-modified gene transfection agent, polyethylenimine (PEI).

The stearic acid-PEI conjugates were used to form clusters of SPIO nanoparticles via self-assembly.  The stearic acid-PEI-SPIO nanocomplexes were employed as MRI contrast agents and displayed an imaging sensitivity limit of 1.5 µg ml-1 Fe, which is essential for effective molecular imaging applications.  The authors demonstrated that the nanoparticle conjugates could be used to effectively shield minicircle (mc) DNA from enzymatic degradation, with transefected MCF-7 cells revealing increased luciferase expression with minimal cytotoxicity.  The magnetic nanoparticle conjugates show potential use in nanomedicine for non-invasive MRI gene delivery.

By Dr Lee Barrett

Read this Nanoscale article in full today:

Self-assembled magnetic theranostic nanoparticles for highly sensitive MRI of minicircle DNA delivery
Qian Wan, Lisi Xie, Lin Gao, Zhiyong Wang, Xiang Nan, Hulong Lei, Xiaojing Long, Zhi-Ying Chen, Cheng-Yi He, Gang Liu, Xin Liu and Bensheng Qiu
DOI: 10.1039/C2NR32438E

Scheme showing: cell with nanoparticle + minicircle DNA and Gene delivery goes to MR imaging and Gene expression

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Bactericides reach new depths: Nanoscale article in Chemistry World

P. aeruginosa: (A) without treatment; treated with (B) bismuth nanoparticles; (C) x-rays; (D) x-rays and bismuth nanoparticles

Scientists in the US and China have come up with a low-risk treatment for bacterial infections in a deep wound.

Treating infections has long been a challenge for healthcare professionals, and infections caused by drug resistant bacteria have made this task even more difficult to manage. Recently, the genome of an MRSA (methicillin-resistant Staphylococcus aureus) outbreak in a hospital was sequenced to identify the source of infection, track its spread and avoid an outbreak.1 Such extreme measures of tracing infection need an equally tough bactericide. X-ray irradiation is known to have bactericidal properties; however, the high doses needed and the associated risks have restricted its use in vivo.

Interested to know more? Read the full article in Chemistry World here…

Read the article from Nanoscale:

Targeted nanoparticles for enhanced X-ray radiation killing of multidrug-resistant bacteria
Yang Luo,  Mainul Hossain,  Chaoming Wang,  Yong Qiao,  Jincui An,  Liyuan Ma and Ming Su
Nanoscale, 2012, Accepted Manuscript
DOI: 10.1039/C2NR33154C

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Functionalised graphene nanosheets with excellent solubility and stability

Functionalised graphene nanosheets have been produced in a green, fast and controllable method by scientists in China. The team used aqueous polycation electrolyte branch poly(ethylenimine) as both a stabiliser and a reducing agent to make the graphene nanosheets, which displayed high solubility and long-term stability in aqueous solution.

The nanosheets did not aggregate and they could be dispersed in aqueous solutions, alkaline solutions, salt solutions and organic solvents. The nanosheets can be used as effective and controllable building templates for applications in various fields, they say.

Read this HOT research in Nanoscale today:


Highly concentrated polycations-functionalized graphene nanosheets with excellent solubility and stability, and its fast,facile and controllable assembly of multiple nanoparticles

Zhaozi Lv, Xuan Yang and Erkang Wang
DOI: 10.1039/C2NR33395C

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Incorporating diatoms in DSSCs leads to 30% improvement in energy conversion efficiency

Diatoms are photosynthetic microorganisms, found in marine and fresh water environments, which possess a porous silica exoskeleton called a frustule. Scientists in Australia and Canada coated the frustule with titanium dioxide nanoparticles – well known for their light harvesting properties – and incorporated the resulting material into dye sensitised solar cells (DSSCs). The DSSCs containing the frustules showed an efficiency increase of 30% compared to the titania coating alone, which the authors attribute to enhanced light scattering and trapping. The synthetic procedure is also inexpensive and simple.

Read the full details of this exciting Nanoscale communication today:

Diatom frustules as light traps enhance DSSC efficiency
Jeremiah Toster, K. Swaminathan Iyer, Wanchun Xiang, Federico Rosei, Leone Spiccia and Colin L. Raston
DOI: 10.1039/C2NR32716C

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Oil loving membranes for oil spill clean-ups: Nanoscale article in Chemistry World

Researchers in China have made a new type of membrane that can separate oil from water and could potentially be used in oil spills, such as the one in the Gulf of Mexico. The membrane works by interacting differently with the substances as it is both superhydrophobic and superoleophilic, so that it repels water but attracts oil. This means that the oil is absorbed through the membrane, but the water can’t penetrate.

Oil and water separation using the membrane. The water and oil were dyed by methyl blue and oil red, respectively

The membrane is made from a polymerised fluorinated polybenzoxazine (F-PBZ) layer on top of cellulose acetate nanofibres. The scientists used an electrospinning technique (in which a viscous liquid is passed through a conducting needle to form a thread) to create a porous structure that makes the membrane even better at absorbing the oil.

Interested to know more? Read the full article in Chemistry World here…

Read the article from Nanoscale:

In situ polymerization approach to the synthesis of superhydrophobic and superoleophilic nanofibrous membranes for oil/water separation
Yanwei Shang ,  Yang Si ,  Aikifa Raza ,  Liping Yang ,  Xue Mao ,  Bin Ding and Jianyong Yu
Nanoscale, 2012, Accepted Manuscript
DOI: 10.1039/C2NR33063F

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Smaller, more affordable scaffold to open up new possibilities for DNA origami

Folding DNA to make new nanoscale shapes – so called DNA origami – has potential applications including in drug delivery and immobilising enzymes. The 7249 nucleotide-long M13mp18 strand is frequently used in DNA origami, but it is expensive, its long length makes it more prone to strand cleavage and it can be difficult to analyse on the molecular level.

Scientists in Germany have come up with a convenient method for making a 704 nucleotide-long fragment, which is suitable for making small origami structures, is large enough to analyse by TEM and is more affordable.

Read this HOT Nanoscale article in full today:

M1.3 – A Small Scaffold for DNA Origami
Clemens Richert, Hassan Said, Verena Schüller, Fabian Eber, Christina Wege and Tim Liedl
DOI: 10.1039/C2NR32393A

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Hybrid assemblies with switchable luminescence – potential LED materials

Table of contents imageResearchers based at the Chinese Academy of Sciences have prepared a  composite electrode of organic–inorganic polymers and Pyronin Y-doped silica nanoparticles, which was coated with poly (3,4-ethylenedioxythiophene) (PEDOT), in the presence of phosphododecamolybdic acid (PMo12).

The fluoresence of the nanoparticles can be switched on and off in aqueous solution by oxidation and reduction of the PEDOT, with fast colouration and bleaching of the film.

The materials have potential applications in organic LEDs and other photoelectric devices.

Reversible electroswitchable luminescence in thin films of organic–inorganic hybrid assemblies
Yanling Zhai, Lihua Jin, Chengzhou Zhu, Peng Hu, Lei Han, Erkang Wang and Shaojun Dong
DOI: 10.1039/C2NR32623J

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Nanoscale article idea to benefit from RSC support of Marblar

Marblar logoThe RSC has teamed up with an Oxford University spin-out to sponsor six challenges on Marblar – a radical new online platform for finding applications for unused scientific discoveries.

More than 95% of technologies developed in universities never make it to market, leaving publicly or philanthropy-funded research collecting dust on the shelf.  Often, given that academic research can be so ahead of its time, the commercial relevance of these technologies isn’t immediately obvious.

Marblar aims to remove this bottleneck by crowdsourcing ideas for real-world applications from the global science and technology community, with the ultimate goal to create new products and new companies that will drive job creation around these innovative discoveries.

One of the projects to be selected is based on an article in Nanoscale: Take Two is an exciting new technique developed by Dr Sergio Bertazzo in Professor Molly Stevens’ lab at Imperial College London. It enables bioengineers to study interactions between cells and biomaterials by combining two forms of microscopy in an innovative way.

You can find more details on the Marblar website and read the Nanoscale article for free by following the link below:

Correlative light-ion microscopy for biological applications
Sergio Bertazzo, Thomas von Erlach, Silvia Goldoni, Pelin L Çandarlıoğlu and Molly M Stevens
DOI: 10.1039/C2NR30431G

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Hot graphene research in Nanoscale

Nanoscale journal cover imageWe would like to share with you some recent high impact graphene articles, published in Nanoscale.

Photo of Andrea Ferrari

Graphene expert and Nanoscale Editorial Board member Prof. Andrea Ferrari

With an international readership, across the many disciplines involved with nanoscience and nanotechnology and a first (2011) Impact Factor of 5.91, Nanoscale is the ideal place to publish your research.

Nanoscale has very fast times to publication. Our Accepted Manuscript service means research is published and can be cited on average within 1 day of acceptance – we invite you to submit your best research to Nanoscale.

Sign up to receive our free table-of-contents e-alert at www.rsc.org/alerts and be among the first to read our newest articles.

Read this high-impact graphene research today:

Review Articles

Graphene transfer: key for applications
Junmo Kang, Dolly Shin, Sukang Bae and Byung Hee Hong
DOI: 10.1039/C2NR31317K

Graphene edges: a review of their fabrication and characterization
Xiaoting Jia, Jessica Campos-Delgado, Mauricio Terrones, Vincent Meunier and Mildred S. Dresselhaus
DOI: 10.1039/C0NR00600A

Graphene: a versatile nanoplatform for biomedical applications
Yin Zhang, Tapas R. Nayak, Hao Hong and Weibo Cai
DOI: 10.1039/C2NR31040F

Modeling of graphene nanoribbon devices
Jing Guo
DOI: 10.1039/C2NR31437A

Original research

Percolation scaling in composites of exfoliated MoS2 filled with nanotubes and graphene
Graeme Cunningham, Mustafa Lotya, Niall McEvoy, Georg S. Duesberg, Paul van der Schoot and Jonathan N. Coleman
DOI: 10.1039/C2NR31782F

Flexible photovoltaic cells based on a graphene–CdSe quantum dot nanocomposite
Jing Chen, Feng Xu, Jun Wu, Khan Qasim, Yidan Zhou, Wei Lei, Li-Tao Sun and Yan Zhang
DOI: 10.1039/C2NR11656A

Facile synthesis of metal oxide/reduced graphene oxide hybrids with high lithium storage capacity and stable cyclability
Jixin Zhu, Ting Zhu, Xiaozhu Zhou, Yanyan Zhang, Xiong Wen Lou, Xiaodong Chen, Hua Zhang, Huey Hoon Hng and Qingyu Yan
DOI: 10.1039/C0NR00744G

Graphene based gene transfection
Liangzhu Feng, Shuai Zhang and Zhuang Liu
DOI: 10.1039/C0NR00680G

Real-time DNA detection using Pt nanoparticle-decorated reduced graphene oxide field-effect transistors
Zongyou Yin, Qiyuan He, Xiao Huang, Juan Zhang, Shixin Wu, Peng Chen, Gang Lu, Peng Chen, Qichun Zhang, Qingyu Yan and Hua Zhang
DOI: 10.1039/C1NR11149C

Surface plasmon resonance-induced visible light photocatalytic reduction of graphene oxide: Using Ag nanoparticles as a plasmonic photocatalyst
Tongshun Wu, Sen Liu, Yonglan Luo, Wenbo Lu, Lei Wang and Xuping Sun
DOI: 10.1039/C1NR10128E

In situ synthesis of high-loading Li4Ti5O12–graphene hybrid nanostructures for high rate lithium ion batteries
Laifa Shen, Changzhou Yuan, Hongjun Luo, Xiaogang Zhang, Sudong Yang and Xiangjun Lu
DOI: 10.1039/C0NR00639D

Graphene decoration with metal nanoparticles: Towards easy integration for sensing applications
Albert Gutés, Ben Hsia, Allen Sussman, Willi Mickelson, Alex Zettl, Carlo Carraro and Roya Maboudian
DOI: 10.1039/C1NR11537E

Enhanced photocatalytic H2-production activity of graphene-modified titania nanosheets
Quanjun Xiang, Jiaguo Yu and Mietek Jaroniec
DOI: 10.1039/C1NR10610D

Highly dispersed ultrafine Pt and PtRu nanoparticles on graphene: formation mechanism and electrocatalytic activity
C. Nethravathi, E. A. Anumol, M. Rajamathi and N. Ravishankar
DOI: 10.1039/C0NR00664E

Fabrication of hybrids based on graphene and metal nanoparticles by in situ and self-assembled methods
Fu-An He, Jin-Tu Fan, Fei Song, Li-Ming Zhang and Helen Lai-Wa Chan
DOI: 10.1039/C0NR00672F

Controlled assembly of Fe3O4 magnetic nanoparticles on graphene oxide
Yi Zhang, Biao Chen, Liming Zhang, Jie Huang, Fenghua Chen, Zupei Yang, Jianlin Yao and Zhijun Zhang
DOI: 10.1039/C0NR00776E

Synthesis of reduced graphene oxide-anatase TiO2 nanocomposite and its improved photo-induced charge transfer properties
Ping Wang, Yueming Zhai, Dejun Wang and Shaojun Dong
DOI: 10.1039/C0NR00714E

Check out our previous collection of graphene reviews and our graphene web collection for even more fascinating articles in this exciting research area.

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